Incidental Mutation 'R5401:Vmn2r67'
| ID |
429990 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
042972-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.111)
|
| Stock # |
R5401 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84785765 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 747
(Y747N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168730
AA Change: Y747N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: Y747N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
97% (66/68) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001J11Rik |
A |
G |
9: 39,962,338 (GRCm39) |
|
noncoding transcript |
Het |
| 1700025H01Rik |
G |
T |
16: 30,018,801 (GRCm39) |
|
noncoding transcript |
Het |
| 9330159F19Rik |
T |
C |
10: 29,101,136 (GRCm39) |
V503A |
probably benign |
Het |
| Acacb |
A |
G |
5: 114,347,914 (GRCm39) |
N995S |
possibly damaging |
Het |
| Anapc4 |
A |
G |
5: 53,020,991 (GRCm39) |
K630R |
probably benign |
Het |
| Ankrd13a |
A |
C |
5: 114,930,234 (GRCm39) |
Q206H |
probably damaging |
Het |
| Ano10 |
A |
T |
9: 122,090,356 (GRCm39) |
L319Q |
probably damaging |
Het |
| Camkk2 |
T |
A |
5: 122,884,398 (GRCm39) |
D341V |
probably damaging |
Het |
| Ccdc88a |
A |
G |
11: 29,413,279 (GRCm39) |
I606V |
probably benign |
Het |
| Cdv3 |
G |
T |
9: 103,242,316 (GRCm39) |
|
probably benign |
Het |
| Cep97 |
A |
G |
16: 55,745,315 (GRCm39) |
V155A |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,228,476 (GRCm39) |
E2204G |
probably damaging |
Het |
| Cracr2b |
A |
G |
7: 141,046,136 (GRCm39) |
*395W |
probably null |
Het |
| Defa27 |
A |
G |
8: 21,805,710 (GRCm39) |
E50G |
possibly damaging |
Het |
| Dnah7a |
A |
G |
1: 53,670,812 (GRCm39) |
I480T |
probably benign |
Het |
| Ep400 |
C |
A |
5: 110,831,037 (GRCm39) |
D2210Y |
unknown |
Het |
| Fam170a |
T |
A |
18: 50,413,618 (GRCm39) |
S28T |
probably benign |
Het |
| Fancc |
C |
A |
13: 63,550,767 (GRCm39) |
K18N |
probably damaging |
Het |
| Flt4 |
AC |
ACC |
11: 49,541,861 (GRCm39) |
|
probably null |
Het |
| Fndc8 |
T |
G |
11: 82,788,676 (GRCm39) |
S169A |
possibly damaging |
Het |
| Get3 |
A |
T |
8: 85,745,173 (GRCm39) |
I298N |
possibly damaging |
Het |
| Herc1 |
T |
C |
9: 66,409,338 (GRCm39) |
Y4688H |
probably damaging |
Het |
| Ighv11-2 |
A |
T |
12: 114,011,959 (GRCm39) |
D85E |
possibly damaging |
Het |
| Kat14 |
T |
C |
2: 144,231,180 (GRCm39) |
F196L |
possibly damaging |
Het |
| Kctd19 |
C |
T |
8: 106,109,617 (GRCm39) |
V942I |
probably benign |
Het |
| Llgl1 |
A |
G |
11: 60,597,297 (GRCm39) |
S249G |
probably benign |
Het |
| Map1a |
T |
C |
2: 121,130,153 (GRCm39) |
V323A |
probably damaging |
Het |
| Or4m1 |
C |
A |
14: 50,557,566 (GRCm39) |
C242F |
probably damaging |
Het |
| Phf21a |
C |
A |
2: 92,182,097 (GRCm39) |
T342K |
possibly damaging |
Het |
| Piezo2 |
T |
A |
18: 63,217,811 (GRCm39) |
D1122V |
possibly damaging |
Het |
| Pklr |
A |
G |
3: 89,049,173 (GRCm39) |
Y173C |
probably damaging |
Het |
| Plcz1 |
G |
T |
6: 139,938,778 (GRCm39) |
|
probably null |
Het |
| Polr3a |
T |
C |
14: 24,505,009 (GRCm39) |
I1084V |
possibly damaging |
Het |
| Prom1 |
A |
T |
5: 44,158,147 (GRCm39) |
Y845N |
probably damaging |
Het |
| Qng1 |
C |
A |
13: 58,530,405 (GRCm39) |
A202S |
probably benign |
Het |
| Ret |
A |
T |
6: 118,158,936 (GRCm39) |
S159T |
probably benign |
Het |
| Rfx1 |
C |
A |
8: 84,793,005 (GRCm39) |
|
probably null |
Het |
| Scp2 |
A |
T |
4: 108,001,976 (GRCm39) |
|
probably null |
Het |
| Sh3bp5 |
C |
A |
14: 31,099,452 (GRCm39) |
R265L |
probably benign |
Het |
| Slc22a30 |
G |
A |
19: 8,321,757 (GRCm39) |
Q436* |
probably null |
Het |
| Smad5 |
T |
C |
13: 56,875,282 (GRCm39) |
F157L |
probably benign |
Het |
| Smarcc2 |
C |
A |
10: 128,301,373 (GRCm39) |
D210E |
probably damaging |
Het |
| Sptlc3 |
T |
C |
2: 139,478,643 (GRCm39) |
L534P |
possibly damaging |
Het |
| Srrm1 |
A |
G |
4: 135,051,380 (GRCm39) |
|
probably benign |
Het |
| Srsf11 |
C |
T |
3: 157,728,981 (GRCm39) |
|
probably benign |
Het |
| Sugct |
T |
A |
13: 17,032,455 (GRCm39) |
Q432H |
probably damaging |
Het |
| Tex9 |
A |
T |
9: 72,394,060 (GRCm39) |
|
probably null |
Het |
| Tsc1 |
C |
A |
2: 28,576,920 (GRCm39) |
S1073* |
probably null |
Het |
| Vmn1r72 |
T |
C |
7: 11,403,843 (GRCm39) |
S202G |
probably damaging |
Het |
| Vmn2r55 |
A |
G |
7: 12,385,871 (GRCm39) |
V703A |
probably benign |
Het |
| Zcchc4 |
A |
G |
5: 52,964,419 (GRCm39) |
I292V |
probably benign |
Het |
| Zfp998 |
T |
C |
13: 66,579,722 (GRCm39) |
R254G |
probably benign |
Het |
| Zswim2 |
C |
T |
2: 83,755,589 (GRCm39) |
G104E |
possibly damaging |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAACCATAGTCTTGCCTTTG -3'
(R):5'- GCCATTGCTTTCACTGTGGC -3'
Sequencing Primer
(F):5'- CCTTTGGTGCTATGGTAGACAG -3'
(R):5'- AAGAATGAGGTGGCTGCTTC -3'
|
| Posted On |
2016-09-06 |
Incidental Mutation