Incidental Mutation 'R5436:Hfm1'
| ID |
428333 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hfm1
|
| Ensembl Gene |
ENSMUSG00000043410 |
| Gene Name |
HFM1, ATP-dependent DNA helicase homolog |
| Synonyms |
LOC381663, A330009G12Rik, Mer3, Sec63d1 |
| MMRRC Submission |
043001-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
R5436 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
106988058-107074187 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 107040638 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 709
(D709G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112590
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112690]
[ENSMUST00000117588]
[ENSMUST00000148495]
|
| AlphaFold |
D3Z4R1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112690
AA Change: D709G
PolyPhen 2
Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000108310
Gene: ENSMUSG00000043410
AA Change: D709G
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117588
AA Change: D709G
PolyPhen 2
Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000112590
Gene: ENSMUSG00000043410
AA Change: D709G
| Domain | Start | End | E-Value | Type |
|---|
|
DEXDc
|
276 |
490 |
3.66e-29 |
SMART |
|
HELICc
|
571 |
657 |
1.56e-14 |
SMART |
|
low complexity region
|
751 |
764 |
N/A |
INTRINSIC |
|
Sec63
|
775 |
1090 |
5.66e-60 |
SMART |
|
Blast:Sec63
|
1130 |
1188 |
2e-18 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148495
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155171
|
| SMART Domains |
Protein: ENSMUSP00000118674
Gene: ENSMUSG00000043410
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
22 |
N/A |
INTRINSIC |
|
Sec63
|
33 |
304 |
3.04e-42 |
SMART |
|
Blast:Sec63
|
344 |
402 |
7e-19 |
BLAST |
|
| Meta Mutation Damage Score |
0.2388 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
99% (106/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
PHENOTYPE: Meiosis ais disrupted in homozygotes and bothe sexes are sterile [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930449A18Rik |
T |
C |
3: 59,754,114 (GRCm39) |
|
noncoding transcript |
Het |
| Abca9 |
G |
A |
11: 110,025,062 (GRCm39) |
L994F |
probably damaging |
Het |
| Abl2 |
A |
T |
1: 156,457,450 (GRCm39) |
S239C |
probably damaging |
Het |
| Acsl5 |
T |
A |
19: 55,267,997 (GRCm39) |
|
probably null |
Het |
| Aff1 |
C |
T |
5: 103,931,736 (GRCm39) |
T126I |
probably damaging |
Het |
| Amtn |
T |
C |
5: 88,529,485 (GRCm39) |
L107P |
probably damaging |
Het |
| Ankrd45 |
A |
G |
1: 160,986,682 (GRCm39) |
|
probably benign |
Het |
| Arl6ip5 |
G |
A |
6: 97,187,887 (GRCm39) |
V36I |
probably damaging |
Het |
| Ascc3 |
T |
A |
10: 50,535,079 (GRCm39) |
D657E |
probably damaging |
Het |
| Ascl1 |
T |
A |
10: 87,328,808 (GRCm39) |
Q48L |
unknown |
Het |
| Asic4 |
T |
A |
1: 75,427,963 (GRCm39) |
V163E |
probably benign |
Het |
| Atm |
A |
T |
9: 53,371,104 (GRCm39) |
M2245K |
probably benign |
Het |
| Barx2 |
T |
G |
9: 31,824,285 (GRCm39) |
T35P |
probably damaging |
Het |
| Bdh1 |
C |
T |
16: 31,275,475 (GRCm39) |
R235C |
probably damaging |
Het |
| C8b |
T |
A |
4: 104,657,546 (GRCm39) |
Y404* |
probably null |
Het |
| Car5a |
A |
G |
8: 122,643,981 (GRCm39) |
|
probably benign |
Het |
| Ccdc13 |
T |
C |
9: 121,628,109 (GRCm39) |
I169M |
probably benign |
Het |
| Cd163 |
A |
T |
6: 124,304,923 (GRCm39) |
D1100V |
probably benign |
Het |
| Cimap2 |
A |
T |
4: 106,467,690 (GRCm39) |
H315Q |
probably benign |
Het |
| Cntfr |
T |
C |
4: 41,663,322 (GRCm39) |
N162D |
probably damaging |
Het |
| Cops3 |
T |
G |
11: 59,715,171 (GRCm39) |
D289A |
probably damaging |
Het |
| Crbn |
A |
T |
6: 106,772,861 (GRCm39) |
S42R |
