Incidental Mutation 'R5435:Neto1'
ID 428299
Institutional Source Beutler Lab
Gene Symbol Neto1
Ensembl Gene ENSMUSG00000050321
Gene Name neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms C130005O10Rik
MMRRC Submission 043000-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5435 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 86413077-86524843 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86416388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 32 (T32S)
Ref Sequence ENSEMBL: ENSMUSP00000057340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058829]
AlphaFold Q8R4I7
Predicted Effect probably benign
Transcript: ENSMUST00000058829
AA Change: T32S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000057340
Gene: ENSMUSG00000050321
AA Change: T32S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CUB 41 155 2.06e-35 SMART
CUB 172 287 3.1e-7 SMART
LDLa 291 328 3.11e-3 SMART
transmembrane domain 341 363 N/A INTRINSIC
low complexity region 485 497 N/A INTRINSIC
Meta Mutation Damage Score 0.0609 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A G 14: 32,383,413 (GRCm39) F851L probably benign Het
Abca17 C T 17: 24,486,588 (GRCm39) V1480I possibly damaging Het
Acsbg1 G T 9: 54,523,153 (GRCm39) Y491* probably null Het
Acsf3 T A 8: 123,507,020 (GRCm39) N104K probably damaging Het
Adam23 T C 1: 63,585,612 (GRCm39) Y400H possibly damaging Het
Adgra3 G A 5: 50,147,468 (GRCm39) T524M probably damaging Het
Aff1 G A 5: 103,902,198 (GRCm39) probably benign Het
Anxa9 T C 3: 95,204,561 (GRCm39) Y321C probably damaging Het
Ap1g1 T A 8: 110,565,552 (GRCm39) Y329N probably damaging Het
Aph1c A T 9: 66,741,783 (GRCm39) I33N possibly damaging Het
B3galnt2 A G 13: 14,171,575 (GRCm39) E491G probably benign Het
Bdh1 C T 16: 31,275,475 (GRCm39) R235C probably damaging Het
Ccar2 A G 14: 70,376,776 (GRCm39) L856P probably damaging Het
Ccdc107 A T 4: 43,493,519 (GRCm39) D30V probably damaging Het
Ccdc116 G T 16: 16,960,626 (GRCm39) H64N probably benign Het
Ccl12 T C 11: 81,994,001 (GRCm39) I86T possibly damaging Het
Col2a1 T C 15: 97,898,391 (GRCm39) probably benign Het
Col4a4 T A 1: 82,431,728 (GRCm39) I1519F unknown Het
Ddx19b T C 8: 111,735,458 (GRCm39) Q416R possibly damaging Het
Dnah6 T A 6: 73,037,121 (GRCm39) M3374L probably benign Het
Dnajc6 A T 4: 101,463,807 (GRCm39) I119F probably damaging Het
Ensa C A 3: 95,529,769 (GRCm39) probably benign Het
Fbxo4 C T 15: 3,995,274 (GRCm39) V357I possibly damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Foxf1 G A 8: 121,811,231 (GRCm39) G32S probably damaging Het
Gls2 G A 10: 128,030,995 (GRCm39) probably benign Het
Gm13599 T A 2: 67,226,496 (GRCm39) noncoding transcript Het
Gmnn A G 13: 24,936,084 (GRCm39) S197P probably benign Het
Guf1 A T 5: 69,720,512 (GRCm39) H324L probably benign Het
H2-Q6 A G 17: 35,644,661 (GRCm39) D150G probably damaging Het
Herc3 T A 6: 58,832,791 (GRCm39) L152Q probably damaging Het
Hnrnpul2 T G 19: 8,797,682 (GRCm39) S13A probably benign Het
Ighv5-4 A G 12: 113,561,283 (GRCm39) F46L probably benign Het
Kank1 T G 19: 25,388,507 (GRCm39) S727A probably benign Het
Kcnma1 A T 14: 23,578,472 (GRCm39) Y201* probably null Het
Lyst A T 13: 13,951,649 (GRCm39) H3750L possibly damaging Het
Mettl25 A G 10: 105,615,447 (GRCm39) probably null Het
Mpdz A G 4: 81,201,724 (GRCm39) probably benign Het
Myh9 C T 15: 77,653,809 (GRCm39) V1280I probably benign Het
Nol7 C A 13: 43,554,848 (GRCm39) H187Q possibly damaging Het
Or5ak22 T A 2: 85,230,814 (GRCm39) N21I probably benign Het
Pcdha8 A G 18: 37,126,652 (GRCm39) D378G probably damaging Het
Peak1 A G 9: 56,113,770 (GRCm39) S694P probably damaging Het
Pih1d1 T A 7: 44,805,696 (GRCm39) probably null Het
Pik3c2g T G 6: 139,661,581 (GRCm39) probably null Het
Prkar2a A G 9: 108,617,682 (GRCm39) R247G probably damaging Het
Psg26 A G 7: 18,212,398 (GRCm39) I319T possibly damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Rasa3 T C 8: 13,681,811 (GRCm39) E46G possibly damaging Het
