Incidental Mutation 'R5459:Oog3'
| ID |
432918 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oog3
|
| Ensembl Gene |
ENSMUSG00000050810 |
| Gene Name |
oogenesin 3 |
| Synonyms |
|
| MMRRC Submission |
043022-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R5459 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
143884126-143889221 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 143885815 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 261
(T261I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000059834
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050933]
|
| AlphaFold |
Q3UWY1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000050933
AA Change: T261I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000059834
Gene: ENSMUSG00000050810
AA Change: T261I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
26 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
42 |
N/A |
INTRINSIC |
|
SCOP:d1a4ya_
|
226 |
428 |
7e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2300002M23Rik |
A |
G |
17: 35,879,079 (GRCm39) |
E139G |
possibly damaging |
Het |
| Abcc6 |
T |
C |
7: 45,631,607 (GRCm39) |
N1223S |
probably benign |
Het |
| Adamts3 |
A |
T |
5: 89,839,332 (GRCm39) |
|
probably null |
Het |
| Aloxe3 |
T |
A |
11: 69,023,654 (GRCm39) |
F259Y |
possibly damaging |
Het |
| Armc9 |
G |
A |
1: 86,135,694 (GRCm39) |
R550Q |
probably damaging |
Het |
| Ctnnd2 |
A |
G |
15: 30,887,334 (GRCm39) |
D787G |
probably damaging |
Het |
| Dnah7b |
A |
G |
1: 46,148,472 (GRCm39) |
I283V |
probably null |
Het |
| Ebf2 |
A |
G |
14: 67,472,650 (GRCm39) |
M23V |
probably benign |
Het |
| Fbxw11 |
T |
C |
11: 32,689,191 (GRCm39) |
V438A |
possibly damaging |
Het |
| Fcrla |
G |
A |
1: 170,745,738 (GRCm39) |
T348M |
possibly damaging |
Het |
| Gpr179 |
A |
T |
11: 97,227,483 (GRCm39) |
H1557Q |
probably benign |
Het |
| Gpr87 |
A |
G |
3: 59,087,148 (GRCm39) |
V119A |
possibly damaging |
Het |
| Grep1 |
C |
T |
17: 23,930,817 (GRCm39) |
|
probably benign |
Het |
| Hfm1 |
A |
G |
5: 107,052,629 (GRCm39) |
S285P |
probably damaging |
Het |
| Hs3st5 |
T |
C |
10: 36,704,742 (GRCm39) |
V15A |
possibly damaging |
Het |
| Hyal5 |
C |
T |
6: 24,891,250 (GRCm39) |
H355Y |
probably damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Map4k3 |
T |
A |
17: 80,917,216 (GRCm39) |
N587Y |
probably damaging |
Het |
| Mcm3ap |
T |
A |
10: 76,332,316 (GRCm39) |
L1211* |
probably null |
Het |
| Mcmdc2 |
A |
G |
1: 10,007,309 (GRCm39) |
I620V |
probably benign |
Het |
| Mical2 |
C |
T |
7: 111,981,444 (GRCm39) |
H539Y |
probably benign |
Het |
| Myo9a |
T |
C |
9: 59,791,803 (GRCm39) |
L1802P |
probably damaging |
Het |
| Neto2 |
T |
A |
8: 86,397,112 (GRCm39) |
I47F |
probably benign |
Het |
| Or5b95 |
A |
G |
19: 12,657,799 (GRCm39) |
E109G |
probably damaging |
Het |
| Pdilt |
A |
G |
7: 119,086,158 (GRCm39) |
L519P |
probably benign |
Het |
| Pnpla6 |
A |
T |
8: 3,585,829 (GRCm39) |
M844L |
probably benign |
Het |
| Polk |
C |
T |
13: 96,631,984 (GRCm39) |
G250R |
probably damaging |
Het |
| Rasal2 |
A |
G |
1: 156,985,231 (GRCm39) |
S839P |
probably damaging |
Het |
| Siae |
T |
C |
9: 37,528,119 (GRCm39) |
Y31H |
probably damaging |
Het |
| Slc27a2 |
T |
C |
2: 126,422,912 (GRCm39) |
V379A |
probably damaging |
Het |
| Snx9 |
C |
T |
17: 5,970,913 (GRCm39) |
T418M |
probably damaging |
Het |
| Spata31e2 |
A |
C |
1: 26,724,272 (GRCm39) |
S303A |
probably damaging |
Het |
| Srp72 |
A |
G |
5: 77,132,185 (GRCm39) |
T258A |
probably benign |
Het |
| Tango6 |
T |
A |
8: 107,576,921 (GRCm39) |
D1058E |
probably damaging |
Het |
| Tecpr1 |
T |
A |
