Mutagenetix > Incidental Mutation

Incidental Mutation 'R5510:Zfp672'

431166

Institutional Source

Beutler Lab

Gene Symbol

Zfp672

Ensembl Gene

ENSMUSG00000049755

Gene Name

zinc finger protein 672

Synonyms

4930511N19Rik, 4930488P06Rik

MMRRC Submission

043071-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

R5510 (G1)

Quality Score

213

Status

Validated

Chromosome

Chromosomal Location

58205940-58221165 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 58207456 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 288 (C288*)

Ref Sequence

ENSEMBL: ENSMUSP00000104457 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049353] [ENSMUST00000057836] [ENSMUST00000064786] [ENSMUST00000108829] [ENSMUST00000153510] [ENSMUST00000155662] [ENSMUST00000186859]

AlphaFold

Q99LH4

Predicted Effect

probably benign
Transcript: ENSMUST00000049353

SMART Domains

Protein: ENSMUSP00000131896
Gene: ENSMUSG00000037243

Domain	Start	End	E-Value	Type
low complexity region	10	23	N/A	INTRINSIC
low complexity region	94	110	N/A	INTRINSIC
low complexity region	159	175	N/A	INTRINSIC
low complexity region	193	204	N/A	INTRINSIC
low complexity region	215	232	N/A	INTRINSIC
ZnF_C2H2	327	352	4.11e-2	SMART
ZnF_C2H2	358	382	2.05e-2	SMART
ZnF_C2H2	388	410	1.69e-3	SMART
ZnF_C2H2	416	438	1.69e-3	SMART
ZnF_C2H2	447	470	6.23e-2	SMART
low complexity region	502	520	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000057836
AA Change: C288*

SMART Domains

Protein: ENSMUSP00000060088
Gene: ENSMUSG00000049755
AA Change: C288*

Domain	Start	End	E-Value	Type
ZnF_C2H2	15	37	4.17e-3	SMART
ZnF_C2H2	43	65	8.75e0	SMART
ZnF_C2H2	71	93	1.18e-2	SMART
ZnF_C2H2	100	123	1.76e-1	SMART
ZnF_C2H2	129	151	1.59e1	SMART
ZnF_C2H2	167	189	4.47e-3	SMART
ZnF_C2H2	202	224	9.58e-3	SMART
ZnF_C2H2	230	252	7.37e-4	SMART
ZnF_C2H2	258	280	3.16e-3	SMART
ZnF_C2H2	286	308	1.45e-2	SMART
ZnF_C2H2	314	336	4.01e-5	SMART
ZnF_C2H2	342	364	5.5e-3	SMART
ZnF_C2H2	370	392	1.12e-3	SMART
ZnF_C2H2	398	420	6.67e-2	SMART
low complexity region	421	441	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000064786
AA Change: C288*

SMART Domains

Protein: ENSMUSP00000070567
Gene: ENSMUSG00000049755
AA Change: C288*

Domain	Start	End	E-Value	Type
ZnF_C2H2	15	37	4.17e-3	SMART
ZnF_C2H2	43	65	8.75e0	SMART
ZnF_C2H2	71	93	1.18e-2	SMART
ZnF_C2H2	100	123	1.76e-1	SMART
ZnF_C2H2	129	151	1.59e1	SMART
ZnF_C2H2	167	189	4.47e-3	SMART
ZnF_C2H2	202	224	9.58e-3	SMART
ZnF_C2H2	230	252	7.37e-4	SMART
ZnF_C2H2	258	280	3.16e-3	SMART
ZnF_C2H2	286	308	1.45e-2	SMART
ZnF_C2H2	314	336	4.01e-5	SMART
ZnF_C2H2	342	364	5.5e-3	SMART
ZnF_C2H2	370	392	1.12e-3	SMART
ZnF_C2H2	398	420	6.67e-2	SMART
low complexity region	421	441	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000108829
AA Change: C288*

