Incidental Mutation 'R5386:Dchs1'
| ID |
425222 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dchs1
|
| Ensembl Gene |
ENSMUSG00000036862 |
| Gene Name |
dachsous cadherin related 1 |
| Synonyms |
C130033F22Rik, 3110041P15Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5386 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
105402197-105436861 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 105407236 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 2119
(V2119G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077574
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078482]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000078482
AA Change: V2119G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: V2119G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
36 |
N/A |
INTRINSIC |
|
CA
|
58 |
135 |
5.2e-11 |
SMART |
|
CA
|
159 |
247 |
6.1e-17 |
SMART |
|
CA
|
271 |
354 |
2.6e-30 |
SMART |
|
CA
|
382 |
464 |
7.8e-26 |
SMART |
|
CA
|
489 |
570 |
1.2e-34 |
SMART |
|
CA
|
594 |
677 |
1.9e-27 |
SMART |
|
CA
|
701 |
782 |
5.3e-11 |
SMART |
|
CA
|
806 |
886 |
1e-12 |
SMART |
|
CA
|
910 |
990 |
3.3e-14 |
SMART |
|
CA
|
1016 |
1097 |
3.6e-18 |
SMART |
|
CA
|
1121 |
1203 |
3.1e-34 |
SMART |
|
CA
|
1233 |
1307 |
8.8e-16 |
SMART |
|
low complexity region
|
1323 |
1335 |
N/A |
INTRINSIC |
|
CA
|
1344 |
1427 |
9.9e-9 |
SMART |
|
CA
|
1451 |
1537 |
1.5e-23 |
SMART |
|
CA
|
1560 |
1640 |
7.2e-32 |
SMART |
|
CA
|
1664 |
1742 |
1.8e-31 |
SMART |
|
CA
|
1765 |
1846 |
7.8e-30 |
SMART |
|
CA
|
1870 |
1951 |
3.7e-26 |
SMART |
|
low complexity region
|
1957 |
1965 |
N/A |
INTRINSIC |
|
CA
|
1979 |
2059 |
1.1e-6 |
SMART |
|
CA
|
2083 |
2162 |
2.7e-18 |
SMART |
|
CA
|
2186 |
2268 |
2.2e-26 |
SMART |
|
CA
|
2291 |
2367 |
1e-18 |
SMART |
|
CA
|
2391 |
2473 |
1.8e-23 |
SMART |
|
CA
|
2497 |
2593 |
3.5e-21 |
SMART |
|
CA
|
2617 |
2697 |
1.2e-25 |
SMART |
|
CA
|
2721 |
2804 |
1.9e-18 |
SMART |
|
CA
|
2828 |
2919 |
3e-3 |
SMART |
|
transmembrane domain
|
2932 |
2954 |
N/A |
INTRINSIC |
|
low complexity region
|
3001 |
3017 |
N/A |
INTRINSIC |
|
low complexity region
|
3046 |
3055 |
N/A |
INTRINSIC |
|
low complexity region
|
3088 |
3097 |
N/A |
INTRINSIC |
|
low complexity region
|
3185 |
3196 |
N/A |
INTRINSIC |
|
low complexity region
|
3237 |
3259 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131504
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140959
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 134 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc12 |
T |
G |
8: 87,244,118 (GRCm39) |
K1012Q |
possibly damaging |
Het |
| Afmid |
G |
A |
11: 117,718,968 (GRCm39) |
G33R |
probably benign |
Het |
| Agbl3 |
G |
T |
6: 34,776,131 (GRCm39) |
W207C |
probably damaging |
Het |
| Ajuba |
T |
C |
14: 54,807,855 (GRCm39) |
Y459C |
probably damaging |
Het |
| Ak2 |
T |
C |
4: 128,901,965 (GRCm39) |
S213P |
probably benign |
Het |
| Alk |
T |
A |
17: 72,182,007 (GRCm39) |
N1339Y |
probably damaging |
Het |
| Angpt1 |
T |
C |
15: 42,301,761 (GRCm39) |
S416G |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,775,582 (GRCm39) |
V854M |
probably benign |
Het |
| Ankrd61 |
G |
T |
5: 143,828,482 (GRCm39) |
N122K |
possibly damaging |
Het |
| Armc9 |
T |
A |
1: 86,126,011 (GRCm39) |
L34Q |
probably null |
Het |
| Aspg |
T |
A |
12: 112,089,466 (GRCm39) |
V418E |
probably benign |
Het |
| Baz1b |
C |
T |
5: 135,266,913 (GRCm39) |
R1241C |
probably damaging |
Het |
| Bclaf1 |
T |
