Incidental Mutation 'R5394:Wdr17'
| ID |
426049 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
042966-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5394 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 55092524 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1087
(S1087P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135805
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000144711]
[ENSMUST00000150488]
[ENSMUST00000175915]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127511
AA Change: S1126P
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: S1126P
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128850
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: S1101P
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: S1101P
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150488
AA Change: S1094P
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: S1094P
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000175915
AA Change: S1087P
PolyPhen 2
Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: S1087P
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.0728 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
97% (96/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930503B20Rik |
A |
G |
3: 146,356,363 (GRCm39) |
F182L |
probably damaging |
Het |
| 4930503B20Rik |
T |
C |
3: 146,356,713 (GRCm39) |
Y65C |
probably damaging |
Het |
| 4930590J08Rik |
A |
G |
6: 91,896,174 (GRCm39) |
T341A |
probably benign |
Het |
| Adamts13 |
G |
A |
2: 26,876,570 (GRCm39) |
V495I |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,600,070 (GRCm39) |
T2101K |
probably benign |
Het |
| Als2 |
T |
C |
1: 59,214,105 (GRCm39) |
D1361G |
probably benign |
Het |
| Ankdd1a |
A |
T |
9: 65,412,496 (GRCm39) |
M275K |
probably benign |
Het |
| Arfip2 |
A |
T |
7: 105,286,183 (GRCm39) |
Y161* |
probably null |
Het |
| Asap3 |
A |
T |
4: 135,968,570 (GRCm39) |
E707D |
probably benign |
Het |
| Atm |
C |
T |
9: 53,419,077 (GRCm39) |
|
probably null |
Het |
| Atp9b |
A |
T |
18: 80,820,052 (GRCm39) |
S577R |
probably benign |
Het |
| Bltp1 |
G |
T |
3: 36,971,817 (GRCm39) |
V517F |
probably damaging |
Het |
| Camk1d |
G |
C |
2: 5,308,177 (GRCm39) |
D274E |
probably benign |
Het |
| Cebpz |
C |
T |
17: 79,229,634 (GRCm39) |
D907N |
probably benign |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Cnst |
T |
A |
1: 179,429,301 (GRCm39) |
|
probably benign |
Het |
| Cog2 |
G |
T |
8: 125,259,268 (GRCm39) |
V196L |
probably benign |
Het |
| Col11a1 |
A |
G |
3: 113,987,833 (GRCm39) |
|
probably null |
Het |
| Cops6 |
T |
A |
5: 138,161,762 (GRCm39) |
|
probably null |
Het |
| Cspg4 |
A |
G |
9: 56,797,484 (GRCm39) |
E1316G |
probably damaging |
Het |
| Cwc22 |
G |
C |
2: 77,759,683 (GRCm39) |
D122E |
possibly damaging |
Het |
| Dapk2 |
G |
A |
9: 66,176,000 (GRCm39) |
V300M |
probably benign |
Het |
| Dcp1b |
C |
A |
6: 119,152,328 (GRCm39) |
D25E |
probably damaging |
Het |
| Ddx10 |
A |
T |
9: 53,145,157 (GRCm39) |
Y273* |
probably null |
Het |
| Dhx58 |
T |
C |
11: 100,589,034 (GRCm39) |
E504G |
probably benign |
Het |
| Dync2h1 |
C |
T |
9: 7,120,899 (GRCm39) |
W2129* |
probably null |
Het |
| Egr4 |
A |
T |
6: 85,489,442 (GRCm39) |
L206Q |
probably damaging |
Het |
| Eif4g3 |
A |
G |
4: 137,830,709 (GRCm39) |
|
probably null |
Het |
| Fbxo46 |
A |
G |
7: 18,870,541 (GRCm39) |
N387D |
possibly damaging |
Het |
| Fpr-rs3 |
T |
G |
17: 20,844,470 (GRCm39) |
M224L |
probably benign |
Het |
| Gm14325 |
G |
A |
2: 177,474,777 (GRCm39) |
H102Y |
possibly damaging |
Het |
| Gxylt2 |
A |
G |
6: 100,682,075 (GRCm39) |
K91E |
probably benign |
Het |
| Hecw1 |
A |
T |
13: 14,497,174 (GRCm39) |
V278E |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,266,474 (GRCm39) |
|
probably null |
Het |
| Iars1 |
T |
C |
13: 49,875,641 (GRCm39) |
L776P |
probably damaging |
Het |
| Kcnh2 |
T |
A |
5: 24,537,039 (GRCm39) |
T182S |
probably benign |
Het |
| Kplce |
T |
C |
3: 92,776,005 (GRCm39) |
E226G |
probably damaging |
Het |
| Lats2 |
T |
G |
14: 57,928,810 (GRCm39) |
S1022R |
probably benign |
