Incidental Mutation 'R5400:Or1n2'
ID 429913
Institutional Source Beutler Lab
Gene Symbol Or1n2
Ensembl Gene ENSMUSG00000055088
Gene Name olfactory receptor family 1 subfamily N member 2
Synonyms GA_x6K02T2NLDC-33601476-33602429, MOR127-4, Olfr354
MMRRC Submission 042971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R5400 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 36796960-36797913 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36797833 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 292 (I292F)
Ref Sequence ENSEMBL: ENSMUSP00000149298 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068475] [ENSMUST00000217479]
AlphaFold Q8VGJ8
Predicted Effect probably damaging
Transcript: ENSMUST00000068475
AA Change: I292F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000068986
Gene: ENSMUSG00000055088
AA Change: I292F

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2.1e-62 PFAM
Pfam:7tm_1 44 293 2.9e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121665
Predicted Effect probably damaging
Transcript: ENSMUST00000217479
AA Change: I292F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218102
Meta Mutation Damage Score 0.4546 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accsl T C 2: 93,689,767 (GRCm39) D380G probably damaging Het
Afm T C 5: 90,699,257 (GRCm39) L567P possibly damaging Het
Anks1b A T 10: 90,348,686 (GRCm39) I785L probably damaging Het
Arpc5l G A 2: 38,903,747 (GRCm39) G79S probably benign Het
Arvcf G T 16: 18,217,820 (GRCm39) R440L probably benign Het
Atm T C 9: 53,414,318 (GRCm39) D924G probably damaging Het
Atp8b1 A T 18: 64,679,060 (GRCm39) probably null Het
Cd19 C T 7: 126,013,624 (GRCm39) G55D probably benign Het
Cd34 A G 1: 194,621,266 (GRCm39) probably benign Het
Cd69 T A 6: 129,246,954 (GRCm39) M88L probably benign Het
Ces2h A G 8: 105,745,057 (GRCm39) E397G probably benign Het
Ddx60 T C 8: 62,463,036 (GRCm39) F1306L possibly damaging Het
Dennd5b T C 6: 148,901,514 (GRCm39) E1124G probably damaging Het
Dio1 A T 4: 107,164,185 (GRCm39) M44K probably damaging Het
Elapor2 A T 5: 9,529,247 (GRCm39) N1027Y probably damaging Het
En1 A G 1: 120,531,324 (GRCm39) D188G probably damaging Het
Epha10 C T 4: 124,807,914 (GRCm39) probably benign Het
Fam120b A T 17: 15,623,388 (GRCm39) L455F possibly damaging Het
Flt4 AC ACC 11: 49,541,861 (GRCm39) probably null Het
Incenp A G 19: 9,855,039 (GRCm39) probably null Het
Kansl3 A G 1: 36,397,230 (GRCm39) V86A possibly damaging Het
Klhl7 C G 5: 24,331,918 (GRCm39) F73L probably damaging Het
Med28 T A 5: 45,682,541 (GRCm39) V69D probably damaging Het
Mknk1 C A 4: 115,721,749 (GRCm39) L98M probably damaging Het
Mknk1 T A 4: 115,721,750 (GRCm39) L98Q probably damaging Het
Myo3b T A 2: 69,935,724 (GRCm39) C97S probably damaging Het
Neto1 A G 18: 86,414,033 (GRCm39) H9R possibly damaging Het
Omd A T 13: 49,745,703 (GRCm39) E371V probably benign Het
Or2w3b T C 11: 58,623,146 (GRCm39) T282A possibly damaging Het
Or4c123 T C 2: 89,127,257 (GRCm39) D119G probably damaging Het
