Incidental Mutation 'R5453:Igll1'
Institutional Source Beutler Lab
Gene Symbol Igll1
Ensembl Gene ENSMUSG00000075370
Gene Nameimmunoglobulin lambda-like polypeptide 1
SynonymsIgll, Igl-5, Lambda 5
MMRRC Submission 043017-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #R5453 (G1)
Quality Score225
Status Not validated
Chromosomal Location16860671-16863985 bp(-) (GRCm38)
Type of Mutationunclassified (2 bp from exon)
DNA Base Change (assembly) A to G at 16863694 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075017] [ENSMUST00000100136] [ENSMUST00000124890]
Predicted Effect probably benign
Transcript: ENSMUST00000075017
SMART Domains Protein: ENSMUSP00000074537
Gene: ENSMUSG00000059305

signal peptide 1 19 N/A INTRINSIC
IGv 36 117 3.96e-25 SMART
Predicted Effect probably null
Transcript: ENSMUST00000100136
SMART Domains Protein: ENSMUSP00000097713
Gene: ENSMUSG00000075370

signal peptide 1 30 N/A INTRINSIC
IGc1 126 200 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124649
Predicted Effect probably null
Transcript: ENSMUST00000124890
SMART Domains Protein: ENSMUSP00000122045
Gene: ENSMUSG00000075370

IGc1 102 176 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132272
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135276
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231439
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231704
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921507P07Rik A G 6: 50,595,796 probably null Het
Abca5 G A 11: 110,319,796 Q186* probably null Het
Adamts20 T C 15: 94,326,088 E1253G possibly damaging Het
Adgrd1 T C 5: 129,179,583 F640S probably damaging Het
Anxa1 C T 19: 20,380,339 probably null Het
Babam2 A G 5: 32,007,246 E288G probably damaging Het
Cd163 C T 6: 124,312,541 A406V probably damaging Het
Cdh13 A T 8: 119,198,967 D358V probably damaging Het
Cdk10 A G 8: 123,226,392 I45V probably benign Het
Crybg2 A T 4: 134,078,836 probably null Het
Dnhd1 A G 7: 105,710,123 D3555G probably damaging Het
Dync1h1 A G 12: 110,632,665 D1818G probably benign Het
Emsy T C 7: 98,600,806 K758R probably damaging Het
Fam126a A G 5: 23,987,879 probably null Het
Fat3 A G 9: 15,996,864 V2614A probably damaging Het
Hivep2 T C 10: 14,128,228 I190T possibly damaging Het
Hoxb3 T C 11: 96,344,654 S136P probably damaging Het
Hras A C 7: 141,192,855 V29G probably damaging Het
Insr G A 8: 3,155,694 T1365I probably benign Het
Kitl T A 10: 100,087,385 W187R probably damaging Het
Klb T A 5: 65,383,385 F940L probably benign Het
Lrp1b C T 2: 41,282,237 R725K probably damaging Het
Map4 C T 9: 110,037,783 probably benign Het
Mrps35 A G 6: 147,070,617 S253G probably benign Het
Mycbp2 C T 14: 103,201,401 E2015K probably damaging Het
Nyap2 A C 1: 81,192,142 I205L probably benign Het
Olfr103 T C 17: 37,337,062 M57V possibly damaging Het
Olfr427 A G 1: 174,099,467 K3R probably benign Het
Rab11fip3 C T 17: 25,992,581 probably null Het
Rbm47 A G 5: 66,027,182 V26A probably benign Het
Ripk2 A T 4: 16,151,989 I190N probably damaging Het
Tns2 C T 15: 102,108,934 R281C probably damaging Het
Ttc17 A T 2: 94,303,560 N1150K probably damaging Het
Zfp108 G T 7: 24,261,264 G427W probably damaging Het
Zfp84 A G 7: 29,776,297 E138G possibly damaging Het
Other mutations in Igll1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Igll1 APN 16 16860919 missense probably benign 0.04
IGL03060:Igll1 APN 16 16862427 critical splice donor site probably null
R0058:Igll1 UTSW 16 16863876 missense probably benign 0.02
R0058:Igll1 UTSW 16 16863876 missense probably benign 0.02
R2014:Igll1 UTSW 16 16863775 missense probably benign
R2015:Igll1 UTSW 16 16863775 missense probably benign
R4242:Igll1 UTSW 16 16863700 missense probably benign 0.15
R5024:Igll1 UTSW 16 16863793 missense probably benign 0.05
R5855:Igll1 UTSW 16 16861057 missense probably damaging 1.00
R6000:Igll1 UTSW 16 16863941 start gained probably benign
R6946:Igll1 UTSW 16 16861056 missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On2016-10-06