C |
10: 20,201,338 (GRCm39) |
V201A |
possibly damaging |
Het |
| C1ql3 |
A |
T |
2: 13,009,169 (GRCm39) |
D225E |
probably damaging |
Het |
| Capn9 |
A |
G |
8: 125,332,279 (GRCm39) |
T417A |
possibly damaging |
Het |
| Card14 |
C |
T |
11: 119,208,115 (GRCm39) |
R62C |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,887,383 (GRCm39) |
N1271S |
probably benign |
Het |
| Ccpg1 |
G |
A |
9: 72,920,326 (GRCm39) |
S647N |
probably benign |
Het |
| Cdv3 |
T |
C |
9: 103,232,429 (GRCm39) |
K133R |
possibly damaging |
Het |
| Cep128 |
A |
C |
12: 90,966,345 (GRCm39) |
S1087R |
probably benign |
Het |
| Cep70 |
T |
A |
9: 99,163,128 (GRCm39) |
L325Q |
probably damaging |
Het |
| Chit1 |
T |
G |
1: 134,077,192 (GRCm39) |
F332V |
probably damaging |
Het |
| Chodl |
C |
A |
16: 78,743,585 (GRCm39) |
T219K |
probably damaging |
Het |
| Cntn4 |
T |
C |
6: 106,158,765 (GRCm39) |
L10P |
possibly damaging |
Het |
| Copg1 |
G |
T |
6: 87,867,189 (GRCm39) |
M87I |
possibly damaging |
Het |
| Cplane1 |
G |
A |
15: 8,223,897 (GRCm39) |
G887R |
probably damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,022,578 (GRCm39) |
Y28C |
probably benign |
Het |
| Dedd |
T |
C |
1: 171,165,951 (GRCm39) |
L23P |
probably damaging |
Het |
| Dmxl2 |
A |
G |
9: 54,286,041 (GRCm39) |
S2715P |
probably benign |
Het |
| Dnah9 |
T |
C |
11: 65,920,182 (GRCm39) |
N2237S |
probably damaging |
Het |
| Drosha |
A |
G |
15: 12,842,207 (GRCm39) |
I337V |
probably benign |
Het |
| Duox2 |
A |
G |
2: 122,125,617 (GRCm39) |
V330A |
probably benign |
Het |
| Dusp11 |
T |
C |
6: 85,924,587 (GRCm39) |
*322W |
probably null |
Het |
| Dusp8 |
T |
A |
7: 141,643,730 (GRCm39) |
Q61L |
possibly damaging |
Het |
| Ears2 |
G |
C |
7: 121,643,600 (GRCm39) |
T426S |
probably benign |
Het |
| Elmo1 |
T |
C |
13: 20,784,380 (GRCm39) |
Y646H |
probably benign |
Het |
| Eps15 |
T |
A |
4: 109,178,422 (GRCm39) |
I220K |
possibly damaging |
Het |
| Faap100 |
T |
A |
11: 120,268,458 (GRCm39) |
E105V |
possibly damaging |
Het |
| Fam171a2 |
C |
A |
11: 102,328,693 (GRCm39) |
V689L |
possibly damaging |
Het |
| Fam91a1 |
G |
A |
15: 58,320,243 (GRCm39) |
S645N |
probably benign |
Het |
| Fancg |
G |
A |
4: 43,007,076 (GRCm39) |
Q234* |
probably null |
Het |
| Garre1 |
A |
G |
7: 33,941,813 (GRCm39) |
F120L |
probably damaging |
Het |
| Gid4 |
T |
A |
11: 60,323,268 (GRCm39) |
|
probably null |
Het |
| Gm7361 |
A |
C |
5: 26,463,903 (GRCm39) |
T53P |
probably benign |
Het |
| Golgb1 |
T |
A |
16: 36,732,677 (GRCm39) |
C641* |
probably null |
Het |
| Gon4l |
T |
A |
3: 88,765,803 (GRCm39) |
M409K |
probably benign |
Het |
| Gpatch8 |
A |
T |
11: 102,399,053 (GRCm39) |
|
probably null |
Het |
| Gpr156 |
T |
A |
16: 37,768,671 (GRCm39) |
V64E |
possibly damaging |
Het |
| Grid2 |
T |
A |
6: 63,908,089 (GRCm39) |
I243K |
probably damaging |
Het |
| Gucy2g |
G |
A |
19: 55,203,548 (GRCm39) |
A750V |
probably damaging |
Het |
| Hdac5 |
T |
C |
11: 102,092,967 (GRCm39) |
E590G |
possibly damaging |
Het |
| Herc3 |
T |
A |
6: 58,851,263 (GRCm39) |
M504K |
probably damaging |
Het |
| Hif1a |
A |
G |
12: 73,990,867 (GRCm39) |
E713G |
probably benign |
Het |
| Hmx3 |
A |
G |
7: 131,146,033 (GRCm39) |
D247G |
probably damaging |
Het |
| Hoxd11 |
G |
T |
2: 74,513,163 (GRCm39) |
E143* |
probably null |
Het |
| Ifitm3 |
T |
C |
7: 140,590,554 (GRCm39) |
N2S |
probably benign |
Het |
| Il17f |
T |
C |
1: 20,848,181 (GRCm39) |
Q99R |
probably benign |
Het |
| Itga6 |
T |
A |
