Mutagenetix > Incidental Mutation

Incidental Mutation 'R5508:Clec4b2'

431031

Institutional Source

Beutler Lab

Gene Symbol

Clec4b2

Ensembl Gene

ENSMUSG00000067767

Gene Name

C-type lectin domain family 4, member b2

Synonyms

mDCAR1, F830043G12Rik

MMRRC Submission

043069-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R5508 (G1)

Quality Score

223

Status

Not validated

Chromosome

Chromosomal Location

123149852-123181630 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 123150001 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000085802 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088455]

AlphaFold

Q67DU8

Predicted Effect

probably benign
Transcript: ENSMUST00000088455

SMART Domains

Protein: ENSMUSP00000085802
Gene: ENSMUSG00000067767

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
CLECT	79	202	1.87e-33	SMART

Coding Region Coverage

1x: 98.4%
3x: 97.4%
10x: 95.7%
20x: 92.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ank3	G	A	10: 69,838,395 (GRCm39)	R1566K	possibly damaging	Het
Apc	A	G	18: 34,431,633 (GRCm39)	D344G	probably damaging	Het
Asphd2	A	T	5: 112,534,649 (GRCm39)	F300I	probably damaging	Het
BC016579	T	A	16: 45,453,369 (GRCm39)	T149S	possibly damaging	Het
Bcl6b	A	T	11: 70,116,919 (GRCm39)	H453Q	probably damaging	Het
Ccdc192	G	A	18: 57,671,156 (GRCm39)		probably null	Het
Crispld1	G	T	1: 17,823,207 (GRCm39)	C396F	probably damaging	Het
Dnase1l3	A	G	14: 7,968,146 (GRCm38)	V253A	probably damaging	Het
Efhd1	A	G	1: 87,237,516 (GRCm39)	*241W	probably null	Het
Flvcr1	C	T	1: 190,757,656 (GRCm39)	G212D	probably damaging	Het
Golga2	T	A	2: 32,178,199 (GRCm39)	L36*	probably null	Het
Gprc5c	G	T	11: 114,755,093 (GRCm39)	V257L	possibly damaging	Het
Gtf3c2	G	T	5: 31,331,805 (GRCm39)	C4*	probably null	Het
Kit	G	T	5: 75,810,208 (GRCm39)	C786F	probably damaging	Het
Klf14	T	C	6: 30,934,977 (GRCm39)	H219R	probably damaging	Het
Large2	A	G	2: 92,200,248 (GRCm39)	V122A	possibly damaging	Het
Lct	G	A	1: 128,221,868 (GRCm39)	A1557V	probably damaging	Het
Lrp6	T	G	6: 134,441,479 (GRCm39)	K1162N	probably benign	Het
Mtmr11	G	A	3: 96,071,084 (GRCm39)	R147Q	probably damaging	Het
Pbld2	T	A	10: 62,902,444 (GRCm39)		probably null	Het
Pcdhb3	A	T	18: 37,434,179 (GRCm39)	L48F	probably damaging	Het
Pdcd2	C	T	17: 15,742,001 (GRCm39)	D310N	probably damaging	Het
Phlpp1	G	T	1: 106,292,120 (GRCm39)	R993L	probably benign	Het
Prr36	G	A	8: 4,266,488 (GRCm39)	P21S	probably damaging	Het
Ptprq	C	A	10: 107,522,092 (GRCm39)	V620L	probably benign	Het
Ranbp2	T	A	10: 58,315,827 (GRCm39)	D2182E	probably damaging	Het
Sass6	G	A	3: 116,413,752 (GRCm39)	R485K	probably benign	Het
Scoc	A	T	8: 84,162,571 (GRCm39)	S68T	probably damaging	Het
Speer3	T	A	5: 13,844,678 (GRCm39)	L114I	probably damaging	Het
Ss18l1	C	G	2: 179,699,446 (GRCm39)	Q215E	probably damaging	Het
Stab2	T	C	10: 86,796,143 (GRCm39)	N368S	probably benign	Het
Trim80	T	A	11: 115,335,904 (GRCm39)	S275R	probably benign	Het
Tubb5	T	C	17: 36,145,962 (GRCm39)	N416S	probably benign	Het
Ugt2a3	A	T	5: 87,475,059 (GRCm39)	M395K	probably damaging	Het
Vmn2r61	T	A	7: 41,916,242 (GRCm39)	M285K	possibly damaging	Het
Xpo1	A	G	11: 23,244,645 (GRCm39)	I1008V	probably benign	Het

Other mutations in Clec4b2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00956:Clec4b2	APN	6	123,179,110 (GRCm39)	nonsense	probably null
IGL01753:Clec4b2	APN	6	123,179,169 (GRCm39)	missense	possibly damaging	0.90
IGL02168:Clec4b2	APN	6	123,181,156 (GRCm39)	missense	probably damaging	0.98
IGL02388:Clec4b2	APN	6	123,179,187 (GRCm39)	splice site	probably null
IGL03194:Clec4b2	APN	6	123,177,946 (GRCm39)	missense	probably benign	0.07
P0041:Clec4b2	UTSW	6	123,158,253 (GRCm39)	missense	possibly damaging	0.72
R0013:Clec4b2	UTSW	6	123,179,108 (GRCm39)	missense	probably damaging	1.00
R0121:Clec4b2	UTSW	6	123,181,131 (GRCm39)	missense	probably benign	0.02
R0401:Clec4b2	UTSW	6	123,158,259 (GRCm39)	nonsense	probably null
R1072:Clec4b2	UTSW	6	123,181,233 (GRCm39)	missense	probably damaging	0.99
R2520:Clec4b2	UTSW	6	123,177,942 (GRCm39)	missense	probably damaging	1.00
R4575:Clec4b2	UTSW	6	123,150,639 (GRCm39)	missense	probably damaging	0.99
R4897:Clec4b2	UTSW	6	123,177,999 (GRCm39)	nonsense	probably null
R4898:Clec4b2	UTSW	6	123,181,163 (GRCm39)	missense	probably benign	0.36
R5022:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5023:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5057:Clec4b2	UTSW	6	123,177,915 (GRCm39)	missense	probably null	1.00
R5404:Clec4b2	UTSW	6	123,158,308 (GRCm39)	missense	probably benign	0.06
R6082:Clec4b2	UTSW	6	123,181,100 (GRCm39)	critical splice acceptor site	probably null
R6333:Clec4b2	UTSW	6	123,177,637 (GRCm39)	splice site	probably null
R6902:Clec4b2	UTSW	6	123,177,987 (GRCm39)	nonsense	probably null
R6946:Clec4b2	UTSW	6	123,177,987 (GRCm39)	nonsense	probably null
R7144:Clec4b2	UTSW	6	123,158,343 (GRCm39)	missense	probably benign	0.02
R7709:Clec4b2	UTSW	6	123,149,974 (GRCm39)	start gained	probably benign
R7973:Clec4b2	UTSW	6	123,181,148 (GRCm39)	missense	probably benign	0.05
R8810:Clec4b2	UTSW	6	123,158,269 (GRCm39)	missense	probably benign	0.23
R9278:Clec4b2	UTSW	6	123,181,224 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2016-10-05