Incidental Mutation 'R5390:Clec4g'
ID 425518
Institutional Source Beutler Lab
Gene Symbol Clec4g
Ensembl Gene ENSMUSG00000074491
Gene Name C-type lectin domain family 4, member g
Synonyms 4930572L20Rik
MMRRC Submission 042962-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5390 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 3757064-3770651 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 3768441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 97 (V97L)
Ref Sequence ENSEMBL: ENSMUSP00000059574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]
AlphaFold Q8BNX1
Predicted Effect probably benign
Transcript: ENSMUST00000058040
Predicted Effect probably benign
Transcript: ENSMUST00000062037
AA Change: V97L

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491
AA Change: V97L

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
coiled coil region 98 153 N/A INTRINSIC
CLECT 165 288 8.85e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159612
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160490
Predicted Effect probably benign
Transcript: ENSMUST00000160527
SMART Domains Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
CLECT 2 97 7.75e-8 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830454E08Rik T C 9: 120,406,772 (GRCm39) probably benign Het
Anxa4 G A 6: 86,730,865 (GRCm39) T104M probably damaging Het
BC048562 G T 9: 108,313,777 (GRCm39) W9L probably damaging Het
Cachd1 T A 4: 100,838,203 (GRCm39) M822K probably damaging Het
Ddx19a G A 8: 111,707,263 (GRCm39) Q176* probably null Het
Eml6 T C 11: 29,710,096 (GRCm39) H1413R probably damaging Het
Fam161b C T 12: 84,395,408 (GRCm39) V512M probably damaging Het
Glcci1 A T 6: 8,537,835 (GRCm39) Q151L probably benign Het
Gm10801 TC TCGAC 2: 98,494,151 (GRCm39) probably benign Het
Gpnmb A T 6: 49,024,775 (GRCm39) D269V probably damaging Het
Gpx3 A T 11: 54,800,375 (GRCm39) D191V probably damaging Het
Grm4 C T 17: 27,653,712 (GRCm39) C491Y probably damaging Het
H2-M10.4 T A 17: 36,771,533 (GRCm39) H215L probably damaging Het
Hrc T A 7: 44,984,909 (GRCm39) L20Q probably damaging Het
Hsd17b6 T A 10: 127,827,308 (GRCm39) M255L probably benign Het
Hydin A T 8: 111,322,099 (GRCm39) I4584L probably benign Het
Ift70a2 A T 2: 75,807,630 (GRCm39) L294Q probably damaging Het
Ints5 T A 19: 8,873,931 (GRCm39) I630K possibly damaging Het
Kctd10 A G 5: 114,503,764 (GRCm39) I296T possibly damaging Het
Ltv1 G A 10: 13,058,103 (GRCm39) R234C probably damaging Het
Macf1 A G 4: 123,365,546 (GRCm39) S1507P probably damaging Het
Megf8 G A 7: 25,039,714 (GRCm39) G936D possibly damaging Het
Ms4a4d T C 19: 11,526,004 (GRCm39) probably null Het
Net1 C T 13: 3,943,379 (GRCm39) A3T probably benign Het
Nlrp2 T C 7: 5,303,908 (GRCm39) M206V probably benign Het
Or1j1 C T 2: 36,702,444 (GRCm39) R220H probably benign Het
Or5an1b T A 19: 12,299,505 (GRCm39) I229F probably damaging Het
Pcyox1l T C 18: 61,832,433 (GRCm39) I205V probably benign Het
Pigo A G 4: 43,019,645 (GRCm39) probably null Het
Pla2g6 A T 15: 79,173,893 (GRCm39) S590T possibly damaging Het
Pwp2 T C 10: 78,013,605 (GRCm39) T539A possibly damaging Het
Rag1 T C 2: 101,473,079 (GRCm39) T688A probably benign Het
Senp7 A G 16: 55,990,279 (GRCm39) T676A probably benign Het
Slc26a6 T C 9: 108,738,499 (GRCm39) probably benign Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Sorbs2 A G 8: 46,272,778 (GRCm39) H653R probably damaging Het
Stk3 T A 15: 35,114,706 (GRCm39) K67* probably null Het
Tctn2 A ACC 5: 124,762,400 (GRCm39) probably benign Homo
Ttn T C 2: 76,540,395 (GRCm39) Y34197C probably damaging Het
Ufc1 A C 1: 171,117,746 (GRCm39) L56R probably damaging Het
Usp34 T A 11: 23,394,202 (GRCm39) probably null Het
Vnn3 T A 10: 23,727,483 (GRCm39) M1K probably null Het
Zfp653 C A 9: 21,969,099 (GRCm39) probably null Het
Other mutations in Clec4g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Clec4g APN 8 3,766,410 (GRCm39) intron probably benign
IGL01090:Clec4g APN 8 3,769,482 (GRCm39) missense probably damaging 1.00
IGL01331:Clec4g APN 8 3,767,190 (GRCm39) splice site probably benign
IGL01593:Clec4g APN 8 3,769,474 (GRCm39) critical splice donor site probably null
IGL02942:Clec4g APN 8 3,768,356 (GRCm39) missense probably damaging 0.96
IGL03176:Clec4g APN 8 3,768,441 (GRCm39) missense possibly damaging 0.90
bluedog UTSW 8 3,768,766 (GRCm39) critical splice donor site probably null
R0071:Clec4g UTSW 8 3,767,489 (GRCm39) start gained probably benign
R0379:Clec4g UTSW 8 3,768,440 (GRCm39) missense probably benign 0.00
R4571:Clec4g UTSW 8 3,768,766 (GRCm39) critical splice donor site probably null
R4854:Clec4g UTSW 8 3,766,534 (GRCm39) missense probably damaging 1.00
R4856:Clec4g UTSW 8 3,766,419 (GRCm39) intron probably benign
R4886:Clec4g UTSW 8 3,766,419 (GRCm39) intron probably benign
R5370:Clec4g UTSW 8 3,768,344 (GRCm39) missense probably benign 0.13
R6522:Clec4g UTSW 8 3,768,803 (GRCm39) missense probably benign 0.11
R6737:Clec4g UTSW 8 3,757,716 (GRCm39) utr 3 prime probably benign
R7097:Clec4g UTSW 8 3,769,518 (GRCm39) missense possibly damaging 0.58
R7834:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R8372:Clec4g UTSW 8 3,757,990 (GRCm39) utr 3 prime probably benign
R9297:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R9312:Clec4g UTSW 8 3,768,371 (GRCm39) missense probably null 1.00
R9318:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R9517:Clec4g UTSW 8 3,767,452 (GRCm39) missense probably damaging 0.98
R9526:Clec4g UTSW 8 3,768,565 (GRCm39) missense probably benign 0.33
R9682:Clec4g UTSW 8 3,757,713 (GRCm39) missense unknown
Z1088:Clec4g UTSW 8 3,766,548 (GRCm39) missense probably damaging 1.00
Z1088:Clec4g UTSW 8 3,757,796 (GRCm39) utr 3 prime probably benign
Predicted Primers PCR Primer
(F):5'- ACTACCAAGAAGCGGTGTGG -3'
(R):5'- GGTAGTGAATAGCTGAGGCC -3'

Sequencing Primer
(F):5'- TACCAAGAAGCGGTGTGGCTATG -3'
(R):5'- TTTCCAGCCTCAGAGCAGAAGATG -3'
Posted On 2016-08-04