Incidental Mutation 'R5506:Or7e166'
ID 430926
Institutional Source Beutler Lab
Gene Symbol Or7e166
Ensembl Gene ENSMUSG00000094678
Gene Name olfactory receptor family 7 subfamily E member 166
Synonyms MOR146-8P, Olfr857, GA_x6K02T2PVTD-13452606-13453535
MMRRC Submission 043067-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R5506 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19624125-19625054 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19624570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 149 (L149P)
Ref Sequence ENSEMBL: ENSMUSP00000150889 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077023] [ENSMUST00000212013] [ENSMUST00000217450]
AlphaFold A0A1L1SUS1
Predicted Effect probably benign
Transcript: ENSMUST00000077023
AA Change: L149P

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000076281
Gene: ENSMUSG00000094678
AA Change: L149P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 304 1.5e-5 PFAM
Pfam:7tm_1 41 290 9.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212013
AA Change: L149P

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212753
AA Change: L114P
Predicted Effect possibly damaging
Transcript: ENSMUST00000217450
AA Change: L149P

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.4%
  • 20x: 91.4%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G T 3: 137,773,708 (GRCm39) G966W probably damaging Het
A930009A15Rik G T 10: 115,414,267 (GRCm39) probably null Het
Cant1 G T 11: 118,302,268 (GRCm39) H16Q probably benign Het
Capn3 G T 2: 120,332,901 (GRCm39) V612F probably damaging Het
Cep112 A T 11: 108,555,429 (GRCm39) E141D probably damaging Het
Cept1 A G 3: 106,438,564 (GRCm39) V173A probably benign Het
CN725425 A G 15: 91,120,029 (GRCm39) D50G possibly damaging Het
Cubn A T 2: 13,496,506 (GRCm39) probably null Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dpp8 A G 9: 64,985,391 (GRCm39) probably null Het
Ecm1 G A 3: 95,643,169 (GRCm39) T377I probably benign Het
Exosc8 A G 3: 54,638,600 (GRCm39) probably benign Het
Fasn C T 11: 120,700,336 (GRCm39) D2165N probably benign Het
Gab2 A G 7: 96,952,320 (GRCm39) E571G probably damaging Het
Galnt5 C A 2: 57,889,637 (GRCm39) H412Q probably benign Het
Galr1 T A 18: 82,423,989 (GRCm39) Y96F possibly damaging Het
Garin1b G A 6: 29,319,297 (GRCm39) E34K probably damaging Het
Gnl2 C A 4: 124,949,158 (GRCm39) probably benign Het
H2ac22 A C 13: 21,971,081 (GRCm39) I103S probably damaging Het
H2ax T C 9: 44,246,402 (GRCm39) V115A probably benign Het
Heatr9 T C 11: 83,405,592 (GRCm39) N317S possibly damaging Het
Kndc1 A G 7: 139,507,804 (GRCm39) Y1254C probably damaging Het
Lrp6 A T 6: 134,436,259 (GRCm39) D1302E probably benign Het
Mc2r A T 18: 68,541,019 (GRCm39) Y91* probably null Het
Meis1 T G 11: 18,891,747 (GRCm39) D267A possibly damaging Het
Mki67 T C 7: 135,301,710 (GRCm39) K1108R possibly damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Myh3 T G 11: 66,974,915 (GRCm39) D219E probably damaging Het
Niban2 G A 2: 32,810,994 (GRCm39) V335M probably damaging Het
Or10g1b T C 14: 52,628,084 (GRCm39) I49V probably damaging Het
Pi4ka A G 16: 17,111,817 (GRCm39) C1553R probably damaging Het
Plekhb1 C A 7: 100,294,150 (GRCm39) probably null Het
Polr3d A T 14: 70,678,199 (GRCm39) D165E possibly damaging Het
