Incidental Mutation 'R5457:Or10j2'
ID 432787
Institutional Source Beutler Lab
Gene Symbol Or10j2
Ensembl Gene ENSMUSG00000049605
Gene Name olfactory receptor family 10 subfamily J member 2
Synonyms MOR267-8, Olfr418, Olfr1403, GA_x6K02T2P20D-20826777-20827719, Olfr418-ps1, MOR267-12P, GA_x6K02T2R7CC-581296-580364
MMRRC Submission 043020-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5457 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173097714-173098704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 173098141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 133 (S133L)
Ref Sequence ENSEMBL: ENSMUSP00000150427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059754] [ENSMUST00000111224] [ENSMUST00000213420]
AlphaFold A0A140T8J6
Predicted Effect probably benign
Transcript: ENSMUST00000059754
AA Change: S133L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000052418
Gene: ENSMUSG00000049605
AA Change: S133L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.6e-55 PFAM
Pfam:7tm_1 41 289 5.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111224
SMART Domains Protein: ENSMUSP00000106855
Gene: ENSMUSG00000079180

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PTX 20 219 1.93e-94 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213420
AA Change: S133L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 C A 8: 87,236,473 (GRCm39) V1114L probably benign Het
Actr5 G A 2: 158,477,918 (GRCm39) probably null Het
Adcy7 T C 8: 89,037,649 (GRCm39) L239P probably damaging Het
Afg3l1 T A 8: 124,216,707 (GRCm39) F315L possibly damaging Het
Agps A G 2: 75,684,596 (GRCm39) Y188C probably benign Het
Akt1 T C 12: 112,623,525 (GRCm39) T312A probably damaging Het
Ang2 T C 14: 51,433,292 (GRCm39) Y30C probably damaging Het
Angpt1 G A 15: 42,386,916 (GRCm39) T146I probably damaging Het
Atg16l1 T C 1: 87,702,813 (GRCm39) S288P probably damaging Het
Atp1b2 C T 11: 69,493,558 (GRCm39) G4R probably damaging Het
Best3 T C 10: 116,840,416 (GRCm39) F282S probably damaging Het
Cdkn2b A G 4: 89,225,391 (GRCm39) L98P probably damaging Het
Cenps A G 4: 149,216,094 (GRCm39) probably null Het
Clec16a G T 16: 10,363,396 (GRCm39) probably null Het
Cxcl13 A T 5: 96,104,830 (GRCm39) M1L unknown Het
Dcun1d4 A T 5: 73,688,908 (GRCm39) E149D probably damaging Het
Dlst G A 12: 85,168,914 (GRCm39) probably null Het
Dock10 C A 1: 80,501,781 (GRCm39) C1803F probably damaging Het
Dpp10 T A 1: 123,339,539 (GRCm39) K329N possibly damaging Het
Drosha T G 15: 12,926,115 (GRCm39) Y1235D probably benign Het
Eif2s3y G A Y: 1,016,057 (GRCm39) G213D probably damaging Homo
Eps8 A T 6: 137,489,175 (GRCm39) S408T probably damaging Het
Fam171a2 T C 11: 102,328,362 (GRCm39) D799G possibly damaging Het
Fcho2 T C 13: 98,926,275 (GRCm39) K103E probably damaging Het
Fcrlb T C 1: 170,739,726 (GRCm39) T59A probably damaging Het
Fgd4 T C 16: 16,279,873 (GRCm39) R395G probably benign Het
Gm14496 A T 2: 181,639,401 (GRCm39) D497V probably damaging Het
Gpt2 A C 8: 86,238,967 (GRCm39) N267H possibly damaging Het
Grb14 A T 2: 64,747,442 (GRCm39) C43S probably damaging Het
Hjurp T TN 1: 88,194,247 (GRCm39) probably null Het
Igkv8-16 A G 6: 70,363,689 (GRCm39) V111A possibly damaging Het
Klra2 T A 6: 131,198,852 (GRCm39) S230C possibly damaging Het
Lamb3 G A 1: 193,008,302 (GRCm39) R245H probably damaging Het
Lamc3 A G 2: 31,821,997 (GRCm39) E1315G probably benign Het
Lpin2 A G 17: 71,550,367 (GRCm39) T672A probably damaging Het
Mcoln3 T A 3: 145,833,877 (GRCm39) I139N probably benign Het
Mcpt8 C T 14: 56,319,793 (GRCm39) C219Y probably benign Het
Mtcl3 A C 10: 29,072,720 (GRCm39) I671L probably benign Het
Mug2 G T 6: 122,026,688 (GRCm39) G541* probably null Het
Myo7b G T 18: 32,104,503 (GRCm39) probably null Het
Or10j7 A G 1: 173,011,180 (GRCm39) S274P probably damaging Het
Or5ac22 T C 16: 59,135,213 (GRCm39) I186V probably benign Het
Or5k8 A T 16: 58,644,796 (GRCm39) I92N probably damaging Het
Or7e176 A T 9: 20,171,574 (GRCm39) Y146F probably damaging Het
