Incidental Mutation 'R5381:Dctd'
ID 424723
Institutional Source Beutler Lab
Gene Symbol Dctd
Ensembl Gene ENSMUSG00000031562
Gene Name dCMP deaminase
Synonyms 6030466N05Rik
MMRRC Submission 042956-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5381 (G1)
Quality Score 194
Status Validated
Chromosome 8
Chromosomal Location 48552127-48594702 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to T at 48590449 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033966] [ENSMUST00000170263] [ENSMUST00000174278] [ENSMUST00000174379] [ENSMUST00000174818]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000033966
SMART Domains Protein: ENSMUSP00000033966
Gene: ENSMUSG00000031562

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 135 5e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098773
Predicted Effect probably benign
Transcript: ENSMUST00000170263
SMART Domains Protein: ENSMUSP00000126733
Gene: ENSMUSG00000031562

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 135 1.2e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173991
Predicted Effect probably benign
Transcript: ENSMUST00000174278
SMART Domains Protein: ENSMUSP00000133445
Gene: ENSMUSG00000031562

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 135 1.2e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174379
SMART Domains Protein: ENSMUSP00000134195
Gene: ENSMUSG00000031562

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 103 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174818
SMART Domains Protein: ENSMUSP00000134003
Gene: ENSMUSG00000031562

