Incidental Mutation 'R0478:Or1x6'
ID 43208
Institutional Source Beutler Lab
Gene Symbol Or1x6
Ensembl Gene ENSMUSG00000057890
Gene Name olfactory receptor family 1 subfamily X member 6
Synonyms MOR126-2, Olfr1375, Olfr1375-ps1, GA_x6K02T2QP88-4389999-4389056
MMRRC Submission 038678-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R0478 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 50938936-50939877 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50939539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 202 (S202P)
Ref Sequence ENSEMBL: ENSMUSP00000144756 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073543]
AlphaFold A0A0N4SUP0
Predicted Effect probably benign
Transcript: ENSMUST00000073543
AA Change: S202P

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000073233
Gene: ENSMUSG00000057890
AA Change: S202P

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 37 306 3.9e-6 PFAM
Pfam:7tm_1 43 291 9.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000073543
AA Change: S202P

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000144756
Gene: ENSMUSG00000057890
AA Change: S202P

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 37 306 3.9e-6 PFAM
Pfam:7tm_1 43 291 9.5e-26 PFAM
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.0%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A T 7: 29,262,014 (GRCm39) noncoding transcript Het
4930556J24Rik T G 11: 3,926,259 (GRCm39) probably benign Het
Acnat1 T G 4: 49,450,901 (GRCm39) D70A probably damaging Het
Adnp2 A G 18: 80,172,549 (GRCm39) V620A probably benign Het
Aldoart1 T A 4: 72,770,580 (GRCm39) H21L probably benign Het
Birc2 A G 9: 7,860,348 (GRCm39) V290A probably damaging Het
Bpifb3 C T 2: 153,773,400 (GRCm39) probably benign Het
Camta1 C A 4: 151,159,597 (GRCm39) R1614L probably damaging Het
Clmn A G 12: 104,751,750 (GRCm39) M235T probably damaging Het
Dmbt1 A G 7: 130,642,917 (GRCm39) E245G possibly damaging Het
Epgn G T 5: 91,178,987 (GRCm39) V36L probably benign Het
Ets2 C A 16: 95,517,306 (GRCm39) P346Q probably damaging Het
Fam222b T C 11: 78,044,682 (GRCm39) L81P probably damaging Het
Fancf A C 7: 51,511,440 (GRCm39) L188R probably damaging Het
Fibin T C 2: 110,193,079 (GRCm39) D21G possibly damaging Het
Fzd6 A G 15: 38,897,429 (GRCm39) probably null Het
Gbp4 T A 5: 105,267,299 (GRCm39) Q540L probably benign Het
Greb1l T A 18: 10,509,281 (GRCm39) L531Q probably damaging Het
Il5ra A G 6: 106,715,423 (GRCm39) V137A probably benign Het
Kif26a G A 12: 112,142,223 (GRCm39) A826T probably damaging Het
Kiz T C 2: 146,784,078 (GRCm39) V537A possibly damaging Het
Klhl32 C T 4: 24,792,777 (GRCm39) G15D probably damaging Het
Kmt2d G A 15: 98,751,462 (GRCm39) probably benign Het
Lbp T C 2: 158,159,448 (GRCm39) probably benign Het
Mmp25 T C 17: 23,851,756 (GRCm39) T318A probably benign Het
Mrpl50 A G 4: 49,514,513 (GRCm39) C53R probably damaging Het
Msl3l2 G C 10: 55,991,411 (GRCm39) E45D probably damaging Het
Nfxl1 A G 5: 72,681,988 (GRCm39) probably null Het
Noc3l A G 19: 38,798,450 (GRCm39) probably null Het
Or12e7 T A 2: 87,288,370 (GRCm39) V287E probably damaging Het
Pgm5 A T 19: 24,812,233 (GRCm39) S100T possibly damaging Het