Rbbp5 T A 1: 132,422,013 (GRCm39) H304Q probably damaging Het
Relch T A 1: 105,668,975 (GRCm39) probably benign Het
Scn1a T A 2: 66,103,878 (GRCm39) E1783V probably damaging Het
Stag1 A G 9: 100,835,603 (GRCm39) N151S probably benign Het
Tbc1d32 C A 10: 55,916,246 (GRCm39) A1191S probably damaging Het
Tchh C A 3: 93,350,979 (GRCm39) R140S possibly damaging Het
Trank1 A G 9: 111,220,958 (GRCm39) Y2565C probably benign Het
Ttn A T 2: 76,744,702 (GRCm39) V5449D probably damaging Het
Tubgcp2 G A 7: 139,575,985 (GRCm39) P893S possibly damaging Het
Wdfy4 A G 14: 32,742,268 (GRCm39) F2325S probably damaging Het
Wdr35 A G 12: 9,039,951 (GRCm39) D352G probably benign Het
Wee1 TCCCC TCCC 7: 109,723,776 (GRCm39) probably null Het
Ypel3 A G 7: 126,374,960 (GRCm39) probably benign Het
Zan T A 5: 137,402,024 (GRCm39) T4023S unknown Het
Zfp735 T A 11: 73,602,939 (GRCm39) C628S possibly damaging Het
Other mutations in Neto1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00764:Neto1 APN 18 86,516,937 (GRCm39) missense probably damaging 0.98
IGL01505:Neto1 APN 18 86,491,814 (GRCm39) missense possibly damaging 0.82
IGL01511:Neto1 APN 18 86,414,033 (GRCm39) missense possibly damaging 0.96
IGL02704:Neto1 APN 18 86,491,948 (GRCm39) missense probably damaging 1.00
IGL03072:Neto1 APN 18 86,516,714 (GRCm39) missense probably benign 0.23
R0119:Neto1 UTSW 18 86,479,445 (GRCm39) missense probably benign 0.17
R0136:Neto1 UTSW 18 86,479,445 (GRCm39) missense probably benign 0.17
R0299:Neto1 UTSW 18 86,479,445 (GRCm39) missense probably benign 0.17
R0603:Neto1 UTSW 18 86,491,785 (GRCm39) missense possibly damaging 0.95
R0633:Neto1 UTSW 18 86,422,854 (GRCm39) nonsense probably null
R0657:Neto1 UTSW 18 86,479,445 (GRCm39) missense probably benign 0.17
R1395:Neto1 UTSW 18 86,416,144 (GRCm39) splice site probably benign
R1648:Neto1 UTSW 18 86,518,179 (GRCm39) missense probably damaging 1.00
R1852:Neto1 UTSW 18 86,414,009 (GRCm39) start codon destroyed probably null 0.53
R2249:Neto1 UTSW 18 86,479,399 (GRCm39) missense probably benign 0.02
R4418:Neto1 UTSW 18 86,422,981 (GRCm39) missense probably benign
R4476:Neto1 UTSW 18 86,422,798 (GRCm39) missense probably damaging 0.98
R4676:Neto1 UTSW 18 86,416,427 (GRCm39) missense possibly damaging 0.47
R5095:Neto1 UTSW 18 86,416,406 (GRCm39) missense probably benign
R5282:Neto1 UTSW 18 86,422,998 (GRCm39) missense probably damaging 1.00
R5337:Neto1 UTSW 18 86,416,434 (GRCm39) missense probably benign 0.00
R5400:Neto1 UTSW 18 86,414,033 (GRCm39) missense possibly damaging 0.86
R5632:Neto1 UTSW 18 86,516,768 (GRCm39) missense probably benign 0.00
R5755:Neto1 UTSW 18 86,517,219 (GRCm39) missense probably damaging 0.99
R6272:Neto1 UTSW 18 86,512,940 (GRCm39) missense probably damaging 1.00
R6486:Neto1 UTSW 18 86,479,371 (GRCm39) missense probably benign
R6505:Neto1 UTSW 18 86,516,699 (GRCm39) missense possibly damaging 0.81
R6526:Neto1 UTSW 18 86,516,873 (GRCm39) missense possibly damaging 0.47
R6582:Neto1 UTSW 18 86,512,985 (GRCm39) nonsense probably null
R6887:Neto1 UTSW 18 86,516,760 (GRCm39) missense probably benign 0.16
R7452:Neto1 UTSW 18 86,517,056 (GRCm39) missense probably benign
R7469:Neto1 UTSW 18 86,516,813 (GRCm39) missense probably benign
R7795:Neto1 UTSW 18 86,479,198 (GRCm39) missense probably benign 0.00
R8912:Neto1 UTSW 18 86,479,173 (GRCm39) missense probably damaging 0.98
R9191:Neto1 UTSW 18 86,516,781 (GRCm39) missense probably damaging 1.00
R9196:Neto1 UTSW 18 86,413,965 (GRCm39) start gained probably benign
R9384:Neto1 UTSW 18 86,413,965 (GRCm39) start gained probably benign
R9597:Neto1 UTSW 18 86,422,821 (GRCm39) missense possibly damaging 0.95
R9674:Neto1 UTSW 18 86,491,827 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCATGCCCATTATATTTCCAGAATACC -3'
(R):5'- ACACACTTGGGGACTCTCAC -3'

Sequencing Primer
(F):5'- GGTTTTGAGTAAAAGACCGT -3'
(R):5'- TTGGGGACTCTCACAAGCCTG -3'
Posted On 2016-09-01