probably damaging |
Het |
| Cth |
T |
A |
3: 157,600,463 (GRCm39) |
H397L |
probably benign |
Het |
| Dact2 |
A |
G |
17: 14,416,010 (GRCm39) |
L730P |
probably damaging |
Het |
| Dhx37 |
C |
T |
5: 125,506,867 (GRCm39) |
G210R |
probably benign |
Het |
| Dnaaf9 |
C |
A |
2: 130,606,419 (GRCm39) |
K415N |
probably benign |
Het |
| Dnah1 |
T |
C |
14: 31,038,704 (GRCm39) |
I126V |
probably benign |
Het |
| Dnttip2 |
T |
C |
3: 122,072,418 (GRCm39) |
I566T |
probably damaging |
Het |
| Ehbp1l1 |
G |
T |
19: 5,766,276 (GRCm39) |
R412S |
possibly damaging |
Het |
| Fam110b |
A |
C |
4: 5,799,104 (GRCm39) |
Q174P |
probably benign |
Het |
| Fam149a |
A |
T |
8: 45,801,508 (GRCm39) |
S457T |
probably benign |
Het |
| Fat3 |
A |
C |
9: 15,871,810 (GRCm39) |
V3527G |
probably benign |
Het |
| Fat4 |
A |
G |
3: 38,945,495 (GRCm39) |
M1463V |
probably benign |
Het |
| Gak |
T |
A |
5: 108,740,218 (GRCm39) |
I566F |
possibly damaging |
Het |
| Gdf10 |
T |
A |
14: 33,654,213 (GRCm39) |
I240N |
probably damaging |
Het |
| Gprc6a |
T |
A |
10: 51,502,798 (GRCm39) |
H355L |
probably benign |
Het |
| Gxylt1 |
T |
C |
15: 93,145,780 (GRCm39) |
K338R |
probably damaging |
Het |
| Hexim2 |
A |
T |
11: 103,029,095 (GRCm39) |
E49V |
probably null |
Het |
| Ighv1-49 |
T |
C |
12: 115,019,081 (GRCm39) |
K19R |
probably damaging |
Het |
| Il17a |
T |
A |
1: 20,803,870 (GRCm39) |
Y88* |
probably null |
Het |
| Iqsec1 |
A |
T |
6: 90,822,343 (GRCm39) |
|
probably benign |
Het |
| Itih2 |
T |
C |
2: 10,110,007 (GRCm39) |
D582G |
probably benign |
Het |
| Klc3 |
T |
C |
7: 19,131,884 (GRCm39) |
|
probably null |
Het |
| Larp4 |
T |
A |
15: 99,883,995 (GRCm39) |
N78K |
probably damaging |
Het |
| Larp4b |
A |
G |
13: 9,218,936 (GRCm39) |
D526G |
possibly damaging |
Het |
| Limch1 |
T |
C |
5: 67,131,909 (GRCm39) |
V133A |
possibly damaging |
Het |
| Lmbr1l |
G |
A |
15: 98,802,672 (GRCm39) |
R426C |
probably damaging |
Het |
| Lox |
T |
A |
18: 52,662,175 (GRCm39) |
D76V |
probably benign |
Het |
| Lrrc8d |
T |
A |
5: 105,960,418 (GRCm39) |
I276N |
probably damaging |
Het |
| Ltbr |
G |
A |
6: 125,289,757 (GRCm39) |
R146W |
probably damaging |
Het |
| Marchf10 |
A |
T |
11: 105,292,991 (GRCm39) |
Y139N |
possibly damaging |
Het |
| Mrc1 |
T |
G |
2: 14,271,326 (GRCm39) |
I410S |
probably damaging |
Het |
| Mrto4 |
A |
T |
4: 139,075,276 (GRCm39) |
C176S |
probably damaging |
Het |
| Mtch1 |
G |
T |
17: 29,566,564 (GRCm39) |
D66E |
probably benign |
Het |
| Nbas |
T |
G |
12: 13,424,812 (GRCm39) |
L1017R |
probably damaging |
Het |
| Nherf4 |
A |
G |
9: 44,159,652 (GRCm39) |
V448A |
possibly damaging |
Het |
| Nim1k |
A |
G |
13: 120,189,065 (GRCm39) |
|
probably benign |
Het |
| Nlrp6 |
T |
A |
7: 140,502,630 (GRCm39) |
Y245* |
probably null |
Het |
| Or11g7 |
T |
G |
14: 50,691,184 (GRCm39) |
V225G |
probably damaging |
Het |
| Or2t43 |
T |
A |
11: 58,457,763 (GRCm39) |
H136L |
probably benign |
Het |
| Or4c3 |
T |
A |
2: 89,852,009 (GRCm39) |
M134L |
probably benign |
Het |
| Or51q1 |
A |
T |
7: 103,628,473 (GRCm39) |
I25F |
probably benign |
Het |
| Or5h24 |
C |
T |
16: 58,919,182 (GRCm39) |
V58I |
unknown |
Het |
| Or8b1 |
A |
C |
9: 38,399,835 (GRCm39) |
D170A |
probably benign |
Het |
| Pcare |
A |
T |
17: 72,057,837 (GRCm39) |
S613R |
probably damaging |
Het |
| Pcnx1 |
G |
T |
12: 81,907,180 (GRCm39) |
G12V |
probably damaging |
Het |
| Pkp1 |
T |
A |
1: 135,846,656 (GRCm39) |
K32M |
probably damaging |
Het |
| Poc5 |
T |
C |
13: 96,533,321 (GRCm39) |
W150R |
probably damaging |
Het |
| Ppp1r16b |
T |
A |
2: 158,599,253 (GRCm39) |
|
probably benign |
Het |
| Prune2 |
T |
A |
19: 16,998,007 (GRCm39) |
M248K |
