Incidental Mutation 'R5445:Vmn2r90'
ID 427429
Institutional Source Beutler Lab
Gene Symbol Vmn2r90
Ensembl Gene ENSMUSG00000092120
Gene Name vomeronasal 2, receptor 90
Synonyms EG626942
MMRRC Submission 043010-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R5445 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 17924203-17954429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 17954386 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 850 (H850L)
Ref Sequence ENSEMBL: ENSMUSP00000126650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]
AlphaFold E9PXJ8
Predicted Effect probably benign
Transcript: ENSMUST00000169805
AA Change: H850L

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: H850L

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-43 PFAM
Pfam:NCD3G 514 567 3e-22 PFAM
Pfam:7tm_3 600 835 9.8e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231659
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231940
Predicted Effect probably benign
Transcript: ENSMUST00000232078
Predicted Effect probably benign
Transcript: ENSMUST00000232113
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A T 17: 84,978,557 (GRCm39) D300E probably damaging Het
Apbb1ip T C 2: 22,725,960 (GRCm39) V244A possibly damaging Het
Arhgap32 T C 9: 32,159,678 (GRCm39) S232P probably benign Het
Atf7ip G A 6: 136,564,255 (GRCm39) V833M probably damaging Het
Casp7 A G 19: 56,421,770 (GRCm39) probably null Het
Ccdc9b T C 2: 118,590,067 (GRCm39) D259G probably damaging Het
Celsr2 T A 3: 108,299,974 (GRCm39) E2911D probably benign Het
Cep350 T C 1: 155,770,469 (GRCm39) D1807G probably benign Het
Cfap251 C T 5: 123,425,240 (GRCm39) T294M probably damaging Het
Chrd A G 16: 20,557,660 (GRCm39) T753A possibly damaging Het
Clasp2 A G 9: 113,733,014 (GRCm39) D971G probably damaging Het
Cnnm2 A G 19: 46,865,727 (GRCm39) T772A possibly damaging Het
Cntn1 A T 15: 92,192,958 (GRCm39) N687Y probably damaging Het
Col6a3 G A 1: 90,709,761 (GRCm39) R1812* probably null Het
Dsc2 T C 18: 20,168,360 (GRCm39) I700V possibly damaging Het
Flt3 G A 5: 147,291,905 (GRCm39) Q540* probably null Het
Fmo4 T A 1: 162,632,842 (GRCm39) I170F probably benign Het
Fra10ac1 T A 19: 38,207,910 (GRCm39) D72V possibly damaging Het
Garin2 G A 12: 78,761,890 (GRCm39) E185K probably damaging Het
Gemin6 T G 17: 80,535,178 (GRCm39) V46G probably damaging Het
Gm2381 T G 7: 42,469,425 (GRCm39) H233P probably damaging Het
Gm5148 T A 3: 37,768,995 (GRCm39) Q75L probably damaging Het
Gm8369 T C 19: 11,482,170 (GRCm39) V27A possibly damaging Het
Gpr157 T C 4: 150,186,825 (GRCm39) S318P probably benign Het
Hectd4 G A 5: 121,404,337 (GRCm39) V405M probably benign Het
Hemgn T C 4: 46,400,738 (GRCm39) R41G probably benign Het
Hhipl1 T A 12: 108,294,467 (GRCm39) L791Q probably damaging Het
Hjurp T G 1: 88,194,038 (GRCm39) K290T probably benign Het
Ifi207 T C 1: 173,555,363 (GRCm39) E773G probably damaging Het
Kcnh6 T C 11: 105,914,685 (GRCm39) Y697H probably damaging Het
Lonrf2 T C 1: 38,846,234 (GRCm39) T313A probably benign Het
