Incidental Mutation 'R5415:Myh15'
ID 427702
Institutional Source Beutler Lab
Gene Symbol Myh15
Ensembl Gene ENSMUSG00000092009
Gene Name myosin, heavy chain 15
Synonyms EG667772
MMRRC Submission 042984-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R5415 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 48877849-49019467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 48937658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 753 (K753R)
Ref Sequence ENSEMBL: ENSMUSP00000127539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168680] [ENSMUST00000168680]
AlphaFold E9Q264
Predicted Effect probably null
Transcript: ENSMUST00000168680
AA Change: K753R

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: K753R

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000168680
AA Change: K753R

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: K753R

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef18 G A 8: 3,438,075 (GRCm39) R303H probably damaging Het
Ark2c C A 18: 77,554,435 (GRCm39) V60L probably damaging Het
Asb15 A T 6: 24,570,690 (GRCm39) Q556L probably benign Het
Ccr1 G T 9: 123,764,413 (GRCm39) P39H probably damaging Het
Cd177 A T 7: 24,451,816 (GRCm39) L400Q probably damaging Het
Cfap298 G T 16: 90,722,953 (GRCm39) D260E probably benign Het
Cideb T C 14: 55,995,312 (GRCm39) E58G probably damaging Het
Drd2 A G 9: 49,313,553 (GRCm39) K241E possibly damaging Het
Ect2 C T 3: 27,201,002 (GRCm39) C126Y probably damaging Het
Eef1d T C 15: 75,775,030 (GRCm39) T210A probably benign Het
Enpp2 G A 15: 54,745,552 (GRCm39) H315Y probably damaging Het
Ero1b A T 13: 12,616,656 (GRCm39) M362L probably benign Het
Exosc2 A G 2: 31,562,578 (GRCm39) K73E possibly damaging Het
Gm9637 T A 14: 19,402,143 (GRCm38) noncoding transcript Het
Gstm5 A G 3: 107,804,811 (GRCm39) D101G probably damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kmt2c T C 5: 25,519,699 (GRCm39) D2137G probably benign Het
Mecom T C 3: 30,011,675 (GRCm39) D619G possibly damaging Het
Met A G 6: 17,527,084 (GRCm39) I512V probably benign Het
Nfatc4 A G 14: 56,070,091 (GRCm39) D753G probably benign Het
Or2l5 T A 16: 19,333,996 (GRCm39) H130L possibly damaging Het
Or4c113 T A 2: 88,885,240 (GRCm39) T177S probably benign Het
Or4c12 T A 2: 89,773,731 (GRCm39) T243S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp9 C T 16: 35,763,752 (GRCm39) A10V probably damaging Het
Pcdh8 C A 14: 80,007,688 (GRCm39) E292* probably null Het
Pdpn A T 4: 142,995,788 (GRCm39) V161D probably damaging Het
Peg3 A G 7: 6,711,628 (GRCm39) V1198A probably benign Het
Phykpl T C 11: 51,476,342 (GRCm39) S21P probably benign Het
Plcb1 G T 2: 135,189,322 (GRCm39) V817F possibly damaging Het
Polk T C 13: 96,620,463 (GRCm39) Y579C probably benign Het
Ppp1r18 A G 17: 36,178,511 (GRCm39) N129D probably benign Het
Psg29 C A 7: 16,945,561 (GRCm39) probably null Het
Rims4 C T 2: 163,760,596 (GRCm39) R3H probably benign Het
Rps6kl1 A T 12: 85,186,155 (GRCm39) C292S probably benign Het
Uaca G T 9: 60,777,421 (GRCm39) G603C possibly damaging Het
Vmn1r60 T C 7: 5,547,416 (GRCm39) H228R probably benign Het
Vmn2r7 T C 3: 64,623,658 (GRCm39) T221A probably benign Het
Zfp647 C A 15: 76,795,593 (GRCm39) V356L possibly damaging Het
Other mutations in Myh15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Myh15 APN 16 48,986,176 (GRCm39) missense probably damaging 0.98
IGL01095:Myh15 APN 16 48,952,378 (GRCm39) missense probably damaging 1.00
IGL01343:Myh15 APN 16 48,976,040 (GRCm39) missense probably benign 0.09
IGL01474:Myh15 APN 16 48,952,461 (GRCm39) missense probably damaging 1.00
IGL01572:Myh15 APN 16 48,920,585 (GRCm39) missense possibly damaging 0.55
IGL01595:Myh15 APN 16 48,993,312 (GRCm39) missense probably damaging 1.00
IGL01632:Myh15 APN 16 48,881,874 (GRCm39) missense probably benign 0.00
IGL01638:Myh15 APN 16 48,889,843 (GRCm39) missense probably damaging 1.00
