Incidental Mutation 'R5430:Zfp354c'
ID 427139
Institutional Source Beutler Lab
Gene Symbol Zfp354c
Ensembl Gene ENSMUSG00000044807
Gene Name zinc finger protein 354C
Synonyms 5330421P20Rik, Kid3, AJ18
MMRRC Submission 042996-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5430 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 50701913-50718551 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50706022 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 351 (I351T)
Ref Sequence ENSEMBL: ENSMUSP00000104763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000632] [ENSMUST00000109135]
AlphaFold Q571J5
Predicted Effect probably benign
Transcript: ENSMUST00000000632
AA Change: I351T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000000632
Gene: ENSMUSG00000044807
AA Change: I351T

DomainStartEndE-ValueType
KRAB 14 74 9.98e-33 SMART
ZnF_C2H2 218 240 5.9e-3 SMART
ZnF_C2H2 246 268 3.74e-5 SMART
ZnF_C2H2 274 296 1.72e-4 SMART
ZnF_C2H2 302 324 7.78e-3 SMART
ZnF_C2H2 330 352 1.92e-2 SMART
ZnF_C2H2 358 380 4.79e-3 SMART
ZnF_C2H2 386 408 1.1e-2 SMART
ZnF_C2H2 414 436 5.67e-5 SMART
ZnF_C2H2 442 464 9.08e-4 SMART
ZnF_C2H2 470 492 5.59e-4 SMART
ZnF_C2H2 498 520 3.39e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109135
AA Change: I351T

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000104763
Gene: ENSMUSG00000044807
AA Change: I351T

