Incidental Mutation 'R0492:Adgrb2'
| ID |
42537 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| MMRRC Submission |
038690-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0492 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 129901624 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Arginine
at position 416
(P416R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112524
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030571
AA Change: P471R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: P471R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097868
AA Change: P471R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: P471R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000106012
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106015
AA Change: P471R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: P471R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106017
AA Change: P471R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: P471R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106018
AA Change: P416R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: P416R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120204
AA Change: P416R
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: P416R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121049
AA Change: P416R
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: P416R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166118
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149282
|
| Meta Mutation Damage Score |
0.3974 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgre1 |
A |
G |
17: 57,709,742 (GRCm39) |
D133G |
unknown |
Het |
| Alpl |
A |
C |
4: 137,476,887 (GRCm39) |
|
probably null |
Het |
| Ankrd65 |
T |
C |
4: 155,875,133 (GRCm39) |
|
probably benign |
Het |
| Baalc |
A |
T |
15: 38,797,480 (GRCm39) |
|
probably benign |
Het |
| Bpifb5 |
A |
G |
2: 154,070,820 (GRCm39) |
T204A |
probably benign |
Het |
| Bud31 |
A |
G |
5: 145,083,265 (GRCm39) |
Y77C |
probably damaging |
Het |
| Calhm6 |
G |
A |
10: 34,003,647 (GRCm39) |
R87* |
probably null |
Het |
| Capsl |
A |
G |
15: 9,461,930 (GRCm39) |
|
probably benign |
Het |
| Ccna1 |
A |
G |
3: 54,956,004 (GRCm39) |
V116A |
probably damaging |
Het |
| Cdc42bpa |
C |
A |
1: 179,928,755 (GRCm39) |
H723N |
probably benign |
Het |
| Cfap161 |
T |
C |
7: 83,443,245 (GRCm39) |
I40V |
possibly damaging |
Het |
| CK137956 |
C |
T |
4: 127,845,093 (GRCm39) |
V217I |
probably benign |
Het |
| Cog5 |
A |
G |
12: 31,919,460 (GRCm39) |
T540A |
probably damaging |
Het |
| Cps1 |
T |
C |
1: 67,196,995 (GRCm39) |
W349R |
probably damaging |
Het |
| Crispld2 |
G |
T |
8: 120,752,806 (GRCm39) |
V285L |
probably benign |
Het |
| Crtc2 |
T |
A |
3: 90,170,804 (GRCm39) |
F626I |
probably damaging |
Het |
| Daam1 |
G |
A |
12: 71,991,154 (GRCm39) |
R256H |
unknown |
Het |
| Dhx38 |
G |
T |
8: 110,288,576 (GRCm39) |
|
probably benign |
Het |
| Dok4 |
G |
A |
8: 95,591,764 (GRCm39) |
A324V |
probably benign |
Het |
| Dscam |
T |
C |
16: 96,626,982 (GRCm39) |
|
probably null |
Het |
| Dusp16 |
A |
T |
6: 134,695,365 (GRCm39) |