2: 71,671,494 (GRCm39) |
S341R |
probably damaging |
Het |
| Itgam |
A |
G |
7: 127,707,152 (GRCm39) |
N661S |
probably benign |
Het |
| Jag1 |
A |
T |
2: 136,937,464 (GRCm39) |
H303Q |
possibly damaging |
Het |
| Kcnh8 |
T |
A |
17: 53,033,023 (GRCm39) |
N103K |
probably benign |
Het |
| Kdm6b |
T |
C |
11: 69,291,636 (GRCm39) |
|
probably benign |
Het |
| Keg1 |
A |
C |
19: 12,691,902 (GRCm39) |
N63T |
probably damaging |
Het |
| Klf12 |
T |
A |
14: 100,137,595 (GRCm39) |
H317L |
probably damaging |
Het |
| Lrp1 |
A |
T |
10: 127,427,983 (GRCm39) |
V530E |
probably damaging |
Het |
| Mrgpra6 |
A |
G |
7: 46,838,629 (GRCm39) |
C190R |
probably damaging |
Het |
| Myo1a |
G |
T |
10: 127,541,766 (GRCm39) |
E102* |
probably null |
Het |
| Napa |
A |
T |
7: 15,850,397 (GRCm39) |
E265D |
probably benign |
Het |
| Ncam1 |
A |
C |
9: 49,476,174 (GRCm39) |
V305G |
probably damaging |
Het |
| Nek8 |
T |
C |
11: 78,061,263 (GRCm39) |
|
probably null |
Het |
| Or10ag53 |
C |
T |
2: 87,082,827 (GRCm39) |
P182L |
probably benign |
Het |
| Or11g24 |
T |
A |
14: 50,662,846 (GRCm39) |
V290E |
possibly damaging |
Het |
| Or4a70 |
G |
T |
2: 89,324,481 (GRCm39) |
Y58* |
probably null |
Het |
| Or4f52 |
T |
C |
2: 111,061,539 (GRCm39) |
T200A |
probably benign |
Het |
| Or52a20 |
T |
C |
7: 103,366,562 (GRCm39) |
F254L |
probably benign |
Het |
| Or5ak4 |
T |
C |
2: 85,161,979 (GRCm39) |
T88A |
probably benign |
Het |
| Or5h23 |
T |
A |
16: 58,906,253 (GRCm39) |
M198L |
probably benign |
Het |
| Or8c11 |
A |
T |
9: 38,289,281 (GRCm39) |
I29F |
probably benign |
Het |
| Or8g2b |
A |
G |
9: 39,751,126 (GRCm39) |
Y132C |
possibly damaging |
Het |
| Pabpc4 |
A |
G |
4: 123,188,790 (GRCm39) |
Q417R |
probably benign |
Het |
| Panx3 |
A |
T |
9: 37,580,320 (GRCm39) |
M11K |
probably damaging |
Het |
| Pcbp1 |
C |
T |
6: 86,502,471 (GRCm39) |
E143K |
probably damaging |
Het |
| Pdcd7 |
G |
A |
9: 65,265,974 (GRCm39) |
W477* |
probably null |
Het |
| Pi4k2a |
G |
A |
19: 42,078,954 (GRCm39) |
S5N |
probably damaging |
Het |
| Plag1 |
T |
A |
4: 3,904,075 (GRCm39) |
Q372L |
probably benign |
Het |
| Plce1 |
C |
A |
19: 38,748,535 (GRCm39) |
N1755K |
probably damaging |
Het |
| Pld4 |
G |
T |
12: 112,730,422 (GRCm39) |
E102* |
probably null |
Het |
| Pnlip |
A |
G |
19: 58,668,039 (GRCm39) |
N345S |
probably benign |
Het |
| Ppm1e |
A |
T |
11: 87,249,377 (GRCm39) |
L118Q |
possibly damaging |
Het |
| Prkra |
T |
G |
2: 76,469,622 (GRCm39) |
T146P |
probably damaging |
Het |
| Prpf8 |
A |
G |
11: 75,386,625 (GRCm39) |
D1038G |
probably damaging |
Het |
| Prss51 |
T |
A |
14: 64,334,543 (GRCm39) |
V108E |
probably damaging |
Het |
| Prxl2b |
T |
A |
4: 154,983,462 (GRCm39) |
M1L |
probably benign |
Het |
| Ptch1 |
A |
G |
13: 63,692,857 (GRCm39) |
Y181H |
probably damaging |
Het |
| Reln |
A |
G |
5: 22,244,527 (GRCm39) |
V817A |
probably benign |
Het |
| Rictor |
C |
A |
15: 6,818,985 (GRCm39) |
Q1403K |
probably benign |
Het |
| Rims1 |
T |
A |
1: 22,482,469 (GRCm39) |
I882F |
probably damaging |
Het |
| Rnf19a |
A |
G |
15: 36,242,185 (GRCm39) |
V618A |
probably benign |
Het |
| Ryr1 |
A |
T |
7: 28,816,841 (GRCm39) |
I65N |
probably damaging |
Het |
| S1pr2 |
T |
C |
9: 20,878,890 (GRCm39) |
T313A |
probably benign |
Het |
| Serpine2 |
A |
T |
1: 79,799,004 (GRCm39) |
Y83* |
probably null |
Het |
| Sfi1 |
A |
ATCTTCCCAAAGCCAGTGC |
11: 3,103,384 (GRCm39) |
|
probably benign |
Het |
| Sgip1 |
T |
C |
4: 102,772,256 (GRCm39) |
