Incidental Mutation 'R5390:Vnn3'
ID |
425528 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vnn3
|
Ensembl Gene |
ENSMUSG00000020010 |
Gene Name |
vanin 3 |
Synonyms |
|
MMRRC Submission |
042962-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.053)
|
Stock # |
R5390 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
10 |
Chromosomal Location |
23727360-23745741 bp(+) (GRCm39) |
Type of Mutation |
start codon destroyed |
DNA Base Change (assembly) |
T to A
at 23727483 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 1
(M1K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000020190
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020190]
|
AlphaFold |
Q9QZ25 |
Predicted Effect |
probably null
Transcript: ENSMUST00000020190
AA Change: M1K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000020190 Gene: ENSMUSG00000020010 AA Change: M1K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:CN_hydrolase
|
51 |
296 |
6.9e-19 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.6%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
5830454E08Rik |
T |
C |
9: 120,406,772 (GRCm39) |
|
probably benign |
Het |
Anxa4 |
G |
A |
6: 86,730,865 (GRCm39) |
T104M |
probably damaging |
Het |
BC048562 |
G |
T |
9: 108,313,777 (GRCm39) |
W9L |
probably damaging |
Het |
Cachd1 |
T |
A |
4: 100,838,203 (GRCm39) |
M822K |
probably damaging |
Het |
Clec4g |
C |
A |
8: 3,768,441 (GRCm39) |
V97L |
probably benign |
Het |
Ddx19a |
G |
A |
8: 111,707,263 (GRCm39) |
Q176* |
probably null |
Het |
Eml6 |
T |
C |
11: 29,710,096 (GRCm39) |
H1413R |
probably damaging |
Het |
Fam161b |
C |
T |
12: 84,395,408 (GRCm39) |
V512M |
probably damaging |
Het |
Glcci1 |
A |
T |
6: 8,537,835 (GRCm39) |
Q151L |
probably benign |
Het |
Gm10801 |
TC |
TCGAC |
2: 98,494,151 (GRCm39) |
|
probably benign |
Het |
Gpnmb |
A |
T |
6: 49,024,775 (GRCm39) |
D269V |
probably damaging |
Het |
Gpx3 |
A |
T |
11: 54,800,375 (GRCm39) |
D191V |
probably damaging |
Het |
Grm4 |
C |
T |
17: 27,653,712 (GRCm39) |
C491Y |
probably damaging |
Het |
H2-M10.4 |
T |
A |
17: 36,771,533 (GRCm39) |
H215L |
probably damaging |
Het |
Hrc |
T |
A |
7: 44,984,909 (GRCm39) |
L20Q |
probably damaging |
Het |
Hsd17b6 |
T |
A |
10: 127,827,308 (GRCm39) |
M255L |
probably benign |
Het |
Hydin |
A |
T |
8: 111,322,099 (GRCm39) |
I4584L |
probably benign |
Het |
Ift70a2 |
A |
T |
2: 75,807,630 (GRCm39) |
L294Q |
probably damaging |
Het |
Ints5 |
T |
A |
19: 8,873,931 (GRCm39) |
I630K |
possibly damaging |
Het |
Kctd10 |
A |
G |
5: 114,503,764 (GRCm39) |
I296T |
possibly damaging |
Het |
Ltv1 |
G |
A |
10: 13,058,103 (GRCm39) |
R234C |
probably damaging |
Het |
Macf1 |
A |
G |
4: 123,365,546 (GRCm39) |
S1507P |
probably damaging |
Het |
Megf8 |
G |
A |
7: 25,039,714 (GRCm39) |
G936D |
possibly damaging |
Het |
Ms4a4d |
T |
C |
19: 11,526,004 (GRCm39) |
|
probably null |
Het |
Net1 |
C |
T |
13: 3,943,379 (GRCm39) |
A3T |
probably benign |
Het |
Nlrp2 |
T |
C |
7: 5,303,908 (GRCm39) |
M206V |
probably benign |
Het |
Or1j1 |
C |
T |
2: 36,702,444 (GRCm39) |
R220H |
probably benign |
Het |
Or5an1b |
T |
A |
19: 12,299,505 (GRCm39) |
I229F |
probably damaging |
Het |
Pcyox1l |
T |
C |
18: 61,832,433 (GRCm39) |
I205V |
probably benign |
Het |
Pigo |
A |
G |
4: 43,019,645 (GRCm39) |
|
probably null |
Het |
Pla2g6 |
A |
T |
15: 79,173,893 (GRCm39) |
S590T |
possibly damaging |
Het |
Pwp2 |
T |
C |
10: 78,013,605 (GRCm39) |
T539A |
possibly damaging |
Het |
Rag1 |
T |
C |
2: 101,473,079 (GRCm39) |
T688A |
probably benign |
Het |
Senp7 |
A |
G |
16: 55,990,279 (GRCm39) |
T676A |
probably benign |
Het |
Slc26a6 |
T |
C |
9: 108,738,499 (GRCm39) |
|
probably benign |
Het |
Slc45a2 |
C |
T |
15: 11,027,871 (GRCm39) |
T480I |
probably damaging |
Het |
Sorbs2 |
A |
G |
8: 46,272,778 (GRCm39) |
H653R |
probably damaging |
Het |
Stk3 |
T |
A |
15: 35,114,706 (GRCm39) |
K67* |
probably null |
Het |
Tctn2 |
A |
ACC |
5: 124,762,400 (GRCm39) |
|
probably benign |
Homo |
Ttn |
T |
C |
2: 76,540,395 (GRCm39) |
Y34197C |
probably damaging |
Het |
Ufc1 |
A |
C |
1: 171,117,746 (GRCm39) |
L56R |
probably damaging |
Het |
Usp34 |
T |
A |
11: 23,394,202 (GRCm39) |
|
probably null |
Het |
Zfp653 |
C |
A |
9: 21,969,099 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Vnn3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00675:Vnn3
|
APN |
10 |
23,743,066 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL01300:Vnn3
|
APN |
10 |
23,740,263 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01349:Vnn3
|
APN |
10 |
23,727,814 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02491:Vnn3
|
APN |
10 |
23,741,816 (GRCm39) |
missense |
probably benign |
0.11 |
IGL03256:Vnn3
|
APN |
10 |
23,727,698 (GRCm39) |
splice site |
probably benign |
|
IGL03289:Vnn3
|
APN |
10 |
23,741,735 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02799:Vnn3
|
UTSW |
10 |
23,727,869 (GRCm39) |
missense |
possibly damaging |
0.64 |
R0599:Vnn3
|
UTSW |
10 |
23,741,603 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1703:Vnn3
|
UTSW |
10 |
23,741,828 (GRCm39) |
missense |
probably benign |
|
R1753:Vnn3
|
UTSW |
10 |
23,741,718 (GRCm39) |
missense |
probably benign |
0.27 |
R2119:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R2288:Vnn3
|
UTSW |
10 |
23,740,354 (GRCm39) |
missense |
probably benign |
0.03 |
R4255:Vnn3
|
UTSW |
10 |
23,741,720 (GRCm39) |
missense |
probably benign |
0.18 |
R4458:Vnn3
|
UTSW |
10 |
23,741,567 (GRCm39) |
missense |
probably benign |
0.23 |
R4518:Vnn3
|
UTSW |
10 |
23,743,124 (GRCm39) |
missense |
possibly damaging |
0.77 |
R4545:Vnn3
|
UTSW |
10 |
23,732,224 (GRCm39) |
missense |
probably benign |
0.00 |
R4723:Vnn3
|
UTSW |
10 |
23,727,589 (GRCm39) |
missense |
possibly damaging |
0.88 |
R4791:Vnn3
|
UTSW |
10 |
23,740,519 (GRCm39) |
missense |
probably benign |
|
R4921:Vnn3
|
UTSW |
10 |
23,740,473 (GRCm39) |
missense |
probably benign |
0.01 |
R5152:Vnn3
|
UTSW |
10 |
23,740,237 (GRCm39) |
missense |
probably benign |
0.01 |
R5545:Vnn3
|
UTSW |
10 |
23,742,992 (GRCm39) |
missense |
probably benign |
0.00 |
R6197:Vnn3
|
UTSW |
10 |
23,732,187 (GRCm39) |
missense |
probably damaging |
1.00 |
R6751:Vnn3
|
UTSW |
10 |
23,745,523 (GRCm39) |
missense |
probably benign |
0.00 |
R6846:Vnn3
|
UTSW |
10 |
23,727,620 (GRCm39) |
missense |
probably benign |
|
R6917:Vnn3
|
UTSW |
10 |
23,741,832 (GRCm39) |
missense |
possibly damaging |
0.50 |
R7073:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R7100:Vnn3
|
UTSW |
10 |
23,741,840 (GRCm39) |
missense |
probably damaging |
1.00 |
R7152:Vnn3
|
UTSW |
10 |
23,727,513 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7336:Vnn3
|
UTSW |
10 |
23,727,806 (GRCm39) |
missense |
probably benign |
0.42 |
R7421:Vnn3
|
UTSW |
10 |
23,741,666 (GRCm39) |
missense |
probably benign |
0.06 |
R7875:Vnn3
|
UTSW |
10 |
23,743,146 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8353:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
R8453:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
R8465:Vnn3
|
UTSW |
10 |
23,741,780 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9105:Vnn3
|
UTSW |
10 |
23,740,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R9261:Vnn3
|
UTSW |
10 |
23,741,607 (GRCm39) |
missense |
probably damaging |
0.97 |
R9441:Vnn3
|
UTSW |
10 |
23,740,498 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9718:Vnn3
|
UTSW |
10 |
23,745,454 (GRCm39) |
nonsense |
probably null |
|
R9737:Vnn3
|
UTSW |
10 |
23,741,813 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTCAACAATTGCTGCAAACC -3'
(R):5'- TGCCAGCTTGATTGCACTC -3'
Sequencing Primer
(F):5'- ATTGCTGCAAACCCATGCTCATG -3'
(R):5'- CAGCTTGATTGCACTCTCCAAAATG -3'
|
Posted On |
2016-08-04 |