DomainStartEndE-ValueType
KRAB 14 74 9.98e-33 SMART
ZnF_C2H2 218 240 5.9e-3 SMART
ZnF_C2H2 246 268 3.74e-5 SMART
ZnF_C2H2 274 296 1.72e-4 SMART
ZnF_C2H2 302 324 7.78e-3 SMART
ZnF_C2H2 330 352 1.92e-2 SMART
ZnF_C2H2 358 380 4.79e-3 SMART
ZnF_C2H2 386 408 1.1e-2 SMART
ZnF_C2H2 414 436 5.67e-5 SMART
ZnF_C2H2 442 464 9.08e-4 SMART
ZnF_C2H2 470 492 5.59e-4 SMART
ZnF_C2H2 498 520 3.39e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139465
Meta Mutation Damage Score 0.0965 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 96% (54/56)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J11Rik T A 9: 39,963,587 (GRCm39) noncoding transcript Het
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Ankrd34a G A 3: 96,504,837 (GRCm39) G14R probably damaging Het
Arhgef1 C A 7: 24,611,732 (GRCm39) probably null Het
Brsk1 T C 7: 4,713,435 (GRCm39) F702L probably benign Het
Chrna3 C T 9: 54,920,192 (GRCm39) V470I probably damaging Het
Cpm A G 10: 117,511,986 (GRCm39) Q310R possibly damaging Het
Dennd5a T C 7: 109,533,447 (GRCm39) T108A probably damaging Het
Dvl3 C T 16: 20,342,481 (GRCm39) R145W probably damaging Het
E4f1 G A 17: 24,663,944 (GRCm39) A532V probably damaging Het
Eid1 A G 2: 125,515,550 (GRCm39) T147A probably damaging Het
Eipr1 A T 12: 28,913,015 (GRCm39) N239Y probably damaging Het
Eml5 T C 12: 98,760,417 (GRCm39) I1777M probably damaging Het
Gm11787 A T 4: 3,512,786 (GRCm39) noncoding transcript Het
Gnat2 T C 3: 108,005,716 (GRCm39) L227P probably damaging Het
H2-T15 C T 17: 36,366,967 (GRCm39) V359I probably benign Het
Jag1 T C 2: 136,943,626 (GRCm39) H190R possibly damaging Het
Kdm7a A G 6: 39,126,276 (GRCm39) W570R possibly damaging Het
Lmbrd1 A G 1: 24,732,061 (GRCm39) T93A possibly damaging Het
Lrch4 T C 5: 137,636,795 (GRCm39) S433P possibly damaging Het
Lrp1 G A 10: 127,376,930 (GRCm39) R4216W probably damaging Het
Magohb A G 6: 131,266,381 (GRCm39) Y42H probably damaging Het
Melk A G 4: 44,309,033 (GRCm39) H130R probably damaging Het
Mettl24 G T 10: 40,613,780 (GRCm39) R173L probably benign Het
Mup4 A T 4: 59,960,044 (GRCm39) H73Q probably damaging Het
Mylk2 A T 2: 152,759,468 (GRCm39) E386V probably damaging Het
Nppb C T 4: 148,070,838 (GRCm39) P71L probably benign Het
Oca2 T C 7: 55,945,208 (GRCm39) V272A probably damaging Het
Or14j6 T A 17: 38,215,304 (GRCm39) I289N probably damaging Het
Or2t6 C T 14: 14,175,692 (GRCm38) R130H probably benign Het
Or4c10 A T 2: 89,760,257 (GRCm39) I35F probably benign Het
Osbpl6 T C 2: 76,416,482 (GRCm39) S628P probably damaging Het
Papola T C 12: 105,775,843 (GRCm39) V253A probably damaging Het
Pex12 T C 11: 83,188,572 (GRCm39) D141G probably damaging Het
Ppm1k A T 6: 57,501,871 (GRCm39) C97* probably null Het
Ptprh T A 7: 4,554,046 (GRCm39) E807V probably damaging Het
Sema3a A T 5: 13,615,730 (GRCm39) T385S probably damaging Het
Sfn T C 4: 133,328,938 (GRCm39) Y48C probably damaging Het
Slc38a8 A G 8: 120,220,959 (GRCm39) I200T probably benign Het
Smarcal1 T C 1: 72,665,776 (GRCm39) V758A probably damaging Het
Stmn4 A G 14: 66,595,463 (GRCm39) M190V possibly damaging Het
Syt3 T G 7: 44,040,337 (GRCm39) L190R possibly damaging Het
Tbl1xr1 T A 3: 22,246,246 (GRCm39) D255E probably benign Het
Ttbk2 C T 2: 120,608,046 (GRCm39) R191H probably damaging Het
Vmn1r238 G T 18: 3,122,521 (GRCm39) L298M possibly damaging Het
Vmn2r45 A C 7: 8,486,333 (GRCm39) Y318* probably null Het
Vsig8 T C 1: 172,387,196 (GRCm39) I24T probably damaging Het
Wdr3 G A 3: 100,064,643 (GRCm39) T166I possibly damaging Het
Zfp52 A G 17: 21,775,329 (GRCm39) T8A probably benign Het
Other mutations in Zfp354c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Zfp354c APN 11 50,706,440 (GRCm39) missense probably damaging 0.97
IGL01615:Zfp354c APN 11 50,708,732 (GRCm39) missense possibly damaging 0.90
IGL03019:Zfp354c APN 11 50,708,021 (GRCm39) missense probably damaging 1.00
R0546:Zfp354c UTSW 11 50,706,457 (GRCm39) missense probably benign 0.12
R1370:Zfp354c UTSW 11 50,706,667 (GRCm39) missense probably benign
R2109:Zfp354c UTSW 11 50,707,969 (GRCm39) missense probably benign 0.01
R2850:Zfp354c UTSW 11 50,706,158 (GRCm39) nonsense probably null
R4010:Zfp354c UTSW 11 50,705,771 (GRCm39) missense probably damaging 0.98
R5034:Zfp354c UTSW 11 50,705,866 (GRCm39) missense probably benign 0.14
R5439:Zfp354c UTSW 11 50,706,597 (GRCm39) missense probably benign 0.01
R5905:Zfp354c UTSW 11 50,706,253 (GRCm39) missense probably damaging 1.00
R6244:Zfp354c UTSW 11 50,705,798 (GRCm39) missense probably benign 0.41
R6264:Zfp354c UTSW 11 50,706,274 (GRCm39) missense probably benign 0.00
R6591:Zfp354c UTSW 11 50,705,602 (GRCm39) missense probably benign 0.41
R6650:Zfp354c UTSW 11 50,705,518 (GRCm39) missense probably damaging 1.00
R6691:Zfp354c UTSW 11 50,705,602 (GRCm39) missense probably benign 0.41
R7087:Zfp354c UTSW 11 50,706,040 (GRCm39) missense probably damaging 1.00
R7313:Zfp354c UTSW 11 50,705,483 (GRCm39) missense probably damaging 1.00
R7467:Zfp354c UTSW 11 50,706,253 (GRCm39) missense probably damaging 1.00
R7619:Zfp354c UTSW 11 50,708,635 (GRCm39) critical splice donor site probably null
R7699:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7710:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7712:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7747:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7748:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7784:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7816:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7817:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7853:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7855:Zfp354c UTSW 11 50,706,067 (GRCm39) small deletion probably benign
R7870:Zfp354c UTSW 11 50,706,065 (GRCm39) small deletion probably benign
R8852:Zfp354c UTSW 11 50,706,019 (GRCm39) missense probably damaging 1.00
R8860:Zfp354c UTSW 11 50,706,019 (GRCm39) missense probably damaging 1.00
R8862:Zfp354c UTSW 11 50,708,718 (GRCm39) missense probably benign 0.15
R9169:Zfp354c UTSW 11 50,706,088 (GRCm39) missense probably damaging 1.00
R9215:Zfp354c UTSW 11 50,706,666 (GRCm39) missense probably benign 0.31
R9273:Zfp354c UTSW 11 50,706,059 (GRCm39) missense probably damaging 1.00
R9762:Zfp354c UTSW 11 50,706,239 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGTGTCTACAAAGGTTTGACCTG -3'
(R):5'- AGGATTTTGATCTAATGAGAAGCTTT -3'

Sequencing Primer
(F):5'- TCCACACTGGTTACACTGATAGGG -3'
(R):5'- TCTTCTAGAGCACAAGAGGCTTC -3'
Posted On 2016-09-01