V215A |
probably benign |
Het |
| Sgsm3 |
T |
C |
15: 80,892,200 (GRCm39) |
V256A |
probably benign |
Het |
| Shroom4 |
T |
A |
X: 6,497,523 (GRCm39) |
C894* |
probably null |
Het |
| Slc14a2 |
T |
A |
18: 78,229,055 (GRCm39) |
D306V |
possibly damaging |
Het |
| Slc28a2b |
C |
A |
2: 122,353,259 (GRCm39) |
L480I |
probably benign |
Het |
| Slc4a10 |
A |
T |
2: 62,120,402 (GRCm39) |
E843V |
probably damaging |
Het |
| Smyd4 |
T |
A |
11: 75,280,982 (GRCm39) |
C152S |
probably damaging |
Het |
| Snx10 |
T |
C |
6: 51,552,952 (GRCm39) |
Y32H |
probably damaging |
Het |
| Sorl1 |
T |
C |
9: 41,968,580 (GRCm39) |
T558A |
possibly damaging |
Het |
| Spata31d1b |
G |
A |
13: 59,866,866 (GRCm39) |
C1338Y |
possibly damaging |
Het |
| Sppl2c |
T |
A |
11: 104,078,127 (GRCm39) |
I309K |
possibly damaging |
Het |
| Stard9 |
A |
G |
2: 120,531,111 (GRCm39) |
E2456G |
probably damaging |
Het |
| Stx1b |
A |
T |
7: 127,414,575 (GRCm39) |
D16E |
probably benign |
Het |
| Tecpr2 |
T |
C |
12: 110,881,887 (GRCm39) |
V152A |
probably damaging |
Het |
| Tedc1 |
T |
C |
12: 113,120,302 (GRCm39) |
V47A |
probably benign |
Het |
| Tep1 |
A |
T |
14: 51,105,774 (GRCm39) |
L82Q |
probably damaging |
Het |
| Tgm4 |
A |
G |
9: 122,885,559 (GRCm39) |
Y367C |
probably damaging |
Het |
| Tle1 |
C |
T |
4: 72,060,081 (GRCm39) |
V258M |
probably damaging |
Het |
| Tm9sf1 |
C |
T |
14: 55,880,301 (GRCm39) |
G32D |
possibly damaging |
Het |
| Tmco2 |
A |
G |
4: 120,963,181 (GRCm39) |
L106P |
probably damaging |
Het |
| Tmem131 |
A |
T |
1: 36,911,639 (GRCm39) |
C103S |
possibly damaging |
Het |
| Tmprss7 |
T |
A |
16: 45,489,891 (GRCm39) |
I444F |
possibly damaging |
Het |
| Trank1 |
T |
C |
9: 111,191,470 (GRCm39) |
V493A |
probably benign |
Het |
| Trim80 |
A |
T |
11: 115,338,843 (GRCm39) |
T558S |
probably benign |
Het |
| Trmt6 |
C |
A |
2: 132,650,703 (GRCm39) |
A302S |
probably benign |
Het |
| Ttc17 |
A |
T |
2: 94,133,985 (GRCm39) |
W1067R |
probably damaging |
Het |
| Tulp4 |
T |
A |
17: 6,286,568 (GRCm39) |
V1532D |
probably damaging |
Het |
| Ubqlnl |
T |
G |
7: 103,798,424 (GRCm39) |
I358L |
probably benign |
Het |
| Ulk3 |
T |
A |
9: 57,498,023 (GRCm39) |
I108N |
possibly damaging |
Het |
| Vps13b |
A |
T |
15: 35,640,674 (GRCm39) |
|
probably null |
Het |
| Vwa3a |
A |
G |
7: 120,389,365 (GRCm39) |
K68E |
possibly damaging |
Het |
| Zfp746 |
G |
T |
6: 48,041,110 (GRCm39) |
H538N |
possibly damaging |
Het |
|
| Other mutations in Dchs1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00235:Dchs1
|
APN |
7 |
105,407,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00422:Dchs1
|
APN |
7 |
105,407,236 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL00427:Dchs1
|
APN |
7 |
105,407,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00469:Dchs1
|
APN |
7 |
105,404,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00470:Dchs1
|
APN |
7 |
105,407,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00534:Dchs1
|
APN |
7 |
105,407,150 (GRCm39) |
missense |
probably benign |
|
|
IGL01292:Dchs1
|
APN |
7 |
105,410,098 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01380:Dchs1
|
APN |
7 |
105,411,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Dchs1
|
APN |
7 |
105,421,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01448:Dchs1
|
APN |
7 |
105,421,134 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01759:Dchs1
|
APN |
7 |
105,404,509 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01829:Dchs1
