Incidental Mutation 'R5460:Flrt1'
ID 432996
Institutional Source Beutler Lab
Gene Symbol Flrt1
Ensembl Gene ENSMUSG00000047787
Gene Name fibronectin leucine rich transmembrane protein 1
Synonyms D630040I23Rik
MMRRC Submission 042849-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R5460 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 7069366-7083094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 7073105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 481 (T481A)
Ref Sequence ENSEMBL: ENSMUSP00000109010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040261
SMART Domains Protein: ENSMUSP00000039507
Gene: ENSMUSG00000036278

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 25 41 N/A INTRINSIC
low complexity region 59 74 N/A INTRINSIC
A1pp 151 281 7.67e-46 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000113383
AA Change: T481A

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000109010
Gene: ENSMUSG00000047787
AA Change: T481A

DomainStartEndE-ValueType
low complexity region 2 28 N/A INTRINSIC
LRRNT 53 85 4.11e-6 SMART
LRR 127 149 2.61e1 SMART
LRR 150 175 4.71e1 SMART
LRR 177 199 1.76e1 SMART
LRR 200 220 7.36e0 SMART
LRR 221 246 1.49e1 SMART
LRR 247 270 9.77e1 SMART
LRR 271 292 1.53e1 SMART
LRR_TYP 293 316 3.55e-6 SMART
LRRCT 328 379 5.19e-9 SMART
low complexity region 381 392 N/A INTRINSIC
FN3 434 515 1.49e0 SMART
transmembrane domain 556 578 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,392,238 (GRCm39) M191K probably benign Het
Actn1 T C 12: 80,230,342 (GRCm39) N304S probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adamtsl2 T A 2: 26,985,410 (GRCm39) probably null Het
Adgrv1 T C 13: 81,572,377 (GRCm39) E4928G possibly damaging Het
Alms1 T A 6: 85,673,713 (GRCm39) C3103S probably benign Het
Appl2 T A 10: 83,438,696 (GRCm39) I578F probably benign Het
Atp10b T C 11: 43,121,282 (GRCm39) S982P probably benign Het
Brd10 G T 19: 29,732,250 (GRCm39) P254Q probably damaging Het
Capn7 T C 14: 31,090,160 (GRCm39) probably null Het
Cd200r3 A G 16: 44,778,093 (GRCm39) T166A possibly damaging Het
Dctn6 C T 8: 34,572,135 (GRCm39) probably null Het
Duxf4 G A 10: 58,071,717 (GRCm39) H166Y possibly damaging Het
Fam114a1 T A 5: 65,185,776 (GRCm39) F366I probably damaging Het
Fam98b A T 2: 117,089,737 (GRCm39) S85C probably damaging Het
Fat3 T A 9: 15,830,463 (GRCm39) N4344Y probably damaging Het
Fhl3 T G 4: 124,599,796 (GRCm39) C92W probably damaging Het
Gng2 G T 14: 19,941,426 (GRCm39) N5K probably benign Het
Iqcm A T 8: 76,441,417 (GRCm39) D230V probably benign Het
Limk2 T C 11: 3,302,332 (GRCm39) I176V probably benign Het
Lrrk2 T A 15: 91,698,847 (GRCm39) probably null Het
Maml1 T C 11: 50,157,180 (GRCm39) T332A probably benign Het
Matcap2 T C 9: 22,351,216 (GRCm39) F453L probably benign Het
Mbd1 T C 18: 74,402,581 (GRCm39) F28L probably benign Het
Morf4l1 G A 9: 89,977,183 (GRCm39) T246I probably benign Het
Mtres1 T C 10: 43,408,861 (GRCm39) K94R probably benign Het
Naa12 C T 18: 80,255,138 (GRCm39) A144V probably damaging Het
Ndufaf1 T G 2: 119,490,958 (GRCm39) D34A probably benign Het
Or4a77 T A 2: 89,487,414 (GRCm39) I124F probably damaging Het
Or4c114 C T 2: 88,905,208 (GRCm39) V76I probably benign Het
Patl1 C T 19: 11,913,082 (GRCm39) R542C possibly damaging Het
Pcdha2 T C 18: 37,072,474 (GRCm39) V35A probably damaging Het
Phf11b G A 14: 59,568,713 (GRCm39) P67S probably benign Het
Plxnd1 T C 6: 115,934,609 (GRCm39) I1775V probably damaging Het
Ryr1 T A 7: 28,771,386 (GRCm39) T2552S probably damaging Het
Scai A T 2: 38,973,585 (GRCm39) L52H probably damaging Het
Scai G C 2: 38,973,586 (GRCm39) L52V probably damaging Het
Stag1 A T 9: 100,838,506 (GRCm39) probably null Het
Tgs1 A G 4: 3,586,170 (GRCm39) K349R probably benign Het
Tpbgl T C 7: 99,274,961 (GRCm39) I299V probably benign Het
Ttc3 A G 16: 94,258,241 (GRCm39) T1325A probably benign Het
Ubxn11 A T 4: 133,852,396 (GRCm39) E210D probably damaging Het
Unc13c T C 9: 73,453,271 (GRCm39) I1840V probably benign Het
Zfp74 A T 7: 29,635,316 (GRCm39) F131I probably benign Het
Other mutations in Flrt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Flrt1 APN 19 7,074,277 (GRCm39) missense probably damaging 1.00
IGL01082:Flrt1 APN 19 7,073,339 (GRCm39) missense probably benign
IGL02535:Flrt1 APN 19 7,074,098 (GRCm39) missense probably benign 0.00
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0403:Flrt1 UTSW 19 7,073,284 (GRCm39) missense probably benign 0.01
R0645:Flrt1 UTSW 19 7,074,508 (GRCm39) intron probably benign
R0677:Flrt1 UTSW 19 7,073,544 (GRCm39) nonsense probably null
R1818:Flrt1 UTSW 19 7,072,711 (GRCm39) missense probably damaging 1.00
R2191:Flrt1 UTSW 19 7,073,194 (GRCm39) missense probably damaging 0.99
R2228:Flrt1 UTSW 19 7,072,723 (GRCm39) missense probably damaging 1.00
R2471:Flrt1 UTSW 19 7,073,856 (GRCm39) missense probably damaging 1.00
R4978:Flrt1 UTSW 19 7,074,241 (GRCm39) missense probably damaging 1.00
R5630:Flrt1 UTSW 19 7,073,830 (GRCm39) missense probably damaging 1.00
R6326:Flrt1 UTSW 19 7,073,974 (GRCm39) missense probably damaging 1.00
R6734:Flrt1 UTSW 19 7,073,524 (GRCm39) missense possibly damaging 0.91
R6905:Flrt1 UTSW 19 7,072,757 (GRCm39) nonsense probably null
R7239:Flrt1 UTSW 19 7,073,329 (GRCm39) missense probably benign 0.12
R7799:Flrt1 UTSW 19 7,073,229 (GRCm39) missense possibly damaging 0.78
R8168:Flrt1 UTSW 19 7,074,002 (GRCm39) missense probably damaging 1.00
X0024:Flrt1 UTSW 19 7,073,114 (GRCm39) missense probably damaging 1.00
X0062:Flrt1 UTSW 19 7,074,244 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TAGGGCCAGCATTCTGTTCC -3'
(R):5'- TTTACCCTCAAGGCCAAGAG -3'

Sequencing Primer
(F):5'- CCAGCATTCTGTTCCTGGTTGAG -3'
(R):5'- CAAGAGGCCAGGACTGC -3'
Posted On 2016-10-06