Incidental Mutation 'R5520:Or5w20'
ID 431488
Institutional Source Beutler Lab
Gene Symbol Or5w20
Ensembl Gene ENSMUSG00000048197
Gene Name olfactory receptor family 5 subfamily W member 20
Synonyms Olfr1153, MOR177-7, GA_x6K02T2Q125-49395950-49396882
MMRRC Submission 043079-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R5520 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87726521-87727477 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 87726753 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052300] [ENSMUST00000215017] [ENSMUST00000215862] [ENSMUST00000217436]
AlphaFold A2AVC0
Predicted Effect probably benign
Transcript: ENSMUST00000052300
AA Change: I78T

PolyPhen 2 Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000057839
Gene: ENSMUSG00000048197
AA Change: I78T

DomainStartEndE-ValueType
Pfam:7tm_4 38 315 4.9e-45 PFAM
Pfam:7tm_1 48 297 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215017
Predicted Effect probably benign
Transcript: ENSMUST00000215862
Predicted Effect possibly damaging
Transcript: ENSMUST00000217436
AA Change: I70T

PolyPhen 2 Score 0.474 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 97.6%
  • 10x: 94.8%
  • 20x: 88.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 T A 4: 144,504,594 (GRCm39) T186S probably benign Het
AI467606 C T 7: 126,691,998 (GRCm39) P191L probably benign Het
Aoc1l1 C A 6: 48,952,728 (GRCm39) Q218K possibly damaging Het
Arl9 T C 5: 77,154,440 (GRCm39) V56A probably damaging Het
Cacng5 T C 11: 107,768,248 (GRCm39) Q253R probably benign Het
Cc2d1b T C 4: 108,483,556 (GRCm39) M331T possibly damaging Het
Cep97 A G 16: 55,735,659 (GRCm39) S380P probably benign Het
Clpx A T 9: 65,224,730 (GRCm39) K153* probably null Het
Dclk2 A G 3: 86,827,147 (GRCm39) S111P probably damaging Het
E2f7 A G 10: 110,595,806 (GRCm39) E167G probably damaging Het
Edn1 T C 13: 42,455,436 (GRCm39) probably null Het
Farp1 C T 14: 121,472,489 (GRCm39) P208L probably damaging Het
Fbxw18 G T 9: 109,520,589 (GRCm39) H257N probably benign Het
Ftsj3 T C 11: 106,146,414 (GRCm39) T22A probably benign Het
Gm17019 A T 5: 15,082,819 (GRCm39) M45K possibly damaging Het
Gpr162 T C 6: 124,837,876 (GRCm39) D258G probably damaging Het
Grk1 T A 8: 13,459,305 (GRCm39) D285E probably benign Het
Herc6 A T 6: 57,624,105 (GRCm39) D625V possibly damaging Het
Igkv1-135 C T 6: 67,587,324 (GRCm39) P65L possibly damaging Het
Lepr T C 4: 101,602,734 (GRCm39) L174P probably benign Het
Nphp3 A G 9: 103,901,872 (GRCm39) S689G probably benign Het
Or14c44 T A 7: 86,062,064 (GRCm39) S165T probably benign Het
Phf8-ps A G 17: 33,284,367 (GRCm39) Y812H probably benign Het
Plxnb2 T G 15: 89,051,746 (GRCm39) T158P possibly damaging Het
Pramel32 A C 4: 88,548,277 (GRCm39) S43A probably damaging Het
R3hcc1 T A 14: 69,936,057 (GRCm39) K437* probably null Het
Rnf213 C A 11: 119,324,325 (GRCm39) H1428Q probably damaging Het
Ro60 A T 1: 143,646,509 (GRCm39) S79T probably benign Het
Spata31e2 A T 1: 26,724,900 (GRCm39) N93K probably benign Het
Ssx2ip G A 3: 146,143,066 (GRCm39) R548H probably benign Het
Trim23 C T 13: 104,324,035 (GRCm39) R165C probably damaging Het
Ulk2 T G 11: 61,698,970 (GRCm39) T405P probably damaging Het
Unkl G A 17: 25,424,584 (GRCm39) V204I probably damaging Het
Vmn1r43 T C 6: 89,846,728 (GRCm39) T253A probably damaging Het
Zfp534 T C 4: 147,759,887 (GRCm39) I261V possibly damaging Het
Other mutations in Or5w20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01075:Or5w20 APN 2 87,727,265 (GRCm39) missense probably benign 0.00
IGL02024:Or5w20 APN 2 87,727,243 (GRCm39) missense possibly damaging 0.81
IGL02219:Or5w20 APN 2 87,727,317 (GRCm39) missense possibly damaging 0.93
IGL02693:Or5w20 APN 2 87,726,877 (GRCm39) missense probably damaging 1.00
R0121:Or5w20 UTSW 2 87,727,434 (GRCm39) missense possibly damaging 0.93
R0315:Or5w20 UTSW 2 87,727,410 (GRCm39) missense probably damaging 1.00
R0446:Or5w20 UTSW 2 87,727,199 (GRCm39) missense possibly damaging 0.51
R0472:Or5w20 UTSW 2 87,726,837 (GRCm39) missense possibly damaging 0.47
R0720:Or5w20 UTSW 2 87,727,013 (GRCm39) missense probably benign 0.31
R1579:Or5w20 UTSW 2 87,727,286 (GRCm39) missense probably benign 0.05
R1968:Or5w20 UTSW 2 87,727,383 (GRCm39) missense probably damaging 1.00
R3909:Or5w20 UTSW 2 87,727,293 (GRCm39) splice site probably null
R4936:Or5w20 UTSW 2 87,727,157 (GRCm39) missense probably benign 0.06
R5585:Or5w20 UTSW 2 87,727,019 (GRCm39) missense possibly damaging 0.54
R6176:Or5w20 UTSW 2 87,727,280 (GRCm39) missense probably benign 0.18
R6272:Or5w20 UTSW 2 87,727,001 (GRCm39) missense probably benign 0.00
R6451:Or5w20 UTSW 2 87,726,935 (GRCm39) missense probably damaging 1.00
R7312:Or5w20 UTSW 2 87,726,755 (GRCm39) missense possibly damaging 0.54
R7350:Or5w20 UTSW 2 87,726,753 (GRCm39) unclassified probably benign
R8060:Or5w20 UTSW 2 87,727,317 (GRCm39) missense probably damaging 1.00
R8752:Or5w20 UTSW 2 87,726,591 (GRCm39) missense possibly damaging 0.66
R9474:Or5w20 UTSW 2 87,726,693 (GRCm39) missense probably benign 0.00
R9710:Or5w20 UTSW 2 87,726,902 (GRCm39) missense probably damaging 1.00
Z1088:Or5w20 UTSW 2 87,726,977 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GGTTGGAAACTGTTCAGCCAC -3'
(R):5'- CATATCTACCGCATACATCAAGGG -3'

Sequencing Primer
(F):5'- GGAAACTGTTCAGCCACTGAGTTTC -3'
(R):5'- CGCATACATCAAGGGGTTGCTG -3'
Posted On 2016-10-05