probably damaging |
Het |
| Rb1 |
A |
T |
14: 73,450,580 (GRCm39) |
|
probably null |
Het |
| Rhod |
A |
G |
19: 4,476,615 (GRCm39) |
C169R |
probably benign |
Het |
| Rif1 |
T |
C |
2: 52,010,983 (GRCm39) |
|
probably benign |
Het |
| Rnpc3 |
G |
A |
3: 113,418,648 (GRCm39) |
A100V |
probably damaging |
Het |
| Rsf1 |
GCGGC |
GCGGCGGCGTCGGC |
7: 97,229,138 (GRCm39) |
|
probably benign |
Het |
| Scnn1a |
A |
T |
6: 125,319,985 (GRCm39) |
D528V |
possibly damaging |
Het |
| Sdhaf3 |
C |
A |
6: 7,038,855 (GRCm39) |
T59K |
probably benign |
Het |
| Sec31a |
C |
A |
5: 100,511,698 (GRCm39) |
A330S |
probably damaging |
Het |
| Sgk3 |
A |
G |
1: 9,952,097 (GRCm39) |
D241G |
probably damaging |
Het |
| Skint6 |
T |
G |
4: 112,953,788 (GRCm39) |
I459L |
probably benign |
Het |
| Slco1a5 |
A |
T |
6: 142,200,118 (GRCm39) |
V222E |
probably damaging |
Het |
| Slit3 |
T |
A |
11: 35,598,738 (GRCm39) |
N1447K |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,249,038 (GRCm39) |
H628R |
probably damaging |
Het |
| St6galnac2 |
A |
G |
11: 116,575,353 (GRCm39) |
|
probably benign |
Het |
| Tbc1d31 |
T |
C |
15: 57,816,267 (GRCm39) |
V667A |
probably benign |
Het |
| Tbx20 |
A |
T |
9: 24,681,016 (GRCm39) |
Y159N |
probably damaging |
Het |
| Tmprss11b |
T |
A |
5: 86,810,092 (GRCm39) |
Q296L |
probably benign |
Het |
| Ttc6 |
T |
A |
12: 57,721,380 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,701,243 (GRCm39) |
|
probably benign |
Het |
| Tubgcp4 |
T |
A |
2: 121,018,617 (GRCm39) |
L340H |
probably damaging |
Het |
| Tubgcp4 |
T |
A |
2: 121,024,663 (GRCm39) |
F613I |
probably benign |
Het |
| Urb1 |
T |
C |
16: 90,589,650 (GRCm39) |
Y377C |
probably damaging |
Het |
| Utp15 |
G |
A |
13: 98,397,354 (GRCm39) |
|
probably null |
Het |
| Vstm2b |
A |
G |
7: 40,550,707 (GRCm39) |
|
probably null |
Het |
| Vwde |
A |
T |
6: 13,190,627 (GRCm39) |
V488D |
probably damaging |
Het |
| Wee1 |
TCCCC |
TCCC |
7: 109,723,776 (GRCm39) |
|
probably null |
Het |
| Zfp276 |
A |
T |
8: 123,992,021 (GRCm39) |
|
probably benign |
Het |
| Zfp318 |
T |
A |
17: 46,723,975 (GRCm39) |
S1993T |
possibly damaging |
Het |
| Zfp959 |
T |
C |
17: 56,204,626 (GRCm39) |
L218P |
probably benign |
Het |
| Zxdc |
A |
G |
6: 90,347,542 (GRCm39) |
D301G |
probably damaging |
Het |
|
| Other mutations in Hfm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Hfm1
|
APN |
5 |
107,049,996 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01295:Hfm1
|
APN |
5 |
107,065,472 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01725:Hfm1
|
APN |
5 |
107,065,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01758:Hfm1
|
APN |
5 |
107,052,659 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01911:Hfm1
|
APN |
5 |
107,059,410 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02337:Hfm1
|
APN |
5 |
107,052,133 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02472:Hfm1
|
APN |
5 |
107,021,794 (GRCm39) |
splice site |
probably benign |
|
|
IGL02496:Hfm1
|
APN |
5 |
107,049,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02545:Hfm1
|
APN |
5 |
107,043,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02584:Hfm1
|
APN |
5 |
107,026,528 (GRCm39) |
splice site |
probably null |
|
|
IGL02728:Hfm1
|
APN |
5 |
107,026,689 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02881:Hfm1
|
APN |
5 |
107,022,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03108:Hfm1
|
APN |
5 |
107,043,800 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03351:Hfm1
|
APN |
5 |
107,059,441 (GRCm39) |
nonsense |
probably null |
|
|
IGL03353:Hfm1
|
APN |
5 |
107,004,795 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0024:Hfm1
|
UTSW |