SMART Domains

Protein: ENSMUSP00000104457
Gene: ENSMUSG00000049755
AA Change: C288*

Domain	Start	End	E-Value	Type
ZnF_C2H2	15	37	4.17e-3	SMART
ZnF_C2H2	43	65	8.75e0	SMART
ZnF_C2H2	71	93	1.18e-2	SMART
ZnF_C2H2	100	123	1.76e-1	SMART
ZnF_C2H2	129	151	1.59e1	SMART
ZnF_C2H2	167	189	4.47e-3	SMART
ZnF_C2H2	202	224	9.58e-3	SMART
ZnF_C2H2	230	252	7.37e-4	SMART
ZnF_C2H2	258	280	3.16e-3	SMART
ZnF_C2H2	286	308	1.45e-2	SMART
ZnF_C2H2	314	336	4.01e-5	SMART
ZnF_C2H2	342	364	5.5e-3	SMART
ZnF_C2H2	370	392	1.12e-3	SMART
ZnF_C2H2	398	420	6.67e-2	SMART
low complexity region	421	441	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130217

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135097

Predicted Effect

probably benign
Transcript: ENSMUST00000153510

SMART Domains

Protein: ENSMUSP00000126674
Gene: ENSMUSG00000037243

Domain	Start	End	E-Value	Type
low complexity region	10	23	N/A	INTRINSIC
low complexity region	94	110	N/A	INTRINSIC
low complexity region	159	175	N/A	INTRINSIC
low complexity region	193	204	N/A	INTRINSIC
low complexity region	215	232	N/A	INTRINSIC
ZnF_C2H2	327	352	4.11e-2	SMART
ZnF_C2H2	358	382	2.05e-2	SMART
ZnF_C2H2	388	410	1.69e-3	SMART
ZnF_C2H2	416	438	1.69e-3	SMART
ZnF_C2H2	447	470	6.23e-2	SMART
low complexity region	502	520	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000155662

SMART Domains

Protein: ENSMUSP00000114561
Gene: ENSMUSG00000049755

Domain	Start	End	E-Value	Type
ZnF_C2H2	15	37	4.17e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186859

SMART Domains

Protein: ENSMUSP00000140236
Gene: ENSMUSG00000049755

Domain	Start	End	E-Value	Type
ZnF_C2H2	15	37	1.8e-5	SMART
ZnF_C2H2	43	65	3.6e-2	SMART
ZnF_C2H2	71	90	6.1e-1	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 98.5%
3x: 97.3%
10x: 95.1%
20x: 90.1%

Validation Efficiency

99% (91/92)

