Incidental Mutation 'R5519:Or51a42'
ID 431460
Institutional Source Beutler Lab
Gene Symbol Or51a42
Ensembl Gene ENSMUSG00000109824
Gene Name olfactory receptor family 51 subfamily A member 42
Synonyms MOR13-2, Olfr643, GA_x6K02T2PBJ9-6793628-6792684
MMRRC Submission 043078-MU
Accession Numbers
Essential gene? Not available question?
Stock # R5519 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103707863-103708807 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 103708504 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 102 (Q102*)
Ref Sequence ENSEMBL: ENSMUSP00000150133 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074064] [ENSMUST00000138055] [ENSMUST00000217217]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000074064
AA Change: Q102*
SMART Domains Protein: ENSMUSP00000073707
Gene: ENSMUSG00000090219
AA Change: Q102*

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2.6e-124 PFAM
Pfam:7TM_GPCR_Srsx 37 255 3.1e-7 PFAM
Pfam:7tm_1 43 294 3.2e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000217217
AA Change: Q102*
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 97.6%
  • 10x: 94.7%
  • 20x: 88.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700067K01Rik T C 8: 84,729,621 (GRCm39) V99A possibly damaging Het
2510009E07Rik A G 16: 21,472,218 (GRCm39) S91P probably benign Het
2810021J22Rik G A 11: 58,770,923 (GRCm39) S135N probably benign Het
A530084C06Rik T C 13: 31,742,702 (GRCm39) probably benign Het
Acadsb T C 7: 131,031,694 (GRCm39) S177P probably damaging Het
Acp3 C A 9: 104,168,687 (GRCm39) G393W probably damaging Het
Axl G A 7: 25,478,087 (GRCm39) A204V possibly damaging Het
Birc6 A T 17: 74,887,173 (GRCm39) M806L probably benign Het
Cacna1i T C 15: 80,255,700 (GRCm39) L861P probably damaging Het
Cfap44 A T 16: 44,224,451 (GRCm39) D53V probably damaging Het
Col9a1 G A 1: 24,269,335 (GRCm39) probably null Het
Ctf2 T A 7: 127,318,463 (GRCm39) I179L probably benign Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Emilin2 G A 17: 71,559,930 (GRCm39) P1016S probably benign Het
Gm12790 G A 4: 101,824,888 (GRCm39) P127S probably benign Het
Gsap T A 5: 21,494,857 (GRCm39) V24E probably damaging Het
Ipp T C 4: 116,367,964 (GRCm39) F66L possibly damaging Het
Jakmip3 T C 7: 138,609,520 (GRCm39) I208T probably damaging Het
Med30 G T 15: 52,584,462 (GRCm39) D127Y probably damaging Het
Mosmo C T 7: 120,329,733 (GRCm39) P118L probably benign Het
Ncam2 C T 16: 81,231,766 (GRCm39) R77* probably null Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Padi2 A G 4: 140,676,533 (GRCm39) D557G probably damaging Het
Pde11a T A 2: 75,906,299 (GRCm39) K639N probably damaging Het
Pspc1 T C 14: 57,009,413 (GRCm39) I140M probably benign Het
Rundc3a A T 11: 102,292,857 (GRCm39) I417F probably benign Het
Scn1a T A 2: 66,162,557 (GRCm39) I230F probably damaging Het
Serpinb3b A G 1: 107,087,506 (GRCm39) M1T probably null Het
Sin3a T C 9: 57,025,457 (GRCm39) probably null Het
St8sia1 T C 6: 142,909,287 (GRCm39) N70D probably damaging Het
Tdpoz4 A T 3: 93,704,806 (GRCm39) T368S probably benign Het
Tpm2 T G 4: 43,522,751 (GRCm39) D55A possibly damaging Het
Trdv1 T A 14: 54,119,405 (GRCm39) M22K probably benign Het
Zc3h4 A T 7: 16,169,157 (GRCm39) T1089S unknown Het
Zfp518b G A 5: 38,831,441 (GRCm39) T188M probably damaging Het
Zfp74 G T 7: 29,634,559 (GRCm39) A383D probably damaging Het
Other mutations in Or51a42
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Or51a42 APN 7 103,708,623 (GRCm39) missense probably damaging 1.00
IGL00958:Or51a42 APN 7 103,708,620 (GRCm39) missense probably benign 0.14
IGL02319:Or51a42 APN 7 103,708,140 (GRCm39) missense probably damaging 1.00
IGL03184:Or51a42 APN 7 103,708,054 (GRCm39) missense probably damaging 0.97
R0254:Or51a42 UTSW 7 103,708,728 (GRCm39) missense probably benign 0.00
R0850:Or51a42 UTSW 7 103,708,252 (GRCm39) missense probably benign
R1443:Or51a42 UTSW 7 103,707,930 (GRCm39) missense probably damaging 1.00
R1544:Or51a42 UTSW 7 103,708,431 (GRCm39) missense probably damaging 0.99
R1669:Or51a42 UTSW 7 103,708,516 (GRCm39) missense probably benign 0.32
R1990:Or51a42 UTSW 7 103,708,335 (GRCm39) missense possibly damaging 0.96
R2207:Or51a42 UTSW 7 103,708,612 (GRCm39) missense probably damaging 1.00
R4456:Or51a42 UTSW 7 103,708,507 (GRCm39) missense possibly damaging 0.70
R4719:Or51a42 UTSW 7 103,707,940 (GRCm39) missense probably damaging 1.00
Z1088:Or51a42 UTSW 7 103,708,523 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GCATGGGAAAGCACATTAGC -3'
(R):5'- CCTGATCCTGTTCATCATCAAGG -3'

Sequencing Primer
(F):5'- CATGGGAAAGCACATTAGCCTTGC -3'
(R):5'- TCCTGTTCATCATCAAGGAGGAAG -3'
Posted On 2016-10-05