Incidental Mutation 'R5394:Iars1'
| ID |
426073 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Iars1
|
| Ensembl Gene |
ENSMUSG00000037851 |
| Gene Name |
isoleucyl-tRNA synthetase 1 |
| Synonyms |
Iars, 2510016L12Rik, E430001P04Rik |
| MMRRC Submission |
042966-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5394 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
49835606-49887743 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 49875641 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 776
(L776P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132082
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047363]
[ENSMUST00000164260]
[ENSMUST00000165316]
|
| AlphaFold |
Q8BU30 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047363
AA Change: L776P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000048096
Gene: ENSMUSG00000037851
AA Change: L776P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
9.2e-242 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
197 |
3.7e-6 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
1.1e-23 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164260
AA Change: L776P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000126806
Gene: ENSMUSG00000037851
AA Change: L776P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165270
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165316
AA Change: L776P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000132082
Gene: ENSMUSG00000037851
AA Change: L776P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:tRNA-synt_1
|
17 |
639 |
5.5e-238 |
PFAM |
|
Pfam:tRNA-synt_1g
|
46 |
205 |
5.2e-8 |
PFAM |
|
Pfam:tRNA-synt_1g
|
521 |
659 |
2.1e-5 |
PFAM |
|
Pfam:Anticodon_1
|
693 |
852 |
7.1e-24 |
PFAM |
|
low complexity region
|
1159 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1180 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165656
|
| Meta Mutation Damage Score |
0.9211 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
97% (96/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930503B20Rik |
A |
G |
3: 146,356,363 (GRCm39) |
F182L |
probably damaging |
Het |
| 4930503B20Rik |
T |
C |
3: 146,356,713 (GRCm39) |
Y65C |
probably damaging |
Het |
| 4930590J08Rik |
A |
G |
6: 91,896,174 (GRCm39) |
T341A |
probably benign |
Het |
| Adamts13 |
G |
A |
2: 26,876,570 (GRCm39) |
V495I |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,600,070 (GRCm39) |
T2101K |
probably benign |
Het |
| Als2 |
T |
C |
1: 59,214,105 (GRCm39) |
D1361G |
probably benign |
Het |
| Ankdd1a |
A |
T |
9: 65,412,496 (GRCm39) |
M275K |
probably benign |
Het |
| Arfip2 |
A |
T |
7: 105,286,183 (GRCm39) |
Y161* |
probably null |
Het |
| Asap3 |
A |
T |
4: 135,968,570 (GRCm39) |
E707D |
probably benign |
Het |
| Atm |
C |
T |
9: 53,419,077 (GRCm39) |
|
probably null |
Het |
| Atp9b |
A |
T |
18: 80,820,052 (GRCm39) |
S577R |
probably benign |
Het |
| Bltp1 |
G |
T |
3: 36,971,817 (GRCm39) |
V517F |
probably damaging |
Het |
| Camk1d |
G |
C |
2: 5,308,177 (GRCm39) |
D274E |
probably benign |
Het |
| Cebpz |
C |
T |
17: 79,229,634 (GRCm39) |
D907N |
probably benign |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Het |
| Cnst |
T |
A |
1: 179,429,301 (GRCm39) |
|
probably benign |
Het |
| Cog2 |
G |
T |
8: 125,259,268 (GRCm39) |
V196L |
probably benign |
Het |
| Col11a1 |
A |
G |
3: 113,987,833 (GRCm39) |
|
probably null |
Het |
| Cops6 |
T |
A |
5: 138,161,762 (GRCm39) |
|
probably null |
Het |
| Cspg4 |
A |
G |
9: 56,797,484 (GRCm39) |
E1316G |
probably damaging |
Het |
| Cwc22 |
G |
C |
2: 77,759,683 (GRCm39) |
D122E |
possibly damaging |
Het |
| Dapk2 |
G |
A |
9: 66,176,000 (GRCm39) |
V300M |
probably benign |
Het |
| Dcp1b |
C |
A |
6: 119,152,328 (GRCm39) |
D25E |
probably damaging |
Het |
| Ddx10 |
A |
T |
9: 53,145,157 (GRCm39) |
Y273* |
probably null |
Het |
| Dhx58 |
T |
C |
11: 100,589,034 (GRCm39) |