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	T	G	3: 151,203,467 (GRCm39)	I59R	possibly damaging	Het
Adgrv1	T	A	13: 81,593,363 (GRCm39)	D4208V	probably damaging	Het
Aimp2	A	T	5: 143,843,347 (GRCm39)		probably benign	Het
Ank3	G	A	10: 69,838,395 (GRCm39)	R1566K	possibly damaging	Het
Ankib1	A	G	5: 3,779,693 (GRCm39)	V392A	probably benign	Het
Ap2b1	A	G	11: 83,227,563 (GRCm39)		probably null	Het
Arsg	A	G	11: 109,418,700 (GRCm39)	E232G	probably benign	Het
Axdnd1	A	G	1: 156,162,920 (GRCm39)	F144S	probably benign	Het
Bud13	T	A	9: 46,203,498 (GRCm39)	M111K	probably damaging	Het
Cav2	T	C	6: 17,287,012 (GRCm39)	F152S	possibly damaging	Het
Ccdc180	A	G	4: 45,928,046 (GRCm39)	T1194A	probably damaging	Het
Ccdc192	G	A	18: 57,671,156 (GRCm39)		probably null	Het
Ccdc88c	T	C	12: 100,911,290 (GRCm39)	K848R	probably damaging	Het
Ceacam15	A	G	7: 16,406,024 (GRCm39)	W176R	probably damaging	Het
Cenpf	A	T	1: 189,415,100 (GRCm39)	D136E	probably benign	Het
Dclk2	T	C	3: 86,813,344 (GRCm39)	I201V	possibly damaging	Het
Defa24	T	A	8: 22,224,612 (GRCm39)	D20E	probably damaging	Het
Dgcr8	T	C	16: 18,095,039 (GRCm39)	N566D	probably damaging	Het
Dido1	C	A	2: 180,326,966 (GRCm39)	V386L	probably benign	Het
Dnah2	C	T	11: 69,349,746 (GRCm39)	R2399Q	probably benign	Het
Dtx3	G	A	10: 127,028,807 (GRCm39)	P141S	probably benign	Het
Fmn1	T	C	2: 113,426,714 (GRCm39)	Y1144H	probably damaging	Het
Gabbr2	A	G	4: 46,734,113 (GRCm39)	L535P	probably damaging	Het
Gimap3	T	A	6: 48,742,183 (GRCm39)	E249V	possibly damaging	Het
Git2	A	T	5: 114,881,835 (GRCm39)		probably null	Het
Gm4922	T	C	10: 18,659,745 (GRCm39)	T326A	probably benign	Het
Gsdmc2	T	G	15: 63,700,045 (GRCm39)	E242D	probably benign	Het
Hdgfl2	G	A	17: 56,389,118 (GRCm39)	G31S	possibly damaging	Het
Herc2	A	T	7: 55,856,519 (GRCm39)	I3956F	probably damaging	Het
Hsf2bp	G	A	17: 32,165,721 (GRCm39)	R134C	unknown	Het
Igf1r	G	C	7: 67,843,107 (GRCm39)	R739S	probably benign	Het
Igkv4-51	T	C	6: 69,658,443 (GRCm39)	E102G	probably damaging	Het
Kif1a	T	G	1: 92,969,414 (GRCm39)	I1156L	possibly damaging	Het
Kti12	T	C	4: 108,705,821 (GRCm39)	L245S	probably damaging	Het
Med17	A	G	9: 15,181,700 (GRCm39)	S17P	probably benign	Het
Mllt6	G	A	11: 97,560,326 (GRCm39)	S210N	possibly damaging	Het
Mrps18b	A	G	17: 36,225,215 (GRCm39)		probably benign	Het
Ms4a8a	A	G	19: 11,056,828 (GRCm39)	S85P	probably benign	Het
Msln	T	C	17: 25,968,847 (GRCm39)	Q487R	probably benign	Het
Myh13	A	G	11: 67,228,549 (GRCm39)	N363S	probably benign	Het
Myo6	T	C	9: 80,152,942 (GRCm39)	F192L	probably damaging	Het
Nfkbiz	T	C	16: 55,634,383 (GRCm39)	D688G	probably damaging	Het
Nsun4	C	T	4: 115,908,974 (GRCm39)	V529I	possibly damaging	Het
Or12d15	A	T	17: 37,694,192 (GRCm39)	M245L	probably benign	Het
Or1j16	G	A	2: 36,530,975 (GRCm39)	R308K	probably benign	Het
Or5p70	G	A	7: 107,994,332 (GRCm39)	A2T	probably benign	Het
Phf11a	C	A	14: 59,516,834 (GRCm39)	C208F	probably damaging	Het
Plekhh2	G	A	17: 84,874,275 (GRCm39)	C520Y	probably benign	Het
Plxna4	C	A	6: 32,155,293 (GRCm39)	M1550I	probably damaging	Het
Pnpla6	A	T	8: 3,571,397 (GRCm39)	Y140F	probably damaging	Het
Ppp1r12a	T	A	10: 108,085,488 (GRCm39)	S478T	possibly damaging	Het
Prkcz	C	A	4: 155,357,393 (GRCm39)		probably null	Het
Prss55	T	A	14: 64,314,574 (GRCm39)	M199L	probably damaging	Het
Qrich1	G	A	9: 108,433,659 (GRCm39)	V651I	possibly damaging	Het
Ralyl	T	C	3: 13,842,005 (GRCm39)	V47A	probably damaging	Het
Raph1	A	T	1: 60,562,105 (GRCm39)		probably benign	Het
Rgs12	T	C	5: 35,123,383 (GRCm39)	Y389H	probably damaging	Het
Sec24b	C	A	3: 129,834,544 (GRCm39)	G82V	probably damaging	Het
Sema4a	A	G	3: 88,357,293 (GRCm39)		probably null	Het
Slc25a11	A	T	11: 70,536,361 (GRCm39)	W149R	probably damaging	Het
Slc2a7	T	G	4: 150,244,551 (GRCm39)	S340A	probably benign	Het
Slc32a1	T	A	2: 158,456,716 (GRCm39)	M457K	probably damaging	Het
Spata31d1e	T	C	13: 59,890,234 (GRCm39)		probably null	Het
Spint4	C	T	2: 164,542,812 (GRCm39)	T135M	probably damaging	Het
Sult2a2	A	C	7: 13,472,228 (GRCm39)	N142H	probably damaging	Het
Tbc1d1	G	A	5: 64,490,738 (GRCm39)	G863D	probably damaging	Het
Tmem156	G	A	5: 65,232,917 (GRCm39)	T151M	probably benign	Het
Trip12	T	C	1: 84,746,401 (GRCm39)	Q459R	probably damaging	Het
Vmn2r116	G	A	17: 23,605,095 (GRCm39)	C136Y	probably damaging	Het
Vmn2r51	C	T	7: 9,836,545 (GRCm39)	V79M	possibly damaging	Het
Vmn2r67	A	T	7: 84,801,023 (GRCm39)	D304E	probably benign	Het
Wdr93	T	A	7: 79,399,779 (GRCm39)	F123I	probably damaging	Het
Zp1	T	C	19: 10,896,769 (GRCm39)	Y90C	probably damaging	Het

Other mutations in Zfp672

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01391:Zfp672	APN	11	58,208,192 (GRCm39)	missense	probably damaging	1.00
R0326:Zfp672	UTSW	11	58,207,173 (GRCm39)	missense	possibly damaging	0.86
R1485:Zfp672	UTSW	11	58,220,395 (GRCm39)	intron	probably benign
R1664:Zfp672	UTSW	11	58,208,138 (GRCm39)	missense	probably damaging	0.99
R1667:Zfp672	UTSW	11	58,206,921 (GRCm39)	missense	possibly damaging	0.53
R1853:Zfp672	UTSW	11	58,207,790 (GRCm39)	missense	probably benign
R2074:Zfp672	UTSW	11	58,207,462 (GRCm39)	missense	possibly damaging	0.71
R3817:Zfp672	UTSW	11	58,207,462 (GRCm39)	missense	possibly damaging	0.71
R4623:Zfp672	UTSW	11	58,207,281 (GRCm39)	missense	probably benign	0.34
R4745:Zfp672	UTSW	11	58,220,324 (GRCm39)	intron	probably benign
R5157:Zfp672	UTSW	11	58,207,677 (GRCm39)	missense	possibly damaging	0.86
R5240:Zfp672	UTSW	11	58,220,527 (GRCm39)	intron	probably benign
R6207:Zfp672	UTSW	11	58,208,349 (GRCm39)	start gained	probably benign
R6279:Zfp672	UTSW	11	58,208,094 (GRCm39)	missense	probably damaging	0.99
R6300:Zfp672	UTSW	11	58,208,094 (GRCm39)	missense	probably damaging	0.99
R6432:Zfp672	UTSW	11	58,207,758 (GRCm39)	missense	possibly damaging	0.53
R6438:Zfp672	UTSW	11	58,207,563 (GRCm39)	missense	probably benign	0.07
R7777:Zfp672	UTSW	11	58,208,081 (GRCm39)	missense	possibly damaging	0.71
R8401:Zfp672	UTSW	11	58,207,628 (GRCm39)	missense	probably benign	0.28
R8489:Zfp672	UTSW	11	58,220,681 (GRCm39)	intron	probably benign
R8826:Zfp672	UTSW	11	58,220,590 (GRCm39)	missense	unknown
R8858:Zfp672	UTSW	11	58,208,145 (GRCm39)	missense	possibly damaging	0.91
R9298:Zfp672	UTSW	11	58,220,590 (GRCm39)	missense	unknown
RF012:Zfp672	UTSW	11	58,206,938 (GRCm39)	missense	probably benign
Z1186:Zfp672	UTSW	11	58,220,786 (GRCm39)	intron	probably benign
Z1186:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1187:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1188:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1189:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1190:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1191:Zfp672	UTSW	11	58,220,786 (GRCm39)	intron	probably benign
Z1191:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown
Z1192:Zfp672	UTSW	11	58,220,452 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TGCGCAAATGTACATTGAGG -3'
(R):5'- CTTTCAAGTGCCCTGAGTGTG -3'

Sequencing Primer
(F):5'- AATGCAGGTGAATCGCTTGCC -3'
(R):5'- AGTGCCCTGAGTGTGGCAAG -3'

Posted On

2016-10-05