Pclo C T 5: 14,726,157 (GRCm39) probably benign Het
Pdk2 C T 11: 94,919,408 (GRCm39) S289N probably damaging Het
Pex19 G T 1: 171,958,245 (GRCm39) G75W probably damaging Het
Psma3 T G 12: 71,031,339 (GRCm39) S26A probably benign Het
Pth1r A T 9: 110,555,522 (GRCm39) I326N possibly damaging Het
Sbf2 T C 7: 109,912,037 (GRCm39) T1670A probably benign Het
Scn10a A G 9: 119,523,193 (GRCm39) Y67H probably damaging Het
Sec16a A T 2: 26,330,280 (GRCm39) D578E probably benign Het
Spta1 C T 1: 174,044,759 (GRCm39) A1465V probably damaging Het
Taar9 A G 10: 23,985,003 (GRCm39) F144L probably damaging Het
Tal1 T C 4: 114,925,777 (GRCm39) V282A probably benign Het
Tbrg4 C T 11: 6,570,947 (GRCm39) R175Q probably damaging Het
Tdp1 C T 12: 99,861,005 (GRCm39) Q215* probably null Het
Thsd4 A T 9: 59,887,060 (GRCm39) W921R probably damaging Het
Trrap A G 5: 144,786,787 (GRCm39) E3462G probably damaging Het
Try4 T C 6: 41,280,355 (GRCm39) S60P probably damaging Het
Ttn T C 2: 76,541,265 (GRCm39) E25580G probably damaging Het
Ttn A T 2: 76,776,299 (GRCm39) I1581N possibly damaging Het
Vmn2r50 T C 7: 9,781,873 (GRCm39) T291A probably damaging Het
Zkscan14 T C 5: 145,138,169 (GRCm39) D106G probably benign Het
Other mutations in Or10j2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01413:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01418:Or10j2 APN 1 173,098,275 (GRCm39) missense probably damaging 1.00
IGL01930:Or10j2 APN 1 173,098,177 (GRCm39) missense probably benign
IGL01963:Or10j2 APN 1 173,097,919 (GRCm39) missense probably damaging 0.99
IGL02104:Or10j2 APN 1 173,098,603 (GRCm39) missense probably damaging 0.96
IGL02192:Or10j2 APN 1 173,098,417 (GRCm39) missense probably damaging 1.00
IGL02256:Or10j2 APN 1 173,098,194 (GRCm39) missense probably benign 0.04
IGL02340:Or10j2 APN 1 173,097,972 (GRCm39) missense probably benign 0.10
IGL02454:Or10j2 APN 1 173,098,507 (GRCm39) missense probably damaging 0.99
IGL02638:Or10j2 APN 1 173,097,898 (GRCm39) missense probably benign 0.07
FR4737:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
FR4976:Or10j2 UTSW 1 173,098,197 (GRCm39) frame shift probably null
R0552:Or10j2 UTSW 1 173,098,372 (GRCm39) missense probably benign 0.05
R0621:Or10j2 UTSW 1 173,098,242 (GRCm39) missense possibly damaging 0.48
R0735:Or10j2 UTSW 1 173,098,569 (GRCm39) missense probably benign 0.05
R1506:Or10j2 UTSW 1 173,098,336 (GRCm39) missense probably benign 0.04
R1670:Or10j2 UTSW 1 173,098,467 (GRCm39) missense probably damaging 1.00
R2111:Or10j2 UTSW 1 173,097,879 (GRCm39) missense probably benign
R2204:Or10j2 UTSW 1 173,097,703 (GRCm39) splice site probably null
R4475:Or10j2 UTSW 1 173,098,480 (GRCm39) missense probably damaging 0.99
R4909:Or10j2 UTSW 1 173,098,546 (GRCm39) missense probably damaging 0.97
R6124:Or10j2 UTSW 1 173,097,846 (GRCm39) missense probably damaging 1.00
R6456:Or10j2 UTSW 1 173,098,105 (GRCm39) missense probably damaging 1.00
R7220:Or10j2 UTSW 1 173,097,811 (GRCm39) missense possibly damaging 0.56
R7240:Or10j2 UTSW 1 173,098,561 (GRCm39) missense probably benign 0.27
R7672:Or10j2 UTSW 1 173,098,440 (GRCm39) missense probably benign 0.18
R8073:Or10j2 UTSW 1 173,098,552 (GRCm39) missense probably benign 0.42
R8116:Or10j2 UTSW 1 173,098,047 (GRCm39) missense possibly damaging 0.88
R8982:Or10j2 UTSW 1 173,098,306 (GRCm39) missense probably damaging 1.00
R9038:Or10j2 UTSW 1 173,098,147 (GRCm39) missense possibly damaging 0.63
R9668:Or10j2 UTSW 1 173,098,183 (GRCm39) missense possibly damaging 0.94
RF032:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF036:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
RF040:Or10j2 UTSW 1 173,098,276 (GRCm39) frame shift probably null
X0019:Or10j2 UTSW 1 173,098,124 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATTGTACCAAGGATGCTCGC -3'
(R):5'- TGAAAACCAAGCCCATGGGTAC -3'

Sequencing Primer
(F):5'- CCAGCCTTGTGGGTTCAAG -3'
(R):5'- ACTATGTCATGCAGAGTGGTATCAGC -3'
Posted On 2016-10-06