Incidental Mutation 'R5377:Vmn2r66'
ID 425614
Institutional Source Beutler Lab
Gene Symbol Vmn2r66
Ensembl Gene ENSMUSG00000094950
Gene Name vomeronasal 2, receptor 66
Synonyms F830104D24Rik
MMRRC Submission 042845-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5377 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 84643853-84661228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 84656026 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 330 (I330N)
Ref Sequence ENSEMBL: ENSMUSP00000122645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124773]
AlphaFold A0A3B2W842
Predicted Effect probably damaging
Transcript: ENSMUST00000124773
AA Change: I330N

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: I330N

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 463 5e-31 PFAM
Pfam:NCD3G 507 559 6e-21 PFAM
Pfam:7tm_3 589 827 3.8e-52 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m G T 6: 121,622,212 (GRCm39) V372F probably benign Het
Adcy10 G A 1: 165,347,464 (GRCm39) C393Y probably damaging Het
Adgrg7 A C 16: 56,550,669 (GRCm39) I681S possibly damaging Het
Akap8l T C 17: 32,540,485 (GRCm39) probably benign Het
Akr1a1 A T 4: 116,497,092 (GRCm39) V156E probably damaging Het
Alk T G 17: 72,202,734 (GRCm39) D1167A probably damaging Het
Ankrd11 T C 8: 123,620,453 (GRCm39) probably null Het
Aspm T A 1: 139,385,221 (GRCm39) N288K probably damaging Het
Aspm A G 1: 139,398,133 (GRCm39) probably null Het
Asxl2 G A 12: 3,524,618 (GRCm39) probably null Het
Atp6v0a1 A G 11: 100,946,413 (GRCm39) H802R probably damaging Het
B4galnt1 A G 10: 127,007,691 (GRCm39) T531A possibly damaging Het
Cecr2 A G 6: 120,733,530 (GRCm39) N506D possibly damaging Het
Crebrf T C 17: 26,978,839 (GRCm39) V509A probably damaging Het
Cyp4f40 A T 17: 32,894,590 (GRCm39) I413F probably null Het
Defb12 C A 8: 19,164,342 (GRCm39) probably null Het
Dnah2 T C 11: 69,312,674 (GRCm39) E4297G probably damaging Het
Dpysl5 A T 5: 30,948,857 (GRCm39) N371Y probably damaging Het
Eef1d G T 15: 75,775,038 (GRCm39) T207N probably benign Het
Esrrb C T 12: 86,565,783 (GRCm39) Q416* probably null Het
Exd2 T C 12: 80,536,222 (GRCm39) L284P probably damaging Het
Fat3 T A 9: 16,287,739 (GRCm39) I595F probably benign Het
Gm9920 A G 15: 54,972,371 (GRCm39) probably benign Het
Hephl1 T C 9: 14,981,084 (GRCm39) K783E probably damaging Het
Irs2 A G 8: 11,055,277 (GRCm39) S1052P probably benign Het
Kctd18 T C 1: 58,002,252 (GRCm39) I192V probably benign Het
Lama3 A G 18: 12,586,803 (GRCm39) D722G probably damaging Het
Lepr T C 4: 101,672,216 (GRCm39) V1080A possibly damaging Het
Lpin1 C T 12: 16,613,656 (GRCm39) G504S probably damaging Het
Lrit2 A C 14: 36,791,140 (GRCm39) Q273P possibly damaging Het
Mlkl T A 8: 112,054,569 (GRCm39) E189D probably benign Het
Mttp C T 3: 137,810,790 (GRCm39) R608H probably benign Het
Nav2 T C 7: 49,238,908 (GRCm39) V2011A probably benign Het
Nos2 A T 11: 78,848,317 (GRCm39) I1075F probably benign Het
Npat A G 9: 53,461,336 (GRCm39) probably null Het
Nucks1 T C 1: 131,846,771 (GRCm39) F16L probably damaging Het
