Incidental Mutation 'R5498:Or2r11'
ID 432467
Institutional Source Beutler Lab
Gene Symbol Or2r11
Ensembl Gene ENSMUSG00000068574
Gene Name olfactory receptor family 2 subfamily R member 11
Synonyms Olfr458, GA_x6K02T2P3E9-5100053-5100994, MOR257-4
MMRRC Submission 043059-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R5498 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 42437010-42437951 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 42437228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 242 (A242T)
Ref Sequence ENSEMBL: ENSMUSP00000149459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090156] [ENSMUST00000216650]
AlphaFold Q8VF80
Predicted Effect probably benign
Transcript: ENSMUST00000090156
AA Change: A242T

PolyPhen 2 Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000087617
Gene: ENSMUSG00000068574
AA Change: A242T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.6e-52 PFAM
Pfam:7tm_1 41 310 3.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216650
AA Change: A242T

PolyPhen 2 Score 0.110 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 94.8%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik T A 5: 109,885,413 (GRCm39) K148N probably benign Het
Abca6 T A 11: 110,099,670 (GRCm39) D959V possibly damaging Het
Acot12 T C 13: 91,929,352 (GRCm39) V393A probably damaging Het
Ano3 C A 2: 110,527,448 (GRCm39) V587F possibly damaging Het
Bub1 T C 2: 127,656,629 (GRCm39) D471G possibly damaging Het
Cdh15 G T 8: 123,591,917 (GRCm39) V601F possibly damaging Het
Cdt1 C T 8: 123,297,239 (GRCm39) R311W probably damaging Het
Cnot1 A T 8: 96,483,983 (GRCm39) I706N possibly damaging Het
Fbn1 A G 2: 125,202,096 (GRCm39) I1259T probably damaging Het
Furin A T 7: 80,041,542 (GRCm39) W539R probably damaging Het
Hivep1 A T 13: 42,276,634 (GRCm39) probably null Het
Igkv3-9 A G 6: 70,565,727 (GRCm39) M109V probably benign Het
Klf10 G A 15: 38,296,283 (GRCm39) R421W probably damaging Het
Mtor A T 4: 148,624,821 (GRCm39) Y2144F possibly damaging Het
Mybpc2 T C 7: 44,165,689 (GRCm39) Y297C probably damaging Het
Myom2 G A 8: 15,179,142 (GRCm39) E1325K probably benign Het
Nsd1 A T 13: 55,361,115 (GRCm39) K28* probably null Het
Or51b4 T G 7: 103,530,839 (GRCm39) T204P probably damaging Het
Phc2 C A 4: 128,602,787 (GRCm39) N120K probably benign Het
Pias3 A G 3: 96,609,504 (GRCm39) T274A possibly damaging Het
Plcb4 T A 2: 135,818,092 (GRCm39) I786N probably damaging Het
Plec G A 15: 76,061,654 (GRCm39) S2626L probably damaging Het
Polg A G 7: 79,104,418 (GRCm39) L819P probably damaging Het
Ppp2r3d T C 9: 124,439,123 (GRCm38) probably benign Het
Resf1 A G 6: 149,229,738 (GRCm39) D928G probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rnpc3 A G 3: 113,404,856 (GRCm39) probably null Het
Sarnp T A 10: 128,689,063 (GRCm39) D65E probably benign Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Slc16a10 C T 10: 39,913,323 (GRCm39) V462M probably damaging Het
Slc45a2 C T 15: 11,027,871 (GRCm39) T480I probably damaging Het
Slfn5 A T 11: 82,847,973 (GRCm39) H286L possibly damaging Het
Spag17 G A 3: 100,010,661 (GRCm39) A2052T possibly damaging Het
Sptbn5 A T 2: 119,907,119 (GRCm39) probably benign Het
Tlr3 C T 8: 45,851,851 (GRCm39) D349N possibly damaging Het
Trim45 T C 3: 100,832,457 (GRCm39) V230A possibly damaging Het
Ube3b T C 5: 114,556,635 (GRCm39) F989L probably damaging Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Wdr24 A G 17: 26,043,535 (GRCm39) H119R probably damaging Het
Yars2 T A 16: 16,124,387 (GRCm39) H331Q possibly damaging Het
Zscan21 T C 5: 138,131,522 (GRCm39) S349P probably benign Het
Other mutations in Or2r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00915:Or2r11 APN 6 42,437,884 (GRCm39) missense probably benign
IGL00983:Or2r11 APN 6 42,437,029 (GRCm39) missense probably benign
IGL01655:Or2r11 APN 6 42,437,474 (GRCm39) missense probably benign 0.41
IGL02017:Or2r11 APN 6 42,437,758 (GRCm39) missense probably benign 0.40
IGL02420:Or2r11 APN 6 42,437,110 (GRCm39) missense probably benign 0.03
IGL03145:Or2r11 APN 6 42,437,434 (GRCm39) missense probably benign 0.05
IGL03171:Or2r11 APN 6 42,437,464 (GRCm39) missense possibly damaging 0.89
IGL03333:Or2r11 APN 6 42,437,773 (GRCm39) missense probably damaging 1.00
R1768:Or2r11 UTSW 6 42,437,611 (GRCm39) missense probably damaging 1.00
R1908:Or2r11 UTSW 6 42,437,360 (GRCm39) missense probably benign 0.15
R2198:Or2r11 UTSW 6 42,437,950 (GRCm39) start codon destroyed probably null 1.00
R2336:Or2r11 UTSW 6 42,437,663 (GRCm39) missense probably damaging 1.00
R2512:Or2r11 UTSW 6 42,437,207 (GRCm39) missense probably damaging 0.99
R3433:Or2r11 UTSW 6 42,437,888 (GRCm39) missense probably benign
R5338:Or2r11 UTSW 6 42,437,908 (GRCm39) missense probably benign 0.11
R5341:Or2r11 UTSW 6 42,437,098 (GRCm39) missense probably damaging 1.00
R6558:Or2r11 UTSW 6 42,437,711 (GRCm39) missense probably benign 0.02
R6594:Or2r11 UTSW 6 42,437,309 (GRCm39) missense probably benign 0.01
R7107:Or2r11 UTSW 6 42,437,488 (GRCm39) missense possibly damaging 0.78
R7853:Or2r11 UTSW 6 42,437,573 (GRCm39) missense probably damaging 0.99
R8050:Or2r11 UTSW 6 42,437,764 (GRCm39) missense probably damaging 1.00
R8684:Or2r11 UTSW 6 42,437,827 (GRCm39) missense probably damaging 1.00
R9777:Or2r11 UTSW 6 42,437,029 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GACTCAAAGATCTTCATCAGAACTCG -3'
(R):5'- CATGTGAGACACTGGCACTG -3'

Sequencing Primer
(F):5'- GATCTTCATCAGAACTCGACTGAAAG -3'
(R):5'- TGGCACTGGTCAGACTGG -3'
Posted On 2016-10-05