Incidental Mutation 'R5417:Prss39'
ID 427769
Institutional Source Beutler Lab
Gene Symbol Prss39
Ensembl Gene ENSMUSG00000026125
Gene Name serine protease 39
Synonyms Tesp1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.193) question?
Stock # R5417 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 34537493-34542143 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34539209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 150 (S150G)
Ref Sequence ENSEMBL: ENSMUSP00000027299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027299] [ENSMUST00000191604]
AlphaFold O70169
Predicted Effect probably benign
Transcript: ENSMUST00000027299
AA Change: S150G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027299
Gene: ENSMUSG00000026125
AA Change: S150G

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Tryp_SPc 67 307 7.97e-60 SMART
low complexity region 348 361 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191604
SMART Domains Protein: ENSMUSP00000140460
Gene: ENSMUSG00000026125

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
low complexity region 35 47 N/A INTRINSIC
Pfam:Trypsin 68 114 1.5e-12 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap39 A G 15: 76,619,301 (GRCm39) V761A possibly damaging Het
Ccdc47 C T 11: 106,101,176 (GRCm39) R162Q probably benign Het
Cfap65 T C 1: 74,964,259 (GRCm39) E563G probably damaging Het
Clec16a G A 16: 10,549,543 (GRCm39) C872Y probably damaging Het
Col17a1 C A 19: 47,650,829 (GRCm39) G732C probably damaging Het
Cped1 A G 6: 22,233,579 (GRCm39) I812V probably null Het
Dennd1c CCGCCCCTCGCTGACAGC CC 17: 57,373,755 (GRCm39) probably null Het
Dgkg A T 16: 22,407,081 (GRCm39) M168K possibly damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dolpp1 T C 2: 30,286,249 (GRCm39) L18P probably damaging Het
Eif3e A T 15: 43,128,917 (GRCm39) D234E probably benign Het
Epha6 C A 16: 60,245,198 (GRCm39) A334S possibly damaging Het
Fbxw10 G A 11: 62,767,990 (GRCm39) R942Q possibly damaging Het
Flvcr2 T G 12: 85,793,965 (GRCm39) F114V probably damaging Het
Gm14443 A T 2: 175,011,796 (GRCm39) C217S probably damaging Het
Gphb5 A T 12: 75,459,746 (GRCm39) V83E possibly damaging Het
Gpsm1 T C 2: 26,214,045 (GRCm39) probably null Het
Grik4 A G 9: 42,582,544 (GRCm39) F134S probably benign Het
Ibsp G A 5: 104,458,335 (GRCm39) E291K possibly damaging Het
Igfals T G 17: 25,099,290 (GRCm39) L127R probably damaging Het
Igsf9b CGGCCCCGGCCCAG CGGCCCCGGCCCAGGCCCCGGCCCAG 9: 27,245,572 (GRCm39) probably benign Het
Iqcf3 T A 9: 106,431,413 (GRCm39) D63V probably damaging Het
Klc4 A G 17: 46,942,957 (GRCm39) probably null Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mapk8ip2 C A 15: 89,341,642 (GRCm39) D284E probably benign Het
Muc5b A T 7: 141,411,781 (GRCm39) T1576S unknown Het
Nlrp3 G A 11: 59,439,889 (GRCm39) G489S probably damaging Het
Nr5a1 T A 2: 38,598,098 (GRCm39) Q233L possibly damaging Het
Nusap1 G A 2: 119,477,624 (GRCm39) V345I probably damaging Het
Or10q1 A G 19: 13,727,217 (GRCm39) H249R probably benign Het
Or4k51 A G 2: 111,585,265 (GRCm39) T224A possibly damaging Het
Or51aa2 A T 7: 103,187,970 (GRCm39) V157E possibly damaging Het
Oxr1 A G 15: 41,683,767 (GRCm39) T378A probably benign Het
Pcdhb12 T C 18: 37,569,087 (GRCm39) F78L probably benign Het
Pgm2l1 A T 7: 99,921,583 (GRCm39) I605L probably benign Het
Pik3c2g A G 6: 139,682,669 (GRCm39) I17V probably benign Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Scg3 T A 9: 75,576,538 (GRCm39) Y279F probably benign Het
Skic2 C T 17: 35,065,574 (GRCm39) V327I probably damaging Het
Srfbp1 T C 18: 52,621,697 (GRCm39) C253R probably benign Het
Tcirg1 C T 19: 3,953,509 (GRCm39) probably null Het
Trim37 A G 11: 87,057,505 (GRCm39) Y313C probably damaging Het
Ttll9 A T 2: 152,844,912 (GRCm39) M427L probably benign Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Tubgcp5 A G 7: 55,475,409 (GRCm39) R932G possibly damaging Het
Other mutations in Prss39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Prss39 APN 1 34,541,216 (GRCm39) missense probably benign 0.01
IGL01468:Prss39 APN 1 34,538,481 (GRCm39) splice site probably benign
IGL01744:Prss39 APN 1 34,541,280 (GRCm39) splice site probably null
IGL02224:Prss39 APN 1 34,538,459 (GRCm39) missense probably damaging 1.00
R0128:Prss39 UTSW 1 34,541,281 (GRCm39) unclassified probably benign
R0130:Prss39 UTSW 1 34,541,281 (GRCm39) unclassified probably benign
R0269:Prss39 UTSW 1 34,539,279 (GRCm39) missense probably damaging 0.96
R0617:Prss39 UTSW 1 34,539,279 (GRCm39) missense probably damaging 0.96
R1078:Prss39 UTSW 1 34,541,167 (GRCm39) missense probably benign 0.00
R1539:Prss39 UTSW 1 34,537,616 (GRCm39) missense possibly damaging 0.85
R1796:Prss39 UTSW 1 34,539,114 (GRCm39) missense possibly damaging 0.70
R4644:Prss39 UTSW 1 34,541,207 (GRCm39) missense probably damaging 0.96
R5496:Prss39 UTSW 1 34,539,342 (GRCm39) missense possibly damaging 0.92
R5511:Prss39 UTSW 1 34,541,878 (GRCm39) missense possibly damaging 0.65
R5977:Prss39 UTSW 1 34,541,783 (GRCm39) missense probably damaging 1.00
R6333:Prss39 UTSW 1 34,539,150 (GRCm39) missense probably benign 0.02
R6833:Prss39 UTSW 1 34,537,697 (GRCm39) missense possibly damaging 0.84
R6834:Prss39 UTSW 1 34,537,697 (GRCm39) missense possibly damaging 0.84
R7230:Prss39 UTSW 1 34,541,228 (GRCm39) missense probably damaging 0.98
R7261:Prss39 UTSW 1 34,539,369 (GRCm39) missense probably damaging 0.99
R7467:Prss39 UTSW 1 34,538,473 (GRCm39) critical splice donor site probably null
R7509:Prss39 UTSW 1 34,539,280 (GRCm39) missense possibly damaging 0.85
R7709:Prss39 UTSW 1 34,541,709 (GRCm39) missense probably damaging 1.00
R7894:Prss39 UTSW 1 34,539,308 (GRCm39) missense probably benign 0.16
R8730:Prss39 UTSW 1 34,539,198 (GRCm39) missense probably damaging 1.00
R9405:Prss39 UTSW 1 34,538,344 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCAATCCAGGTGACAGTGC -3'
(R):5'- GTTCTCAACTGGAAAGGCCTCC -3'

Sequencing Primer
(F):5'- TCCAGGTGACAGTGCCAACTC -3'
(R):5'- CCACTCCTGTCCTGTCCAG -3'
Posted On 2016-09-01