Nus1 T C 10: 52,305,309 (GRCm39) S150P possibly damaging Het
Odad1 C T 7: 45,591,506 (GRCm39) R257* probably null Het
Oga A T 19: 45,746,461 (GRCm39) Y779* probably null Het
Or4c123 G T 2: 89,127,506 (GRCm39) T36K probably damaging Het
Or8b35 A T 9: 37,903,908 (GRCm39) Y40F probably benign Het
Pclo A G 5: 14,731,367 (GRCm39) T3290A unknown Het
Pign A T 1: 105,585,537 (GRCm39) F4Y probably benign Het
Rfx4 A G 10: 84,696,406 (GRCm39) N233D possibly damaging Het
Rpgrip1 A T 14: 52,397,652 (GRCm39) M1325L possibly damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Scaf11 T A 15: 96,315,001 (GRCm39) H1227L possibly damaging Het
Sec31b G T 19: 44,507,076 (GRCm39) P840T probably damaging Het
Slc16a9 T A 10: 70,118,958 (GRCm39) L426I probably damaging Het
Slc22a30 G A 19: 8,321,757 (GRCm39) Q436* probably null Het
Slc34a1 T C 13: 23,996,575 (GRCm39) S27P probably damaging Het
Tacc1 A G 8: 25,672,299 (GRCm39) S310P possibly damaging Het
Tmem245 G A 4: 56,947,084 (GRCm39) R110C probably damaging Het
Trip12 T C 1: 84,735,152 (GRCm39) Y953C probably damaging Het
Trpm7 C A 2: 126,684,775 (GRCm39) probably null Het
Ush2a G A 1: 188,644,320 (GRCm39) V4561I probably benign Het
Vmn1r192 C T 13: 22,371,801 (GRCm39) V140I probably benign Het
Vmn2r99 T C 17: 19,599,531 (GRCm39) V405A probably damaging Het
Wdhd1 A C 14: 47,509,678 (GRCm39) V172G probably benign Het
Zfhx3 C T 8: 109,677,817 (GRCm39) R2956C possibly damaging Het
Zfp446 T C 7: 12,716,178 (GRCm39) L283P possibly damaging Het
Zfp82 T C 7: 29,756,591 (GRCm39) K164E probably damaging Het
Other mutations in Vmn2r66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Vmn2r66 APN 7 84,656,299 (GRCm39) missense probably benign
IGL01562:Vmn2r66 APN 7 84,656,495 (GRCm39) missense probably benign 0.03
IGL01689:Vmn2r66 APN 7 84,657,033 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r66 APN 7 84,643,908 (GRCm39) missense probably benign
IGL02415:Vmn2r66 APN 7 84,656,020 (GRCm39) missense probably damaging 0.97
IGL02439:Vmn2r66 APN 7 84,654,455 (GRCm39) splice site probably benign
IGL02545:Vmn2r66 APN 7 84,655,798 (GRCm39) missense possibly damaging 0.50
IGL02708:Vmn2r66 APN 7 84,655,796 (GRCm39) missense probably benign 0.00
IGL02794:Vmn2r66 APN 7 84,644,623 (GRCm39) missense probably benign 0.00
IGL02885:Vmn2r66 APN 7 84,644,723 (GRCm39) missense probably benign 0.00
IGL02975:Vmn2r66 APN 7 84,656,182 (GRCm39) missense probably damaging 0.98
IGL03027:Vmn2r66 APN 7 84,644,777 (GRCm39) splice site probably benign
IGL03081:Vmn2r66 APN 7 84,657,138 (GRCm39) missense probably benign
PIT4131001:Vmn2r66 UTSW 7 84,644,301 (GRCm39) missense probably damaging 1.00
R0098:Vmn2r66 UTSW 7 84,654,965 (GRCm39) missense probably damaging 1.00
R0504:Vmn2r66 UTSW 7 84,656,023 (GRCm39) missense probably damaging 0.99
R0557:Vmn2r66 UTSW 7 84,643,972 (GRCm39) missense probably damaging 1.00
R0617:Vmn2r66 UTSW 7 84,644,484 (GRCm39) missense probably benign 0.02
R0883:Vmn2r66 UTSW 7 84,657,070 (GRCm39) missense probably benign
R1159:Vmn2r66 UTSW 7 84,644,613 (GRCm39) missense probably benign 0.44
