Incidental Mutation 'R5492:Tigar'
ID 432115
Institutional Source Beutler Lab
Gene Symbol Tigar
Ensembl Gene ENSMUSG00000038028
Gene Name Trp53 induced glycolysis regulatory phosphatase
Synonyms Tigar, 9630033F20Rik
MMRRC Submission 043053-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5492 (G1)
Quality Score 99
Status Not validated
Chromosome 6
Chromosomal Location 127062079-127086520 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 127066167 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 124 (T124S)
Ref Sequence ENSEMBL: ENSMUSP00000048643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039913] [ENSMUST00000200988]
AlphaFold Q8BZA9
Predicted Effect possibly damaging
Transcript: ENSMUST00000039913
AA Change: T124S

PolyPhen 2 Score 0.796 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000048643
Gene: ENSMUSG00000038028
AA Change: T124S

DomainStartEndE-ValueType
PGAM 5 205 8.71e-20 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200988
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.1%
  • 10x: 94.5%
  • 20x: 89.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit improved response to myocardial infarction associated with increased autophagy, mitophagy, levels of reactive oxygen species production and decreased mitochondria DNA damage. Mice homozygous for a different allele exhibit impaired crypt regeneration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A830018L16Rik C T 1: 11,615,431 (GRCm39) R135C probably damaging Het
Abcd2 A G 15: 91,073,176 (GRCm39) Y328H probably benign Het
Abcg4 T C 9: 44,189,355 (GRCm39) T381A probably benign Het
Adamts12 A G 15: 11,336,384 (GRCm39) N1490D probably benign Het
Aldh18a1 C T 19: 40,539,734 (GRCm39) R747Q probably damaging Het
Armc8 G T 9: 99,409,184 (GRCm39) C169* probably null Het
Birc6 A C 17: 74,977,369 (GRCm39) N4388T probably damaging Het
Bsn G A 9: 107,989,714 (GRCm39) P2013S probably damaging Het
Cdc16 A G 8: 13,813,915 (GRCm39) probably null Het
Cmtr1 T A 17: 29,909,316 (GRCm39) F408L probably damaging Het
Col4a2 C T 8: 11,488,608 (GRCm39) R1104W possibly damaging Het
Drg2 A C 11: 60,352,422 (GRCm39) H208P probably damaging Het
Frem3 A T 8: 81,339,306 (GRCm39) D533V probably damaging Het
Gm9930 T A 10: 9,410,337 (GRCm39) noncoding transcript Het
Haus5 A G 7: 30,358,380 (GRCm39) V305A possibly damaging Het
Hint3 C A 10: 30,494,245 (GRCm39) R30L probably benign Het
Hltf T A 3: 20,152,231 (GRCm39) probably null Het
Hmcn2 T A 2: 31,310,318 (GRCm39) L3304Q probably benign Het
Hspa2 A G 12: 76,451,308 (GRCm39) M1V probably null Het
Htr5b T C 1: 121,455,387 (GRCm39) T178A possibly damaging Het
Ighv1-11 A G 12: 114,576,084 (GRCm39) S44P probably damaging Het
Larp1b C T 3: 40,924,334 (GRCm39) R104W probably damaging Het
Map3k2 A G 18: 32,361,189 (GRCm39) T550A probably damaging Het
Map4 T A 9: 109,881,450 (GRCm39) S105T possibly damaging Het
Mgam T C 6: 40,733,297 (GRCm39) C691R probably damaging Het
Mms19 A G 19: 41,944,270 (GRCm39) I310T possibly damaging Het
Myh2 A C 11: 67,071,701 (GRCm39) K506T probably benign Het
Ngdn T C 14: 55,260,509 (GRCm39) V239A probably benign Het
Plin1 G A 7: 79,375,460 (GRCm39) R151* probably null Het
Rbpjl GCC GC 2: 164,256,330 (GRCm39) probably null Het
Rdh16f2 G T 10: 127,702,623 (GRCm39) E67* probably null Het
Slc25a36 A C 9: 96,982,259 (GRCm39) C25W probably damaging Het
Stk31 G A 6: 49,375,177 (GRCm39) A49T probably damaging Het
Tsn A G 1: 118,232,443 (GRCm39) V144A probably damaging Het
Zfp703 C T 8: 27,469,233 (GRCm39) P299L probably damaging Het
Zfp943 T A 17: 22,212,056 (GRCm39) C381S probably damaging Het
Zfyve19 A T 2: 119,039,595 (GRCm39) probably benign Het
Other mutations in Tigar
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00515:Tigar APN 6 127,065,042 (GRCm39) missense probably damaging 0.98
IGL01099:Tigar APN 6 127,065,108 (GRCm39) missense probably benign
IGL02021:Tigar APN 6 127,066,253 (GRCm39) missense probably damaging 0.97
R0356:Tigar UTSW 6 127,068,145 (GRCm39) critical splice donor site probably null
R1972:Tigar UTSW 6 127,064,889 (GRCm39) missense possibly damaging 0.62
R6063:Tigar UTSW 6 127,068,164 (GRCm39) missense probably benign 0.00
R7447:Tigar UTSW 6 127,065,129 (GRCm39) missense probably benign 0.03
R8759:Tigar UTSW 6 127,068,220 (GRCm39) missense probably benign 0.19
R9281:Tigar UTSW 6 127,068,157 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTTGCTGATTCCCAGTGAC -3'
(R):5'- GCATAGTGTCAGGTTCTCACAGG -3'

Sequencing Primer
(F):5'- TGCTGATTCCCAGTGACTGAGAC -3'
(R):5'- ACAGGCCTTTACCATCATGTCG -3'
Posted On 2016-10-05