Incidental Mutation 'R5449:Vmn1r46'
ID 429218
Institutional Source Beutler Lab
Gene Symbol Vmn1r46
Ensembl Gene ENSMUSG00000061653
Gene Name vomeronasal 1 receptor 46
Synonyms V1rb8
MMRRC Submission 043014-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R5449 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 89953153-89954082 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89953343 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 64 (V64A)
Ref Sequence ENSEMBL: ENSMUSP00000154175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075797] [ENSMUST00000205088] [ENSMUST00000226715] [ENSMUST00000228231] [ENSMUST00000228349] [ENSMUST00000228401]
AlphaFold Q9EQ45
Predicted Effect probably benign
Transcript: ENSMUST00000075797
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000075197
Gene: ENSMUSG00000061653
AA Change: V64A

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 301 5.9e-132 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205088
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000144888
Gene: ENSMUSG00000061653
AA Change: V64A

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 301 5.9e-132 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226715
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228231
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228349
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000228401
AA Change: V64A

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik T A 4: 103,123,579 (GRCm39) I98F probably benign Het
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
A630010A05Rik A G 16: 14,436,537 (GRCm39) K197E possibly damaging Het
Agrn A G 4: 156,251,737 (GRCm39) probably null Het
Atad5 A G 11: 80,014,934 (GRCm39) I1337V probably damaging Het
Cd44 T C 2: 102,662,891 (GRCm39) T550A probably damaging Het
Cdk5rap2 A C 4: 70,194,888 (GRCm39) L952V probably benign Het
Cep104 T A 4: 154,069,762 (GRCm39) probably null Het
Cfl1 A G 19: 5,543,521 (GRCm39) *167W probably null Het
Col22a1 T C 15: 71,693,798 (GRCm39) D734G unknown Het
Cry1 G A 10: 84,968,999 (GRCm39) L581F probably benign Het
Dmpk A G 7: 18,824,916 (GRCm39) D406G probably benign Het
Faah T C 4: 115,856,692 (GRCm39) probably null Het
Fchsd2 T C 7: 100,926,731 (GRCm39) F607S probably damaging Het
Fga CAAAG CAAAGAAAG 3: 82,938,169 (GRCm39) probably null Het
Hdac5 G A 11: 102,086,923 (GRCm39) Q46* probably null Het
Hltf A G 3: 20,123,247 (GRCm39) T212A possibly damaging Het
Ilvbl G A 10: 78,412,862 (GRCm39) probably null Het
Ldhc T C 7: 46,519,082 (GRCm39) S102P possibly damaging Het
Med12l T C 3: 59,167,127 (GRCm39) V1529A probably damaging Het
Nlrp9a A G 7: 26,257,254 (GRCm39) I202V probably benign Het
Nscme3l G A 19: 5,553,292 (GRCm39) T163M probably benign Het
Pdc A C 1: 150,209,190 (GRCm39) L224F probably damaging Het
Pgr T C 9: 8,956,344 (GRCm39) V764A possibly damaging Het
Plxna1 T C 6: 89,300,590 (GRCm39) D1578G probably damaging Het
Prpf40a G T 2: 53,046,938 (GRCm39) T266N possibly damaging Het
Ptrh1 A G 2: 32,666,358 (GRCm39) S37G probably damaging Het
Rgs9 T C 11: 109,116,570 (GRCm39) D411G probably benign Het
Riok3 A T 18: 12,288,303 (GRCm39) E493D probably damaging Het
Rnf213 T C 11: 119,305,902 (GRCm39) M570T probably benign Het
Scamp2 A G 9: 57,488,154 (GRCm39) D187G probably damaging Het
Scn1a T A 2: 66,151,346 (GRCm39) I819F probably damaging Het
Slc7a5 C A 8: 122,613,087 (GRCm39) W330C probably damaging Het
Syn3 A T 10: 86,187,434 (GRCm39) F230Y probably damaging Het
Tmem8b G A 4: 43,673,992 (GRCm39) V208I probably benign Het
Tro T C X: 149,428,966 (GRCm39) probably benign Het
Ubr1 T A 2: 120,793,981 (GRCm39) M68L probably benign Het
Vmn1r120 A C 7: 20,787,074 (GRCm39) H212Q possibly damaging Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Wee1 TCCCC TCCC 7: 109,723,776 (GRCm39) probably null Het
Zfp384 T C 6: 125,001,101 (GRCm39) S58P probably damaging Het
Other mutations in Vmn1r46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02271:Vmn1r46 APN 6 89,953,886 (GRCm39) missense probably damaging 1.00
IGL02488:Vmn1r46 APN 6 89,953,963 (GRCm39) missense probably benign 0.10
IGL03116:Vmn1r46 APN 6 89,953,898 (GRCm39) missense probably benign 0.16
IGL03270:Vmn1r46 APN 6 89,953,756 (GRCm39) missense probably damaging 1.00
R0109:Vmn1r46 UTSW 6 89,954,044 (GRCm39) missense probably benign 0.03
R0126:Vmn1r46 UTSW 6 89,953,935 (GRCm39) missense probably benign
R0681:Vmn1r46 UTSW 6 89,953,946 (GRCm39) missense probably damaging 1.00
R1501:Vmn1r46 UTSW 6 89,953,198 (GRCm39) missense probably benign 0.03
R1717:Vmn1r46 UTSW 6 89,953,811 (GRCm39) missense probably damaging 1.00
R1937:Vmn1r46 UTSW 6 89,953,716 (GRCm39) missense probably benign 0.00
R4323:Vmn1r46 UTSW 6 89,953,349 (GRCm39) missense probably benign 0.06
R6062:Vmn1r46 UTSW 6 89,953,241 (GRCm39) missense possibly damaging 0.64
R6385:Vmn1r46 UTSW 6 89,953,427 (GRCm39) missense probably damaging 0.99
R6431:Vmn1r46 UTSW 6 89,953,389 (GRCm39) missense probably benign 0.13
R7126:Vmn1r46 UTSW 6 89,953,976 (GRCm39) missense possibly damaging 0.79
R7391:Vmn1r46 UTSW 6 89,953,607 (GRCm39) missense probably benign 0.23
R8700:Vmn1r46 UTSW 6 89,953,325 (GRCm39) missense probably benign 0.04
R8950:Vmn1r46 UTSW 6 89,954,053 (GRCm39) missense probably damaging 0.99
R9046:Vmn1r46 UTSW 6 89,953,585 (GRCm39) missense probably damaging 1.00
Z1088:Vmn1r46 UTSW 6 89,953,723 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTTCCTACCCACATACAATG -3'
(R):5'- AGGCACCTGAGATGTGATGG -3'

Sequencing Primer
(F):5'- GCCAACATATTCTGCACCG -3'
(R):5'- CCTGAGATGTGATGGGGAGATTTATG -3'
Posted On 2016-09-06