R1168:Vmn2r66 UTSW 7 84,656,062 (GRCm39) missense possibly damaging 0.46
R1172:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1175:Vmn2r66 UTSW 7 84,654,799 (GRCm39) missense probably benign 0.04
R1538:Vmn2r66 UTSW 7 84,644,166 (GRCm39) missense possibly damaging 0.84
R1658:Vmn2r66 UTSW 7 84,656,955 (GRCm39) missense probably benign 0.07
R1937:Vmn2r66 UTSW 7 84,644,344 (GRCm39) missense probably damaging 0.99
R1989:Vmn2r66 UTSW 7 84,661,201 (GRCm39) missense probably benign 0.01
R2698:Vmn2r66 UTSW 7 84,644,607 (GRCm39) missense probably damaging 1.00
R2890:Vmn2r66 UTSW 7 84,661,027 (GRCm39) splice site probably null
R3686:Vmn2r66 UTSW 7 84,644,397 (GRCm39) missense probably damaging 0.96
R4152:Vmn2r66 UTSW 7 84,654,800 (GRCm39) missense probably benign 0.08
R4500:Vmn2r66 UTSW 7 84,657,162 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r66 UTSW 7 84,644,296 (GRCm39) missense possibly damaging 0.62
R4656:Vmn2r66 UTSW 7 84,661,204 (GRCm39) missense possibly damaging 0.87
R4668:Vmn2r66 UTSW 7 84,643,905 (GRCm39) missense probably damaging 1.00
R4942:Vmn2r66 UTSW 7 84,656,980 (GRCm39) missense probably damaging 1.00
R5163:Vmn2r66 UTSW 7 84,656,017 (GRCm39) missense probably benign 0.01
R5223:Vmn2r66 UTSW 7 84,657,093 (GRCm39) missense probably benign
R5512:Vmn2r66 UTSW 7 84,657,149 (GRCm39) missense probably damaging 1.00
R5611:Vmn2r66 UTSW 7 84,654,951 (GRCm39) nonsense probably null
R5749:Vmn2r66 UTSW 7 84,655,979 (GRCm39) nonsense probably null
R6131:Vmn2r66 UTSW 7 84,644,224 (GRCm39) missense probably damaging 1.00
R6183:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R6509:Vmn2r66 UTSW 7 84,656,054 (GRCm39) missense probably benign 0.12
R6930:Vmn2r66 UTSW 7 84,661,216 (GRCm39) missense possibly damaging 0.80
R6992:Vmn2r66 UTSW 7 84,654,436 (GRCm39) missense possibly damaging 0.90
R7015:Vmn2r66 UTSW 7 84,644,766 (GRCm39) missense possibly damaging 0.81
R7302:Vmn2r66 UTSW 7 84,654,423 (GRCm39) missense probably benign 0.00
R7516:Vmn2r66 UTSW 7 84,661,176 (GRCm39) missense possibly damaging 0.51
R7763:Vmn2r66 UTSW 7 84,654,909 (GRCm39) missense probably benign 0.01
R7814:Vmn2r66 UTSW 7 84,656,472 (GRCm39) missense probably benign 0.02
R8077:Vmn2r66 UTSW 7 84,656,093 (GRCm39) missense probably benign
R8307:Vmn2r66 UTSW 7 84,656,270 (GRCm39) missense probably benign
R8315:Vmn2r66 UTSW 7 84,643,932 (GRCm39) missense possibly damaging 0.90
R8490:Vmn2r66 UTSW 7 84,654,794 (GRCm39) critical splice donor site probably null
R8511:Vmn2r66 UTSW 7 84,656,026 (GRCm39) missense probably damaging 0.99
R8781:Vmn2r66 UTSW 7 84,644,355 (GRCm39) nonsense probably null
R8812:Vmn2r66 UTSW 7 84,654,893 (GRCm39) missense probably damaging 0.99
R9203:Vmn2r66 UTSW 7 84,654,950 (GRCm39) missense probably benign 0.01
R9277:Vmn2r66 UTSW 7 84,661,164 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGCAGAATCATCTCATGGAGTG -3'
(R):5'- AAAGACTCTCCTATACATTTTGCCC -3'

Sequencing Primer
(F):5'- ATAGCATGTATTACTCATGGCCATTC -3'
(R):5'- GCCCTCATTGTGTGGAAATCTAAAGG -3'
Posted On 2016-08-04