Incidental Mutation 'R5413:Or2y1b'
ID 427602
Institutional Source Beutler Lab
Gene Symbol Or2y1b
Ensembl Gene ENSMUSG00000100923
Gene Name olfactory receptor family 2 subfamily Y member 1B
Synonyms L45, MOR256-55, Olfr10, GA_x6K02T2QP88-6117098-6116163
MMRRC Submission 042982-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R5413 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49208375-49209310 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49209240 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 289 (Y289F)
Ref Sequence ENSEMBL: ENSMUSP00000149724 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187570] [ENSMUST00000215671] [ENSMUST00000217290]
AlphaFold Q60883
Predicted Effect probably damaging
Transcript: ENSMUST00000187570
AA Change: Y289F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139744
Gene: ENSMUSG00000100923
AA Change: Y289F

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 222 4.7e-7 PFAM
Pfam:7tm_1 41 289 1.3e-33 PFAM
Pfam:7tm_4 139 282 4.6e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215671
Predicted Effect probably damaging
Transcript: ENSMUST00000217290
AA Change: Y289F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 T A 11: 48,911,204 (GRCm39) T410S possibly damaging Het
Adamts3 A G 5: 89,856,626 (GRCm39) S316P probably damaging Het
Angptl3 A T 4: 98,919,259 (GRCm39) L6F probably benign Het
Clint1 T C 11: 45,777,307 (GRCm39) V98A probably damaging Het
Clk2 A G 3: 89,080,785 (GRCm39) N258S probably benign Het
Col18a1 T C 10: 76,905,310 (GRCm39) D723G probably damaging Het
Csmd3 A T 15: 47,701,831 (GRCm39) W1751R probably damaging Het
Daam1 C A 12: 71,993,066 (GRCm39) L352M unknown Het
Dennd2a A T 6: 39,441,227 (GRCm39) F964I probably damaging Het
Dock5 A G 14: 68,002,104 (GRCm39) L1622P probably damaging Het
Dpy19l4 A G 4: 11,289,700 (GRCm39) L195P probably damaging Het
Esp24 A C 17: 39,350,893 (GRCm39) E31A possibly damaging Het
Fars2 T A 13: 36,388,545 (GRCm39) Y11* probably null Het
Fbxl16 C A 17: 26,035,817 (GRCm39) T138K possibly damaging Het
Frmpd1 A G 4: 45,249,196 (GRCm39) I129V probably benign Het
Gria1 A G 11: 57,108,620 (GRCm39) N241S probably benign Het
Homer1 A G 13: 93,528,287 (GRCm39) E274G probably benign Het
Igdcc3 T C 9: 65,084,797 (GRCm39) V189A possibly damaging Het
Igkv12-98 A G 6: 68,548,078 (GRCm39) Y68C possibly damaging Het
Igkv3-3 G C 6: 70,664,414 (GRCm39) R85S probably damaging Het
Ldha A G 7: 46,500,320 (GRCm39) T144A possibly damaging Het
Lrp1 A G 10: 127,423,936 (GRCm39) probably null Het
Myh9 A T 15: 77,692,186 (GRCm39) Y124* probably null Het
Or14c44 A G 7: 86,061,675 (GRCm39) Y35C probably benign Het
Or2n1d G T 17: 38,646,515 (GRCm39) A156S probably benign Het
Or6b13 A T 7: 139,782,635 (GRCm39) V16E possibly damaging Het
Osbp T C 19: 11,961,855 (GRCm39) Y551H probably damaging Het
Paf1 T C 7: 28,096,040 (GRCm39) M249T possibly damaging Het
Pcsk2 T C 2: 143,538,620 (GRCm39) probably null Het
Piwil1 G A 5: 128,820,944 (GRCm39) V290I possibly damaging Het
Prmt9 A T 8: 78,298,638 (GRCm39) D444V possibly damaging Het
Rapgef2 T C 3: 78,995,173 (GRCm39) D677G probably damaging Het
Tmem59 A G 4: 107,057,659 (GRCm39) E237G probably benign Het
Trpm5 A T 7: 142,634,705 (GRCm39) I664N probably damaging Het
Unc13b G A 4: 43,257,936 (GRCm39) probably null Het
Usp17lc C A 7: 103,067,763 (GRCm39) Q353K probably benign Het
Uvssa G A 5: 33,568,252 (GRCm39) V547M probably damaging Het
Vdac1 G T 11: 52,265,794 (GRCm39) L52F probably null Het
Vmn2r14 T A 5: 109,369,154 (GRCm39) I140L probably benign Het
Wnt3a A G 11: 59,166,182 (GRCm39) S33P probably benign Het
Wwp2 T A 8: 108,281,710 (GRCm39) Y300N probably damaging Het
Zwilch T A 9: 64,075,892 (GRCm39) probably null Het
Other mutations in Or2y1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01349:Or2y1b APN 11 49,209,127 (GRCm39) nonsense probably null 0.00
IGL02283:Or2y1b APN 11 49,209,162 (GRCm39) missense probably benign
IGL03010:Or2y1b APN 11 49,208,973 (GRCm39) missense probably damaging 0.99
R0575:Or2y1b UTSW 11 49,208,880 (GRCm39) missense probably damaging 1.00
R1430:Or2y1b UTSW 11 49,208,928 (GRCm39) splice site probably null
R1891:Or2y1b UTSW 11 49,208,684 (GRCm39) missense probably benign 0.00
R2509:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R2511:Or2y1b UTSW 11 49,209,048 (GRCm39) missense probably damaging 0.97
R4942:Or2y1b UTSW 11 49,208,375 (GRCm39) start codon destroyed probably null 0.99
R5080:Or2y1b UTSW 11 49,208,914 (GRCm39) missense probably benign 0.03
R5843:Or2y1b UTSW 11 49,209,076 (GRCm39) missense probably benign 0.34
R6354:Or2y1b UTSW 11 49,208,465 (GRCm39) missense probably damaging 0.98
R6605:Or2y1b UTSW 11 49,208,541 (GRCm39) missense probably damaging 0.97
R8005:Or2y1b UTSW 11 49,208,968 (GRCm39) missense probably benign 0.12
R8284:Or2y1b UTSW 11 49,209,002 (GRCm39) missense probably benign
R8902:Or2y1b UTSW 11 49,209,206 (GRCm39) missense probably benign 0.03
R9003:Or2y1b UTSW 11 49,209,155 (GRCm39) missense possibly damaging 0.66
R9431:Or2y1b UTSW 11 49,208,459 (GRCm39) missense probably benign
R9696:Or2y1b UTSW 11 49,208,390 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGCAGTGCCTACCATGCTC -3'
(R):5'- GTGGACAGATTCATGCATGTAC -3'

Sequencing Primer
(F):5'- AGGCTCCTATGCACAGATTG -3'
(R):5'- GGACAGATTCATGCATGTACATAAC -3'
Posted On 2016-09-01