Incidental Mutation 'R5510:Tmem156'
ID 431139
Institutional Source Beutler Lab
Gene Symbol Tmem156
Ensembl Gene ENSMUSG00000037913
Gene Name transmembrane protein 156
Synonyms LOC243025
MMRRC Submission 043071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R5510 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 65215558-65249524 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 65232917 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 151 (T151M)
Ref Sequence ENSEMBL: ENSMUSP00000148300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043352] [ENSMUST00000212080] [ENSMUST00000212194] [ENSMUST00000212640]
AlphaFold A0A1D5RLR8
Predicted Effect probably benign
Transcript: ENSMUST00000043352
AA Change: T203M

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000044102
Gene: ENSMUSG00000037913
AA Change: T203M

DomainStartEndE-ValueType
transmembrane domain 5 22 N/A INTRINSIC
Pfam:TMEM156 39 264 1.2e-111 PFAM
Predicted Effect not run
Transcript: ENSMUST00000184193
AA Change: T4M
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203664
Predicted Effect probably benign
Transcript: ENSMUST00000212080
AA Change: T215M

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000212194
AA Change: T180M

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000212640
AA Change: T151M

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.5%
  • 3x: 97.3%
  • 10x: 95.1%
  • 20x: 90.1%
Validation Efficiency 99% (91/92)
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 T G 3: 151,203,467 (GRCm39) I59R possibly damaging Het
Adgrv1 T A 13: 81,593,363 (GRCm39) D4208V probably damaging Het
Aimp2 A T 5: 143,843,347 (GRCm39) probably benign Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Ankib1 A G 5: 3,779,693 (GRCm39) V392A probably benign Het
Ap2b1 A G 11: 83,227,563 (GRCm39) probably null Het
Arsg A G 11: 109,418,700 (GRCm39) E232G probably benign Het
Axdnd1 A G 1: 156,162,920 (GRCm39) F144S probably benign Het
Bud13 T A 9: 46,203,498 (GRCm39) M111K probably damaging Het
Cav2 T C 6: 17,287,012 (GRCm39) F152S possibly damaging Het
Ccdc180 A G 4: 45,928,046 (GRCm39) T1194A probably damaging Het
Ccdc192 G A 18: 57,671,156 (GRCm39) probably null Het
Ccdc88c T C 12: 100,911,290 (GRCm39) K848R probably damaging Het
Ceacam15 A G 7: 16,406,024 (GRCm39) W176R probably damaging Het
Cenpf A T 1: 189,415,100 (GRCm39) D136E probably benign Het
Dclk2 T C 3: 86,813,344 (GRCm39) I201V possibly damaging Het
Defa24 T A 8: 22,224,612 (GRCm39) D20E probably damaging Het
Dgcr8 T C 16: 18,095,039 (GRCm39) N566D probably damaging Het
Dido1 C A 2: 180,326,966 (GRCm39) V386L probably benign Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Dtx3 G A 10: 127,028,807 (GRCm39) P141S probably benign Het
Fmn1 T C 2: 113,426,714 (GRCm39) Y1144H probably damaging Het
Gabbr2 A G 4: 46,734,113 (GRCm39) L535P probably damaging Het
Gimap3 T A 6: 48,742,183 (GRCm39) E249V possibly damaging Het
Git2 A T 5: 114,881,835 (GRCm39) probably null Het
Gm4922 T C 10: 18,659,745 (GRCm39) T326A probably benign Het
Gsdmc2 T G 15: 63,700,045 (GRCm39) E242D probably benign Het
Hdgfl2 G A 17: 56,389,118 (GRCm39) G31S possibly damaging Het
Herc2 A T 7: 55,856,519 (GRCm39) I3956F probably damaging Het
Hsf2bp G A 17: 32,165,721 (GRCm39) R134C unknown Het
Igf1r G C 7: 67,843,107 (GRCm39) R739S probably benign Het
Igkv4-51 T C 6: 69,658,443 (GRCm39) E102G probably damaging Het
Kif1a T G 1: 92,969,414 (GRCm39) I1156L possibly damaging Het
Kti12 T C 4: 108,705,821 (GRCm39) L245S probably damaging Het
Med17 A G 9: 15,181,700 (GRCm39) S17P probably benign Het
Mllt6 G A 11: 97,560,326 (GRCm39) S210N possibly damaging Het
Mrps18b A G 17: 36,225,215 (GRCm39) probably benign Het
Ms4a8a A G 19: 11,056,828 (GRCm39) S85P probably benign Het
Msln T C 17: 25,968,847 (GRCm39) Q487R probably benign Het
Myh13 A G 11: 67,228,549 (GRCm39) N363S probably benign Het
Myo6 T C 9: 80,152,942 (GRCm39) F192L probably damaging Het
Nfkbiz T C 16: 55,634,383 (GRCm39) D688G probably damaging Het
Nsun4 C T 4: 115,908,974 (GRCm39) V529I possibly damaging Het
