Incidental Mutation 'R5403:Or6b2'
ID 430086
Institutional Source Beutler Lab
Gene Symbol Or6b2
Ensembl Gene ENSMUSG00000067064
Gene Name olfactory receptor family 6 subfamily B member 2
Synonyms Olfr1416, GA_x6K02T2R7CC-81277975-81278913, MOR103-3
MMRRC Submission 042974-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R5403 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 92407403-92408341 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 92408019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 108 (V108E)
Ref Sequence ENSEMBL: ENSMUSP00000149576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086837] [ENSMUST00000214928]
AlphaFold Q8VGU4
Predicted Effect possibly damaging
Transcript: ENSMUST00000086837
AA Change: V108E

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000084048
Gene: ENSMUSG00000067064
AA Change: V108E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-53 PFAM
Pfam:7tm_1 41 290 6.7e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203760
AA Change: V108E
SMART Domains Protein: ENSMUSP00000145466
Gene: ENSMUSG00000067064
AA Change: V108E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-53 PFAM
Pfam:7tm_1 41 290 6.7e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214928
AA Change: V108E

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.3040 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 G T 17: 57,183,221 (GRCm39) probably benign Het
Adamts6 A G 13: 104,489,323 (GRCm39) D392G possibly damaging Het
Adcy8 C T 15: 64,588,001 (GRCm39) V929I probably benign Het
Alkbh8 A G 9: 3,385,318 (GRCm39) K537E probably benign Het
Anp32a A T 9: 62,249,275 (GRCm39) I16F possibly damaging Het
Asb18 T C 1: 89,942,110 (GRCm39) T64A probably benign Het
Bpifb4 A T 2: 153,785,912 (GRCm39) I17F probably damaging Het
Brd7 G T 8: 89,084,169 (GRCm39) Q148K probably damaging Het
Brinp1 A G 4: 68,711,201 (GRCm39) W336R probably benign Het
Ccdc88b T A 19: 6,835,108 (GRCm39) T38S unknown Het
Cd46 C T 1: 194,744,719 (GRCm39) V340I possibly damaging Het
Cdr2 G A 7: 120,557,968 (GRCm39) Q186* probably null Het
Ces1e T G 8: 93,935,240 (GRCm39) D404A probably benign Het
Chd3 A T 11: 69,239,895 (GRCm39) probably null Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Cntnap3 G A 13: 64,909,792 (GRCm39) T771I possibly damaging Het
Cops8 C T 1: 90,534,342 (GRCm39) probably benign Het
Csmd2 C T 4: 128,380,677 (GRCm39) R2078C probably benign Het
Ddx50 A G 10: 62,482,809 (GRCm39) S87P probably benign Het
Dennd2b A G 7: 109,156,112 (GRCm39) S213P probably damaging Het
Dlg2 A G 7: 92,080,210 (GRCm39) T598A probably damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Epha6 A T 16: 59,595,933 (GRCm39) D919E probably damaging Het
Fndc9 C T 11: 46,128,541 (GRCm39) S20L probably benign Het
Gpx6 A G 13: 21,501,813 (GRCm39) E145G probably damaging Het
Hc A G 2: 34,947,446 (GRCm39) Y23H probably damaging Het
Insyn2b A T 11: 34,353,058 (GRCm39) T367S probably benign Het
Jmy G T 13: 93,577,904 (GRCm39) Q755K probably benign Het
Krtap4-7 A T 11: 99,534,540 (GRCm39) S108T unknown Het
Mgat5b T G 11: 116,839,483 (GRCm39) I333S probably benign Het
Mrtfb A G 16: 13,218,877 (GRCm39) T519A probably damaging Het
Naip6 G A 13: 100,436,585 (GRCm39) A646V probably benign Het
Opn4 T C 14: 34,314,894 (GRCm39) T460A probably benign Het
Or8g22 G T 9: 38,957,999 (GRCm39) P239T probably damaging Het
Otogl T A 10: 107,644,617 (GRCm39) M1210L probably benign Het
Pheta1 A G 5: 121,990,794 (GRCm39) E52G possibly damaging Het
Phf24 A T 4: 42,933,831 (GRCm39) probably null Het
Ppargc1a G A 5: 51,620,167 (GRCm39) probably benign Het
Ptprd G A 4: 75,872,405 (GRCm39) R1355* probably null Het
Rad50 A G 11: 53,586,108 (GRCm39) probably null Het
Robo4 CGG CG 9: 37,322,786 (GRCm39) probably null Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Tbcd C A 11: 121,451,569 (GRCm39) N546K probably damaging Het
Tenm4 A G 7: 96,538,034 (GRCm39) D1832G probably damaging Het
Tfap2e T C 4: 126,628,439 (GRCm39) I172M probably benign Het
Tnip2 A G 5: 34,671,108 (GRCm39) L45P probably damaging Het
Ttc3 T C 16: 94,260,703 (GRCm39) V1396A probably benign Het
Ube2o A T 11: 116,439,633 (GRCm39) I179N possibly damaging Het
Usp17le T C 7: 104,418,441 (GRCm39) I234V probably damaging Het
Zfp106 T C 2: 120,365,262 (GRCm39) T382A probably benign Het
Zfp607a A G 7: 27,578,744 (GRCm39) K605E possibly damaging Het
Zmynd10 T A 9: 107,427,785 (GRCm39) L363H possibly damaging Het
Other mutations in Or6b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Or6b2 APN 1 92,407,746 (GRCm39) missense probably damaging 0.99
IGL00980:Or6b2 APN 1 92,407,402 (GRCm39) splice site probably null
IGL01540:Or6b2 APN 1 92,408,202 (GRCm39) missense probably damaging 0.96
BB007:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
BB017:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
R1146:Or6b2 UTSW 1 92,407,612 (GRCm39) missense probably damaging 1.00
R1146:Or6b2 UTSW 1 92,407,612 (GRCm39) missense probably damaging 1.00
R4751:Or6b2 UTSW 1 92,407,705 (GRCm39) missense probably benign 0.01
R5207:Or6b2 UTSW 1 92,407,594 (GRCm39) missense probably benign
R5287:Or6b2 UTSW 1 92,408,019 (GRCm39) missense possibly damaging 0.88
R6074:Or6b2 UTSW 1 92,407,497 (GRCm39) missense probably benign 0.45
R6232:Or6b2 UTSW 1 92,408,305 (GRCm39) missense probably benign 0.00
R6355:Or6b2 UTSW 1 92,407,702 (GRCm39) missense probably benign 0.21
R6378:Or6b2 UTSW 1 92,408,178 (GRCm39) missense probably damaging 1.00
R6901:Or6b2 UTSW 1 92,408,327 (GRCm39) missense probably damaging 1.00
R7930:Or6b2 UTSW 1 92,407,570 (GRCm39) missense probably benign 0.01
R8280:Or6b2 UTSW 1 92,407,729 (GRCm39) missense noncoding transcript
R8351:Or6b2 UTSW 1 92,407,660 (GRCm39) missense probably benign 0.09
R8437:Or6b2 UTSW 1 92,408,187 (GRCm39) missense probably benign 0.00
R8451:Or6b2 UTSW 1 92,407,660 (GRCm39) missense probably benign 0.09
X0065:Or6b2 UTSW 1 92,407,484 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCAAGACATTGGAGCCACAG -3'
(R):5'- GGAGAACCTGACCATCATCCTC -3'

Sequencing Primer
(F):5'- CACAGAAGGTGGCGCTG -3'
(R):5'- ATCCTCACTGTCTGGAGCAG -3'
Posted On 2016-09-06