E504G |
probably benign |
Het |
| Dync2h1 |
C |
T |
9: 7,120,899 (GRCm39) |
W2129* |
probably null |
Het |
| Egr4 |
A |
T |
6: 85,489,442 (GRCm39) |
L206Q |
probably damaging |
Het |
| Eif4g3 |
A |
G |
4: 137,830,709 (GRCm39) |
|
probably null |
Het |
| Fbxo46 |
A |
G |
7: 18,870,541 (GRCm39) |
N387D |
possibly damaging |
Het |
| Fpr-rs3 |
T |
G |
17: 20,844,470 (GRCm39) |
M224L |
probably benign |
Het |
| Gm14325 |
G |
A |
2: 177,474,777 (GRCm39) |
H102Y |
possibly damaging |
Het |
| Gxylt2 |
A |
G |
6: 100,682,075 (GRCm39) |
K91E |
probably benign |
Het |
| Hecw1 |
A |
T |
13: 14,497,174 (GRCm39) |
V278E |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,266,474 (GRCm39) |
|
probably null |
Het |
| Kcnh2 |
T |
A |
5: 24,537,039 (GRCm39) |
T182S |
probably benign |
Het |
| Kplce |
T |
C |
3: 92,776,005 (GRCm39) |
E226G |
probably damaging |
Het |
| Lats2 |
T |
G |
14: 57,928,810 (GRCm39) |
S1022R |
probably benign |
Het |
| Lef1 |
C |
T |
3: 130,988,308 (GRCm39) |
P264S |
probably damaging |
Het |
| Lyrm1 |
A |
C |
7: 119,513,471 (GRCm39) |
I79L |
possibly damaging |
Het |
| Macroh2a2 |
G |
A |
10: 61,587,466 (GRCm39) |
T156M |
possibly damaging |
Het |
| Man2b2 |
T |
G |
5: 36,971,862 (GRCm39) |
Q618P |
probably benign |
Het |
| Mei1 |
T |
C |
15: 81,976,957 (GRCm39) |
V180A |
possibly damaging |
Het |
| Mmp15 |
A |
T |
8: 96,093,032 (GRCm39) |
N137I |
probably damaging |
Het |
| Mms22l |
A |
G |
4: 24,517,115 (GRCm39) |
D222G |
possibly damaging |
Het |
| Mmut |
T |
A |
17: 41,258,075 (GRCm39) |
S414T |
probably benign |
Het |
| Myo18a |
T |
C |
11: 77,744,176 (GRCm39) |
M1846T |
probably benign |
Het |
| Neo1 |
A |
T |
9: 58,897,517 (GRCm39) |
N146K |
probably benign |
Het |
| Nos3 |
A |
G |
5: 24,588,888 (GRCm39) |
T1174A |
probably benign |
Het |
| Or10d4b |
A |
T |
9: 39,534,430 (GRCm39) |
T4S |
probably benign |
Het |
| Or10x1 |
T |
C |
1: 174,196,836 (GRCm39) |
Y118H |
probably damaging |
Het |
| Or4c125 |
A |
T |
2: 89,169,806 (GRCm39) |
I280N |
probably damaging |
Het |
| Or51f1 |
A |
T |
7: 102,505,686 (GRCm39) |
S268T |
probably damaging |
Het |
| Pax8 |
A |
T |
2: 24,332,922 (GRCm39) |
|
probably benign |
Het |
| Pde5a |
G |
A |
3: 122,611,658 (GRCm39) |
C532Y |
probably damaging |
Het |
| Pigq |
T |
C |
17: 26,150,446 (GRCm39) |
D442G |
possibly damaging |
Het |
| Pik3c2g |
T |
C |
6: 139,665,808 (GRCm39) |
V43A |
probably benign |
Het |
| Pik3cb |
T |
C |
9: 98,970,716 (GRCm39) |
N325S |
probably benign |
Het |
| Pot1b |
T |
C |
17: 56,007,063 (GRCm39) |
K18R |
probably benign |
Het |
| Ppp1r42 |
A |
T |
1: 10,069,630 (GRCm39) |
L144Q |
probably damaging |
Het |
| Prdm13 |
T |
A |
4: 21,679,455 (GRCm39) |
Q345L |
unknown |
Het |
| Pyroxd2 |
T |
A |
19: 42,728,898 (GRCm39) |
K167N |
probably benign |
Het |
| Rnf123 |
T |
C |
9: 107,947,930 (GRCm39) |
Y131C |
probably damaging |
Het |
| Rnf25 |
T |
C |
1: 74,634,411 (GRCm39) |
D204G |
probably damaging |
Het |
| Rpf2 |
G |
A |
10: 40,109,181 (GRCm39) |
T60I |
possibly damaging |
Het |
| Scaf11 |
T |
C |
15: 96,317,339 (GRCm39) |
N742D |
probably benign |
Het |
| Shank1 |
G |
A |
7: 44,002,075 (GRCm39) |
D1257N |
possibly damaging |
Het |
| Shc2 |
A |
G |
10: 79,465,933 (GRCm39) |
V168A |
probably damaging |
Het |
| Slc16a4 |
G |
A |
3: 107,199,758 (GRCm39) |
V2M |
probably benign |
Het |
| Slc24a3 |
T |
C |
2: 145,455,494 (GRCm39) |
V461A |
probably benign |
Het |
| Slc45a2 |
C |
T |
15: 11,027,871 (GRCm39) |
T480I |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,345,623 (GRCm39) |
|
probably null |
Het |
| Snx30 |
T |
A |
4: 59,879,329 (GRCm39) |
D189E |
probably benign |
Het |
| Sspo |
A |
G |
6: 48,472,194 (GRCm39) |
Q4653R |
possibly damaging |
Het |
| Tpte |
G |
T |
8: 22,817,806 (GRCm39) |
R264I |
probably damaging |
Het |
| Tsc22d4 |
T |
A |
5: 137,757,036 (GRCm39) |
|
probably benign |
Het |
| Ubn1 |
T |
C |
