Incidental Mutation 'R5436:Marchf10'
ID 428370
Institutional Source Beutler Lab
Gene Symbol Marchf10
Ensembl Gene ENSMUSG00000078627
Gene Name membrane associated ring-CH-type finger 10
Synonyms Rnf190, 4933417C16Rik, OTTMUSG00000002847, March10
MMRRC Submission 043001-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R5436 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 105251624-105347561 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 105292991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 139 (Y139N)
Ref Sequence ENSEMBL: ENSMUSP00000097906 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049995] [ENSMUST00000100332] [ENSMUST00000138977]
AlphaFold E9PX79
Predicted Effect probably benign
Transcript: ENSMUST00000049995
SMART Domains Protein: ENSMUSP00000063198
Gene: ENSMUSG00000078627

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000100332
AA Change: Y139N

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000097906
Gene: ENSMUSG00000078627
AA Change: Y139N

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 126 N/A INTRINSIC
low complexity region 161 168 N/A INTRINSIC
low complexity region 181 206 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138977
SMART Domains Protein: ENSMUSP00000121919
Gene: ENSMUSG00000078627

DomainStartEndE-ValueType
low complexity region 36 49 N/A INTRINSIC
low complexity region 56 71 N/A INTRINSIC
low complexity region 114 130 N/A INTRINSIC
low complexity region 292 304 N/A INTRINSIC
RINGv 638 695 7.45e-22 SMART
low complexity region 728 737 N/A INTRINSIC
low complexity region 767 781 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000151305
AA Change: Y34N
SMART Domains Protein: ENSMUSP00000118401
Gene: ENSMUSG00000078627
AA Change: Y34N