IGL01667:Myh15 APN 16 49,015,942 (GRCm39) missense probably benign 0.20
IGL01715:Myh15 APN 16 48,877,847 (GRCm39) unclassified probably benign
IGL01833:Myh15 APN 16 48,934,421 (GRCm39) missense probably damaging 1.00
IGL02004:Myh15 APN 16 48,930,892 (GRCm39) splice site probably benign
IGL02033:Myh15 APN 16 48,965,707 (GRCm39) missense probably benign 0.05
IGL02148:Myh15 APN 16 48,936,678 (GRCm39) missense probably damaging 1.00
IGL02225:Myh15 APN 16 48,911,526 (GRCm39) missense probably benign 0.14
IGL02249:Myh15 APN 16 48,930,847 (GRCm39) missense probably damaging 0.99
IGL02505:Myh15 APN 16 48,937,626 (GRCm39) missense possibly damaging 0.90
IGL02622:Myh15 APN 16 48,997,317 (GRCm39) missense probably benign 0.02
IGL02814:Myh15 APN 16 48,965,801 (GRCm39) splice site probably benign
IGL02869:Myh15 APN 16 48,965,767 (GRCm39) missense probably benign
IGL02879:Myh15 APN 16 48,993,422 (GRCm39) missense possibly damaging 0.68
IGL02881:Myh15 APN 16 48,937,628 (GRCm39) missense possibly damaging 0.51
IGL03077:Myh15 APN 16 48,916,901 (GRCm39) missense probably benign 0.10
IGL03354:Myh15 APN 16 48,992,373 (GRCm39) missense probably benign 0.01
IGL03411:Myh15 APN 16 48,980,330 (GRCm39) missense possibly damaging 0.58
ANU74:Myh15 UTSW 16 48,993,295 (GRCm39) missense possibly damaging 0.58
P0027:Myh15 UTSW 16 48,901,571 (GRCm39) missense possibly damaging 0.77
PIT1430001:Myh15 UTSW 16 49,017,254 (GRCm39) critical splice donor site probably null
R0017:Myh15 UTSW 16 48,983,423 (GRCm39) missense probably damaging 0.97
R0038:Myh15 UTSW 16 48,891,504 (GRCm39) splice site probably benign
R0149:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0361:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0373:Myh15 UTSW 16 49,003,322 (GRCm39) missense possibly damaging 0.86
R0433:Myh15 UTSW 16 48,965,599 (GRCm39) missense probably damaging 1.00
R0525:Myh15 UTSW 16 48,952,414 (GRCm39) missense probably benign 0.03
R0586:Myh15 UTSW 16 48,992,250 (GRCm39) splice site probably benign
R0601:Myh15 UTSW 16 48,881,944 (GRCm39) missense probably damaging 1.00
R0717:Myh15 UTSW 16 48,963,356 (GRCm39) missense probably benign 0.03
R0963:Myh15 UTSW 16 48,952,512 (GRCm39) missense probably damaging 0.97
R1075:Myh15 UTSW 16 48,940,417 (GRCm39) missense possibly damaging 0.63
R1143:Myh15 UTSW 16 48,885,449 (GRCm39) missense probably benign 0.02
R1200:Myh15 UTSW 16 48,916,882 (GRCm39) missense probably damaging 1.00
R1644:Myh15 UTSW 16 48,952,566 (GRCm39) missense probably benign 0.12
R1646:Myh15 UTSW 16 49,015,931 (GRCm39) missense probably damaging 1.00
R1720:Myh15 UTSW 16 48,913,145 (GRCm39) missense probably damaging 1.00
R1768:Myh15 UTSW 16 48,983,498 (GRCm39) missense probably benign 0.27
R1881:Myh15 UTSW 16 48,891,446 (GRCm39) missense probably damaging 0.98
R2048:Myh15 UTSW 16 48,975,928 (GRCm39) missense probably damaging 0.99
R2064:Myh15 UTSW 16 48,975,984 (GRCm39) missense possibly damaging 0.50
R2184:Myh15 UTSW 16 48,957,874 (GRCm39) missense probably damaging 0.99
R2212:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R2216:Myh15 UTSW 16 48,986,201 (GRCm39) nonsense probably null
R2321:Myh15 UTSW 16 48,933,436 (GRCm39) missense possibly damaging 0.93
R2327:Myh15 UTSW 16 48,963,313 (GRCm39) missense probably benign 0.01
R2395:Myh15 UTSW 16 48,889,877 (GRCm39) missense probably benign 0.04
R2399:Myh15 UTSW 16 48,957,952 (GRCm39) missense probably damaging 0.97
R3413:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R4234:Myh15 UTSW 16 48,983,405 (GRCm39) missense probably benign 0.04
R4382:Myh15 UTSW 16 48,963,306 (GRCm39) missense probably benign 0.03
R4421:Myh15 UTSW 16 48,929,707 (GRCm39) missense probably damaging 0.99
R4580:Myh15 UTSW 16 48,885,388 (GRCm39) missense possibly damaging 0.93
R4657:Myh15 UTSW 16 48,992,421 (GRCm39) nonsense probably null
R4780:Myh15 UTSW 16 48,940,420 (GRCm39) missense probably benign 0.13
R5004:Myh15 UTSW 16 48,952,411 (GRCm39) missense probably damaging 0.99