Lrba G T 3: 86,275,902 (GRCm39) V1757L probably benign Het
Lrrc24 T C 15: 76,600,306 (GRCm39) T278A probably benign Het
Ltbp2 T C 12: 84,856,428 (GRCm39) I679V probably null Het
Mapk4 G T 18: 74,064,073 (GRCm39) T383K probably benign Het
Mdn1 C T 4: 32,723,690 (GRCm39) P2542L probably damaging Het
Mia3 A G 1: 183,117,471 (GRCm39) V208A probably benign Het
Myo15a C A 11: 60,411,603 (GRCm39) C3234* probably null Het
Nlrp1b G T 11: 71,108,701 (GRCm39) Q267K probably benign Het
Nphp3 A G 9: 103,881,922 (GRCm39) K37E probably damaging Het
Nwd2 T C 5: 63,962,681 (GRCm39) M755T probably damaging Het
Or10u4 T A 10: 129,802,158 (GRCm39) H137L probably benign Het
Or52ac1 A G 7: 104,246,028 (GRCm39) F120S probably damaging Het
Or5p58 A G 7: 107,693,949 (GRCm39) V276A possibly damaging Het
Pdlim5 C T 3: 142,058,495 (GRCm39) R83K probably null Het
Plekha5 A T 6: 140,498,459 (GRCm39) R173* probably null Het
Pramel25 T A 4: 143,521,707 (GRCm39) V441E possibly damaging Het
Rbms3 T A 9: 117,080,853 (GRCm39) D6V possibly damaging Het
Rhoq A T 17: 87,271,755 (GRCm39) Y57F probably benign Het
Rrm1 A T 7: 102,100,230 (GRCm39) T204S possibly damaging Het
Slf1 A T 13: 77,239,323 (GRCm39) I447N probably benign Het
Smarcc2 T A 10: 128,323,943 (GRCm39) probably benign Het
Spdye4c C T 2: 128,438,484 (GRCm39) Q281* probably null Het
Tert T A 13: 73,792,403 (GRCm39) M890K probably benign Het
Tln1 C A 4: 43,543,905 (GRCm39) R1198L probably benign Het
Tmco4 A G 4: 138,748,178 (GRCm39) M253V probably damaging Het
Usp19 G T 9: 108,375,119 (GRCm39) V782F possibly damaging Het
Usp33 T A 3: 152,080,260 (GRCm39) S464T probably damaging Het
Usp47 A T 7: 111,673,928 (GRCm39) Y397F probably damaging Het
Vmn1r12 A G 6: 57,136,466 (GRCm39) T144A probably benign Het
Zfhx3 A T 8: 109,682,842 (GRCm39) Q3427L unknown Het
Zfp236 G T 18: 82,700,281 (GRCm39) Q63K probably benign Het
Zfp7 T A 15: 76,775,054 (GRCm39) C365* probably null Het
Zfp786 T C 6: 47,796,619 (GRCm39) E773G probably damaging Het
Other mutations in Vmn2r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Vmn2r90 APN 17 17,953,758 (GRCm39) missense probably benign 0.00
IGL01330:Vmn2r90 APN 17 17,953,542 (GRCm39) missense probably benign 0.00
IGL01989:Vmn2r90 APN 17 17,933,494 (GRCm39) nonsense probably null
IGL02080:Vmn2r90 APN 17 17,933,120 (GRCm39) missense probably damaging 1.00
IGL02112:Vmn2r90 APN 17 17,932,465 (GRCm39) missense probably damaging 0.98
IGL02123:Vmn2r90 APN 17 17,953,744 (GRCm39) missense probably benign 0.01
IGL02749:Vmn2r90 APN 17 17,947,122 (GRCm39) makesense probably null
IGL03114:Vmn2r90 APN 17 17,953,771 (GRCm39) missense probably damaging 1.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0132:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0184:Vmn2r90 UTSW 17 17,947,139 (GRCm39) nonsense probably null
R0379:Vmn2r90 UTSW 17 17,948,401 (GRCm39) missense probably damaging 1.00
R1022:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1024:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r90 UTSW 17 17,953,566 (GRCm39) missense probably damaging 1.00
