Incidental Mutation 'R5462:Nt5m'
ID |
433075 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nt5m
|
Ensembl Gene |
ENSMUSG00000032615 |
Gene Name |
5',3'-nucleotidase, mitochondrial |
Synonyms |
dNT-2, 2010013E09Rik |
MMRRC Submission |
043024-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.076)
|
Stock # |
R5462 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
59730233-59767359 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 59765385 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tryptophan to Arginine
at position 138
(W138R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099756
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102695]
|
AlphaFold |
Q8VCE6 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000102695
AA Change: W138R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000099756 Gene: ENSMUSG00000032615 AA Change: W138R
Domain | Start | End | E-Value | Type |
Pfam:NT5C
|
26 |
219 |
2.9e-30 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137695
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149076
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154699
|
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.5%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930562C15Rik |
G |
A |
16: 4,682,227 (GRCm39) |
G180E |
probably damaging |
Het |
4933412E24Rik |
A |
G |
15: 59,886,917 (GRCm39) |
F508L |
probably benign |
Het |
Acyp2 |
C |
T |
11: 30,456,354 (GRCm39) |
E98K |
possibly damaging |
Het |
Amz1 |
A |
G |
5: 140,733,976 (GRCm39) |
Y184C |
probably damaging |
Het |
Calm3 |
A |
T |
7: 16,651,619 (GRCm39) |
D23E |
possibly damaging |
Het |
Cep112 |
T |
A |
11: 108,409,570 (GRCm39) |
N479K |
probably damaging |
Het |
Cfap251 |
T |
C |
5: 123,436,695 (GRCm39) |
|
probably null |
Het |
Csmd1 |
A |
C |
8: 16,011,486 (GRCm39) |
N2522K |
probably benign |
Het |
Dhx30 |
A |
G |
9: 109,930,042 (GRCm39) |
L18P |
probably damaging |
Het |
E2f2 |
A |
T |
4: 135,900,224 (GRCm39) |
T45S |
probably benign |
Het |
Grk3 |
T |
C |
5: 113,117,074 (GRCm39) |
Y67C |
probably damaging |
Het |
Htt |
T |
A |
5: 35,042,851 (GRCm39) |
C2290* |
probably null |
Het |
Igsf10 |
T |
C |
3: 59,233,175 (GRCm39) |
T1853A |
probably damaging |
Het |
Kmt2d |
G |
A |
15: 98,749,990 (GRCm39) |
|
probably benign |
Het |
Mast2 |
A |
G |
4: 116,164,655 (GRCm39) |
L1587P |
probably damaging |
Het |
Mdn1 |
A |
G |
4: 32,720,897 (GRCm39) |
N2337D |
probably benign |
Het |
Mettl3 |
T |
C |
14: 52,537,336 (GRCm39) |
Q182R |
probably damaging |
Het |
Mterf1b |
A |
G |
5: 4,246,541 (GRCm39) |
S61G |
probably benign |
Het |
Mycbp2 |
T |
C |
14: 103,437,562 (GRCm39) |
Y2100C |
probably damaging |
Het |
Or5g29 |
A |
G |
2: 85,421,640 (GRCm39) |
Y252C |
probably damaging |
Het |
Prex1 |
A |
G |
2: 166,486,728 (GRCm39) |
Y114H |
probably benign |
Het |
Rasa2 |
A |
T |
9: 96,453,971 (GRCm39) |
S322T |
probably damaging |
Het |
Sis |
A |
T |
3: 72,857,171 (GRCm39) |
D373E |
probably damaging |
Het |
Snx29 |
A |
T |
16: 11,328,876 (GRCm39) |
M552L |
possibly damaging |
Het |
Sptbn1 |
G |
T |
11: 30,050,520 (GRCm39) |
F2356L |
possibly damaging |
Het |
Tbc1d10c |
G |
T |
19: 4,238,052 (GRCm39) |
Q241K |
probably benign |
Het |
Vmn1r222 |
A |
G |
13: 23,417,045 (GRCm39) |
I56T |
probably benign |
Het |
Vmn2r111 |
T |
C |
17: 22,767,238 (GRCm39) |
Y753C |
probably damaging |
Het |
Vmn2r37 |
A |
G |
7: 9,220,973 (GRCm39) |
W297R |
probably damaging |
Het |
Zbtb47 |
G |
T |
9: 121,596,729 (GRCm39) |
R695L |
probably damaging |
Het |
Zfp267 |
C |
T |
3: 36,219,969 (GRCm39) |
T664I |
possibly damaging |
Het |
|
Other mutations in Nt5m |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
PIT4520001:Nt5m
|
UTSW |
11 |
59,765,415 (GRCm39) |
missense |
probably benign |
0.31 |
R0442:Nt5m
|
UTSW |
11 |
59,765,445 (GRCm39) |
missense |
possibly damaging |
0.92 |
R2201:Nt5m
|
UTSW |
11 |
59,766,741 (GRCm39) |
missense |
probably benign |
0.14 |
R2237:Nt5m
|
UTSW |
11 |
59,743,696 (GRCm39) |
missense |
probably benign |
0.00 |
R4487:Nt5m
|
UTSW |
11 |
59,739,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R4976:Nt5m
|
UTSW |
11 |
59,765,381 (GRCm39) |
nonsense |
probably null |
|
R5156:Nt5m
|
UTSW |
11 |
59,765,487 (GRCm39) |
missense |
probably damaging |
1.00 |
R5476:Nt5m
|
UTSW |
11 |
59,766,733 (GRCm39) |
missense |
probably damaging |
0.96 |
R5687:Nt5m
|
UTSW |
11 |
59,743,649 (GRCm39) |
missense |
probably benign |
0.31 |
R7982:Nt5m
|
UTSW |
11 |
59,739,157 (GRCm39) |
missense |
possibly damaging |
0.61 |
Z1177:Nt5m
|
UTSW |
11 |
59,765,382 (GRCm39) |
missense |
probably benign |
0.05 |
|
Predicted Primers |
PCR Primer
(F):5'- TTCTAGGGGACAAGTATGCAGG -3'
(R):5'- AACCTCCTGGCTGGGTATTG -3'
Sequencing Primer
(F):5'- GTATGCAGGTACACAGCTCC -3'
(R):5'- CTCCTGGCTGGGTATTGCTAAATAC -3'
|
Posted On |
2016-10-06 |