|
APN |
7 |
105,404,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01946:Dchs1
|
APN |
7 |
105,408,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01955:Dchs1
|
APN |
7 |
105,406,798 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02012:Dchs1
|
APN |
7 |
105,413,504 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02222:Dchs1
|
APN |
7 |
105,414,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02261:Dchs1
|
APN |
7 |
105,421,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02365:Dchs1
|
APN |
7 |
105,404,395 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02430:Dchs1
|
APN |
7 |
105,421,178 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL02500:Dchs1
|
APN |
7 |
105,405,013 (GRCm39) |
missense |
probably benign |
|
|
IGL02741:Dchs1
|
APN |
7 |
105,406,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02890:Dchs1
|
APN |
7 |
105,405,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03213:Dchs1
|
APN |
7 |
105,404,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
G1patch:Dchs1
|
UTSW |
7 |
105,408,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
P0026:Dchs1
|
UTSW |
7 |
105,407,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4377001:Dchs1
|
UTSW |
7 |
105,406,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4791001:Dchs1
|
UTSW |
7 |
105,408,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0013:Dchs1
|
UTSW |
7 |
105,405,043 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0090:Dchs1
|
UTSW |
7 |
105,405,139 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0091:Dchs1
|
UTSW |
7 |
105,415,301 (GRCm39) |
splice site |
probably benign |
|
|
R0193:Dchs1
|
UTSW |
7 |
105,414,190 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0395:Dchs1
|
UTSW |
7 |
105,407,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0448:Dchs1
|
UTSW |
7 |
105,415,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0480:Dchs1
|
UTSW |
7 |
105,420,696 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0485:Dchs1
|
UTSW |
7 |
105,421,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0566:Dchs1
|
UTSW |
7 |
105,408,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0571:Dchs1
|
UTSW |
7 |
105,421,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Dchs1
|
UTSW |
7 |
105,407,985 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0577:Dchs1
|
UTSW |
7 |
105,413,462 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0622:Dchs1
|
UTSW |
7 |
105,412,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0654:Dchs1
|
UTSW |
7 |
105,421,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0677:Dchs1
|
UTSW |
7 |
105,414,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1171:Dchs1
|
UTSW |
7 |
105,406,921 (GRCm39) |
missense |
probably benign |
|
|
R1241:Dchs1
|
UTSW |
7 |
105,407,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1389:Dchs1
|
UTSW |
7 |
105,404,778 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1427:Dchs1
|
UTSW |
7 |
105,415,398 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1458:Dchs1
|
UTSW |
7 |
105,404,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Dchs1
|
UTSW |
7 |
105,421,278 (GRCm39) |
nonsense |
probably null |
|
|
R1524:Dchs1
|
UTSW |
7 |
105,413,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1525:Dchs1
|
UTSW |
7 |
105,408,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1534:Dchs1
|
UTSW |
7 |
105,421,247 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1567:Dchs1
|
UTSW |
7 |
105,421,068 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1577:Dchs1
|
UTSW |
7 |
105,415,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1603:Dchs1
|
UTSW |
7 |
105,411,977 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1676:Dchs1
|
UTSW |
7 |
105,404,128 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1794:Dchs1
|
UTSW |
7 |
105,420,927 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1826:Dchs1
|
UTSW |
7 |
105,406,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1892:Dchs1
|
UTSW |
7 |
105,413,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1924:Dchs1
|
UTSW |
7 |
105,421,487 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1932:Dchs1
|
UTSW |
7 |
105,415,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Dchs1
|
UTSW |
7 |
105,413,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Dchs1
|
UTSW |
7 |
105,421,605 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R1993:Dchs1
|
UTSW |
7 |
105,411,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2007:Dchs1
|
UTSW |
7 |
105,404,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2316:Dchs1
|
UTSW |
7 |
105,413,411 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2351:Dchs1
|
UTSW |
7 |
105,403,301 (GRCm39) |
missense |
probably benign |
|
|
R2474:Dchs1
|
UTSW |
7 |
105,404,281 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2474:Dchs1
|
UTSW |
7 |
105,422,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3429:Dchs1
|
UTSW |
7 |
105,405,711 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3430:Dchs1
|
UTSW |
7 |
105,405,711 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3737:Dchs1
|
UTSW |
7 |
105,411,523 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3767:Dchs1
|
UTSW |
7 |
105,406,292 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R3874:Dchs1
|
UTSW |
7 |
105,410,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3883:Dchs1
|
UTSW |
7 |
105,411,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4105:Dchs1
|
UTSW |
7 |
105,414,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4209:Dchs1
|
UTSW |
7 |
105,415,397 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4329:Dchs1
|
UTSW |
7 |
105,402,966 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4516:Dchs1
|
UTSW |
7 |
105,404,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4579:Dchs1
|
UTSW |
7 |
105,408,180 (GRCm39) |
missense |
probably benign |
|
|
R4579:Dchs1
|
UTSW |
7 |
105,403,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4588:Dchs1
|
UTSW |
7 |
105,405,248 (GRCm39) |
missense |
probably benign |
|
|
R4613:Dchs1
|
UTSW |
7 |
105,421,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4632:Dchs1
|
UTSW |
7 |
105,403,562 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4696:Dchs1
|
UTSW |
7 |
105,413,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Dchs1
|
UTSW |
7 |
105,414,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Dchs1
|
UTSW |
7 |
105,404,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4738:Dchs1
|
UTSW |
7 |
105,407,880 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4768:Dchs1
|
UTSW |
7 |
105,420,827 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4784:Dchs1
|
UTSW |
7 |
105,415,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4864:Dchs1
|
UTSW |
7 |
105,404,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4880:Dchs1
|
UTSW |
7 |
105,404,937 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4909:Dchs1
|
UTSW |
7 |
105,415,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5102:Dchs1
|
UTSW |
7 |
105,421,384 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5109:Dchs1
|
UTSW |
7 |
105,414,221 (GRCm39) |
missense |
probably benign |
|
|
R5126:Dchs1
|
UTSW |
7 |
105,402,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5149:Dchs1
|
UTSW |
7 |
105,404,865 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5330:Dchs1
|
UTSW |
7 |
105,403,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Dchs1
|
UTSW |
7 |
105,421,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Dchs1
|
UTSW |
7 |
105,407,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5622:Dchs1
|
UTSW |
7 |
105,404,500 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5623:Dchs1
|
UTSW |
7 |
105,421,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Dchs1
|
UTSW |
7 |
105,422,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Dchs1
|
UTSW |
7 |
105,404,955 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5743:Dchs1
|
UTSW |
7 |
105,420,803 (GRCm39) |
missense |
probably benign |
|
|
R5759:Dchs1
|
UTSW |
7 |
105,413,383 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5772:Dchs1
|
UTSW |
7 |
105,422,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Dchs1
|
UTSW |
7 |
105,421,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5916:Dchs1
|
UTSW |
7 |
105,408,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Dchs1
|
UTSW |
7 |
105,405,132 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5997:Dchs1
|
UTSW |
7 |
105,403,302 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6065:Dchs1
|
UTSW |
7 |
105,404,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Dchs1
|
UTSW |
7 |
105,410,132 (GRCm39) |
missense |
probably benign |
|
|
R6137:Dchs1
|
UTSW |
7 |
105,414,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6324:Dchs1
|
UTSW |
7 |
105,414,145 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6363:Dchs1
|
UTSW |
7 |
105,407,679 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6466:Dchs1
|
UTSW |
7 |
105,413,748 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6544:Dchs1
|
UTSW |
7 |
105,407,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6572:Dchs1
|
UTSW |
7 |
105,408,013 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6579:Dchs1
|
UTSW |
7 |
105,412,120 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6632:Dchs1
|
UTSW |
7 |
105,411,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6725:Dchs1
|
UTSW |
7 |
105,408,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6789:Dchs1
|
UTSW |
7 |
105,406,210 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6868:Dchs1
|
UTSW |
7 |
105,412,710 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7058:Dchs1
|
UTSW |
7 |
105,406,228 (GRCm39) |
missense |
probably benign |
|
|
R7064:Dchs1
|
UTSW |
7 |
105,412,392 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7076:Dchs1
|
UTSW |
7 |
105,411,078 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7191:Dchs1
|
UTSW |
7 |
105,414,646 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7298:Dchs1
|
UTSW |
7 |
105,404,338 (GRCm39) |
nonsense |
probably null |
|
|
R7380:Dchs1
|
UTSW |
7 |
105,407,835 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7438:Dchs1
|
UTSW |
7 |
105,404,155 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7496:Dchs1
|
UTSW |
7 |
105,411,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7534:Dchs1
|
UTSW |
7 |
105,421,580 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7604:Dchs1
|
UTSW |
7 |
105,415,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7631:Dchs1
|
UTSW |
7 |
105,408,445 (GRCm39) |
missense |
probably benign |
|
|
R7821:Dchs1
|
UTSW |
7 |
105,414,352 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7834:Dchs1
|
UTSW |
7 |
105,414,774 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7841:Dchs1
|
UTSW |
7 |
105,412,180 (GRCm39) |
missense |
probably benign |
|
|
R7913:Dchs1
|
UTSW |
7 |
105,408,435 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8041:Dchs1
|
UTSW |
7 |
105,404,395 (GRCm39) |
missense |
probably benign |
0.45 |
|
R8076:Dchs1
|
UTSW |
7 |
105,411,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Dchs1
|
UTSW |
7 |
105,405,128 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8087:Dchs1
|
UTSW |
7 |
105,402,706 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8125:Dchs1
|
UTSW |
7 |
105,414,089 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8223:Dchs1
|
UTSW |
7 |
105,411,824 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8239:Dchs1
|
UTSW |
7 |
105,414,718 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8476:Dchs1
|
UTSW |
7 |
105,408,015 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8497:Dchs1
|
UTSW |
7 |
105,408,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8770:Dchs1
|
UTSW |
7 |
105,420,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Dchs1
|
UTSW |
7 |
105,410,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8866:Dchs1
|
UTSW |
7 |
105,404,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8948:Dchs1
|
UTSW |
7 |
105,408,212 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8950:Dchs1
|
UTSW |
7 |
105,408,212 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9029:Dchs1
|
UTSW |
7 |
105,402,919 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9039:Dchs1
|
UTSW |
7 |
105,405,215 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9081:Dchs1
|
UTSW |
7 |
105,403,636 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9134:Dchs1
|
UTSW |
7 |
105,404,910 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9159:Dchs1
|
UTSW |
7 |
105,415,126 (GRCm39) |
missense |
probably benign |
|
|
R9162:Dchs1
|
UTSW |
7 |
105,414,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9169:Dchs1
|
UTSW |
7 |
105,422,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9262:Dchs1
|
UTSW |
7 |
105,404,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9292:Dchs1
|
UTSW |
7 |
105,403,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Dchs1
|
UTSW |
7 |
105,415,402 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9376:Dchs1
|
UTSW |
7 |
105,414,981 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9392:Dchs1
|
UTSW |
7 |
105,421,869 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9619:Dchs1
|
UTSW |
7 |
105,413,662 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9680:Dchs1
|
UTSW |
7 |
105,411,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9687:Dchs1
|
UTSW |
7 |
105,407,191 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9747:Dchs1
|
UTSW |
7 |
105,412,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Dchs1
|
UTSW |
7 |
105,406,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Dchs1
|
UTSW |
7 |
105,407,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCACAAGTAAGCCTGAC -3'
(R):5'- TAGCATTCTCAGTGGGAATGAG -3'
Sequencing Primer
(F):5'- AGTAAGCCTGACCAGCCCTG -3'
(R):5'- TGGGAATGAGAGAGGGATATTCTCC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation