Incidental Mutation 'R5510:Vmn2r67'
| ID |
431153 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
043071-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.111)
|
| Stock # |
R5510 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84801023 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 304
(D304E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168730
AA Change: D304E
PolyPhen 2
Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: D304E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.5%
- 3x: 97.3%
- 10x: 95.1%
- 20x: 90.1%
|
| Validation Efficiency |
99% (91/92) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl4 |
T |
G |
3: 151,203,467 (GRCm39) |
I59R |
possibly damaging |
Het |
| Adgrv1 |
T |
A |
13: 81,593,363 (GRCm39) |
D4208V |
probably damaging |
Het |
| Aimp2 |
A |
T |
5: 143,843,347 (GRCm39) |
|
probably benign |
Het |
| Ank3 |
G |
A |
10: 69,838,395 (GRCm39) |
R1566K |
possibly damaging |
Het |
| Ankib1 |
A |
G |
5: 3,779,693 (GRCm39) |
V392A |
probably benign |
Het |
| Ap2b1 |
A |
G |
11: 83,227,563 (GRCm39) |
|
probably null |
Het |
| Arsg |
A |
G |
11: 109,418,700 (GRCm39) |
E232G |
probably benign |
Het |
| Axdnd1 |
A |
G |
1: 156,162,920 (GRCm39) |
F144S |
probably benign |
Het |
| Bud13 |
T |
A |
9: 46,203,498 (GRCm39) |
M111K |
probably damaging |
Het |
| Cav2 |
T |
C |
6: 17,287,012 (GRCm39) |
F152S |
possibly damaging |
Het |
| Ccdc180 |
A |
G |
4: 45,928,046 (GRCm39) |
T1194A |
probably damaging |
Het |
| Ccdc192 |
G |
A |
18: 57,671,156 (GRCm39) |
|
probably null |
Het |
| Ccdc88c |
T |
C |
12: 100,911,290 (GRCm39) |
K848R |
probably damaging |
Het |
| Ceacam15 |
A |
G |
7: 16,406,024 (GRCm39) |
W176R |
probably damaging |
Het |
| Cenpf |
A |
T |
1: 189,415,100 (GRCm39) |
D136E |
probably benign |
Het |
| Dclk2 |
T |
C |
3: 86,813,344 (GRCm39) |
I201V |
possibly damaging |
Het |
| Defa24 |
T |
A |
8: 22,224,612 (GRCm39) |
D20E |
probably damaging |
Het |
| Dgcr8 |
T |
C |
16: 18,095,039 (GRCm39) |
N566D |
probably damaging |
Het |
| Dido1 |
C |
A |
2: 180,326,966 (GRCm39) |
V386L |
probably benign |
Het |
| Dnah2 |
C |
T |
11: 69,349,746 (GRCm39) |
R2399Q |
probably benign |
Het |
| Dtx3 |
G |
A |
10: 127,028,807 (GRCm39) |
P141S |
probably benign |
Het |
| Fmn1 |
T |
C |
2: 113,426,714 (GRCm39) |
Y1144H |
probably damaging |
Het |
| Gabbr2 |
A |
G |
4: 46,734,113 (GRCm39) |
L535P |
probably damaging |
Het |
| Gimap3 |
T |
A |
6: 48,742,183 (GRCm39) |
E249V |
possibly damaging |
Het |
| Git2 |
A |
T |
5: 114,881,835 (GRCm39) |
|
probably null |
Het |
| Gm4922 |
T |
C |
10: 18,659,745 (GRCm39) |
T326A |
probably benign |
Het |
| Gsdmc2 |
T |
G |
15: 63,700,045 (GRCm39) |
E242D |
probably benign |
Het |
| Hdgfl2 |
G |
A |
17: 56,389,118 (GRCm39) |
G31S |
possibly damaging |
Het |
| Herc2 |
A |
T |
7: 55,856,519 (GRCm39) |
I3956F |
probably damaging |
Het |
| Hsf2bp |
G |
A |
17: 32,165,721 (GRCm39) |
R134C |
unknown |
Het |
| Igf1r |
G |
C |
7: 67,843,107 (GRCm39) |
R739S |
probably benign |
Het |
| Igkv4-51 |
T |
C |
6: 69,658,443 (GRCm39) |
E102G |
probably damaging |
Het |
| Kif1a |
T |
G |
1: 92,969,414 (GRCm39) |
I1156L |
possibly damaging |
Het |
| Kti12 |
T |
C |
4: 108,705,821 (GRCm39) |
L245S |
probably damaging |
Het |