Pi4ka C T 16: 17,127,175 (GRCm39) G1093S possibly damaging Het
Pitrm1 T A 13: 6,609,431 (GRCm39) S350T probably damaging Het
Ptk2b G T 14: 66,450,821 (GRCm39) N48K probably damaging Het
Septin3 T C 15: 82,175,007 (GRCm39) L172P probably damaging Het
Sirt3 A T 7: 140,458,027 (GRCm39) C41S Het
Sphkap C T 1: 83,256,432 (GRCm39) R152H probably damaging Het
St3gal1 T C 15: 66,985,579 (GRCm39) Y25C probably damaging Het
Tbc1d31 T C 15: 57,795,932 (GRCm39) F175S probably damaging Het
Tfdp2 T A 9: 96,172,636 (GRCm39) D43E probably benign Het
Tgm1 G A 14: 55,937,791 (GRCm39) Q773* probably null Het
Tmc3 A T 7: 83,271,360 (GRCm39) R837S possibly damaging Het
Unc13a A G 8: 72,103,792 (GRCm39) V880A possibly damaging Het
Vmn1r237 T A 17: 21,535,081 (GRCm39) V268E probably damaging Het
Zan C T 5: 137,398,788 (GRCm39) probably benign Het
Zfp760 G T 17: 21,940,995 (GRCm39) E57* probably null Het
Other mutations in Or1x6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or1x6 APN 11 50,939,227 (GRCm39) missense probably benign 0.00
R0268:Or1x6 UTSW 11 50,939,768 (GRCm39) missense probably damaging 1.00
R0462:Or1x6 UTSW 11 50,939,336 (GRCm39) missense probably damaging 1.00
R0839:Or1x6 UTSW 11 50,939,254 (GRCm39) missense probably benign 0.06
R2517:Or1x6 UTSW 11 50,939,300 (GRCm39) missense probably damaging 1.00
R4688:Or1x6 UTSW 11 50,939,815 (GRCm39) missense probably damaging 1.00
R4781:Or1x6 UTSW 11 50,939,307 (GRCm39) missense probably damaging 1.00
R5396:Or1x6 UTSW 11 50,939,297 (GRCm39) missense probably damaging 1.00
R6163:Or1x6 UTSW 11 50,939,595 (GRCm39) nonsense probably null
R6739:Or1x6 UTSW 11 50,939,564 (GRCm39) missense probably damaging 0.97
R7344:Or1x6 UTSW 11 50,939,122 (GRCm39) missense probably damaging 1.00
R7994:Or1x6 UTSW 11 50,938,967 (GRCm39) missense probably benign 0.31
R8054:Or1x6 UTSW 11 50,939,090 (GRCm39) missense probably benign 0.22
R8129:Or1x6 UTSW 11 50,939,210 (GRCm39) missense probably benign 0.00
R8940:Or1x6 UTSW 11 50,939,455 (GRCm39) missense probably benign 0.01
R9005:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9008:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9016:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9018:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9028:Or1x6 UTSW 11 50,939,660 (GRCm39) missense probably damaging 1.00
R9051:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9052:Or1x6 UTSW 11 50,938,938 (GRCm39) start codon destroyed probably null 0.18
R9203:Or1x6 UTSW 11 50,939,161 (GRCm39) missense possibly damaging 0.82
R9364:Or1x6 UTSW 11 50,939,223 (GRCm39) nonsense probably null
R9376:Or1x6 UTSW 11 50,939,662 (GRCm39) missense probably damaging 1.00
R9554:Or1x6 UTSW 11 50,939,223 (GRCm39) nonsense probably null
R9641:Or1x6 UTSW 11 50,939,207 (GRCm39) missense probably benign 0.34
Z1176:Or1x6 UTSW 11 50,939,662 (GRCm39) missense probably damaging 1.00
Z1177:Or1x6 UTSW 11 50,939,353 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAACGAGGACCATCTCTTATGCAC -3'
(R):5'- TCGTCCCATAGAACAGGATGACCAC -3'

Sequencing Primer
(F):5'- CATGGCCCTGGACAGATTC -3'
(R):5'- GATGACCACAGACAAATGTGAAC -3'
Posted On 2013-05-23