5: 144,144,234 (GRCm39) |
Y656F |
probably damaging |
Het |
| Tnik |
T |
A |
3: 28,715,890 (GRCm39) |
I1168K |
probably damaging |
Het |
| Togaram1 |
A |
G |
12: 65,014,510 (GRCm39) |
E587G |
probably damaging |
Het |
| Tyw1 |
A |
C |
5: 130,303,547 (GRCm39) |
D305A |
probably damaging |
Het |
| Vmn1r19 |
T |
A |
6: 57,381,475 (GRCm39) |
Y9* |
probably null |
Het |
| Zkscan3 |
A |
T |
13: 21,578,982 (GRCm39) |
V142E |
probably damaging |
Het |
|
| Other mutations in Oog3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02413:Oog3
|
APN |
4 |
143,884,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02517:Oog3
|
APN |
4 |
143,885,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02635:Oog3
|
APN |
4 |
143,884,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Oog3
|
UTSW |
4 |
143,884,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Oog3
|
UTSW |
4 |
143,884,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0269:Oog3
|
UTSW |
4 |
143,886,784 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0617:Oog3
|
UTSW |
4 |
143,886,784 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1147:Oog3
|
UTSW |
4 |
143,884,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1147:Oog3
|
UTSW |
4 |
143,884,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1562:Oog3
|
UTSW |
4 |
143,889,169 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1669:Oog3
|
UTSW |
4 |
143,885,008 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1766:Oog3
|
UTSW |
4 |
143,885,692 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R2002:Oog3
|
UTSW |
4 |
143,884,675 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2109:Oog3
|
UTSW |
4 |
143,886,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2394:Oog3
|
UTSW |
4 |
143,885,884 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4615:Oog3
|
UTSW |
4 |
143,884,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4632:Oog3
|
UTSW |
4 |
143,884,698 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Oog3
|
UTSW |
4 |
143,885,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5547:Oog3
|
UTSW |
4 |
143,884,598 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6811:Oog3
|
UTSW |
4 |
143,886,152 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6931:Oog3
|
UTSW |
4 |
143,885,923 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Oog3
|
UTSW |
4 |
143,887,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Oog3
|
UTSW |
4 |
143,889,169 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7312:Oog3
|
UTSW |
4 |
143,886,801 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7486:Oog3
|
UTSW |
4 |
143,884,742 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7622:Oog3
|
UTSW |
4 |
143,884,889 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8782:Oog3
|
UTSW |
4 |
143,885,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8790:Oog3
|
UTSW |
4 |
143,885,710 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8794:Oog3
|
UTSW |
4 |
143,884,556 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9586:Oog3
|
UTSW |
4 |
143,884,966 (GRCm39) |
nonsense |
probably null |
|
|
R9652:Oog3
|
UTSW |
4 |
143,884,489 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9653:Oog3
|
UTSW |
4 |
143,884,489 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Oog3
|
UTSW |
4 |
143,886,206 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Oog3
|
UTSW |
4 |
143,884,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTATCTGGTGTATGACATGACCC -3'
(R):5'- ATACTTGTTGGAGTGGGCCC -3'
Sequencing Primer
(F):5'- GTGTATGACATGACCCCCTCAG -3'
(R):5'- CCTACTCTGCAGAAAGCTGGTAATTG -3'
|
| Posted On |
2016-10-06 |
Incidental Mutation