Incidental Mutation 'R5464:Crot'
ID 433154
Institutional Source Beutler Lab
Gene Symbol Crot
Ensembl Gene ENSMUSG00000003623
Gene Name carnitine O-octanoyltransferase
Synonyms 1200003H03Rik
MMRRC Submission 042850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5464 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 9016033-9047324 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 9033690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000003720 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003720]
AlphaFold Q9DC50
PDB Structure Crystal Structure of Mouse Carnitine Octanoyltransferase [X-RAY DIFFRACTION]
Crystal structure of mouse carnitine octanoyltransferase in complex with octanoylcarnitine [X-RAY DIFFRACTION]
C323M mutant structure of mouse carnitine octanoyltransferase [X-RAY DIFFRACTION]
M335V mutant structure of mouse carnitine octanoyltransferase [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000003720
SMART Domains Protein: ENSMUSP00000003720
Gene: ENSMUSG00000003623

DomainStartEndE-ValueType
Pfam:Carn_acyltransf 20 604 2.3e-167 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157024
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G A 16: 4,682,227 (GRCm39) G180E probably damaging Het
Acsl1 T A 8: 46,958,775 (GRCm39) D95E probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adamts16 T A 13: 70,909,868 (GRCm39) H895L probably benign Het
Alox12e T C 11: 70,208,505 (GRCm39) Y483C probably damaging Het
Atp13a2 T A 4: 140,733,381 (GRCm39) F952I probably damaging Het
Dnaja1 T A 4: 40,724,133 (GRCm39) M98K probably benign Het
Eps8 C T 6: 137,504,473 (GRCm39) G87R probably damaging Het
Flg2 C A 3: 93,109,277 (GRCm39) T435K possibly damaging Het
Gpatch4 T C 3: 87,962,062 (GRCm39) probably null Het
Heatr1 T A 13: 12,448,524 (GRCm39) M1795K probably benign Het
Ift52 T C 2: 162,871,735 (GRCm39) V189A probably benign Het
Kif21a T A 15: 90,878,058 (GRCm39) D250V probably damaging Het
Lrrc66 T C 5: 73,765,622 (GRCm39) T474A probably benign Het
Mcub T C 3: 129,709,365 (GRCm39) E316G probably benign Het
Mettl15 C T 2: 109,021,967 (GRCm39) V113I probably benign Het
Mroh8 T A 2: 157,063,150 (GRCm39) I824F probably damaging Het
Mrpl19 A G 6: 81,938,992 (GRCm39) M270T probably damaging Het
Naa12 C T 18: 80,255,138 (GRCm39) A144V probably damaging Het
Or10d4 A T 9: 39,581,066 (GRCm39) T238S probably damaging Het
Or4ac1-ps1 T C 2: 88,370,599 (GRCm39) Y58C probably null Het
Or51a25 A G 7: 102,373,124 (GRCm39) V191A possibly damaging Het
Or51a39 T C 7: 102,362,889 (GRCm39) T244A probably benign Het
Or51a43 C A 7: 103,717,674 (GRCm39) R188L possibly damaging Het
Or51f5 A G 7: 102,424,640 (GRCm39) K303R probably benign Het
Or52a24 T A 7: 103,381,396 (GRCm39) W88R probably damaging Het
Or5ak23 AAGTCTGGAGTC AAGTC 2: 85,245,057 (GRCm39) probably null Het
Or6x1 T C 9: 40,099,080 (GRCm39) I223T probably damaging Het
Pacs1 T C 19: 5,197,235 (GRCm39) M430V probably benign Het
Piezo2 A G 18: 63,278,176 (GRCm39) S243P probably damaging Het
Ppp1r36 A T 12: 76,474,852 (GRCm39) probably null Het
Prdm16 T A 4: 154,430,601 (GRCm39) probably null Het
Prss36 A T 7: 127,533,405 (GRCm39) W97R probably damaging Het
Psmg4 A T 13: 34,362,047 (GRCm39) I112F probably damaging Het
Ptpru C T 4: 131,499,868 (GRCm39) G1259R probably damaging Het
Rsph4a T C 10: 33,785,337 (GRCm39) I416T possibly damaging Het
Scn2a C T 2: 65,532,100 (GRCm39) R571C probably damaging Het
Selenbp1 A G 3: 94,851,727 (GRCm39) M423V probably benign Het
Serpina3i G A 12: 104,234,751 (GRCm39) A361T possibly damaging Het
Serpinb3c A T 1: 107,199,434 (GRCm39) D362E probably damaging Het
Sf3a3 T C 4: 124,622,033 (GRCm39) probably null Het
Sgcg A G 14: 61,474,304 (GRCm39) V113A possibly damaging Het
Slc3a2 T C 19: 8,691,008 (GRCm39) K74R probably damaging Het
Smco1 T A 16: 32,092,694 (GRCm39) W122R probably damaging Het