5 |
107,004,790 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0024:Hfm1
|
UTSW |
5 |
107,004,790 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0094:Hfm1
|
UTSW |
5 |
107,065,344 (GRCm39) |
missense |
probably benign |
|
|
R0633:Hfm1
|
UTSW |
5 |
107,065,467 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0644:Hfm1
|
UTSW |
5 |
107,046,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1078:Hfm1
|
UTSW |
5 |
107,026,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Hfm1
|
UTSW |
5 |
107,052,084 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Hfm1
|
UTSW |
5 |
107,059,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1242:Hfm1
|
UTSW |
5 |
107,022,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1414:Hfm1
|
UTSW |
5 |
107,020,219 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1450:Hfm1
|
UTSW |
5 |
107,066,324 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1529:Hfm1
|
UTSW |
5 |
107,000,989 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1622:Hfm1
|
UTSW |
5 |
107,041,389 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1710:Hfm1
|
UTSW |
5 |
107,043,869 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1710:Hfm1
|
UTSW |
5 |
107,028,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1757:Hfm1
|
UTSW |
5 |
107,028,226 (GRCm39) |
splice site |
probably null |
|
|
R1856:Hfm1
|
UTSW |
5 |
106,995,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1984:Hfm1
|
UTSW |
5 |
107,046,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1985:Hfm1
|
UTSW |
5 |
107,046,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2040:Hfm1
|
UTSW |
5 |
107,049,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Hfm1
|
UTSW |
5 |
107,044,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Hfm1
|
UTSW |
5 |
106,995,519 (GRCm39) |
splice site |
probably null |
|
|
R2474:Hfm1
|
UTSW |
5 |
107,020,282 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2926:Hfm1
|
UTSW |
5 |
107,022,148 (GRCm39) |
nonsense |
probably null |
|
|
R2944:Hfm1
|
UTSW |
5 |
107,020,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3705:Hfm1
|
UTSW |
5 |
107,040,705 (GRCm39) |
unclassified |
probably benign |
|
|
R4256:Hfm1
|
UTSW |
5 |
107,052,663 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4455:Hfm1
|
UTSW |
5 |
107,034,374 (GRCm39) |
splice site |
probably null |
|
|
R4538:Hfm1
|
UTSW |
5 |
107,022,756 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4540:Hfm1
|
UTSW |
5 |
107,022,087 (GRCm39) |
nonsense |
probably null |
|
|
R4591:Hfm1
|
UTSW |
5 |
106,995,533 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4745:Hfm1
|
UTSW |
5 |
107,049,709 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4747:Hfm1
|
UTSW |
5 |
107,065,389 (GRCm39) |
missense |
probably benign |
|
|
R4765:Hfm1
|
UTSW |
5 |
106,990,405 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4821:Hfm1
|
UTSW |
5 |
107,002,606 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4842:Hfm1
|
UTSW |
5 |
107,040,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4944:Hfm1
|
UTSW |
5 |
107,022,079 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5093:Hfm1
|
UTSW |
5 |
107,049,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Hfm1
|
UTSW |
5 |
107,065,428 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5414:Hfm1
|
UTSW |
5 |
107,049,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5459:Hfm1
|
UTSW |
5 |
107,052,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5485:Hfm1
|
UTSW |
5 |
106,995,528 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5585:Hfm1
|
UTSW |
5 |
107,059,305 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5631:Hfm1
|
UTSW |
5 |