| Med17 |
A |
G |
9: 15,181,700 (GRCm39) |
S17P |
probably benign |
Het |
| Mllt6 |
G |
A |
11: 97,560,326 (GRCm39) |
S210N |
possibly damaging |
Het |
| Mrps18b |
A |
G |
17: 36,225,215 (GRCm39) |
|
probably benign |
Het |
| Ms4a8a |
A |
G |
19: 11,056,828 (GRCm39) |
S85P |
probably benign |
Het |
| Msln |
T |
C |
17: 25,968,847 (GRCm39) |
Q487R |
probably benign |
Het |
| Myh13 |
A |
G |
11: 67,228,549 (GRCm39) |
N363S |
probably benign |
Het |
| Myo6 |
T |
C |
9: 80,152,942 (GRCm39) |
F192L |
probably damaging |
Het |
| Nfkbiz |
T |
C |
16: 55,634,383 (GRCm39) |
D688G |
probably damaging |
Het |
| Nsun4 |
C |
T |
4: 115,908,974 (GRCm39) |
V529I |
possibly damaging |
Het |
| Or12d15 |
A |
T |
17: 37,694,192 (GRCm39) |
M245L |
probably benign |
Het |
| Or1j16 |
G |
A |
2: 36,530,975 (GRCm39) |
R308K |
probably benign |
Het |
| Or5p70 |
G |
A |
7: 107,994,332 (GRCm39) |
A2T |
probably benign |
Het |
| Phf11a |
C |
A |
14: 59,516,834 (GRCm39) |
C208F |
probably damaging |
Het |
| Plekhh2 |
G |
A |
17: 84,874,275 (GRCm39) |
C520Y |
probably benign |
Het |
| Plxna4 |
C |
A |
6: 32,155,293 (GRCm39) |
M1550I |
probably damaging |
Het |
| Pnpla6 |
A |
T |
8: 3,571,397 (GRCm39) |
Y140F |
probably damaging |
Het |
| Ppp1r12a |
T |
A |
10: 108,085,488 (GRCm39) |
S478T |
possibly damaging |
Het |
| Prkcz |
C |
A |
4: 155,357,393 (GRCm39) |
|
probably null |
Het |
| Prss55 |
T |
A |
14: 64,314,574 (GRCm39) |
M199L |
probably damaging |
Het |
| Qrich1 |
G |
A |
9: 108,433,659 (GRCm39) |
V651I |
possibly damaging |
Het |
| Ralyl |
T |
C |
3: 13,842,005 (GRCm39) |
V47A |
probably damaging |
Het |
| Raph1 |
A |
T |
1: 60,562,105 (GRCm39) |
|
probably benign |
Het |
| Rgs12 |
T |
C |
5: 35,123,383 (GRCm39) |
Y389H |
probably damaging |
Het |
| Sec24b |
C |
A |
3: 129,834,544 (GRCm39) |
G82V |
probably damaging |
Het |
| Sema4a |
A |
G |
3: 88,357,293 (GRCm39) |
|
probably null |
Het |
| Slc25a11 |
A |
T |
11: 70,536,361 (GRCm39) |
W149R |
probably damaging |
Het |
| Slc2a7 |
T |
G |
4: 150,244,551 (GRCm39) |
S340A |
probably benign |
Het |
| Slc32a1 |
T |
A |
2: 158,456,716 (GRCm39) |
M457K |
probably damaging |
Het |
| Spata31d1e |
T |
C |
13: 59,890,234 (GRCm39) |
|
probably null |
Het |
| Spint4 |
C |
T |
2: 164,542,812 (GRCm39) |
T135M |
probably damaging |
Het |
| Sult2a2 |
A |
C |
7: 13,472,228 (GRCm39) |
N142H |
probably damaging |
Het |
| Tbc1d1 |
G |
A |
5: 64,490,738 (GRCm39) |
G863D |
probably damaging |
Het |
| Tmem156 |
G |
A |
5: 65,232,917 (GRCm39) |
T151M |
probably benign |
Het |
| Trip12 |
T |
C |
1: 84,746,401 (GRCm39) |
Q459R |
probably damaging |
Het |
| Vmn2r116 |
G |
A |
17: 23,605,095 (GRCm39) |
C136Y |
probably damaging |
Het |
| Vmn2r51 |
C |
T |
7: 9,836,545 (GRCm39) |
V79M |
possibly damaging |
Het |
| Wdr93 |
T |
A |
7: 79,399,779 (GRCm39) |
F123I |
probably damaging |
Het |
| Zfp672 |
A |
T |
11: 58,207,456 (GRCm39) |
C288* |
probably null |
Het |
| Zp1 |
T |
C |
19: 10,896,769 (GRCm39) |
Y90C |
probably damaging |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCCAAGTGGTGTCATGAATAACC -3'
(R):5'- GGCCCGTAAAGAGTTTCAAAG -3'
Sequencing Primer
(F):5'- TCAGCTTCTTACAATTAGATGGTGGC -3'
(R):5'- CCCATAGATCTTGTCCTCCA -3'
|
| Posted On |
2016-10-05 |
Incidental Mutation