Het |
| Lef1 |
C |
T |
3: 130,988,308 (GRCm39) |
P264S |
probably damaging |
Het |
| Lyrm1 |
A |
C |
7: 119,513,471 (GRCm39) |
I79L |
possibly damaging |
Het |
| Macroh2a2 |
G |
A |
10: 61,587,466 (GRCm39) |
T156M |
possibly damaging |
Het |
| Man2b2 |
T |
G |
5: 36,971,862 (GRCm39) |
Q618P |
probably benign |
Het |
| Mei1 |
T |
C |
15: 81,976,957 (GRCm39) |
V180A |
possibly damaging |
Het |
| Mmp15 |
A |
T |
8: 96,093,032 (GRCm39) |
N137I |
probably damaging |
Het |
| Mms22l |
A |
G |
4: 24,517,115 (GRCm39) |
D222G |
possibly damaging |
Het |
| Mmut |
T |
A |
17: 41,258,075 (GRCm39) |
S414T |
probably benign |
Het |
| Myo18a |
T |
C |
11: 77,744,176 (GRCm39) |
M1846T |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,897,517 (GRCm39) |
N146K |
probably benign |
Het |
| Nos3 |
A |
G |
5: 24,588,888 (GRCm39) |
T1174A |
probably benign |
Het |
| Or10d4b |
A |
T |
9: 39,534,430 (GRCm39) |
T4S |
probably benign |
Het |
| Or10x1 |
T |
C |
1: 174,196,836 (GRCm39) |
Y118H |
probably damaging |
Het |
| Or4c125 |
A |
T |
2: 89,169,806 (GRCm39) |
I280N |
probably damaging |
Het |
| Or51f1 |
A |
T |
7: 102,505,686 (GRCm39) |
S268T |
probably damaging |
Het |
| Pax8 |
A |
T |
2: 24,332,922 (GRCm39) |
|
probably benign |
Het |
| Pde5a |
G |
A |
3: 122,611,658 (GRCm39) |
C532Y |
probably damaging |
Het |
| Pigq |
T |
C |
17: 26,150,446 (GRCm39) |
D442G |
possibly damaging |
Het |
| Pik3c2g |
T |
C |
6: 139,665,808 (GRCm39) |
V43A |
probably benign |
Het |
| Pik3cb |
T |
C |
9: 98,970,716 (GRCm39) |
N325S |
probably benign |
Het |
| Pot1b |
T |
C |
17: 56,007,063 (GRCm39) |
K18R |
probably benign |
Het |
| Ppp1r42 |
A |
T |
1: 10,069,630 (GRCm39) |
L144Q |
probably damaging |
Het |
| Prdm13 |
T |
A |
4: 21,679,455 (GRCm39) |
Q345L |
unknown |
Het |
| Pyroxd2 |
T |
A |
19: 42,728,898 (GRCm39) |
K167N |
probably benign |
Het |
| Rnf123 |
T |
C |
9: 107,947,930 (GRCm39) |
Y131C |
probably damaging |
Het |
| Rnf25 |
T |
C |
1: 74,634,411 (GRCm39) |
D204G |
probably damaging |
Het |
| Rpf2 |
G |
A |
10: 40,109,181 (GRCm39) |
T60I |
possibly damaging |
Het |
| Scaf11 |
T |
C |
15: 96,317,339 (GRCm39) |
N742D |
probably benign |
Het |
| Shank1 |
G |
A |
7: 44,002,075 (GRCm39) |
D1257N |
possibly damaging |
Het |
| Shc2 |
A |
G |
10: 79,465,933 (GRCm39) |
V168A |
probably damaging |
Het |
| Slc16a4 |
G |
A |
3: 107,199,758 (GRCm39) |
V2M |
probably benign |
Het |
| Slc24a3 |
T |
C |
2: 145,455,494 (GRCm39) |
V461A |
probably benign |
Het |
| Slc45a2 |
C |
T |
15: 11,027,871 (GRCm39) |
T480I |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,345,623 (GRCm39) |
|
probably null |
Het |
| Snx30 |
T |
A |
4: 59,879,329 (GRCm39) |
D189E |
probably benign |
Het |
| Sspo |
A |
G |
6: 48,472,194 (GRCm39) |
Q4653R |
possibly damaging |
Het |
| Tpte |
G |
T |
8: 22,817,806 (GRCm39) |
R264I |
probably damaging |
Het |
| Tsc22d4 |
T |
A |
5: 137,757,036 (GRCm39) |
|
probably benign |
Het |
| Ubn1 |
T |
C |
16: 4,892,233 (GRCm39) |
L585P |
possibly damaging |
Het |
| Usp24 |
A |
T |
4: 106,265,210 (GRCm39) |
D1781V |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,608,777 (GRCm39) |
Y1514* |
probably null |
Het |
| Vmn1r55 |
A |
T |
7: 5,149,995 (GRCm39) |
Y143N |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,595,862 (GRCm39) |
V274A |
probably benign |
Het |
| Wnt5b |
C |
A |
6: 119,417,283 (GRCm39) |
R156L |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,433,896 (GRCm39) |
D2279G |
unknown |
Het |
| Zan |
T |
C |
5: 137,462,336 (GRCm39) |
T948A |
unknown |
Het |
| Zfp758 |
T |
C |
17: 22,591,049 (GRCm39) |
S4P |
probably damaging |
Het |
| Zfp839 |
A |
G |
12: 110,822,020 (GRCm39) |
E278G |
probably benign |
Het |
| Zfp994 |
T |
A |
17: 22,419,506 (GRCm39) |
H481L |
probably damaging |
Het |
| Zswim9 |
G |
A |
7: 12,994,909 (GRCm39) |
R416C |
probably damaging |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAACACATGCTAGCTGTTG -3'
(R):5'- ACCAGGAATGGACCAATAGTTTG -3'
Sequencing Primer
(F):5'- ACACATGCTAGCTGTTGTTAATAG -3'
(R):5'- ATGGACCAATAGTTTGTGATACGG -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation