Incidental Mutation 'R5508:Trim80'
ID 431044
Institutional Source Beutler Lab
Gene Symbol Trim80
Ensembl Gene ENSMUSG00000070332
Gene Name tripartite motif-containing 80
Synonyms 4933422H20Rik
MMRRC Submission 043069-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5508 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 115331371-115339094 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 115335904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 275 (S275R)
Ref Sequence ENSEMBL: ENSMUSP00000091442 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093914]
AlphaFold Q3V061
Predicted Effect probably benign
Transcript: ENSMUST00000093914
AA Change: S275R

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000091442
Gene: ENSMUSG00000070332
AA Change: S275R

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
RING 71 114 4.48e-7 SMART
Blast:BBOX 154 202 7e-22 BLAST
Pfam:zf-B_box 207 246 2.2e-10 PFAM
Blast:PRY 441 496 2e-18 BLAST
Pfam:SPRY 499 621 3.9e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175355
Coding Region Coverage
  • 1x: 98.4%
  • 3x: 97.4%
  • 10x: 95.7%
  • 20x: 92.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Apc A G 18: 34,431,633 (GRCm39) D344G probably damaging Het
Asphd2 A T 5: 112,534,649 (GRCm39) F300I probably damaging Het
BC016579 T A 16: 45,453,369 (GRCm39) T149S possibly damaging Het
Bcl6b A T 11: 70,116,919 (GRCm39) H453Q probably damaging Het
Ccdc192 G A 18: 57,671,156 (GRCm39) probably null Het
Clec4b2 A G 6: 123,150,001 (GRCm39) probably benign Het
Crispld1 G T 1: 17,823,207 (GRCm39) C396F probably damaging Het
Dnase1l3 A G 14: 7,968,146 (GRCm38) V253A probably damaging Het
Efhd1 A G 1: 87,237,516 (GRCm39) *241W probably null Het
Flvcr1 C T 1: 190,757,656 (GRCm39) G212D probably damaging Het
Golga2 T A 2: 32,178,199 (GRCm39) L36* probably null Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Gtf3c2 G T 5: 31,331,805 (GRCm39) C4* probably null Het
Kit G T 5: 75,810,208 (GRCm39) C786F probably damaging Het
Klf14 T C 6: 30,934,977 (GRCm39) H219R probably damaging Het
Large2 A G 2: 92,200,248 (GRCm39) V122A possibly damaging Het
Lct G A 1: 128,221,868 (GRCm39) A1557V probably damaging Het
Lrp6 T G 6: 134,441,479 (GRCm39) K1162N probably benign Het
Mtmr11 G A 3: 96,071,084 (GRCm39) R147Q probably damaging Het
Pbld2 T A 10: 62,902,444 (GRCm39) probably null Het
Pcdhb3 A T 18: 37,434,179 (GRCm39) L48F probably damaging Het
Pdcd2 C T 17: 15,742,001 (GRCm39) D310N probably damaging Het
Phlpp1 G T 1: 106,292,120 (GRCm39) R993L probably benign Het
Prr36 G A 8: 4,266,488 (GRCm39) P21S probably damaging Het
Ptprq C A 10: 107,522,092 (GRCm39) V620L probably benign Het
Ranbp2 T A 10: 58,315,827 (GRCm39) D2182E probably damaging Het
Sass6 G A 3: 116,413,752 (GRCm39) R485K probably benign Het
Scoc A T 8: 84,162,571 (GRCm39) S68T probably damaging Het
Speer3 T A 5: 13,844,678 (GRCm39) L114I probably damaging Het
Ss18l1 C G 2: 179,699,446 (GRCm39) Q215E probably damaging Het
Stab2 T C 10: 86,796,143 (GRCm39) N368S probably benign Het
Tubb5 T C 17: 36,145,962 (GRCm39) N416S probably benign Het
Ugt2a3 A T 5: 87,475,059 (GRCm39) M395K probably damaging Het
Vmn2r61 T A 7: 41,916,242 (GRCm39) M285K possibly damaging Het
Xpo1 A G 11: 23,244,645 (GRCm39) I1008V probably benign Het
Other mutations in Trim80
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00899:Trim80 APN 11 115,338,491 (GRCm39) missense probably benign 0.21
IGL00921:Trim80 APN 11 115,338,490 (GRCm39) missense probably benign 0.00
IGL02948:Trim80 APN 11 115,332,419 (GRCm39) missense possibly damaging 0.81
IGL03037:Trim80 APN 11 115,332,419 (GRCm39) missense possibly damaging 0.81
R0019:Trim80 UTSW 11 115,338,768 (GRCm39) missense probably damaging 1.00
R0019:Trim80 UTSW 11 115,338,768 (GRCm39) missense probably damaging 1.00
R0409:Trim80 UTSW 11 115,332,039 (GRCm39) missense probably damaging 1.00
R1069:Trim80 UTSW 11 115,338,909 (GRCm39) missense probably damaging 1.00
R1832:Trim80 UTSW 11 115,337,619 (GRCm39) missense probably benign
R1952:Trim80 UTSW 11 115,332,155 (GRCm39) nonsense probably null
R2892:Trim80 UTSW 11 115,338,849 (GRCm39) missense possibly damaging 0.81
R4301:Trim80 UTSW 11 115,335,939 (GRCm39) critical splice donor site probably null
R4748:Trim80 UTSW 11 115,338,964 (GRCm39) missense possibly damaging 0.84
R4795:Trim80 UTSW 11 115,338,769 (GRCm39) missense probably damaging 1.00
R4819:Trim80 UTSW 11 115,338,769 (GRCm39) missense probably damaging 1.00
R4910:Trim80 UTSW 11 115,337,281 (GRCm39) missense probably damaging 0.99
R5245:Trim80 UTSW 11 115,332,398 (GRCm39) missense probably damaging 1.00
R5288:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5384:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5386:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R5645:Trim80 UTSW 11 115,337,611 (GRCm39) missense probably damaging 1.00
R5785:Trim80 UTSW 11 115,337,301 (GRCm39) nonsense probably null
R5822:Trim80 UTSW 11 115,338,747 (GRCm39) missense probably damaging 0.99
R6754:Trim80 UTSW 11 115,339,000 (GRCm39) missense probably damaging 1.00
R6785:Trim80 UTSW 11 115,332,027 (GRCm39) missense probably damaging 0.99
R6788:Trim80 UTSW 11 115,338,843 (GRCm39) missense probably benign 0.07
R7336:Trim80 UTSW 11 115,332,042 (GRCm39) missense probably damaging 1.00
R8316:Trim80 UTSW 11 115,332,006 (GRCm39) missense probably damaging 1.00
R8386:Trim80 UTSW 11 115,335,900 (GRCm39) missense probably damaging 0.99
R8955:Trim80 UTSW 11 115,331,538 (GRCm39) missense probably benign
R9764:Trim80 UTSW 11 115,338,757 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- GATACACTTGCTCTTCTACCCTGG -3'
(R):5'- TCTGAGGTAGATGTGCAGGG -3'

Sequencing Primer
(F):5'- CCCTGGTCTTGGGTTCACTAAAG -3'
(R):5'- TGTACTCCACTATACTGGTCCAAAG -3'
Posted On 2016-10-05