Incidental Mutation 'R5516:Ugt2b38'
ID 431274
Institutional Source Beutler Lab
Gene Symbol Ugt2b38
Ensembl Gene ENSMUSG00000061906
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms 9430041C03Rik
MMRRC Submission 043075-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R5516 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 87557801-87572062 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87559702 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 397 (F397L)
Ref Sequence ENSEMBL: ENSMUSP00000072598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072818]
AlphaFold Q91WH2
Predicted Effect probably damaging
Transcript: ENSMUST00000072818
AA Change: F397L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072598
Gene: ENSMUSG00000061906
AA Change: F397L

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 4.1e-255 PFAM
Pfam:Glyco_tran_28_C 330 444 1.2e-7 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.5%
  • 3x: 97.4%
  • 10x: 95.2%
  • 20x: 90.4%
Validation Efficiency 97% (58/60)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb T C 10: 10,306,901 (GRCm39) K334R probably damaging Het
Aldh1l1 A T 6: 90,573,927 (GRCm39) I809F possibly damaging Het
Bmp2k T A 5: 97,235,312 (GRCm39) probably benign Het
C1qtnf9 T A 14: 61,017,198 (GRCm39) C243S probably damaging Het
Cacna1c G A 6: 119,034,179 (GRCm39) A146V probably damaging Het
Ccdc85c A G 12: 108,174,109 (GRCm39) V353A probably damaging Het
Cd300ld2 G T 11: 114,903,270 (GRCm39) probably benign Het
Cd320 A G 17: 34,067,021 (GRCm39) Q170R possibly damaging Het
Cfap43 C T 19: 47,726,648 (GRCm39) probably null Het
Chid1 A G 7: 141,076,059 (GRCm39) S365P probably damaging Het
Chrna7 T G 7: 62,749,046 (GRCm39) T479P probably damaging Het
Clasp1 G T 1: 118,425,451 (GRCm39) R35L probably damaging Het
Cluh G A 11: 74,551,270 (GRCm39) R373H probably damaging Het
Cyp2b23 G A 7: 26,372,482 (GRCm39) R378* probably null Het
Cyp2d9 T G 15: 82,338,528 (GRCm39) N136K probably null Het
Efcab5 A T 11: 77,079,615 (GRCm39) S44T possibly damaging Het
Esrrg A T 1: 187,930,927 (GRCm39) L316F possibly damaging Het
Fam222a T C 5: 114,749,889 (GRCm39) Y362H probably damaging Het
Fat3 A G 9: 15,910,005 (GRCm39) V1999A probably damaging Het
Fes A T 7: 80,036,931 (GRCm39) M51K probably damaging Het
Fmo3 T A 1: 162,781,995 (GRCm39) K453* probably null Het
Galnt1 A G 18: 24,413,074 (GRCm39) N458S probably benign Het
Gm8888 T A 15: 96,664,855 (GRCm39) noncoding transcript Het
Gpn2 G A 4: 133,312,190 (GRCm39) probably null Het
Grm4 G A 17: 27,657,385 (GRCm39) T464I probably benign Het
Insr T A 8: 3,205,764 (GRCm39) K1342* probably null Het
Krt87 T A 15: 101,385,002 (GRCm39) K365* probably null Het
Lfng T C 5: 140,599,018 (GRCm39) L309P probably damaging Het
Lnpk T C 2: 74,378,132 (GRCm39) probably benign Het
Lrrc8e A C 8: 4,285,818 (GRCm39) D681A probably damaging Het
Lyst G A 13: 13,818,707 (GRCm39) D1326N probably benign Het
Mmp27 A G 9: 7,579,063 (GRCm39) R413G probably null Het
Nags C T 11: 102,036,773 (GRCm39) Q121* probably null Het
Nectin1 A G 9: 43,715,090 (GRCm39) E442G probably benign Het
Nek1 G C 8: 61,542,523 (GRCm39) A729P probably benign Het
Or51a24 A G 7: 103,733,444 (GRCm39) I281T possibly damaging Het
Pnp2 C T 14: 51,201,195 (GRCm39) A189V probably benign Het
Ppm1m T A 9: 106,075,138 (GRCm39) I136F probably damaging Het
Pramel21 A G 4: 143,342,253 (GRCm39) Q120R possibly damaging Het
Psg17 G T 7: 18,548,458 (GRCm39) Q438K probably benign Het
Ptprk C T 10: 28,372,926 (GRCm39) R726* probably null Het
Rab3gap2 A T 1: 184,967,684 (GRCm39) Y163F probably benign Het
Scrib A T 15: 75,934,712 (GRCm39) L627Q possibly damaging Het
Tcp1 A G 17: 13,143,221 (GRCm39) K510R probably damaging Het
Tle4 A T 19: 14,432,253 (GRCm39) I481N probably damaging Het
Tmem43 G T 6: 91,455,192 (GRCm39) R56L possibly damaging Het
Trmt10a T C 3: 137,857,957 (GRCm39) I168T possibly damaging Het
Trpv1 A T 11: 73,136,809 (GRCm39) Y96F probably benign Het
