Incidental Mutation 'R5425:Dipk2a'
ID 426828
Institutional Source Beutler Lab
Gene Symbol Dipk2a
Ensembl Gene ENSMUSG00000045414
Gene Name divergent protein kinase domain 2A
Synonyms GoPro49, 1190002N15Rik
MMRRC Submission 042991-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5425 (G1)
Quality Score 104
Status Not validated
Chromosome 9
Chromosomal Location 94399917-94420134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 94419745 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 62 (S62G)
Ref Sequence ENSEMBL: ENSMUSP00000108651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113028]
AlphaFold Q3USZ8
Predicted Effect probably damaging
Transcript: ENSMUST00000113028
AA Change: S62G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000108651
Gene: ENSMUSG00000045414
AA Change: S62G

DomainStartEndE-ValueType
low complexity region 7 38 N/A INTRINSIC
low complexity region 97 113 N/A INTRINSIC
Pfam:PIP49_C 206 405 2e-56 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace A G 11: 105,864,254 (GRCm39) E465G probably damaging Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Aida T A 1: 183,103,201 (GRCm39) C174S possibly damaging Het
Aldh1a2 G A 9: 71,160,286 (GRCm39) R104H probably benign Het
Aldh3a1 T C 11: 61,104,407 (GRCm39) L98P probably benign Het
Ankmy1 G T 1: 92,798,679 (GRCm39) Y20* probably null Het
Arhgap9 C A 10: 127,162,287 (GRCm39) N314K probably damaging Het
Atxn7l1 T C 12: 33,417,119 (GRCm39) Y427H probably damaging Het
Bltp3a G A 17: 28,106,489 (GRCm39) S1005N probably benign Het
Bola3 G T 6: 83,326,534 (GRCm39) G18W probably benign Het
Carmil3 A G 14: 55,731,334 (GRCm39) T138A probably benign Het
Castor1 T A 11: 4,171,689 (GRCm39) H304Q probably damaging Het
Ccnd2 A G 6: 127,127,580 (GRCm39) Y53H probably benign Het
Cd101 T A 3: 100,926,002 (GRCm39) D239V probably damaging Het
Ces1g T A 8: 94,052,428 (GRCm39) Q287L probably benign Het
Cfap43 C T 19: 47,885,371 (GRCm39) A415T possibly damaging Het
Cfap74 A G 4: 155,540,149 (GRCm39) probably benign Het
Crnn A G 3: 93,056,456 (GRCm39) K414R probably benign Het
Csf1 A G 3: 107,656,212 (GRCm39) L273P possibly damaging Het
Dab2ip T G 2: 35,600,003 (GRCm39) H206Q probably benign Het
Diras2 A G 13: 52,662,083 (GRCm39) S75P probably damaging Het
Dst T C 1: 34,218,831 (GRCm39) V1757A probably benign Het
Dus4l A T 12: 31,690,807 (GRCm39) H281Q probably damaging Het
Faah A T 4: 115,857,993 (GRCm39) M436K probably null Het
Fat1 T C 8: 45,478,922 (GRCm39) V2656A possibly damaging Het
Ffar1 A C 7: 30,560,204 (GRCm39) L231R probably damaging Het
Gab1 T C 8: 81,527,018 (GRCm39) K27E probably damaging Het
Gm14403 AAACCCTA AA 2: 177,201,448 (GRCm39) probably benign Het
H2-T5 A C 17: 36,479,377 (GRCm39) L8R probably damaging Het
Irx6 T C 8: 93,404,145 (GRCm39) probably null Het
Mcrs1 C A 15: 99,141,569 (GRCm39) R376L probably damaging Het
Mrgprb1 T A 7: 48,097,719 (GRCm39) L64F possibly damaging Het
Nck2 T G 1: 43,593,552 (GRCm39) V253G probably benign Het
Paip1 C T 13: 119,566,702 (GRCm39) T12M possibly damaging Het
Pdpk1 A T 17: 24,317,095 (GRCm39) L256Q probably damaging Het
Perm1 A G 4: 156,302,752 (GRCm39) D432G probably benign Het
Psg25 A T 7: 18,258,709 (GRCm39) Y322* probably null Het
Pzp G A 6: 128,466,011 (GRCm39) A1223V probably damaging Het
Rassf8 A T 6: 145,761,268 (GRCm39) Y198F probably benign Het
Repin1 A G 6: 48,573,365 (GRCm39) Q42R probably benign Het
Sirpb1b A C 3: 15,613,729 (GRCm39) C51G probably damaging Het
Snx13 C T 12: 35,150,643 (GRCm39) Q316* probably null Het
Spesp1 A G 9: 62,189,331 (GRCm39) V5A possibly damaging Het
Sprr2e G A 3: 92,260,370 (GRCm39) C67Y unknown Het
Tcaf3 G A 6: 42,573,697 (GRCm39) P172S probably damaging Het
Tmem126b A G 7: 90,120,155 (GRCm39) I72T probably benign Het
Tmem17 G T 11: 22,468,624 (GRCm39) V188L probably benign Het
Tnfrsf1b T C 4: 144,955,678 (GRCm39) probably null Het
Tshz2 A T 2: 169,725,944 (GRCm39) Q180L probably damaging Het
Ttc41 A T 10: 86,612,494 (GRCm39) I1256F probably damaging Het
Wdr17 C T 8: 55,134,434 (GRCm39) G349R probably damaging Het
Ywhag G T 5: 135,940,119 (GRCm39) H158Q probably benign Het
Other mutations in Dipk2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01925:Dipk2a APN 9 94,402,509 (GRCm39) missense probably damaging 1.00
R0153:Dipk2a UTSW 9 94,406,533 (GRCm39) missense probably benign 0.17
R2109:Dipk2a UTSW 9 94,406,498 (GRCm39) missense probably damaging 0.99
R2986:Dipk2a UTSW 9 94,402,570 (GRCm39) missense probably damaging 1.00
R4623:Dipk2a UTSW 9 94,402,451 (GRCm39) missense possibly damaging 0.48
R4677:Dipk2a UTSW 9 94,402,457 (GRCm39) missense probably damaging 1.00
R4705:Dipk2a UTSW 9 94,402,688 (GRCm39) missense possibly damaging 0.68
R4876:Dipk2a UTSW 9 94,419,630 (GRCm39) missense probably damaging 0.99
R4994:Dipk2a UTSW 9 94,419,486 (GRCm39) missense probably benign 0.06
R5322:Dipk2a UTSW 9 94,402,615 (GRCm39) missense probably benign 0.00
R5739:Dipk2a UTSW 9 94,402,594 (GRCm39) missense possibly damaging 0.84
R6788:Dipk2a UTSW 9 94,406,502 (GRCm39) missense probably benign 0.14
R7390:Dipk2a UTSW 9 94,419,436 (GRCm39) missense probably damaging 1.00
R7557:Dipk2a UTSW 9 94,402,591 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCAGATGCTCTGGTCGAG -3'
(R):5'- TATAACTTGGCGGGCAAGG -3'

Sequencing Primer
(F):5'- TGGTCGAGCTGCGCCAG -3'
(R):5'- TTGTGGAGACAGCCGATCG -3'
Posted On 2016-09-01