Incidental Mutation 'R5526:Vmn2r58'
| ID |
431853 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r58
|
| Ensembl Gene |
ENSMUSG00000090383 |
| Gene Name |
vomeronasal 2, receptor 58 |
| Synonyms |
EG628422 |
| MMRRC Submission |
043084-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.377)
|
| Stock # |
R5526 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41486305-41522094 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41522069 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 9
(L9P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126966
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171671]
|
| AlphaFold |
K7N6V2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171671
AA Change: L9P
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000126966
Gene: ENSMUSG00000090383
AA Change: L9P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.8e-23 |
PFAM |
|
Pfam:7tm_3
|
597 |
835 |
2.9e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 98.3%
- 3x: 97.3%
- 10x: 95.2%
- 20x: 90.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
T |
1: 71,331,605 (GRCm39) |
M1315K |
probably benign |
Het |
| Abcc4 |
C |
T |
14: 118,868,449 (GRCm39) |
V168I |
probably benign |
Het |
| Add3 |
T |
A |
19: 53,215,038 (GRCm39) |
L71Q |
probably damaging |
Het |
| Agbl5 |
G |
A |
5: 31,051,247 (GRCm39) |
|
probably null |
Het |
| Angpt1 |
A |
G |
15: 42,375,737 (GRCm39) |
L173P |
probably damaging |
Het |
| Crls1 |
T |
A |
2: 132,703,165 (GRCm39) |
M205K |
possibly damaging |
Het |
| Cspg4b |
T |
C |
13: 113,504,427 (GRCm39) |
V1852A |
probably benign |
Het |
| Dhtkd1 |
A |
T |
2: 5,916,662 (GRCm39) |
N671K |
probably damaging |
Het |
| Dmbt1 |
A |
T |
7: 130,642,920 (GRCm39) |
D246V |
probably damaging |
Het |
| Dolk |
G |
A |
2: 30,175,820 (GRCm39) |
A75V |
probably damaging |
Het |
| Dtna |
T |
A |
18: 23,779,287 (GRCm39) |
V623E |
probably damaging |
Het |
| Elavl3 |
T |
C |
9: 21,947,622 (GRCm39) |
T106A |
probably benign |
Het |
| Ergic1 |
T |
C |
17: 26,843,652 (GRCm39) |
C41R |
probably damaging |
Het |
| Fat2 |
T |
A |
11: 55,160,187 (GRCm39) |
I3309F |
possibly damaging |
Het |
| Fbn1 |
C |
A |
2: 125,207,559 (GRCm39) |
R978L |
possibly damaging |
Het |
| Fzd6 |
A |
T |
15: 38,894,559 (GRCm39) |
S242C |
possibly damaging |
Het |
| Galntl6 |
T |
A |
8: 58,926,004 (GRCm39) |
H87L |
probably benign |
Het |
| Gatad2a |
T |
C |
8: 70,388,591 (GRCm39) |
E32G |
probably damaging |
Het |
| Gemin6 |
T |
G |
17: 80,535,178 (GRCm39) |
V46G |
probably damaging |
Het |
| Gm11541 |
G |
T |
11: 94,594,944 (GRCm39) |
H41Q |
unknown |
Het |
| Has3 |
A |
G |
8: 107,600,579 (GRCm39) |
T14A |
probably damaging |
Het |
| Kmt2b |
A |
G |
7: 30,279,869 (GRCm39) |
L1377P |
probably damaging |
Het |
| Lcorl |
T |
C |
5: 45,891,069 (GRCm39) |
N428S |
probably benign |
Het |
| Lipo5 |
A |
T |
19: 33,445,284 (GRCm39) |
V95D |
unknown |
Het |
| Lrp1 |
A |
T |
10: 127,391,593 (GRCm39) |
V2942D |
probably benign |
Het |
| Map1a |
T |
C |
2: 121,136,143 (GRCm39) |
S2082P |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,890,723 (GRCm39) |
S852G |
possibly damaging |
Het |
| Mlh3 |
A |
T |
12: 85,316,147 (GRCm39) |
L13* |
probably null |
Het |
| Ncam2 |
C |
T |
16: 81,231,766 (GRCm39) |
R77* |
probably null |
Het |
| Nlrp9c |
T |
A |
7: 26,081,791 (GRCm39) |
N645I |
possibly damaging |
Het |
| Or12d17 |
T |
A |
17: 37,778,003 (GRCm39) |
L302Q |
unknown |
Het |
| Or12e7 |
T |
C |
2: 87,288,109 (GRCm39) |
I200T |
probably benign |
Het |
| Or14j7 |
T |
A |
17: 38,235,383 (GRCm39) |
*309K |
probably null |
Het |
| Or7e166 |
C |
A |
9: 19,624,994 (GRCm39) |
Y290* |
probably null |
Het |
| Or8g52 |
A |
T |
9: 39,630,892 (GRCm39) |
Y123F |
possibly damaging |
Het |
| Pex12 |
A |
G |
11: 83,187,090 (GRCm39) |
V286A |
possibly damaging |
Het |
| Phax |
C |
T |
18: 56,717,382 (GRCm39) |
T275I |
probably damaging |
Het |
| Phf21b |
A |
G |
15: 84,676,006 (GRCm39) |