107,052,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Hfm1
|
UTSW |
5 |
107,059,319 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5804:Hfm1
|
UTSW |
5 |
107,026,455 (GRCm39) |
splice site |
probably null |
|
|
R5959:Hfm1
|
UTSW |
5 |
107,022,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6046:Hfm1
|
UTSW |
5 |
107,046,509 (GRCm39) |
splice site |
probably null |
|
|
R6191:Hfm1
|
UTSW |
5 |
107,034,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6345:Hfm1
|
UTSW |
5 |
106,989,504 (GRCm39) |
missense |
probably benign |
|
|
R6580:Hfm1
|
UTSW |
5 |
106,995,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6651:Hfm1
|
UTSW |
5 |
106,995,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6761:Hfm1
|
UTSW |
5 |
107,043,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Hfm1
|
UTSW |
5 |
107,026,681 (GRCm39) |
nonsense |
probably null |
|
|
R6891:Hfm1
|
UTSW |
5 |
107,065,240 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R6924:Hfm1
|
UTSW |
5 |
106,998,276 (GRCm39) |
splice site |
probably null |
|
|
R6980:Hfm1
|
UTSW |
5 |
107,028,343 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7054:Hfm1
|
UTSW |
5 |
107,043,909 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7058:Hfm1
|
UTSW |
5 |
107,059,306 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7189:Hfm1
|
UTSW |
5 |
107,049,569 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7250:Hfm1
|
UTSW |
5 |
107,052,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7376:Hfm1
|
UTSW |
5 |
107,043,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7577:Hfm1
|
UTSW |
5 |
107,043,909 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7636:Hfm1
|
UTSW |
5 |
107,065,332 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7639:Hfm1
|
UTSW |
5 |
107,046,341 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7639:Hfm1
|
UTSW |
5 |
107,037,791 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7763:Hfm1
|
UTSW |
5 |
107,029,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7828:Hfm1
|
UTSW |
5 |
107,029,657 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7905:Hfm1
|
UTSW |
5 |
107,046,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8160:Hfm1
|
UTSW |
5 |
107,043,899 (GRCm39) |
missense |
probably null |
0.00 |
|
R8477:Hfm1
|
UTSW |
5 |
107,029,684 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8739:Hfm1
|
UTSW |
5 |
107,046,371 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8968:Hfm1
|
UTSW |
5 |
107,065,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Hfm1
|
UTSW |
5 |
107,046,146 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9073:Hfm1
|
UTSW |
5 |
107,046,146 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9152:Hfm1
|
UTSW |
5 |
106,989,611 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9234:Hfm1
|
UTSW |
5 |
107,041,334 (GRCm39) |
missense |
probably benign |
|
|
R9244:Hfm1
|
UTSW |
5 |
107,022,766 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9576:Hfm1
|
UTSW |
5 |
107,021,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9649:Hfm1
|
UTSW |
5 |
107,066,329 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9743:Hfm1
|
UTSW |
5 |
107,022,125 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9782:Hfm1
|
UTSW |
5 |
107,021,896 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9789:Hfm1
|
UTSW |
5 |
107,065,346 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Hfm1
|
UTSW |
5 |
107,019,686 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCTGAATATACTGGTGACTGC -3'
(R):5'- GGAGAAACCTCAGTTCTTTAAGATC -3'
Sequencing Primer
(F):5'- TTTTTCTGTTGGTTATTAGTTGTTGG -3'
(R):5'- TCAGTTCTTTAAGATCTTTAACTGCC -3'
|
| Posted On |
2016-09-01 |
Incidental Mutation