Incidental Mutation 'R5505:Or5t9'
ID 430864
Institutional Source Beutler Lab
Gene Symbol Or5t9
Ensembl Gene ENSMUSG00000044213
Gene Name olfactory receptor family 5 subfamily T member 9
Synonyms Olfr1094, GA_x6K02T2Q125-48321457-48322449, MOR179-7
MMRRC Submission 043066-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.240) question?
Stock # R5505 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86659020-86660166 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86659845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 250 (F250L)
Ref Sequence ENSEMBL: ENSMUSP00000148902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105211] [ENSMUST00000217509]
AlphaFold Q8VF13
Predicted Effect possibly damaging
Transcript: ENSMUST00000105211
AA Change: F250L

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000100846
Gene: ENSMUSG00000044213
AA Change: F250L

DomainStartEndE-ValueType
Pfam:7tm_4 43 320 4.6e-52 PFAM
Pfam:7tm_1 53 316 3.5e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217509
AA Change: F250L

PolyPhen 2 Score 0.879 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.2611 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 90.9%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 T A 5: 24,606,036 (GRCm39) D240E probably damaging Het
Alpk3 G A 7: 80,728,309 (GRCm39) E480K possibly damaging Het
Arhgap20 A G 9: 51,750,248 (GRCm39) E372G probably damaging Het
Atp23 G T 10: 126,723,499 (GRCm39) A201D probably damaging Het
Bpifb1 A G 2: 154,046,699 (GRCm39) D73G probably benign Het
Ccdc7a A G 8: 129,706,655 (GRCm39) S325P possibly damaging Het
Cckar A G 5: 53,860,410 (GRCm39) Y140H probably damaging Het
Cd46 A T 1: 194,767,688 (GRCm39) D124E possibly damaging Het
Cep290 T C 10: 100,335,048 (GRCm39) probably null Het
Cmklr1 C G 5: 113,752,990 (GRCm39) D4H possibly damaging Het
Eif2ak1 T C 5: 143,803,745 (GRCm39) S34P probably benign Het
Enah T A 1: 181,734,018 (GRCm39) probably benign Het
Gad2 C G 2: 22,514,845 (GRCm39) L108V probably benign Het
Gpr22 T C 12: 31,759,724 (GRCm39) I133V probably damaging Het
Hdac4 T C 1: 91,903,187 (GRCm39) T13A probably benign Het
Ighv1-4 A G 12: 114,451,057 (GRCm39) V17A possibly damaging Het
Ints8 T A 4: 11,221,143 (GRCm39) Q744L probably benign Het
Lrit3 C T 3: 129,585,087 (GRCm39) V224I possibly damaging Het
Mgat4a T C 1: 37,535,035 (GRCm39) I108V probably benign Het
Mmp9 T C 2: 164,795,528 (GRCm39) I682T probably benign Het
Myh7b G A 2: 155,474,592 (GRCm39) A1742T probably benign Het
Nlrp12 C T 7: 3,298,015 (GRCm39) G52D probably damaging Het
Pcnx1 T C 12: 81,996,927 (GRCm39) L941P probably damaging Het
Pla2g4e T C 2: 120,075,256 (GRCm39) R45G probably benign Het
Plcz1 C G 6: 139,961,942 (GRCm39) G203A probably damaging Het
Poldip2 A G 11: 78,406,001 (GRCm39) T76A probably benign Het
Prdm15 T A 16: 97,618,183 (GRCm39) H325L possibly damaging Het
Ralyl A T 3: 13,841,980 (GRCm39) I39F probably damaging Het
Rnf220 A C 4: 117,153,288 (GRCm39) probably benign Het
Rnpc3 T C 3: 113,409,102 (GRCm39) K318E probably damaging Het
Rsbn1 T A 3: 103,836,259 (GRCm39) N432K probably damaging Het
Sh3yl1 T A 12: 30,992,072 (GRCm39) Y176N probably damaging Het
Slc25a30 G A 14: 76,000,789 (GRCm39) L272F probably damaging Het
Spag1 T C 15: 36,234,772 (GRCm39) V844A probably damaging Het
Srsf5 T C 12: 80,995,857 (GRCm39) probably benign Het
Tle2 T A 10: 81,417,574 (GRCm39) D223E probably benign Het
Tmem192 A G 8: 65,416,898 (GRCm39) E39G possibly damaging Het
Trpc6 T A 9: 8,626,736 (GRCm39) L362H probably damaging Het
Tuba4a A G 1: 75,193,060 (GRCm39) Y185H probably damaging Het
Uba6 A G 5: 86,268,405 (GRCm39) V941A probably benign Het
Vmn2r35 A T 7: 7,789,479 (GRCm39) Y753N probably damaging Het
Zfp941 C T 7: 140,391,830 (GRCm39) V510I probably benign Het
Other mutations in Or5t9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02839:Or5t9 APN 2 86,659,712 (GRCm39) missense probably benign
IGL03053:Or5t9 APN 2 86,659,607 (GRCm39) missense possibly damaging 0.93
IGL03168:Or5t9 APN 2 86,659,607 (GRCm39) missense possibly damaging 0.93
IGL02799:Or5t9 UTSW 2 86,659,300 (GRCm39) missense probably damaging 0.99
R0511:Or5t9 UTSW 2 86,659,950 (GRCm39) missense probably benign 0.02
R0944:Or5t9 UTSW 2 86,659,281 (GRCm39) missense probably benign 0.01
R1065:Or5t9 UTSW 2 86,659,888 (GRCm39) missense probably damaging 0.98
R1476:Or5t9 UTSW 2 86,659,542 (GRCm39) missense probably benign 0.31
R1807:Or5t9 UTSW 2 86,659,445 (GRCm39) missense probably benign 0.03
R2865:Or5t9 UTSW 2 86,659,198 (GRCm39) missense probably benign 0.21
R2915:Or5t9 UTSW 2 86,659,570 (GRCm39) missense probably benign 0.02
R3055:Or5t9 UTSW 2 86,659,471 (GRCm39) missense possibly damaging 0.94
R3104:Or5t9 UTSW 2 86,660,035 (GRCm39) missense probably benign 0.03
R4862:Or5t9 UTSW 2 86,659,876 (GRCm39) missense probably damaging 1.00
R4874:Or5t9 UTSW 2 86,659,598 (GRCm39) missense probably damaging 0.98
R5507:Or5t9 UTSW 2 86,659,661 (GRCm39) missense probably damaging 1.00
R6318:Or5t9 UTSW 2 86,659,998 (GRCm39) missense possibly damaging 0.73
R6538:Or5t9 UTSW 2 86,659,869 (GRCm39) missense possibly damaging 0.55
R8058:Or5t9 UTSW 2 86,660,052 (GRCm39) missense probably benign 0.01
R8285:Or5t9 UTSW 2 86,659,443 (GRCm39) missense probably benign 0.03
R9563:Or5t9 UTSW 2 86,659,098 (GRCm39) start codon destroyed probably null 0.04
Predicted Primers PCR Primer
(F):5'- GCTACTATACATACAGTGGCTACC -3'
(R):5'- TGTTTCTCAGACTGTAGATGATAGG -3'

Sequencing Primer
(F):5'- CTGTGCATCCAATGAGATTAGGC -3'
(R):5'- TCAGACTGTAGATGATAGGATTCAGC -3'
Posted On 2016-10-05