DomainStartEndE-ValueType
Pfam:dCMP_cyt_deam_1 19 131 1.5e-27 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700086D15Rik G T 11: 65,044,137 (GRCm39) S19* probably null Het
4930432E11Rik A T 7: 29,262,393 (GRCm39) noncoding transcript Het
Acvr1c T C 2: 58,177,747 (GRCm39) T241A probably damaging Het
Ankmy1 T C 1: 92,804,284 (GRCm39) T900A probably benign Het
Anp32a A C 9: 62,279,459 (GRCm39) E107A probably damaging Het
Arhgef40 T C 14: 52,229,306 (GRCm39) I623T probably damaging Het
Camsap3 T A 8: 3,653,812 (GRCm39) I483N probably damaging Het
Card9 G A 2: 26,248,895 (GRCm39) L85F probably damaging Het
Cbfa2t2 T G 2: 154,365,849 (GRCm39) V353G probably damaging Het
Ccdc166 A T 15: 75,852,701 (GRCm39) L422* probably null Het
Ccdc198 T C 14: 49,470,364 (GRCm39) D185G probably damaging Het
Ccdc73 A T 2: 104,820,270 (GRCm39) N416Y probably damaging Het
Celsr2 A T 3: 108,310,073 (GRCm39) D1552E probably damaging Het
Ces1b A T 8: 93,791,647 (GRCm39) N317K probably benign Het
Col6a3 T C 1: 90,703,334 (GRCm39) R2471G unknown Het
Crocc C T 4: 140,756,622 (GRCm39) R1165H possibly damaging Het
Csmd3 T A 15: 47,604,611 (GRCm39) Y1955F probably benign Het
Ctbp1 A T 5: 33,407,034 (GRCm39) D232E probably benign Het
Cuedc1 T A 11: 88,078,812 (GRCm39) probably null Het
Dusp6 G A 10: 99,102,129 (GRCm39) V226I possibly damaging Het
Gpr152 A G 19: 4,192,516 (GRCm39) E19G probably damaging Het
Ighv16-1 T C 12: 114,032,593 (GRCm39) T70A probably benign Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Il12b C A 11: 44,298,699 (GRCm39) D51E possibly damaging Het
Il9r T G 11: 32,140,715 (GRCm39) D435A probably benign Het
Jakmip2 T C 18: 43,715,025 (GRCm39) D167G probably damaging Het
Klrd1 A G 6: 129,572,397 (GRCm39) D63G possibly damaging Het
Lactb A G 9: 66,863,297 (GRCm39) L439P probably damaging Het
Laptm5 T C 4: 130,660,969 (GRCm39) probably benign Het
Lgals1 A G 15: 78,814,223 (GRCm39) D96G probably benign Het
Lrp8 A T 4: 107,726,307 (GRCm39) H871L probably damaging Het
Mfap4 A T 11: 61,378,756 (GRCm39) I235F probably benign Het
Muc6 G A 7: 141,217,836 (GRCm39) T2279I possibly damaging Het
Nlrp4b T A 7: 10,449,172 (GRCm39) Y91* probably null Het
Osbp2 A G 11: 3,655,593 (GRCm39) Y383H probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Palb2 G T 7: 121,727,636 (GRCm39) T78K probably benign Het
Panx2 G T 15: 88,944,433 (GRCm39) V53L probably damaging Het
Pip4p1 T C 14: 51,166,495 (GRCm39) E161G probably benign Het
Pitx1 T C 13: 55,973,892 (GRCm39) Y313C probably damaging Het
Pjvk A G 2: 76,481,904 (GRCm39) probably null Het
Pnldc1 T G 17: 13,109,283 (GRCm39) K439T probably benign Het
Ppp4r4 A C 12: 103,559,357 (GRCm39) T513P probably benign Het
Pram1 A T 17: 33,860,600 (GRCm39) Q389L probably damaging Het
Prg4 T C 1: 150,330,204 (GRCm39) probably benign Het
Prkch C A 12: 73,738,366 (GRCm39) R158S probably damaging Het
Ptpn7 A T 1: 135,070,906 (GRCm39) M332L probably damaging Het
Rad51c A T 11: 87,288,459 (GRCm39) D241E probably benign Het
Rara T G 11: 98,862,410 (GRCm39) I270M possibly damaging Het
Ryr2 T A 13: 11,571,544 (GRCm39) D4898V probably damaging Het
Sec31b C T 19: 44,522,810 (GRCm39) G218S probably damaging Het
Slc9a1 T A 4: 133,149,382 (GRCm39) L736Q probably damaging Het
Slco2a1 A T 9: 102,945,213 (GRCm39) D196V probably damaging Het
Sp3 C A 2: 72,800,910 (GRCm39) A368S probably benign Het
Stk24 A T 14: 121,531,645 (GRCm39) L337Q possibly damaging Het
Tbc1d13 A G 2: 30,027,379 (GRCm39) T96A probably benign Het
Tm2d3 G A 7: 65,351,420 (GRCm39) G225S probably damaging Het
Urb2 T C 8: 124,756,651 (GRCm39) V786A probably benign Het
Usp32 C T 11: 84,949,953 (GRCm39) probably benign Het
Usp54 C T 14: 20,636,144 (GRCm39) G300D probably damaging Het
Vmn1r124 T A 7: 20,994,323 (GRCm39) N74Y probably damaging Het
Vmn1r77 T A 7: 11,775,952 (GRCm39) C175S probably damaging Het
Vmn2r62 G T 7: 42,437,219 (GRCm39) Q422K probably benign Het
Vmn2r76 A G 7: 85,874,496 (GRCm39) F827S probably damaging Het
Vps52 A G 17: 34,177,275 (GRCm39) S106G possibly damaging Het
Zdhhc1 CGGGGG CGGGGGG 8: 106,210,376 (GRCm39) probably null Het
Zic2 A G 14: 122,713,227 (GRCm39) N47S probably damaging Het
Other mutations in Dctd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01912:Dctd APN 8 48,564,697 (GRCm39) start gained probably benign
R0194:Dctd UTSW 8 48,565,113 (GRCm39) missense probably benign 0.01
R4871:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R5007:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R5008:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R5009:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R5010:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R5083:Dctd UTSW 8 48,564,751 (GRCm39) missense probably damaging 1.00
R5382:Dctd UTSW 8 48,590,449 (GRCm39) intron probably benign
R7131:Dctd UTSW 8 48,565,075 (GRCm39) missense probably benign 0.02
R8152:Dctd UTSW 8 48,564,725 (GRCm39) missense probably benign
R8693:Dctd UTSW 8 48,565,046 (GRCm39) missense probably damaging 1.00
R8739:Dctd UTSW 8 48,591,883 (GRCm39) missense probably benign 0.00
R9009:Dctd UTSW 8 48,564,712 (GRCm39) missense probably benign
R9408:Dctd UTSW 8 48,590,385 (GRCm39) missense probably damaging 1.00
X0057:Dctd UTSW 8 48,593,395 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTCCAAGGTGGTGACAGAAATAC -3'
(R):5'- CAATTAAGTCTCGGAATACCTGGC -3'

Sequencing Primer
(F):5'- TTCATGAGCTACAGTCCAAGTC -3'
(R):5'- GTCTCGGAATACCTGGCACCAC -3'
Posted On 2016-08-04