Snx19 A G 9: 30,339,269 (GRCm39) K136E possibly damaging Het
Trim32 A G 4: 65,532,625 (GRCm39) N394S probably damaging Het
Uqcrb T C 13: 67,048,889 (GRCm39) D87G probably damaging Het
Wipf3 T C 6: 54,462,308 (GRCm39) S173P possibly damaging Het
Zfp473 T C 7: 44,382,062 (GRCm39) E756G probably damaging Het
Other mutations in Crot
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00756:Crot APN 5 9,026,072 (GRCm39) missense probably damaging 1.00
IGL01013:Crot APN 5 9,043,575 (GRCm39) missense probably benign 0.06
IGL01085:Crot APN 5 9,023,955 (GRCm39) missense probably damaging 1.00
IGL02017:Crot APN 5 9,020,046 (GRCm39) splice site probably benign
IGL02306:Crot APN 5 9,018,701 (GRCm39) missense possibly damaging 0.94
IGL02612:Crot APN 5 9,019,945 (GRCm39) missense probably damaging 1.00
IGL02884:Crot APN 5 9,028,197 (GRCm39) critical splice donor site probably null
IGL03091:Crot APN 5 9,016,897 (GRCm39) missense probably benign
IGL03356:Crot APN 5 9,038,295 (GRCm39) splice site probably benign
ouray UTSW 5 9,043,504 (GRCm39) critical splice donor site probably null
R0383:Crot UTSW 5 9,018,734 (GRCm39) missense probably damaging 1.00
R0396:Crot UTSW 5 9,019,959 (GRCm39) missense probably damaging 1.00
R0502:Crot UTSW 5 9,026,075 (GRCm39) missense possibly damaging 0.66
R0503:Crot UTSW 5 9,026,075 (GRCm39) missense possibly damaging 0.66
R0676:Crot UTSW 5 9,043,622 (GRCm39) utr 5 prime probably benign
R1079:Crot UTSW 5 9,043,504 (GRCm39) critical splice donor site probably null
R1472:Crot UTSW 5 9,016,941 (GRCm39) missense probably damaging 1.00
R1595:Crot UTSW 5 9,024,186 (GRCm39) missense probably benign 0.00
R1757:Crot UTSW 5 9,037,828 (GRCm39) missense probably damaging 1.00
R1828:Crot UTSW 5 9,019,080 (GRCm39) missense probably benign 0.01
R1846:Crot UTSW 5 9,038,248 (GRCm39) missense probably benign 0.36
R2142:Crot UTSW 5 9,037,780 (GRCm39) missense possibly damaging 0.94
R3973:Crot UTSW 5 9,027,541 (GRCm39) missense probably benign
R3974:Crot UTSW 5 9,027,541 (GRCm39) missense probably benign
R3975:Crot UTSW 5 9,027,541 (GRCm39) missense probably benign
R4445:Crot UTSW 5 9,023,643 (GRCm39) missense probably damaging 1.00
R4446:Crot UTSW 5 9,023,643 (GRCm39) missense probably damaging 1.00
R4995:Crot UTSW 5 9,024,000 (GRCm39) missense probably damaging 1.00
R5084:Crot UTSW 5 9,019,994 (GRCm39) missense probably damaging 1.00
R5673:Crot UTSW 5 9,038,131 (GRCm39) missense probably benign 0.00
R5814:Crot UTSW 5 9,023,996 (GRCm39) missense probably damaging 0.99
R5935:Crot UTSW 5 9,024,192 (GRCm39) missense probably benign
R5951:Crot UTSW 5 9,019,120 (GRCm39) nonsense probably null
R6862:Crot UTSW 5 9,039,641 (GRCm39) missense probably damaging 0.99
R6885:Crot UTSW 5 9,023,635 (GRCm39) missense probably benign 0.00
R6983:Crot UTSW 5 9,028,280 (GRCm39) missense probably benign 0.06
R7150:Crot UTSW 5 9,037,878 (GRCm39) missense probably damaging 0.99
R7228:Crot UTSW 5 9,026,051 (GRCm39) missense probably damaging 1.00
R7361:Crot UTSW 5 9,027,534 (GRCm39) missense probably damaging 1.00
R7662:Crot UTSW 5 9,019,072 (GRCm39) missense probably damaging 1.00
R7747:Crot UTSW 5 9,018,869 (GRCm39) critical splice donor site probably null
R8002:Crot UTSW 5 9,043,599 (GRCm39) missense probably benign 0.36
R8105:Crot UTSW 5 9,027,505 (GRCm39) missense probably damaging 0.99
R8233:Crot UTSW 5 9,026,027 (GRCm39) missense possibly damaging 0.77
R8474:Crot UTSW 5 9,043,518 (GRCm39) missense probably damaging 1.00
R8519:Crot UTSW 5 9,023,629 (GRCm39) missense probably benign
R8734:Crot UTSW 5 9,028,208 (GRCm39) missense probably benign 0.02
R9528:Crot UTSW 5 9,043,575 (GRCm39) missense possibly damaging 0.46
R9649:Crot UTSW 5 9,024,170 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CTGGTCAAACTCCATGAATCAC -3'
(R):5'- GTGAGCACTTTGTCTAGAAGATTC -3'

Sequencing Primer
(F):5'- CAACAAAACAAAATGTCATGAATGTG -3'
(R):5'- GTGAAGGGCATTGTCCAA -3'
Posted On 2016-10-06