Incidental Mutation 'R5375:Dpp9'
ID 429046
Institutional Source Beutler Lab
Gene Symbol Dpp9
Ensembl Gene ENSMUSG00000001229
Gene Name dipeptidylpeptidase 9
Synonyms DPRP2, 6430584G11Rik
MMRRC Submission 042951-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5375 (G1)
Quality Score 212
Status Not validated
Chromosome 17
Chromosomal Location 56493807-56525905 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to C at 56496424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 761 (Y761*)
Ref Sequence ENSEMBL: ENSMUSP00000046604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038794]
AlphaFold Q8BVG4
Predicted Effect probably null
Transcript: ENSMUST00000038794
AA Change: Y761*
SMART Domains Protein: ENSMUSP00000046604
Gene: ENSMUSG00000001229
AA Change: Y761*

DomainStartEndE-ValueType
low complexity region 122 133 N/A INTRINSIC
Pfam:DPPIV_N 145 569 5.2e-109 PFAM
Pfam:Peptidase_S15 617 793 2.8e-10 PFAM
Pfam:Peptidase_S9 657 862 2.5e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223616
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy3 T A 12: 4,260,870 (GRCm39) N995K probably damaging Het
Aldh4a1 T C 4: 139,361,233 (GRCm39) M60T probably benign Het
Alpk2 A T 18: 65,505,809 (GRCm39) H70Q probably damaging Het
Babam2 T A 5: 31,859,207 (GRCm39) I5N possibly damaging Het
Blm T C 7: 80,162,977 (GRCm39) T125A probably benign Het
Bloc1s1 T C 10: 128,759,826 (GRCm39) probably benign Het
Calcr G T 6: 3,714,651 (GRCm39) Q160K probably benign Het
Ccdc43 C T 11: 102,581,058 (GRCm39) A131T probably damaging Het
Cdh15 A T 8: 123,591,839 (GRCm39) N575Y probably damaging Het
Chd8 T C 14: 52,441,611 (GRCm39) D827G probably damaging Het
Col3a1 A G 1: 45,387,059 (GRCm39) probably null Het
Creb5 A T 6: 53,658,002 (GRCm39) M255L possibly damaging Het
Cst8 A G 2: 148,646,503 (GRCm39) I78V probably benign Het
Cyld A G 8: 89,459,664 (GRCm39) E440G possibly damaging Het
Cyp2b9 A C 7: 25,887,167 (GRCm39) D192A probably damaging Het
Dclre1b C T 3: 103,711,290 (GRCm39) R207H probably damaging Het
Dnah6 A T 6: 73,100,838 (GRCm39) F1936L probably damaging Het
Drc1 A T 5: 30,513,745 (GRCm39) M434L probably benign Het
Dtx3l A T 16: 35,753,397 (GRCm39) I403N probably damaging Het
Ecpas T A 4: 58,809,401 (GRCm39) K1658* probably null Het
Efcab9 A G 11: 32,477,484 (GRCm39) Y13H probably damaging Het
Efhb T A 17: 53,708,654 (GRCm39) N672I possibly damaging Het
Eif5b T C 1: 38,084,835 (GRCm39) V894A possibly damaging Het
Elovl3 T C 19: 46,123,135 (GRCm39) F237S probably benign Het
Emc1 T A 4: 139,093,802 (GRCm39) D637E probably damaging Het
Erbb2 C A 11: 98,324,238 (GRCm39) P742Q probably damaging Het
Fam234b C A 6: 135,210,355 (GRCm39) L584M probably damaging Het
Fancd2 A T 6: 113,545,673 (GRCm39) D14V possibly damaging Het
Fat2 T C 11: 55,153,646 (GRCm39) H3522R probably benign Het
Fgfr2 T C 7: 129,842,945 (GRCm39) N147D possibly damaging Het
Gm26657 A G 4: 56,741,180 (GRCm39) probably benign Het
Hcrtr1 C T 4: 130,029,518 (GRCm39) V188M probably benign Het
Herc1 T C 9: 66,375,169 (GRCm39) V3331A probably damaging Het
Hmcn2 T C 2: 31,320,453 (GRCm39) V3978A possibly damaging Het
Invs G A 4: 48,385,262 (GRCm39) R202K probably benign Het
Lgr5 C T 10: 115,314,469 (GRCm39) S156N probably benign Het
Mras T G 9: 99,276,669 (GRCm39) D67A probably damaging Het
Mrpl39 A G 16: 84,520,790 (GRCm39) L283P probably damaging Het
Ncoa6 A T 2: 155,275,915 (GRCm39) I110N probably benign Het
Neb T C 2: 52,102,596 (GRCm39) D544G possibly damaging Het
Nlrc3 A G 16: 3,782,617 (GRCm39) I264T possibly damaging Het
Or10a2 T A 7: 106,673,080 (GRCm39) M15K probably benign Het
Or1j13 A G 2: 36,369,309 (GRCm39) Y278H probably damaging Het
Or5k16 T C 16: 58,736,248 (GRCm39) Y252C possibly damaging Het
Or7g18 A G 9: 18,787,442 (GRCm39) K273R probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Phf11d T C 14: 59,590,120 (GRCm39) D234G probably null Het
Polq A T 16: 36,903,146 (GRCm39) D1980V probably damaging Het
Rasa1 A T 13: 85,437,022 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sec23a A G 12: 59,053,791 (GRCm39) V69A probably benign Het
Sipa1 A G 19: 5,709,640 (GRCm39) I260T probably damaging Het
Smarcc1 T A 9: 110,020,017 (GRCm39) L628H probably damaging Het
Snx31 A G 15: 36,525,730 (GRCm39) V323A probably damaging Het
Sun2 A G 15: 79,611,723 (GRCm39) S565P probably damaging Het
Tmem74 C T 15: 43,730,564 (GRCm39) D160N possibly damaging Het
Tnik T C 3: 28,648,241 (GRCm39) M431T probably benign Het
Trp53inp1 A G 4: 11,165,305 (GRCm39) T110A probably benign Het
Ttll9 G T 2: 152,826,144 (GRCm39) C118F probably benign Het
Vps4b A G 1: 106,719,422 (GRCm39) L42P probably benign Het
Xirp2 A T 2: 67,342,250 (GRCm39) N1497I probably damaging Het
Xpo4 A G 14: 57,875,764 (GRCm39) V123A probably damaging Het
Zfhx4 A T 3: 5,477,485 (GRCm39) T3367S probably damaging Het
Zfp236 T C 18: 82,615,813 (GRCm39) E1782G possibly damaging Het
Zfp35 T A 18: 24,135,973 (GRCm39) C106S possibly damaging Het
Zfpm1 A G 8: 123,062,812 (GRCm39) T624A probably benign Het
Zmiz2 C T 11: 6,347,519 (GRCm39) Q276* probably null Het
Other mutations in Dpp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Dpp9 APN 17 56,512,240 (GRCm39) missense probably damaging 0.99
IGL00920:Dpp9 APN 17 56,507,599 (GRCm39) missense probably benign 0.01
IGL01568:Dpp9 APN 17 56,498,159 (GRCm39) missense probably benign
IGL01583:Dpp9 APN 17 56,518,666 (GRCm39) missense probably benign 0.00
IGL01613:Dpp9 APN 17 56,497,713 (GRCm39) missense probably benign
IGL03371:Dpp9 APN 17 56,494,377 (GRCm39) missense probably benign 0.00
R0100:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R0100:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R0418:Dpp9 UTSW 17 56,501,404 (GRCm39) splice site probably benign
R1163:Dpp9 UTSW 17 56,506,426 (GRCm39) missense possibly damaging 0.90
R1680:Dpp9 UTSW 17 56,497,103 (GRCm39) missense probably benign 0.00
R1709:Dpp9 UTSW 17 56,501,431 (GRCm39) missense probably benign
R1762:Dpp9 UTSW 17 56,495,362 (GRCm39) missense probably damaging 1.00
R1809:Dpp9 UTSW 17 56,506,038 (GRCm39) missense probably damaging 1.00
R1853:Dpp9 UTSW 17 56,509,885 (GRCm39) missense probably benign 0.00
R1854:Dpp9 UTSW 17 56,509,885 (GRCm39) missense probably benign 0.00
R2162:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R2205:Dpp9 UTSW 17 56,506,287 (GRCm39) missense possibly damaging 0.87
R2301:Dpp9 UTSW 17 56,501,973 (GRCm39) missense probably benign 0.00
R2520:Dpp9 UTSW 17 56,513,868 (GRCm39) missense probably damaging 1.00
R3831:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R3833:Dpp9 UTSW 17 56,506,113 (GRCm39) missense possibly damaging 0.81
R4364:Dpp9 UTSW 17 56,494,391 (GRCm39) missense possibly damaging 0.79
R4737:Dpp9 UTSW 17 56,505,970 (GRCm39) critical splice donor site probably null
R4740:Dpp9 UTSW 17 56,505,970 (GRCm39) critical splice donor site probably null
R4741:Dpp9 UTSW 17 56,512,286 (GRCm39) missense probably benign
R4798:Dpp9 UTSW 17 56,498,016 (GRCm39) missense probably damaging 0.96
R4806:Dpp9 UTSW 17 56,497,030 (GRCm39) missense probably damaging 1.00
R5709:Dpp9 UTSW 17 56,496,393 (GRCm39) missense probably benign
R5783:Dpp9 UTSW 17 56,518,655 (GRCm39) missense probably damaging 0.98
R6454:Dpp9 UTSW 17 56,513,808 (GRCm39) missense probably damaging 1.00
R6532:Dpp9 UTSW 17 56,512,854 (GRCm39) missense possibly damaging 0.75
R6894:Dpp9 UTSW 17 56,495,321 (GRCm39) missense probably damaging 1.00
R7398:Dpp9 UTSW 17 56,496,405 (GRCm39) nonsense probably null
R7494:Dpp9 UTSW 17 56,507,619 (GRCm39) missense probably damaging 1.00
R7495:Dpp9 UTSW 17 56,502,044 (GRCm39) missense probably benign
R7511:Dpp9 UTSW 17 56,512,611 (GRCm39) missense possibly damaging 0.52
R7556:Dpp9 UTSW 17 56,497,012 (GRCm39) missense possibly damaging 0.66
R8228:Dpp9 UTSW 17 56,498,129 (GRCm39) missense probably damaging 1.00
R8481:Dpp9 UTSW 17 56,501,467 (GRCm39) missense possibly damaging 0.75
R8724:Dpp9 UTSW 17 56,512,867 (GRCm39) missense probably benign 0.03
R8798:Dpp9 UTSW 17 56,506,037 (GRCm39) missense probably damaging 1.00
R9209:Dpp9 UTSW 17 56,512,765 (GRCm39) missense probably damaging 1.00
R9660:Dpp9 UTSW 17 56,494,458 (GRCm39) missense probably damaging 1.00
R9666:Dpp9 UTSW 17 56,501,946 (GRCm39) missense probably damaging 0.99
X0065:Dpp9 UTSW 17 56,502,006 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TGGGGCCTGCTCTAACAATAC -3'
(R):5'- TTCAAGGTGGGTTTCGCTCC -3'

Sequencing Primer
(F):5'- AGACACCTGGACGCCTGAG -3'
(R):5'- TTAAGGCCCACAGGACCTGTC -3'
Posted On 2016-09-06