Tshz3 C T 7: 36,469,775 (GRCm39) T588I probably benign Het
Vmn2r11 A G 5: 109,195,032 (GRCm39) S765P probably damaging Het
Zfp668 A G 7: 127,466,318 (GRCm39) F289L probably damaging Het
Zfp735 A G 11: 73,601,640 (GRCm39) T195A probably benign Het
Zscan10 A G 17: 23,828,333 (GRCm39) T182A possibly damaging Het
Other mutations in Ugt2b38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00959:Ugt2b38 APN 5 87,559,682 (GRCm39) missense probably damaging 1.00
IGL02326:Ugt2b38 APN 5 87,571,592 (GRCm39) missense probably damaging 1.00
IGL02537:Ugt2b38 APN 5 87,569,590 (GRCm39) missense possibly damaging 0.91
IGL02543:Ugt2b38 APN 5 87,571,342 (GRCm39) missense probably benign 0.00
IGL02852:Ugt2b38 APN 5 87,559,600 (GRCm39) missense probably benign
IGL03008:Ugt2b38 APN 5 87,560,282 (GRCm39) missense probably benign 0.00
over_easy UTSW 5 87,571,601 (GRCm39) missense probably benign 0.25
R0089:Ugt2b38 UTSW 5 87,568,417 (GRCm39) missense probably benign 0.00
R0647:Ugt2b38 UTSW 5 87,571,328 (GRCm39) missense probably benign 0.00
R0731:Ugt2b38 UTSW 5 87,568,311 (GRCm39) missense probably damaging 1.00
R0837:Ugt2b38 UTSW 5 87,559,632 (GRCm39) missense probably damaging 1.00
R0966:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0969:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0970:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0971:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1068:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1070:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1071:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1073:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1133:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1134:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1367:Ugt2b38 UTSW 5 87,571,973 (GRCm39) missense probably benign 0.11
R1383:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1467:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1467:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1565:Ugt2b38 UTSW 5 87,559,773 (GRCm39) missense probably damaging 0.99
R1691:Ugt2b38 UTSW 5 87,571,991 (GRCm39) missense probably benign
R1725:Ugt2b38 UTSW 5 87,559,730 (GRCm39) missense probably damaging 1.00
R1736:Ugt2b38 UTSW 5 87,571,492 (GRCm39) missense probably benign
R2230:Ugt2b38 UTSW 5 87,569,527 (GRCm39) missense probably benign 0.05
R2419:Ugt2b38 UTSW 5 87,571,591 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b38 UTSW 5 87,569,551 (GRCm39) missense probably damaging 1.00
R3196:Ugt2b38 UTSW 5 87,558,078 (GRCm39) missense probably damaging 0.96
R3773:Ugt2b38 UTSW 5 87,571,954 (GRCm39) missense probably damaging 0.99
R5125:Ugt2b38 UTSW 5 87,559,671 (GRCm39) missense probably damaging 1.00
R5224:Ugt2b38 UTSW 5 87,571,601 (GRCm39) missense probably benign 0.25
R5765:Ugt2b38 UTSW 5 87,571,954 (GRCm39) missense probably damaging 0.99
R6352:Ugt2b38 UTSW 5 87,571,860 (GRCm39) missense possibly damaging 0.73
R7166:Ugt2b38 UTSW 5 87,558,305 (GRCm39) missense probably damaging 1.00
R7210:Ugt2b38 UTSW 5 87,558,284 (GRCm39) missense probably damaging 0.99
R7291:Ugt2b38 UTSW 5 87,559,754 (GRCm39) missense probably damaging 1.00
R7483:Ugt2b38 UTSW 5 87,571,973 (GRCm39) missense probably damaging 0.96
R7969:Ugt2b38 UTSW 5 87,571,891 (GRCm39) missense probably benign 0.02
R8118:Ugt2b38 UTSW 5 87,571,630 (GRCm39) missense probably damaging 1.00
R8239:Ugt2b38 UTSW 5 87,571,659 (GRCm39) missense probably benign 0.02
R8676:Ugt2b38 UTSW 5 87,559,681 (GRCm39) missense probably benign 0.12
R9178:Ugt2b38 UTSW 5 87,568,396 (GRCm39) missense probably damaging 1.00
R9193:Ugt2b38 UTSW 5 87,571,729 (GRCm39) missense probably benign 0.05
R9566:Ugt2b38 UTSW 5 87,558,209 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAATCATGCCCTAATGTATCTCTG -3'
(R):5'- CTGAGACAGAGAAATATTTCAGTGG -3'

Sequencing Primer
(F):5'- TGTTTGGCTTTCAGTAAGAAGAC -3'
(R):5'- CATCTTCTTCTAGGTCATCCAA -3'
Posted On 2016-10-05