S489T |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,864,418 (GRCm39) |
W288R |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,970,866 (GRCm39) |
Y917N |
probably damaging |
Het |
| F13b |
A |
T |
1: 139,450,297 (GRCm39) |
|
probably null |
Het |
| Fdx1 |
C |
A |
9: 51,874,725 (GRCm39) |
A15S |
probably benign |
Het |
| Ffar4 |
A |
T |
19: 38,085,630 (GRCm39) |
Q19L |
probably benign |
Het |
| Folh1 |
A |
C |
7: 86,395,400 (GRCm39) |
V344G |
probably damaging |
Het |
| Fscb |
T |
A |
12: 64,520,292 (GRCm39) |
E391D |
possibly damaging |
Het |
| Gigyf2 |
G |
A |
1: 87,368,568 (GRCm39) |
G1083R |
probably damaging |
Het |
| Gm14403 |
C |
A |
2: 177,200,359 (GRCm39) |
H102N |
probably benign |
Het |
| Gm4847 |
A |
G |
1: 166,457,961 (GRCm39) |
F464S |
probably damaging |
Het |
| Gpam |
A |
T |
19: 55,084,611 (GRCm39) |
M56K |
possibly damaging |
Het |
| Gpr165 |
T |
A |
X: 95,760,778 (GRCm39) |
F352I |
probably damaging |
Het |
| Grik2 |
T |
G |
10: 48,977,260 (GRCm39) |
I891L |
probably damaging |
Het |
| Gsr |
T |
C |
8: 34,171,603 (GRCm39) |
|
probably benign |
Het |
| Hhla1 |
A |
G |
15: 65,808,140 (GRCm39) |
F302L |
probably benign |
Het |
| Impg1 |
T |
C |
9: 80,252,590 (GRCm39) |
D453G |
possibly damaging |
Het |
| Inpp5d |
T |
A |
1: 87,625,872 (GRCm39) |
V495E |
possibly damaging |
Het |
| Iqca1l |
A |
T |
5: 24,759,626 (GRCm39) |
L48Q |
probably damaging |
Het |
| Iqce |
A |
T |
5: 140,660,990 (GRCm39) |
L450H |
probably damaging |
Het |
| Itfg2 |
A |
G |
6: 128,390,486 (GRCm39) |
|
probably null |
Het |
| Kif13a |
A |
G |
13: 46,966,218 (GRCm39) |
V400A |
possibly damaging |
Het |
| Kif7 |
T |
C |
7: 79,363,629 (GRCm39) |
Y93C |
probably damaging |
Het |
| Krt33a |
A |
G |
11: 99,906,909 (GRCm39) |
V22A |
probably benign |
Het |
| Lct |
T |
C |
1: 128,228,319 (GRCm39) |
D1058G |
probably damaging |
Het |
| Lrp6 |
G |
T |
6: 134,457,481 (GRCm39) |
D774E |
possibly damaging |
Het |
| Lrrc9 |
T |
A |
12: 72,525,537 (GRCm39) |
S828R |
possibly damaging |
Het |
| Ly75 |
A |
G |
2: 60,138,620 (GRCm39) |
W1416R |
probably damaging |
Het |
| Mdh2 |
T |
C |
5: 135,819,004 (GRCm39) |
I320T |
possibly damaging |
Het |
| Med13l |
T |
A |
5: 118,876,560 (GRCm39) |
V912E |
probably damaging |
Het |
| Mgarp |
T |
C |
3: 51,296,456 (GRCm39) |
D182G |
possibly damaging |
Het |
| Mllt10 |
T |
C |
2: 18,151,698 (GRCm39) |
|
probably benign |
Het |
| Mmp28 |
G |
A |
11: 83,334,629 (GRCm39) |
A375V |
probably damaging |
Het |
| Mrps23 |
T |
A |
11: 88,101,511 (GRCm39) |
H133Q |
probably benign |
Het |
| Msh6 |
T |
C |
17: 88,282,679 (GRCm39) |
S35P |
probably benign |
Het |
| Myo3a |
A |
G |
2: 22,328,447 (GRCm39) |
D347G |
possibly damaging |
Het |
| Npc1l1 |
T |
C |
11: 6,173,040 (GRCm39) |
K800E |
possibly damaging |
Het |
| Or2ag13 |
A |
T |
7: 106,473,084 (GRCm39) |
Y123N |
probably damaging |
Het |
| Or51ai2 |
T |
C |
7: 103,586,971 (GRCm39) |
I128T |
probably benign |
Het |
| Or5i1 |
T |
G |
2: 87,613,166 (GRCm39) |
I94S |
probably damaging |
Het |
| Or5m9 |
T |
C |
2: 85,876,931 (GRCm39) |
V35A |
probably benign |
Het |
| Or5m9 |
T |
C |
2: 85,877,278 (GRCm39) |
