|Institutional Source||Beutler Lab|
|Gene Name||DnaJ heat shock protein family (Hsp40) member C3|
|Synonyms||Dnajc3, Dnajc3a, Dnajc3b, mp58, p58IPK, Prkri|
|Is this an essential gene?||Possibly non essential (E-score: 0.257)|
|Stock #||R5398 (G1)|
|Chromosomal Location||118937976-118981697 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 118972387 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 291 (Y291*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000022734 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000022734]|
|Predicted Effect||probably null
AA Change: Y291*
AA Change: Y291*
|Meta Mutation Damage Score||0.604|
|Coding Region Coverage||
|Validation Efficiency||95% (59/62)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
PHENOTYPE: Homozygous null mice are smaller in size, have a lower percentage of body fat and develop a gradual onset of glucosuria and hyperglycemia associated with increasing apoptosis of pancreatic islet cells. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Dnajc3||
(F):5'- CGTGCTTTAGAGACTCCTGTC -3'
(R):5'- CCAGAGTGATGGCTCAGTAGTG -3'
(F):5'- GCCCCATGCTTTAGAGACTCTG -3'
(R):5'- TGTGTGCACTGAACAAGCATGC -3'