Incidental Mutation 'R5455:Vmn1r89'
ID432712
Institutional Source Beutler Lab
Gene Symbol Vmn1r89
Ensembl Gene ENSMUSG00000095629
Gene Namevomeronasal 1 receptor 89
SynonymsV1rj2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #R5455 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location13213020-13220657 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 13220267 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Leucine at position 121 (H121L)
Ref Sequence ENSEMBL: ENSMUSP00000154046 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053008] [ENSMUST00000226717] [ENSMUST00000227176] [ENSMUST00000227239] [ENSMUST00000227276] [ENSMUST00000227319] [ENSMUST00000227390] [ENSMUST00000228587]
Predicted Effect probably benign
Transcript: ENSMUST00000053008
AA Change: H310L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: H310L

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.9e-15 PFAM
Pfam:7tm_1 25 295 1.1e-6 PFAM
Pfam:V1R 36 301 1.5e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226717
AA Change: H310L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227176
AA Change: H310L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227239
AA Change: H310L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227276
AA Change: H265L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227319
AA Change: H121L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000227390
AA Change: H242L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000228587
AA Change: H310L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228825
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930452B06Rik A T 14: 8,536,516 probably null Het
Adgrf1 T A 17: 43,321,143 probably null Het
Ascc3 T C 10: 50,849,583 V2134A probably benign Het
Cct6b T G 11: 82,755,117 I80L probably benign Het
Crebbp C A 16: 4,085,967 V1765L probably benign Het
Cul9 C T 17: 46,510,846 probably null Het
Cyp2c40 A G 19: 39,803,792 I236T possibly damaging Het
Dbndd2 C A 2: 164,490,193 T112K possibly damaging Het
Dmrtc2 A C 7: 24,872,491 S4R probably benign Het
Dnah6 C T 6: 73,075,734 V2988I probably benign Het
Dnajb12 GC G 10: 59,892,752 probably null Het
Ercc3 T C 18: 32,267,209 S705P possibly damaging Het
Gm10306 T G 4: 94,556,840 probably benign Het
H2-Q6 T C 17: 35,424,884 L3P unknown Het
Kcnn4 T C 7: 24,377,553 S176P probably damaging Het
Maml2 T A 9: 13,705,743 Y128* probably null Het
Map2 G A 1: 66,399,391 E25K probably damaging Het
Morc2b T A 17: 33,138,610 M63L probably benign Het
Mthfd1 A G 12: 76,301,288 I569V probably benign Het
Myh8 G A 11: 67,301,418 R1399H possibly damaging Het
Nop2 T C 6: 125,140,643 I424T probably benign Het
Olfm5 T C 7: 104,154,462 R265G probably damaging Het
Olfr1352 C T 10: 78,984,537 S249F possibly damaging Het
Olfr1406 A G 1: 173,184,251 F61S probably damaging Het
Opalin T C 19: 41,069,953 T14A probably benign Het
Pced1b C A 15: 97,384,393 S104R probably benign Het
Pdia2 T G 17: 26,197,163 Q310P probably null Het
Ppil6 A G 10: 41,498,545 T141A probably benign Het
Prrc2b A G 2: 32,221,343 probably null Het
Stxbp5 A G 10: 9,808,508 S573P probably benign Het
Synpo2l C A 14: 20,662,292 A87S probably damaging Het
Tor1b GGACG GG 2: 30,956,945 probably benign Het
Vmn2r99 T A 17: 19,394,146 C709* probably null Het
Vstm4 A G 14: 32,863,878 H134R possibly damaging Het
Zan C T 5: 137,454,000 C1569Y unknown Het
Zdhhc13 A G 7: 48,805,575 T122A possibly damaging Het
Zpbp2 G T 11: 98,557,603 V249L probably benign Het
Other mutations in Vmn1r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r89 APN 7 13219505 missense probably benign 0.28
IGL02085:Vmn1r89 APN 7 13219538 missense probably damaging 0.96
IGL02694:Vmn1r89 APN 7 13220129 missense probably benign 0.12
IGL02709:Vmn1r89 APN 7 13220204 missense probably damaging 1.00
PIT4142001:Vmn1r89 UTSW 7 13219588 missense probably benign
R0765:Vmn1r89 UTSW 7 13219540 missense probably benign 0.03
R1396:Vmn1r89 UTSW 7 13220011 missense probably damaging 1.00
R2249:Vmn1r89 UTSW 7 13220260 missense possibly damaging 0.90
R4296:Vmn1r89 UTSW 7 13220186 missense possibly damaging 0.78
R4472:Vmn1r89 UTSW 7 13219872 missense probably benign 0.04
R5037:Vmn1r89 UTSW 7 13219387 missense possibly damaging 0.88
R5267:Vmn1r89 UTSW 7 13220213 missense probably damaging 1.00
R5352:Vmn1r89 UTSW 7 13219357 missense probably benign
R5595:Vmn1r89 UTSW 7 13219930 missense possibly damaging 0.93
R5643:Vmn1r89 UTSW 7 13220219 missense possibly damaging 0.94
Predicted Primers
Posted On2016-10-06