R5175:Myh15 UTSW 16 48,889,789 (GRCm39) missense possibly damaging 0.85
R5189:Myh15 UTSW 16 48,921,870 (GRCm39) missense probably benign 0.20
R5311:Myh15 UTSW 16 48,986,204 (GRCm39) missense possibly damaging 0.94
R5318:Myh15 UTSW 16 48,930,834 (GRCm39) missense probably damaging 0.99
R5404:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R5558:Myh15 UTSW 16 48,889,900 (GRCm39) missense probably benign 0.32
R5977:Myh15 UTSW 16 48,973,866 (GRCm39) missense probably damaging 1.00
R6004:Myh15 UTSW 16 48,980,062 (GRCm39) missense probably benign 0.00
R6275:Myh15 UTSW 16 48,965,610 (GRCm39) missense probably benign 0.00
R6381:Myh15 UTSW 16 48,921,844 (GRCm39) missense probably damaging 1.00
R6448:Myh15 UTSW 16 48,992,295 (GRCm39) missense probably damaging 0.99
R6516:Myh15 UTSW 16 48,957,996 (GRCm39) missense probably benign 0.19
R6752:Myh15 UTSW 16 49,003,290 (GRCm39) missense probably damaging 1.00
R6847:Myh15 UTSW 16 48,965,451 (GRCm39) missense possibly damaging 0.70
R6868:Myh15 UTSW 16 48,889,766 (GRCm39) missense probably damaging 1.00
R6889:Myh15 UTSW 16 48,973,474 (GRCm39) missense possibly damaging 0.75
R6896:Myh15 UTSW 16 48,933,434 (GRCm39) missense probably benign 0.44
R6955:Myh15 UTSW 16 48,901,598 (GRCm39) critical splice donor site probably null
R6984:Myh15 UTSW 16 48,930,775 (GRCm39) missense probably damaging 1.00
R7046:Myh15 UTSW 16 48,929,662 (GRCm39) nonsense probably null
R7095:Myh15 UTSW 16 48,992,272 (GRCm39) missense possibly damaging 0.90
R7098:Myh15 UTSW 16 48,997,420 (GRCm39) missense possibly damaging 0.53
R7134:Myh15 UTSW 16 48,901,705 (GRCm39) missense possibly damaging 0.86
R7159:Myh15 UTSW 16 48,881,937 (GRCm39) missense probably damaging 0.97
R7244:Myh15 UTSW 16 49,017,149 (GRCm39) missense probably damaging 1.00
R7278:Myh15 UTSW 16 48,911,468 (GRCm39) missense probably damaging 0.98
R7309:Myh15 UTSW 16 48,916,828 (GRCm39) missense probably benign 0.34
R7327:Myh15 UTSW 16 48,993,369 (GRCm39) missense possibly damaging 0.88
R7418:Myh15 UTSW 16 48,975,900 (GRCm39) missense possibly damaging 0.69
R7937:Myh15 UTSW 16 48,976,009 (GRCm39) missense probably benign 0.00
R8053:Myh15 UTSW 16 48,963,302 (GRCm39) missense possibly damaging 0.89
R8313:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8315:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8316:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8317:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8342:Myh15 UTSW 16 48,913,120 (GRCm39) missense probably benign
R8379:Myh15 UTSW 16 48,901,551 (GRCm39) missense probably benign
R8445:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8707:Myh15 UTSW 16 48,973,450 (GRCm39) missense probably damaging 1.00
R8729:Myh15 UTSW 16 48,881,851 (GRCm39) missense probably damaging 0.97
R8773:Myh15 UTSW 16 49,015,900 (GRCm39) missense possibly damaging 0.89
R8869:Myh15 UTSW 16 48,997,366 (GRCm39) missense probably benign
R8890:Myh15 UTSW 16 48,959,130 (GRCm39) missense probably damaging 1.00
R9026:Myh15 UTSW 16 49,007,433 (GRCm39) missense probably damaging 1.00
R9063:Myh15 UTSW 16 48,913,118 (GRCm39) missense probably benign 0.00
R9290:Myh15 UTSW 16 48,997,375 (GRCm39) missense probably damaging 1.00
R9630:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R9710:Myh15 UTSW 16 48,959,044 (GRCm39) missense probably damaging 1.00
X0012:Myh15 UTSW 16 48,963,341 (GRCm39) missense probably damaging 1.00
X0020:Myh15 UTSW 16 48,986,237 (GRCm39) missense probably damaging 1.00
Z1176:Myh15 UTSW 16 48,916,894 (GRCm39) missense probably damaging 0.98
Z1177:Myh15 UTSW 16 48,980,189 (GRCm39) missense probably benign 0.09
Z1177:Myh15 UTSW 16 48,975,981 (GRCm39) missense probably damaging 0.97
Z1177:Myh15 UTSW 16 48,901,591 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGACCCATTGGACCGATCAC -3'
(R):5'- GGCACAAATTTGGCTAGACAATTAG -3'

Sequencing Primer
(F):5'- ATTGGACCGATCACTGATACC -3'
(R):5'- GGTCCTAGATTTAACCCTGAAGGC -3'
Posted On 2016-09-01