Or12d15 A T 17: 37,694,192 (GRCm39) M245L probably benign Het
Or1j16 G A 2: 36,530,975 (GRCm39) R308K probably benign Het
Or5p70 G A 7: 107,994,332 (GRCm39) A2T probably benign Het
Phf11a C A 14: 59,516,834 (GRCm39) C208F probably damaging Het
Plekhh2 G A 17: 84,874,275 (GRCm39) C520Y probably benign Het
Plxna4 C A 6: 32,155,293 (GRCm39) M1550I probably damaging Het
Pnpla6 A T 8: 3,571,397 (GRCm39) Y140F probably damaging Het
Ppp1r12a T A 10: 108,085,488 (GRCm39) S478T possibly damaging Het
Prkcz C A 4: 155,357,393 (GRCm39) probably null Het
Prss55 T A 14: 64,314,574 (GRCm39) M199L probably damaging Het
Qrich1 G A 9: 108,433,659 (GRCm39) V651I possibly damaging Het
Ralyl T C 3: 13,842,005 (GRCm39) V47A probably damaging Het
Raph1 A T 1: 60,562,105 (GRCm39) probably benign Het
Rgs12 T C 5: 35,123,383 (GRCm39) Y389H probably damaging Het
Sec24b C A 3: 129,834,544 (GRCm39) G82V probably damaging Het
Sema4a A G 3: 88,357,293 (GRCm39) probably null Het
Slc25a11 A T 11: 70,536,361 (GRCm39) W149R probably damaging Het
Slc2a7 T G 4: 150,244,551 (GRCm39) S340A probably benign Het
Slc32a1 T A 2: 158,456,716 (GRCm39) M457K probably damaging Het
Spata31d1e T C 13: 59,890,234 (GRCm39) probably null Het
Spint4 C T 2: 164,542,812 (GRCm39) T135M probably damaging Het
Sult2a2 A C 7: 13,472,228 (GRCm39) N142H probably damaging Het
Tbc1d1 G A 5: 64,490,738 (GRCm39) G863D probably damaging Het
Trip12 T C 1: 84,746,401 (GRCm39) Q459R probably damaging Het
Vmn2r116 G A 17: 23,605,095 (GRCm39) C136Y probably damaging Het
Vmn2r51 C T 7: 9,836,545 (GRCm39) V79M possibly damaging Het
Vmn2r67 A T 7: 84,801,023 (GRCm39) D304E probably benign Het
Wdr93 T A 7: 79,399,779 (GRCm39) F123I probably damaging Het
Zfp672 A T 11: 58,207,456 (GRCm39) C288* probably null Het
Zp1 T C 19: 10,896,769 (GRCm39) Y90C probably damaging Het
Other mutations in Tmem156
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Tmem156 APN 5 65,231,183 (GRCm39) missense probably damaging 1.00
IGL01064:Tmem156 APN 5 65,237,327 (GRCm39) missense probably damaging 0.99
IGL01330:Tmem156 APN 5 65,237,525 (GRCm39) missense probably benign 0.17
IGL03336:Tmem156 APN 5 65,233,107 (GRCm39) missense probably benign 0.01
IGL03383:Tmem156 APN 5 65,233,040 (GRCm39) missense probably damaging 0.98
R0526:Tmem156 UTSW 5 65,233,161 (GRCm39) missense probably benign 0.02
R2006:Tmem156 UTSW 5 65,237,294 (GRCm39) missense probably damaging 1.00
R4721:Tmem156 UTSW 5 65,248,870 (GRCm39) missense probably benign 0.10
R4773:Tmem156 UTSW 5 65,237,502 (GRCm39) missense probably damaging 1.00
R4810:Tmem156 UTSW 5 65,248,790 (GRCm39) intron probably benign
R4910:Tmem156 UTSW 5 65,248,805 (GRCm39) intron probably benign
R5148:Tmem156 UTSW 5 65,231,111 (GRCm39) missense probably benign 0.00
R5809:Tmem156 UTSW 5 65,232,950 (GRCm39) missense possibly damaging 0.55
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R7731:Tmem156 UTSW 5 65,232,905 (GRCm39) critical splice donor site probably null
R7772:Tmem156 UTSW 5 65,237,517 (GRCm39) missense probably damaging 1.00
R7788:Tmem156 UTSW 5 65,232,912 (GRCm39) missense possibly damaging 0.47
R7979:Tmem156 UTSW 5 65,237,352 (GRCm39) missense possibly damaging 0.47
R8017:Tmem156 UTSW 5 65,231,204 (GRCm39) missense probably damaging 1.00
R8132:Tmem156 UTSW 5 65,233,098 (GRCm39) missense probably benign 0.00
R8249:Tmem156 UTSW 5 65,232,969 (GRCm39) nonsense probably null
R8492:Tmem156 UTSW 5 65,222,438 (GRCm39) missense possibly damaging 0.87
R9209:Tmem156 UTSW 5 65,231,127 (GRCm39) missense probably damaging 1.00
R9287:Tmem156 UTSW 5 65,231,148 (GRCm39) missense probably damaging 1.00
R9468:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9470:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9471:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9696:Tmem156 UTSW 5 65,231,147 (GRCm39) missense possibly damaging 0.83
RF020:Tmem156 UTSW 5 65,248,890 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TCTCCGATTATGGTTGAGTCCC -3'
(R):5'- CATCACCGCCGCTCTTATAG -3'

Sequencing Primer
(F):5'- ACTTCCGGTGACATTTGG -3'
(R):5'- TCTTATAGCTGACCCTGTGAAGGAAG -3'
Posted On 2016-10-05