V335A |
probably benign |
Het |
| Psg18 |
A |
T |
7: 18,083,273 (GRCm39) |
L173H |
probably damaging |
Het |
| Rab3ip |
T |
C |
10: 116,754,834 (GRCm39) |
T209A |
possibly damaging |
Het |
| Ralgapb |
T |
C |
2: 158,274,705 (GRCm39) |
V202A |
probably damaging |
Het |
| Rpn2 |
T |
C |
2: 157,165,187 (GRCm39) |
L611P |
probably damaging |
Het |
| Runx2 |
T |
G |
17: 45,035,749 (GRCm39) |
T148P |
probably damaging |
Het |
| Sbpl |
C |
A |
17: 24,173,623 (GRCm39) |
D50Y |
probably damaging |
Het |
| Scn5a |
G |
A |
9: 119,350,237 (GRCm39) |
P879L |
probably damaging |
Het |
| Sfn |
T |
C |
4: 133,328,915 (GRCm39) |
R56G |
probably damaging |
Het |
| Spata31g1 |
T |
C |
4: 42,972,125 (GRCm39) |
V486A |
possibly damaging |
Het |
| Tas2r138 |
C |
T |
6: 40,589,914 (GRCm39) |
A111T |
probably benign |
Het |
| Tasp1 |
A |
T |
2: 139,850,709 (GRCm39) |
S105T |
probably damaging |
Het |
| Tmem225 |
T |
G |
9: 40,062,002 (GRCm39) |
H205Q |
possibly damaging |
Het |
| Tmprss7 |
A |
G |
16: 45,481,267 (GRCm39) |
S640P |
probably damaging |
Het |
| Utp4 |
G |
A |
8: 107,644,265 (GRCm39) |
A535T |
possibly damaging |
Het |
| Vmn1r203 |
A |
T |
13: 22,708,273 (GRCm39) |
D18V |
probably benign |
Het |
| Zcchc2 |
T |
A |
1: 105,957,984 (GRCm39) |
C420* |
probably null |
Het |
| Zfp804a |
A |
G |
2: 82,088,934 (GRCm39) |
D921G |
probably benign |
Het |
|
| Other mutations in Vmn2r58 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Vmn2r58
|
APN |
7 |
41,513,854 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL00924:Vmn2r58
|
APN |
7 |
41,486,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01291:Vmn2r58
|
APN |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01480:Vmn2r58
|
APN |
7 |
41,514,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01551:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01591:Vmn2r58
|
APN |
7 |
41,514,753 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01940:Vmn2r58
|
APN |
7 |
41,487,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01994:Vmn2r58
|
APN |
7 |
41,486,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02041:Vmn2r58
|
APN |
7 |
41,514,703 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02222:Vmn2r58
|
APN |
7 |
41,513,449 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02317:Vmn2r58
|
APN |
7 |
41,486,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02614:Vmn2r58
|
APN |
7 |
41,486,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02673:Vmn2r58
|
APN |
7 |
41,514,082 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03323:Vmn2r58
|
APN |
7 |
41,511,295 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03337:Vmn2r58
|
APN |
7 |
41,513,810 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03380:Vmn2r58
|
APN |
7 |
41,513,874 (GRCm39) |
missense |
probably benign |
0.00 |
|
ANU05:Vmn2r58
|
UTSW |
7 |
41,513,935 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0138:Vmn2r58
|
UTSW |
7 |
41,487,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Vmn2r58
|
UTSW |
7 |
41,511,309 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0421:Vmn2r58
|
UTSW |
7 |
41,514,628 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0604:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0854:Vmn2r58
|
UTSW |
7 |
41,486,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Vmn2r58
|
UTSW |
7 |
41,513,387 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1441:Vmn2r58
|
UTSW |
7 |
41,486,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1678:Vmn2r58
|
UTSW |
7 |
41,513,480 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1691:Vmn2r58
|
UTSW |
7 |
41,486,913 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1699:Vmn2r58
|
UTSW |
7 |
41,509,951 (GRCm39) |
missense |
probably benign |
|
|
R1865:Vmn2r58
|
UTSW |
7 |
41,486,682 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2008:Vmn2r58
|
UTSW |
7 |
41,509,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Vmn2r58
|
UTSW |
7 |
41,513,417 (GRCm39) |
missense |
probably benign |
|
|
R2202:Vmn2r58
|
UTSW |
7 |
41,513,594 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3787:Vmn2r58
|
UTSW |
7 |
41,513,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3883:Vmn2r58
|
UTSW |
7 |
41,513,914 (GRCm39) |
nonsense |
probably null |
|
|
R3944:Vmn2r58
|
UTSW |
7 |
41,513,885 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3949:Vmn2r58
|
UTSW |
7 |
41,513,348 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4232:Vmn2r58
|
UTSW |
7 |
41,487,011 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4409:Vmn2r58
|
UTSW |
7 |
41,522,051 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4411:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4413:Vmn2r58
|
UTSW |
7 |
41,511,360 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4600:Vmn2r58
|
UTSW |
7 |
41,522,046 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4610:Vmn2r58
|
UTSW |
7 |
41,487,117 (GRCm39) |
missense |
probably benign |
|
|
R4646:Vmn2r58
|
UTSW |
7 |
41,509,935 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4793:Vmn2r58
|
UTSW |
7 |
41,514,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4870:Vmn2r58
|
UTSW |
7 |
41,486,639 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4981:Vmn2r58
|
UTSW |
7 |
41,486,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r58
|
UTSW |
7 |
41,487,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5024:Vmn2r58
|
UTSW |
7 |
41,513,746 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5064:Vmn2r58
|
UTSW |
7 |
41,486,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5330:Vmn2r58
|
UTSW |
7 |
41,513,384 (GRCm39) |
nonsense |
probably null |
|
|
R5980:Vmn2r58
|
UTSW |
7 |
41,514,480 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6163:Vmn2r58
|
UTSW |
7 |
41,486,825 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6365:Vmn2r58
|
UTSW |
7 |
41,513,607 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6567:Vmn2r58
|
UTSW |
7 |
41,514,673 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6594:Vmn2r58
|
UTSW |
7 |
41,486,535 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6980:Vmn2r58
|
UTSW |
7 |
41,513,662 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7373:Vmn2r58
|
UTSW |
7 |
41,487,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Vmn2r58
|
UTSW |
7 |
41,487,123 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7630:Vmn2r58
|
UTSW |
7 |
41,513,611 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7807:Vmn2r58
|
UTSW |
7 |
41,521,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8114:Vmn2r58
|
UTSW |
7 |
41,511,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Vmn2r58
|
UTSW |
7 |
41,514,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8313:Vmn2r58
|
UTSW |
7 |
41,521,952 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8412:Vmn2r58
|
UTSW |
7 |
41,513,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8530:Vmn2r58
|
UTSW |
7 |
41,513,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8851:Vmn2r58
|
UTSW |
7 |
41,487,219 (GRCm39) |
missense |
probably benign |
|
|
R8881:Vmn2r58
|
UTSW |
7 |
41,486,609 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8936:Vmn2r58
|
UTSW |
7 |
41,513,981 (GRCm39) |
missense |
|
|
|
R9045:Vmn2r58
|
UTSW |
7 |
41,487,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Vmn2r58
|
UTSW |
7 |
41,513,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9706:Vmn2r58
|
UTSW |
7 |
41,510,000 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF006:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
RF027:Vmn2r58
|
UTSW |
7 |
41,486,383 (GRCm39) |
frame shift |
probably null |
|
|
Z1176:Vmn2r58
|
UTSW |
7 |
41,513,789 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGATAGTCTTGGAAACTGTATGGC -3'
(R):5'- CTCAGATGCAGAGCCTTAGG -3'
Sequencing Primer
(F):5'- GTATGGCAGATATTTACCAGGAAC -3'
(R):5'- CTCTCATTGACAGTGGAGGAAATGTC -3'
|
| Posted On |
2016-10-05 |
Incidental Mutation