Incidental Mutation 'R5486:Tex19.2'
ID 430376
Institutional Source Beutler Lab
Gene Symbol Tex19.2
Ensembl Gene ENSMUSG00000039337
Gene Name testis expressed gene 19.2
Synonyms 4921530G04Rik, Tex19.2
MMRRC Submission 043047-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # R5486 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 121007041-121009503 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 121008304 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 48 (M48K)
Ref Sequence ENSEMBL: ENSMUSP00000037027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039146]
AlphaFold Q9D5S1
Predicted Effect probably benign
Transcript: ENSMUST00000039146
AA Change: M48K

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000037027
Gene: ENSMUSG00000039337
AA Change: M48K

DomainStartEndE-ValueType
Pfam:TEX19 1 145 7.2e-70 PFAM
low complexity region 184 196 N/A INTRINSIC
low complexity region 292 305 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 95.1%
  • 20x: 90.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Double homozygous KO with Tex19.1 causes testis degeneration and male infertility owing to meiotic arrest in the germ cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930009A15Rik G T 10: 115,415,810 (GRCm39) probably benign Het
Acad8 A T 9: 26,910,791 (GRCm39) M1K probably null Het
Adam12 C A 7: 133,509,401 (GRCm39) R786S possibly damaging Het
Add3 G A 19: 53,232,818 (GRCm39) V604I probably benign Het
Alpk2 A T 18: 65,427,425 (GRCm39) probably null Het
Ano3 T C 2: 110,576,215 (GRCm39) D102G probably damaging Het
Bdp1 T C 13: 100,235,018 (GRCm39) Y192C probably damaging Het
Bod1l A T 5: 41,964,524 (GRCm39) D2693E possibly damaging Het
Ccdc7a T C 8: 129,711,884 (GRCm39) N284D probably damaging Het
Clic6 A G 16: 92,326,740 (GRCm39) probably null Het
Cln5 T C 14: 103,313,630 (GRCm39) I294T probably damaging Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Cyp2d9 T A 15: 82,336,779 (GRCm39) W43R probably damaging Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Erlec1 A T 11: 30,885,047 (GRCm39) H413Q probably damaging Het
Fam168a T A 7: 100,483,376 (GRCm39) M203K probably damaging Het
Fat2 A T 11: 55,144,507 (GRCm39) S4122R probably benign Het
Fgd4 A T 16: 16,292,901 (GRCm39) L272Q probably damaging Het
Hpcal4 A G 4: 123,084,557 (GRCm39) K162R probably benign Het
Iars1 T A 13: 49,863,049 (GRCm39) probably null Het
Lbr A G 1: 181,646,403 (GRCm39) probably null Het
Lrp2 T C 2: 69,267,809 (GRCm39) I4259V probably benign Het
Mcm3 C T 1: 20,885,118 (GRCm39) G189S probably damaging Het
Nr1d2 A G 14: 18,206,860 (GRCm38) V137A possibly damaging Het
Or52d1 C A 7: 103,755,705 (GRCm39) T73N probably damaging Het
Or52n3 T A 7: 104,530,168 (GRCm39) C85S probably benign Het
Or7g33 A G 9: 19,448,590 (GRCm39) V212A probably benign Het
Pim3 T C 15: 88,747,425 (GRCm39) V97A possibly damaging Het
Piwil2 T C 14: 70,638,880 (GRCm39) N479S probably benign Het
Pld3 C A 7: 27,233,156 (GRCm39) W365L probably damaging Het
Plk3 C A 4: 116,987,600 (GRCm39) E412* probably null Het
Psmd1 A G 1: 86,064,772 (GRCm39) I935V possibly damaging Het
Sh2b2 A G 5: 136,260,944 (GRCm39) S91P probably benign Het
Skor2 A G 18: 76,946,395 (GRCm39) N39S unknown Het
Slc22a22 A G 15: 57,126,847 (GRCm39) V55A probably damaging Het
Smg7 A G 1: 152,721,927 (GRCm39) S595P probably damaging Het
Snrnp200 C T 2: 127,074,986 (GRCm39) P1520S possibly damaging Het
Taar7a T A 10: 23,868,356 (GRCm39) T342S probably benign Het
Tecpr2 A T 12: 110,899,449 (GRCm39) I606F probably benign Het
Thoc1 A G 18: 9,992,204 (GRCm39) T511A probably benign Het
Trpc2 GTGTCCTA GTGTCCTATGTCCTA 7: 101,744,420 (GRCm39) probably null Het
Ubr5 C A 15: 38,008,983 (GRCm39) A1077S probably benign Het
Wdr95 A T 5: 149,519,795 (GRCm39) R571* probably null Het
Other mutations in Tex19.2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tex19.2 APN 11 121,007,638 (GRCm39) missense possibly damaging 0.93
R1412:Tex19.2 UTSW 11 121,007,761 (GRCm39) missense possibly damaging 0.91
R1828:Tex19.2 UTSW 11 121,008,317 (GRCm39) missense probably benign 0.08
R3082:Tex19.2 UTSW 11 121,007,557 (GRCm39) missense probably benign 0.01
R4902:Tex19.2 UTSW 11 121,007,782 (GRCm39) missense probably damaging 0.99
R8271:Tex19.2 UTSW 11 121,008,010 (GRCm39) missense possibly damaging 0.92
R9369:Tex19.2 UTSW 11 121,007,566 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- AGATCCAGGGGTACAGCTTC -3'
(R):5'- GAGCAAGTCTTCCTCTGTGTG -3'

Sequencing Primer
(F):5'- AGGGGTACAGCTTCCTGAG -3'
(R):5'- TGTCCGCTTAGCTGCAGACAG -3'
Posted On 2016-10-05