Prb1c T C 6: 132,338,819 (GRCm39) N133S unknown Het
Psmb1 A G 17: 15,710,478 (GRCm39) Y24H probably damaging Het
Rab11fip5 A G 6: 85,351,119 (GRCm39) L131P probably damaging Het
Raph1 A T 1: 60,532,657 (GRCm39) probably benign Het
Rmc1 A G 18: 12,322,013 (GRCm39) probably benign Het
Scgb2b27 T G 7: 33,711,484 (GRCm39) probably benign Het
Serpina10 T C 12: 103,592,920 (GRCm39) D264G probably damaging Het
Sftpb A G 6: 72,281,651 (GRCm39) T15A possibly damaging Het
Slc20a1 T C 2: 129,052,739 (GRCm39) F674L probably benign Het
Syne2 A T 12: 75,985,495 (GRCm39) N1648Y probably benign Het
Thsd7a G T 6: 12,332,016 (GRCm39) N1265K possibly damaging Het
Trem2 T C 17: 48,658,802 (GRCm39) L189P probably benign Het
Washc4 A T 10: 83,417,201 (GRCm39) R865S probably damaging Het
Zfp536 A G 7: 37,268,217 (GRCm39) S400P probably damaging Het
Other mutations in Or7e166
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01510:Or7e166 APN 9 19,624,575 (GRCm39) missense probably benign 0.00
IGL01919:Or7e166 APN 9 19,624,638 (GRCm39) missense probably benign 0.00
IGL02157:Or7e166 APN 9 19,624,585 (GRCm39) missense probably benign 0.07
IGL02550:Or7e166 APN 9 19,624,343 (GRCm39) missense possibly damaging 0.92
IGL03329:Or7e166 APN 9 19,624,597 (GRCm39) missense probably benign 0.16
IGL02799:Or7e166 UTSW 9 19,624,314 (GRCm39) missense probably damaging 0.99
R0356:Or7e166 UTSW 9 19,624,743 (GRCm39) missense probably damaging 1.00
R0927:Or7e166 UTSW 9 19,624,945 (GRCm39) missense probably benign 0.39
R1161:Or7e166 UTSW 9 19,624,476 (GRCm39) missense probably damaging 1.00
R1848:Or7e166 UTSW 9 19,624,386 (GRCm39) missense probably benign 0.01
R5191:Or7e166 UTSW 9 19,624,630 (GRCm39) missense probably damaging 0.98
R5216:Or7e166 UTSW 9 19,624,585 (GRCm39) missense probably benign 0.07
R5259:Or7e166 UTSW 9 19,624,109 (GRCm39) splice site probably null
R5342:Or7e166 UTSW 9 19,624,333 (GRCm39) missense probably damaging 1.00
R5526:Or7e166 UTSW 9 19,624,994 (GRCm39) nonsense probably null
R5594:Or7e166 UTSW 9 19,624,302 (GRCm39) missense probably damaging 0.99
R5928:Or7e166 UTSW 9 19,625,049 (GRCm39) missense probably benign 0.02
R6569:Or7e166 UTSW 9 19,624,638 (GRCm39) missense probably benign 0.00
R6858:Or7e166 UTSW 9 19,624,765 (GRCm39) missense probably damaging 0.98
R7077:Or7e166 UTSW 9 19,624,428 (GRCm39) missense probably benign
R7378:Or7e166 UTSW 9 19,624,183 (GRCm39) missense probably damaging 1.00
R7771:Or7e166 UTSW 9 19,624,767 (GRCm39) missense probably benign
R8038:Or7e166 UTSW 9 19,624,976 (GRCm39) missense possibly damaging 0.52
R8160:Or7e166 UTSW 9 19,624,085 (GRCm39) intron probably benign
R8223:Or7e166 UTSW 9 19,624,705 (GRCm39) missense probably benign
R8400:Or7e166 UTSW 9 19,624,389 (GRCm39) missense probably benign 0.45
R8780:Or7e166 UTSW 9 19,624,653 (GRCm39) missense possibly damaging 0.92
R8946:Or7e166 UTSW 9 19,624,885 (GRCm39) missense probably damaging 0.99
R9164:Or7e166 UTSW 9 19,624,954 (GRCm39) missense probably benign 0.25
R9475:Or7e166 UTSW 9 19,624,939 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTGCATGCCCATAACAGATCC -3'
(R):5'- TAGGAGTAAAATATTCCTGAGGCAG -3'

Sequencing Primer
(F):5'- CAGATCCATAACTTATGCTGAATGCC -3'
(R):5'- GAGGAAACCAAGAATGATGCC -3'
Posted On 2016-10-05