16: 4,892,233 (GRCm39) |
L585P |
possibly damaging |
Het |
| Usp24 |
A |
T |
4: 106,265,210 (GRCm39) |
D1781V |
probably damaging |
Het |
| Utp20 |
A |
T |
10: 88,608,777 (GRCm39) |
Y1514* |
probably null |
Het |
| Vmn1r55 |
A |
T |
7: 5,149,995 (GRCm39) |
Y143N |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,595,862 (GRCm39) |
V274A |
probably benign |
Het |
| Wdr17 |
A |
G |
8: 55,092,524 (GRCm39) |
S1087P |
possibly damaging |
Het |
| Wnt5b |
C |
A |
6: 119,417,283 (GRCm39) |
R156L |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,433,896 (GRCm39) |
D2279G |
unknown |
Het |
| Zan |
T |
C |
5: 137,462,336 (GRCm39) |
T948A |
unknown |
Het |
| Zfp758 |
T |
C |
17: 22,591,049 (GRCm39) |
S4P |
probably damaging |
Het |
| Zfp839 |
A |
G |
12: 110,822,020 (GRCm39) |
E278G |
probably benign |
Het |
| Zfp994 |
T |
A |
17: 22,419,506 (GRCm39) |
H481L |
probably damaging |
Het |
| Zswim9 |
G |
A |
7: 12,994,909 (GRCm39) |
R416C |
probably damaging |
Het |
|
| Other mutations in Iars1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00697:Iars1
|
APN |
13 |
49,863,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00764:Iars1
|
APN |
13 |
49,865,303 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01153:Iars1
|
APN |
13 |
49,865,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01481:Iars1
|
APN |
13 |
49,882,174 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01596:Iars1
|
APN |
13 |
49,856,652 (GRCm39) |
missense |
probably benign |
|
|
IGL01682:Iars1
|
APN |
13 |
49,863,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01885:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01907:Iars1
|
APN |
13 |
49,863,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02023:Iars1
|
APN |
13 |
49,841,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Iars1
|
APN |
13 |
49,878,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02365:Iars1
|
APN |
13 |
49,844,975 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02704:Iars1
|
APN |
13 |
49,874,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02838:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02975:Iars1
|
APN |
13 |
49,858,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02982:Iars1
|
APN |
13 |
49,863,185 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03034:Iars1
|
APN |
13 |
49,843,965 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03060:Iars1
|
APN |
13 |
49,843,923 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL03156:Iars1
|
APN |
13 |
49,856,655 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03206:Iars1
|
APN |
13 |
49,846,546 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03343:Iars1
|
APN |
13 |
49,878,223 (GRCm39) |
missense |
probably benign |
0.12 |
|
gannett_peak
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
missouri
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
spacex
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
wind_river
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Iars1
|
UTSW |
13 |
49,846,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Iars1
|
UTSW |
13 |
49,875,688 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Iars1
|
UTSW |
13 |
49,879,678 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0356:Iars1
|
UTSW |
13 |
49,856,709 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0383:Iars1
|
UTSW |
13 |
49,885,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0657:Iars1
|
UTSW |
13 |
49,855,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1005:Iars1
|
UTSW |
13 |
49,840,921 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1427:Iars1
|
UTSW |
13 |
49,857,745 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1449:Iars1
|
UTSW |
13 |
49,887,186 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1647:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1648:Iars1
|
UTSW |
13 |
49,876,478 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1664:Iars1