F151L |
possibly damaging |
Het |
| Or5t7 |
G |
A |
2: 86,506,834 (GRCm39) |
P281L |
probably damaging |
Het |
| Or6p1 |
T |
A |
1: 174,258,129 (GRCm39) |
I45N |
possibly damaging |
Het |
| Osmr |
A |
C |
15: 6,853,999 (GRCm39) |
W570G |
probably damaging |
Het |
| Otol1 |
A |
T |
3: 69,935,117 (GRCm39) |
I370F |
probably damaging |
Het |
| Pank2 |
A |
G |
2: 131,122,180 (GRCm39) |
Y235C |
probably damaging |
Het |
| Pias2 |
T |
C |
18: 77,193,581 (GRCm39) |
S187P |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,383,086 (GRCm39) |
N1115S |
probably benign |
Het |
| Pld1 |
G |
T |
3: 28,163,966 (GRCm39) |
A800S |
probably damaging |
Het |
| Prex2 |
T |
C |
1: 11,256,857 (GRCm39) |
|
probably benign |
Het |
| Ptpn3 |
T |
C |
4: 57,194,304 (GRCm39) |
Q908R |
probably benign |
Het |
| Rab3gap2 |
T |
A |
1: 184,984,589 (GRCm39) |
|
probably benign |
Het |
| Rbm24 |
A |
T |
13: 46,573,826 (GRCm39) |
N82Y |
probably damaging |
Het |
| Rpl27 |
T |
C |
11: 101,336,081 (GRCm39) |
V47A |
possibly damaging |
Het |
| Serpina1f |
A |
G |
12: 103,659,826 (GRCm39) |
V152A |
possibly damaging |
Het |
| Serpina5 |
A |
G |
12: 104,068,392 (GRCm39) |
Y151C |
probably damaging |
Het |
| Serpinb7 |
A |
G |
1: 107,379,737 (GRCm39) |
*381W |
probably null |
Het |
| Sh2b2 |
A |
G |
5: 136,261,117 (GRCm39) |
F33S |
probably damaging |
Het |
| Slc22a2 |
A |
C |
17: 12,834,159 (GRCm39) |
I476L |
probably benign |
Het |
| Slc6a12 |
A |
T |
6: 121,332,331 (GRCm39) |
I222F |
probably benign |
Het |
| Smim26 |
G |
A |
2: 144,437,033 (GRCm39) |
D61N |
probably damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,924 (GRCm39) |
Y209N |
probably benign |
Het |
| Sorl1 |
T |
C |
9: 41,902,667 (GRCm39) |
H1630R |
probably null |
Het |
| Sptlc2 |
A |
T |
12: 87,393,580 (GRCm39) |
|
probably null |
Het |
| Strn3 |
G |
A |
12: 51,657,187 (GRCm39) |
T642I |
probably damaging |
Het |
| Syce1l |
T |
A |
8: 114,380,700 (GRCm39) |
D137E |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,028,837 (GRCm39) |
|
probably null |
Het |
| Tcf25 |
C |
A |
8: 124,108,203 (GRCm39) |
P86Q |
probably benign |
Het |
| Tmem19 |
A |
T |
10: 115,197,715 (GRCm39) |
Y43* |
probably null |
Het |
| Tmem30b |
T |
C |
12: 73,592,942 (GRCm39) |
N58D |
probably benign |
Het |
| Tnn |
A |
C |
1: 159,948,327 (GRCm39) |
I795M |
probably damaging |
Het |
| Tnpo1 |
A |
G |
13: 98,991,954 (GRCm39) |
Y641H |
probably damaging |
Het |
| Tra2a |
A |
T |
6: 49,227,889 (GRCm39) |
|
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,999,243 (GRCm39) |
F295I |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,809,245 (GRCm39) |
W125R |
probably damaging |
Het |
| Vps8 |
C |
A |
16: 21,261,107 (GRCm39) |
F82L |
probably damaging |
Het |
| Ythdf2 |
A |
T |
4: 131,931,779 (GRCm39) |
S460R |
probably damaging |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7197:Adgrb2
|
UTSW |
4 |
129,903,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGTGTCTCCCCATGCAGTGGAAG -3'
(R):5'- GCCCCAGGGTTGTATAAGCAATACC -3'
Sequencing Primer
(F):5'- ATCATCTTGTGCCAATGGGAC -3'
(R):5'- GGTTGTATAAGCAATACCTGGACAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation