Mutagenetix > Incidental Mutation

Incidental Mutation 'R5526:Vmn1r203'

431871

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r203

Ensembl Gene

ENSMUSG00000069289

Gene Name

vomeronasal 1 receptor 203

Synonyms

V1rh11

MMRRC Submission

043084-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R5526 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

22708221-22709156 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 22708273 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 18 (D18V)

Ref Sequence

ENSEMBL: ENSMUSP00000154399 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091729] [ENSMUST00000227520] [ENSMUST00000228889]

AlphaFold

Q8R273

Predicted Effect

probably benign
Transcript: ENSMUST00000091729
AA Change: D18V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000089322
Gene: ENSMUSG00000069289
AA Change: D18V

Domain	Start	End	E-Value	Type
transmembrane domain	19	41	N/A	INTRINSIC
Pfam:V1R	43	304	5.8e-35	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137651

Predicted Effect

probably benign
Transcript: ENSMUST00000227520
AA Change: D18V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

Predicted Effect

probably benign
Transcript: ENSMUST00000228889
AA Change: D18V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

Coding Region Coverage

1x: 98.3%
3x: 97.3%
10x: 95.2%
20x: 90.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	T	1: 71,331,605 (GRCm39)	M1315K	probably benign	Het
Abcc4	C	T	14: 118,868,449 (GRCm39)	V168I	probably benign	Het
Add3	T	A	19: 53,215,038 (GRCm39)	L71Q	probably damaging	Het
Agbl5	G	A	5: 31,051,247 (GRCm39)		probably null	Het
Angpt1	A	G	15: 42,375,737 (GRCm39)	L173P	probably damaging	Het
Crls1	T	A	2: 132,703,165 (GRCm39)	M205K	possibly damaging	Het
Cspg4b	T	C	13: 113,504,427 (GRCm39)	V1852A	probably benign	Het
Dhtkd1	A	T	2: 5,916,662 (GRCm39)	N671K	probably damaging	Het
Dmbt1	A	T	7: 130,642,920 (GRCm39)	D246V	probably damaging	Het
Dolk	G	A	2: 30,175,820 (GRCm39)	A75V	probably damaging	Het
Dtna	T	A	18: 23,779,287 (GRCm39)	V623E	probably damaging	Het
Elavl3	T	C	9: 21,947,622 (GRCm39)	T106A	probably benign	Het
Ergic1	T	C	17: 26,843,652 (GRCm39)	C41R	probably damaging	Het
Fat2	T	A	11: 55,160,187 (GRCm39)	I3309F	possibly damaging	Het
Fbn1	C	A	2: 125,207,559 (GRCm39)	R978L	possibly damaging	Het
Fzd6	A	T	15: 38,894,559 (GRCm39)	S242C	possibly damaging	Het
Galntl6	T	A	8: 58,926,004 (GRCm39)	H87L	probably benign	Het
Gatad2a	T	C	8: 70,388,591 (GRCm39)	E32G	probably damaging	Het
Gemin6	T	G	17: 80,535,178 (GRCm39)	V46G	probably damaging	Het
Gm11541	G	T	11: 94,594,944 (GRCm39)	H41Q	unknown	Het
Has3	A	G	8: 107,600,579 (GRCm39)	T14A	probably damaging	Het
Kmt2b	A	G	7: 30,279,869 (GRCm39)	L1377P	probably damaging	Het
Lcorl	T	C	5: 45,891,069 (GRCm39)	N428S	probably benign	Het
Lipo5	A	T	19: 33,445,284 (GRCm39)	V95D	unknown	Het
Lrp1	A	T	10: 127,391,593 (GRCm39)	V2942D	probably benign	Het
Map1a	T	C	2: 121,136,143 (GRCm39)	S2082P	probably damaging	Het
Mast4	T	C	13: 102,890,723 (GRCm39)	S852G	possibly damaging	Het
Mlh3	A	T	12: 85,316,147 (GRCm39)	L13*	probably null	Het
Ncam2	C	T	16: 81,231,766 (GRCm39)	R77*	probably null	Het
Nlrp9c	T	A	7: 26,081,791 (GRCm39)	N645I	possibly damaging	Het
Or12d17	T	A	17: 37,778,003 (GRCm39)	L302Q	unknown	Het
Or12e7	T	C	2: 87,288,109 (GRCm39)	I200T	probably benign	Het
Or14j7	T	A	17: 38,235,383 (GRCm39)	*309K	probably null	Het
Or7e166	C	A	9: 19,624,994 (GRCm39)	Y290*	probably null	Het
Or8g52	A	T	9: 39,630,892 (GRCm39)	Y123F	possibly damaging	Het
Pex12	A	G	11: 83,187,090 (GRCm39)	V286A	possibly damaging	Het
Phax	C	T	18: 56,717,382 (GRCm39)	T275I	probably damaging	Het
Phf21b	A	G	15: 84,676,006 (GRCm39)	V335A	probably benign	Het
Psg18	A	T	7: 18,083,273 (GRCm39)	L173H	probably damaging	Het
Rab3ip	T	C	10: 116,754,834 (GRCm39)	T209A	possibly damaging	Het
Ralgapb	T	C	2: 158,274,705 (GRCm39)	V202A	probably damaging	Het
Rpn2	T	C	2: 157,165,187 (GRCm39)	L611P	probably damaging	Het
Runx2	T	G	17: 45,035,749 (GRCm39)	T148P	probably damaging	Het
Sbpl	C	A	17: 24,173,623 (GRCm39)	D50Y	probably damaging	Het
Scn5a	G	A	9: 119,350,237 (GRCm39)	P879L	probably damaging	Het
Sfn	T	C	4: 133,328,915 (GRCm39)	R56G	probably damaging	Het
Spata31g1	T	C	4: 42,972,125 (GRCm39)	V486A	possibly damaging	Het
Tas2r138	C	T	6: 40,589,914 (GRCm39)	A111T	probably benign	Het
Tasp1	A	T	2: 139,850,709 (GRCm39)	S105T	probably damaging	Het
Tmem225	T	G	9: 40,062,002 (GRCm39)	H205Q	possibly damaging	Het
Tmprss7	A	G	16: 45,481,267 (GRCm39)	S640P	probably damaging	Het
Utp4	G	A	8: 107,644,265 (GRCm39)	A535T	possibly damaging	Het
Vmn2r58	A	G	7: 41,522,069 (GRCm39)	L9P	probably benign	Het
Zcchc2	T	A	1: 105,957,984 (GRCm39)	C420*	probably null	Het
Zfp804a	A	G	2: 82,088,934 (GRCm39)	D921G	probably benign	Het

Other mutations in Vmn1r203

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01356:Vmn1r203	APN	13	22,708,947 (GRCm39)	missense	probably damaging	1.00
IGL01527:Vmn1r203	APN	13	22,708,447 (GRCm39)	missense	possibly damaging	0.89
IGL01808:Vmn1r203	APN	13	22,708,717 (GRCm39)	missense	probably benign	0.02
IGL01887:Vmn1r203	APN	13	22,709,046 (GRCm39)	missense	probably benign	0.00
IGL02340:Vmn1r203	APN	13	22,708,997 (GRCm39)	nonsense	probably null
IGL02543:Vmn1r203	APN	13	22,709,074 (GRCm39)	missense	probably damaging	1.00
IGL02684:Vmn1r203	APN	13	22,708,539 (GRCm39)	missense	possibly damaging	0.95
BB005:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
BB015:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
PIT4519001:Vmn1r203	UTSW	13	22,708,765 (GRCm39)	missense	probably benign	0.01
R0544:Vmn1r203	UTSW	13	22,708,443 (GRCm39)	missense	possibly damaging	0.94
R1365:Vmn1r203	UTSW	13	22,708,756 (GRCm39)	missense	probably benign	0.00
R1396:Vmn1r203	UTSW	13	22,708,678 (GRCm39)	missense	probably benign	0.01
R1794:Vmn1r203	UTSW	13	22,708,521 (GRCm39)	missense	probably damaging	1.00
R2010:Vmn1r203	UTSW	13	22,708,617 (GRCm39)	missense	possibly damaging	0.56
R2169:Vmn1r203	UTSW	13	22,708,905 (GRCm39)	nonsense	probably null
R2333:Vmn1r203	UTSW	13	22,709,113 (GRCm39)	missense	probably damaging	1.00
R2418:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
R2419:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
R4322:Vmn1r203	UTSW	13	22,708,408 (GRCm39)	missense	probably damaging	1.00
R4460:Vmn1r203	UTSW	13	22,708,852 (GRCm39)	missense	probably damaging	0.98
R4686:Vmn1r203	UTSW	13	22,708,528 (GRCm39)	missense	probably damaging	1.00
R6240:Vmn1r203	UTSW	13	22,708,899 (GRCm39)	missense	possibly damaging	0.89
R6607:Vmn1r203	UTSW	13	22,708,891 (GRCm39)	missense	probably benign	0.23
R7575:Vmn1r203	UTSW	13	22,708,588 (GRCm39)	missense	probably benign	0.12
R7928:Vmn1r203	UTSW	13	22,708,705 (GRCm39)	missense	probably benign	0.01
R8375:Vmn1r203	UTSW	13	22,709,154 (GRCm39)	makesense	probably null
R8421:Vmn1r203	UTSW	13	22,709,154 (GRCm39)	makesense	probably null
R8424:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	probably damaging	1.00
R8845:Vmn1r203	UTSW	13	22,708,720 (GRCm39)	missense	possibly damaging	0.81
R8933:Vmn1r203	UTSW	13	22,708,691 (GRCm39)	missense	possibly damaging	0.69
R8956:Vmn1r203	UTSW	13	22,709,004 (GRCm39)	missense	possibly damaging	0.57
R9493:Vmn1r203	UTSW	13	22,708,423 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn1r203	UTSW	13	22,708,579 (GRCm39)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- TCCTTGAAGCCACAGGAAGAAG -3'
(R):5'- GCTGCTATTGTCTTAGGCAGTC -3'

Sequencing Primer
(F):5'- GACAAGTTTCAGGGACCTAATCTGC -3'
(R):5'- CTTAGGCAGTCCTTTTGCAAGAAG -3'

Posted On

2016-10-05