R1993:Vmn2r90 UTSW 17 17,933,525 (GRCm39) missense probably damaging 1.00
R2472:Vmn2r90 UTSW 17 17,948,408 (GRCm39) missense probably damaging 1.00
R2508:Vmn2r90 UTSW 17 17,954,229 (GRCm39) missense probably damaging 1.00
R2679:Vmn2r90 UTSW 17 17,933,131 (GRCm39) missense possibly damaging 0.46
R3409:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense probably benign 0.00
R4693:Vmn2r90 UTSW 17 17,953,956 (GRCm39) missense possibly damaging 0.91
R4797:Vmn2r90 UTSW 17 17,932,567 (GRCm39) missense probably damaging 1.00
R5258:Vmn2r90 UTSW 17 17,933,114 (GRCm39) missense probably benign 0.12
R5358:Vmn2r90 UTSW 17 17,924,412 (GRCm39) critical splice donor site probably null
R5446:Vmn2r90 UTSW 17 17,932,464 (GRCm39) missense probably damaging 0.99
R5567:Vmn2r90 UTSW 17 17,932,336 (GRCm39) missense probably damaging 1.00
R5680:Vmn2r90 UTSW 17 17,947,034 (GRCm39) missense possibly damaging 0.93
R5686:Vmn2r90 UTSW 17 17,933,712 (GRCm39) missense probably benign 0.02
R5751:Vmn2r90 UTSW 17 17,954,128 (GRCm39) missense probably damaging 0.96
R6156:Vmn2r90 UTSW 17 17,953,606 (GRCm39) missense probably benign 0.01
R6185:Vmn2r90 UTSW 17 17,953,644 (GRCm39) missense probably damaging 1.00
R6450:Vmn2r90 UTSW 17 17,953,498 (GRCm39) missense possibly damaging 0.47
R6707:Vmn2r90 UTSW 17 17,948,364 (GRCm39) missense probably damaging 1.00
R6802:Vmn2r90 UTSW 17 17,932,351 (GRCm39) missense probably damaging 1.00
R6913:Vmn2r90 UTSW 17 17,924,323 (GRCm39) missense probably damaging 1.00
R7070:Vmn2r90 UTSW 17 17,924,313 (GRCm39) missense probably damaging 0.98
R7237:Vmn2r90 UTSW 17 17,924,249 (GRCm39) missense possibly damaging 0.92
R7503:Vmn2r90 UTSW 17 17,933,510 (GRCm39) missense not run
R7698:Vmn2r90 UTSW 17 17,953,596 (GRCm39) missense probably benign
R7943:Vmn2r90 UTSW 17 17,932,566 (GRCm39) missense probably damaging 1.00
R8072:Vmn2r90 UTSW 17 17,947,142 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r90 UTSW 17 17,954,155 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r90 UTSW 17 17,948,358 (GRCm39) missense probably benign 0.03
R8345:Vmn2r90 UTSW 17 17,933,127 (GRCm39) nonsense probably null
R8682:Vmn2r90 UTSW 17 17,932,344 (GRCm39) missense possibly damaging 0.95
R8716:Vmn2r90 UTSW 17 17,924,343 (GRCm39) missense probably damaging 0.98
R9041:Vmn2r90 UTSW 17 17,954,286 (GRCm39) missense probably benign 0.00
R9412:Vmn2r90 UTSW 17 17,954,213 (GRCm39) missense probably damaging 1.00
R9607:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense possibly damaging 0.88
R9705:Vmn2r90 UTSW 17 17,933,039 (GRCm39) missense possibly damaging 0.91
Z1088:Vmn2r90 UTSW 17 17,953,879 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r90 UTSW 17 17,933,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGTGTCTGGATCACCTTCC -3'
(R):5'- TCCCACTGGAAAATGTTTATCTCTG -3'

Sequencing Primer
(F):5'- CTCCCTGTCTACCATAGCACAAAAG -3'
(R):5'- TGATAACAGCCAGTTGTGCC -3'
Posted On 2016-09-01