DomainStartEndE-ValueType
low complexity region 10 22 N/A INTRINSIC
low complexity region 57 64 N/A INTRINSIC
low complexity region 77 102 N/A INTRINSIC
Meta Mutation Damage Score 0.0818 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (106/107)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449A18Rik T C 3: 59,754,114 (GRCm39) noncoding transcript Het
Abca9 G A 11: 110,025,062 (GRCm39) L994F probably damaging Het
Abl2 A T 1: 156,457,450 (GRCm39) S239C probably damaging Het
Acsl5 T A 19: 55,267,997 (GRCm39) probably null Het
Aff1 C T 5: 103,931,736 (GRCm39) T126I probably damaging Het
Amtn T C 5: 88,529,485 (GRCm39) L107P probably damaging Het
Ankrd45 A G 1: 160,986,682 (GRCm39) probably benign Het
Arl6ip5 G A 6: 97,187,887 (GRCm39) V36I probably damaging Het
Ascc3 T A 10: 50,535,079 (GRCm39) D657E probably damaging Het
Ascl1 T A 10: 87,328,808 (GRCm39) Q48L unknown Het
Asic4 T A 1: 75,427,963 (GRCm39) V163E probably benign Het
Atm A T 9: 53,371,104 (GRCm39) M2245K probably benign Het
Barx2 T G 9: 31,824,285 (GRCm39) T35P probably damaging Het
Bdh1 C T 16: 31,275,475 (GRCm39) R235C probably damaging Het
C8b T A 4: 104,657,546 (GRCm39) Y404* probably null Het
Car5a A G 8: 122,643,981 (GRCm39) probably benign Het
Ccdc13 T C 9: 121,628,109 (GRCm39) I169M probably benign Het
Cd163 A T 6: 124,304,923 (GRCm39) D1100V probably benign Het
Cimap2 A T 4: 106,467,690 (GRCm39) H315Q probably benign Het
Cntfr T C 4: 41,663,322 (GRCm39) N162D probably damaging Het
Cops3 T G 11: 59,715,171 (GRCm39) D289A probably damaging Het
Crbn A T 6: 106,772,861 (GRCm39) S42R probably damaging Het
Cth T A 3: 157,600,463 (GRCm39) H397L probably benign Het
Dact2 A G 17: 14,416,010 (GRCm39) L730P probably damaging Het
Dhx37 C T 5: 125,506,867 (GRCm39) G210R probably benign Het
Dnaaf9 C A 2: 130,606,419 (GRCm39) K415N probably benign Het
Dnah1 T C 14: 31,038,704 (GRCm39) I126V probably benign Het
Dnttip2 T C 3: 122,072,418 (GRCm39) I566T probably damaging Het
Ehbp1l1 G T 19: 5,766,276 (GRCm39) R412S possibly damaging Het
Fam110b A C 4: 5,799,104 (GRCm39) Q174P probably benign Het
Fam149a A T 8: 45,801,508 (GRCm39) S457T probably benign Het
Fat3 A C 9: 15,871,810 (GRCm39) V3527G probably benign Het
Fat4 A G 3: 38,945,495 (GRCm39) M1463V probably benign Het
Gak T A 5: 108,740,218 (GRCm39) I566F possibly damaging Het
Gdf10 T A 14: 33,654,213 (GRCm39) I240N probably damaging Het
Gprc6a T A 10: 51,502,798 (GRCm39) H355L probably benign Het
Gxylt1 T C 15: 93,145,780 (GRCm39) K338R probably damaging Het
Hexim2 A T 11: 103,029,095 (GRCm39) E49V probably null Het
Hfm1 T C 5: 107,040,638 (GRCm39) D709G possibly damaging Het
Ighv1-49 T C 12: 115,019,081 (GRCm39) K19R probably damaging Het
Il17a T A 1: 20,803,870 (GRCm39) Y88* probably null Het
Iqsec1 A T 6: 90,822,343 (GRCm39) probably benign Het
Itih2 T C 2: 10,110,007 (GRCm39) D582G probably benign Het
Klc3 T C 7: 19,131,884 (GRCm39) probably null Het
Larp4 T A 15: 99,883,995 (GRCm39) N78K probably damaging Het
Larp4b A G 13: 9,218,936 (GRCm39) D526G possibly damaging Het
Limch1 T C 5: 67,131,909 (GRCm39) V133A possibly damaging Het
Lmbr1l G A 15: 98,802,672 (GRCm39) R426C probably damaging Het
Lox T A 18: 52,662,175 (GRCm39) D76V probably benign Het
Lrrc8d T A 5: 105,960,418 (GRCm39) I276N probably damaging Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Mrc1 T G 2: 14,271,326 (GRCm39) I410S probably damaging Het
Mrto4 A T 4: 139,075,276 (GRCm39) C176S probably damaging Het
Mtch1 G T 17: 29,566,564 (GRCm39) D66E probably benign Het
Nbas T G 12: 13,424,812 (GRCm39) L1017R probably damaging Het
Nherf4 A G 9: 44,159,652 (GRCm39) V448A possibly damaging Het
Nim1k A G 13: 120,189,065 (GRCm39) probably benign Het
Nlrp6 T A 7: 140,502,630 (GRCm39) Y245* probably null Het
Or11g7 T G 14: 50,691,184 (GRCm39) V225G probably damaging Het
Or2t43 T A 11: 58,457,763 (GRCm39) H136L probably benign Het
Or4c3 T A 2: 89,852,009 (GRCm39) M134L probably benign Het
Or51q1 A T 7: 103,628,473 (GRCm39) I25F probably benign Het
Or5h24 C T 16: 58,919,182 (GRCm39) V58I unknown Het
Or8b1 A C 9: 38,399,835 (GRCm39) D170A probably benign Het
Pcare A T 17: 72,057,837 (GRCm39) S613R probably damaging Het
Pcnx1 G T 12: 81,907,180 (GRCm39) G12V probably damaging Het
Pkp1 T A 1: 135,846,656 (GRCm39) K32M probably damaging Het
Poc5 T C 13: 96,533,321 (GRCm39) W150R probably damaging Het
Ppp1r16b T A 2: 158,599,253 (GRCm39) probably benign Het
Prune2 T A 19: 16,998,007 (GRCm39) M248K probably damaging Het
Rb1 A T 14: 73,450,580 (GRCm39) probably null Het
Rhod A G 19: 4,476,615 (GRCm39) C169R probably benign Het
Rif1 T C 2: 52,010,983 (GRCm39) probably benign Het
Rnpc3 G A 3: 113,418,648 (GRCm39) A100V probably damaging Het
Rsf1 GCGGC GCGGCGGCGTCGGC 7: 97,229,138 (GRCm39) probably benign Het
Scnn1a A T 6: 125,319,985 (GRCm39) D528V possibly damaging Het
Sdhaf3 C A 6: 7,038,855 (GRCm39) T59K probably benign Het
Sec31a C A 5: 100,511,698 (GRCm39) A330S probably damaging Het
Sgk3 A G 1: 9,952,097 (GRCm39) D241G probably damaging Het
Skint6 T G 4: 112,953,788 (GRCm39) I459L probably benign Het
Slco1a5 A T 6: 142,200,118 (GRCm39) V222E probably damaging Het
Slit3 T A 11: 35,598,738 (GRCm39) N1447K probably benign Het
Sorbs2 A G 8: 46,249,038 (GRCm39) H628R probably damaging Het
St6galnac2 A G 11: 116,575,353 (GRCm39) probably benign Het
Tbc1d31 T C 15: 57,816,267 (GRCm39) V667A probably benign Het
Tbx20 A T 9: 24,681,016 (GRCm39) Y159N probably damaging Het
Tmprss11b T A 5: 86,810,092 (GRCm39) Q296L probably benign Het
Ttc6 T A 12: 57,721,380 (GRCm39) probably null Het
Ttn T A 2: 76,701,243 (GRCm39) probably benign Het
Tubgcp4 T A 2: 121,018,617 (GRCm39) L340H probably damaging Het
Tubgcp4 T A 2: 121,024,663 (GRCm39) F613I probably benign Het
Urb1 T C 16: 90,589,650 (GRCm39) Y377C probably damaging Het
Utp15 G A 13: 98,397,354 (GRCm39) probably null Het
Vstm2b A G 7: 40,550,707 (GRCm39) probably null Het
Vwde A T 6: 13,190,627 (GRCm39) V488D probably damaging Het
Wee1 TCCCC TCCC 7: 109,723,776 (GRCm39) probably null Het
Zfp276 A T 8: 123,992,021 (GRCm39) probably benign Het
Zfp318 T A 17: 46,723,975 (GRCm39) S1993T possibly damaging Het
Zfp959 T C 17: 56,204,626 (GRCm39) L218P probably benign Het
Zxdc A G 6: 90,347,542 (GRCm39) D301G probably damaging Het
Other mutations in Marchf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Marchf10 APN 11 105,293,014 (GRCm39) missense possibly damaging 0.82
IGL01461:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
IGL01473:Marchf10 APN 11 105,280,431 (GRCm39) missense probably damaging 1.00
Forward UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
PIT4142001:Marchf10 UTSW 11 105,281,346 (GRCm39) missense probably benign 0.17
R0195:Marchf10 UTSW 11 105,276,351 (GRCm39) missense probably damaging 1.00
R0520:Marchf10 UTSW 11 105,280,708 (GRCm39) missense probably benign
R0628:Marchf10 UTSW 11 105,280,986 (GRCm39) missense probably benign 0.00
R1087:Marchf10 UTSW 11 105,281,488 (GRCm39) missense probably damaging 1.00
R1440:Marchf10 UTSW 11 105,281,409 (GRCm39) missense probably damaging 1.00
R1802:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R1855:Marchf10 UTSW 11 105,281,218 (GRCm39) missense probably benign
R1860:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R2504:Marchf10 UTSW 11 105,276,398 (GRCm39) missense probably damaging 1.00
R3788:Marchf10 UTSW 11 105,287,905 (GRCm39) missense probably damaging 1.00
R4629:Marchf10 UTSW 11 105,280,664 (GRCm39) missense probably benign 0.28
R4755:Marchf10 UTSW 11 105,255,302 (GRCm39) intron probably benign
R4776:Marchf10 UTSW 11 105,280,863 (GRCm39) missense probably benign 0.42
R5067:Marchf10 UTSW 11 105,280,933 (GRCm39) missense possibly damaging 0.51
R5192:Marchf10 UTSW 11 105,262,752 (GRCm39) missense possibly damaging 0.68
R5541:Marchf10 UTSW 11 105,280,957 (GRCm39) missense probably damaging 1.00
R5888:Marchf10 UTSW 11 105,292,972 (GRCm39) missense possibly damaging 0.92
R5908:Marchf10 UTSW 11 105,281,065 (GRCm39) missense probably benign 0.00
R5914:Marchf10 UTSW 11 105,276,308 (GRCm39) missense probably damaging 1.00
R6038:Marchf10 UTSW 11 105,292,877 (GRCm39) missense probably damaging 0.96
R6178:Marchf10 UTSW 11 105,280,440 (GRCm39) missense probably damaging 1.00
R6300:Marchf10 UTSW 11 105,273,063 (GRCm39) missense probably damaging 1.00
R6612:Marchf10 UTSW 11 105,287,904 (GRCm39) missense probably damaging 0.99
R6894:Marchf10 UTSW 11 105,287,787 (GRCm39) missense possibly damaging 0.94
R6921:Marchf10 UTSW 11 105,280,603 (GRCm39) missense probably benign 0.00
R7134:Marchf10 UTSW 11 105,299,502 (GRCm39) missense probably benign
R7199:Marchf10 UTSW 11 105,281,532 (GRCm39) missense probably damaging 0.99
R7546:Marchf10 UTSW 11 105,280,906 (GRCm39) missense not run
R7792:Marchf10 UTSW 11 105,281,054 (GRCm39) missense probably benign
R8241:Marchf10 UTSW 11 105,280,741 (GRCm39) missense probably benign 0.00
R8467:Marchf10 UTSW 11 105,280,979 (GRCm39) nonsense probably null
R8843:Marchf10 UTSW 11 105,292,802 (GRCm39) missense possibly damaging 0.83
R8962:Marchf10 UTSW 11 105,280,815 (GRCm39) nonsense probably null
R9214:Marchf10 UTSW 11 105,281,100 (GRCm39) missense probably benign 0.02
R9323:Marchf10 UTSW 11 105,280,581 (GRCm39) missense probably damaging 0.98
Z1088:Marchf10 UTSW 11 105,281,185 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAATTTTACTGGGCCTTCTGGG -3'
(R):5'- GCCAGGTCTCCTTACACCTATG -3'

Sequencing Primer
(F):5'- TAGACACAGCACAGGGGTCTC -3'
(R):5'- TGAATGCTGCTTCCTGAC -3'
Posted On 2016-09-01