Or51e2 G A 7: 102,391,637 (GRCm39) T191I probably benign Het
Osbpl9 G T 4: 108,919,497 (GRCm39) Y733* probably null Het
Pcdh12 A T 18: 38,401,951 (GRCm39) S91R probably damaging Het
Pxk C A 14: 8,136,911 (GRCm38) P144Q probably benign Het
Qser1 A G 2: 104,620,219 (GRCm39) S198P probably damaging Het
Recql T G 6: 142,308,073 (GRCm39) probably benign Het
Reln T C 5: 22,184,712 (GRCm39) D1601G probably damaging Het
Scn10a T C 9: 119,438,100 (GRCm39) D1922G probably damaging Het
Scn11a T A 9: 119,598,974 (GRCm39) R1185S probably damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Shoc1 A G 4: 59,082,432 (GRCm39) S399P possibly damaging Het
Slc13a4 A T 6: 35,278,777 (GRCm39) C37* probably null Het
Slc22a30 G A 19: 8,321,757 (GRCm39) Q436* probably null Het
Slc9a9 T A 9: 94,594,954 (GRCm39) F155I probably damaging Het
Spef2 T A 15: 9,614,367 (GRCm39) K1193M probably damaging Het
Swt1 T C 1: 151,288,585 (GRCm39) T80A probably benign Het
Tmc1 A G 19: 20,781,966 (GRCm39) I584T probably damaging Het
Tsc22d1 C A 14: 76,654,494 (GRCm39) F324L probably benign Het
Usp19 T C 9: 108,377,392 (GRCm39) V1236A probably damaging Het
Vmn2r63 T C 7: 42,577,635 (GRCm39) N301S probably benign Het
Wrn C T 8: 33,784,945 (GRCm39) V476I probably benign Het
Zbed6 G A 1: 133,585,879 (GRCm39) T486I probably damaging Het
Zbtb25 C A 12: 76,396,476 (GRCm39) E249* probably null Het
Zfp54 C A 17: 21,653,962 (GRCm39) T152K probably benign Het
Other mutations in Or1n2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01942:Or1n2 APN 2 36,797,869 (GRCm39) missense probably benign
IGL02573:Or1n2 APN 2 36,797,566 (GRCm39) missense probably damaging 1.00
P0027:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
R0040:Or1n2 UTSW 2 36,797,470 (GRCm39) missense probably damaging 1.00
R0610:Or1n2 UTSW 2 36,797,671 (GRCm39) missense probably damaging 1.00
R0760:Or1n2 UTSW 2 36,797,233 (GRCm39) missense probably benign 0.25
R1727:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R2972:Or1n2 UTSW 2 36,797,416 (GRCm39) missense probably benign 0.03
R4671:Or1n2 UTSW 2 36,797,405 (GRCm39) missense probably benign 0.00
R4750:Or1n2 UTSW 2 36,797,728 (GRCm39) missense probably benign 0.13
R5043:Or1n2 UTSW 2 36,796,977 (GRCm39) missense probably benign 0.01
R5543:Or1n2 UTSW 2 36,797,369 (GRCm39) missense possibly damaging 0.75
R5792:Or1n2 UTSW 2 36,797,113 (GRCm39) missense probably benign 0.00
R6639:Or1n2 UTSW 2 36,797,690 (GRCm39) missense probably damaging 1.00
R6876:Or1n2 UTSW 2 36,797,834 (GRCm39) missense probably damaging 1.00
R7965:Or1n2 UTSW 2 36,796,953 (GRCm39) start gained probably benign
R8351:Or1n2 UTSW 2 36,797,149 (GRCm39) missense probably benign 0.00
R8859:Or1n2 UTSW 2 36,797,516 (GRCm39) missense possibly damaging 0.63
T0722:Or1n2 UTSW 2 36,797,582 (GRCm39) missense probably benign 0.00
Z1176:Or1n2 UTSW 2 36,797,713 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TATGTCTGCATTTCCTGGGC -3'
(R):5'- TTTCACATCACAACCTGGAGG -3'

Sequencing Primer
(F):5'- ATCCCTTCTTCTGGAGGGCG -3'
(R):5'- GAGGAGGTAAATGCCCATTTTG -3'
Posted On 2016-09-06