|
UTSW |
13 |
49,865,251 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1763:Iars1
|
UTSW |
13 |
49,876,553 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2192:Iars1
|
UTSW |
13 |
49,841,605 (GRCm39) |
splice site |
probably null |
|
|
R2203:Iars1
|
UTSW |
13 |
49,876,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2357:Iars1
|
UTSW |
13 |
49,841,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3724:Iars1
|
UTSW |
13 |
49,840,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4785:Iars1
|
UTSW |
13 |
49,878,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4934:Iars1
|
UTSW |
13 |
49,871,460 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4999:Iars1
|
UTSW |
13 |
49,863,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Iars1
|
UTSW |
13 |
49,841,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5268:Iars1
|
UTSW |
13 |
49,843,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5486:Iars1
|
UTSW |
13 |
49,863,049 (GRCm39) |
splice site |
probably null |
|
|
R5960:Iars1
|
UTSW |
13 |
49,878,113 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5972:Iars1
|
UTSW |
13 |
49,863,108 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5978:Iars1
|
UTSW |
13 |
49,876,469 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6031:Iars1
|
UTSW |
13 |
49,859,307 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6092:Iars1
|
UTSW |
13 |
49,861,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6167:Iars1
|
UTSW |
13 |
49,876,190 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Iars1
|
UTSW |
13 |
49,861,921 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6358:Iars1
|
UTSW |
13 |
49,880,619 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6385:Iars1
|
UTSW |
13 |
49,855,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6403:Iars1
|
UTSW |
13 |
49,840,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Iars1
|
UTSW |
13 |
49,878,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Iars1
|
UTSW |
13 |
49,873,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6957:Iars1
|
UTSW |
13 |
49,875,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7207:Iars1
|
UTSW |
13 |
49,841,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7254:Iars1
|
UTSW |
13 |
49,876,554 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7354:Iars1
|
UTSW |
13 |
49,857,796 (GRCm39) |
missense |
probably benign |
|
|
R7397:Iars1
|
UTSW |
13 |
49,882,153 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7696:Iars1
|
UTSW |
13 |
49,860,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7799:Iars1
|
UTSW |
13 |
49,876,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7828:Iars1
|
UTSW |
13 |
49,878,748 (GRCm39) |
missense |
probably benign |
|
|
R8679:Iars1
|
UTSW |
13 |
49,856,675 (GRCm39) |
unclassified |
probably benign |
|
|
R8768:Iars1
|
UTSW |
13 |
49,878,102 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8797:Iars1
|
UTSW |
13 |
49,841,738 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8906:Iars1
|
UTSW |
13 |
49,882,177 (GRCm39) |
missense |
probably benign |
|
|
R8990:Iars1
|
UTSW |
13 |
49,841,752 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9134:Iars1
|
UTSW |
13 |
49,855,323 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Iars1
|
UTSW |
13 |
49,855,350 (GRCm39) |
missense |
probably benign |
|
|
R9394:Iars1
|
UTSW |
13 |
49,883,536 (GRCm39) |
missense |
probably benign |
|
|
R9668:Iars1
|
UTSW |
13 |
49,840,885 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9741:Iars1
|
UTSW |
13 |
49,844,978 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Iars1
|
UTSW |
13 |
49,874,564 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTCCTGTGAGGTAGCTC -3'
(R):5'- GGATGCTATACCCCTGCTACTG -3'
Sequencing Primer
(F):5'- GTGAGGTAGCTCTACTATTACACC -3'
(R):5'- CCTGAGGAGTAGCTGCATCAG -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation