Incidental Mutation 'R5464:Or51a25'
ID 433162
Institutional Source Beutler Lab
Gene Symbol Or51a25
Ensembl Gene ENSMUSG00000066272
Gene Name olfactory receptor family 51 subfamily A member 25
Synonyms MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
MMRRC Submission 042850-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5464 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 102372739-102373695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102373124 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 191 (V191A)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657] [ENSMUST00000216312]
AlphaFold Q8VH14
Predicted Effect possibly damaging
Transcript: ENSMUST00000084816
AA Change: V191A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: V191A

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215657
AA Change: V191A

PolyPhen 2 Score 0.846 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000216312
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik G A 16: 4,682,227 (GRCm39) G180E probably damaging Het
Acsl1 T A 8: 46,958,775 (GRCm39) D95E probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adamts16 T A 13: 70,909,868 (GRCm39) H895L probably benign Het
Alox12e T C 11: 70,208,505 (GRCm39) Y483C probably damaging Het
Atp13a2 T A 4: 140,733,381 (GRCm39) F952I probably damaging Het
Crot T G 5: 9,033,690 (GRCm39) probably null Het
Dnaja1 T A 4: 40,724,133 (GRCm39) M98K probably benign Het
Eps8 C T 6: 137,504,473 (GRCm39) G87R probably damaging Het
Flg2 C A 3: 93,109,277 (GRCm39) T435K possibly damaging Het
Gpatch4 T C 3: 87,962,062 (GRCm39) probably null Het
Heatr1 T A 13: 12,448,524 (GRCm39) M1795K probably benign Het
Ift52 T C 2: 162,871,735 (GRCm39) V189A probably benign Het
Kif21a T A 15: 90,878,058 (GRCm39) D250V probably damaging Het
Lrrc66 T C 5: 73,765,622 (GRCm39) T474A probably benign Het
Mcub T C 3: 129,709,365 (GRCm39) E316G probably benign Het
Mettl15 C T 2: 109,021,967 (GRCm39) V113I probably benign Het
Mroh8 T A 2: 157,063,150 (GRCm39) I824F probably damaging Het
Mrpl19 A G 6: 81,938,992 (GRCm39) M270T probably damaging Het
Naa12 C T 18: 80,255,138 (GRCm39) A144V probably damaging Het
Or10d4 A T 9: 39,581,066 (GRCm39) T238S probably damaging Het
Or4ac1-ps1 T C 2: 88,370,599 (GRCm39) Y58C probably null Het
Or51a39 T C 7: 102,362,889 (GRCm39) T244A probably benign Het
Or51a43 C A 7: 103,717,674 (GRCm39) R188L possibly damaging Het
Or51f5 A G 7: 102,424,640 (GRCm39) K303R probably benign Het
Or52a24 T A 7: 103,381,396 (GRCm39) W88R probably damaging Het
Or5ak23 AAGTCTGGAGTC AAGTC 2: 85,245,057 (GRCm39) probably null Het
Or6x1 T C 9: 40,099,080 (GRCm39) I223T probably damaging Het
Pacs1 T C 19: 5,197,235 (GRCm39) M430V probably benign Het
Piezo2 A G 18: 63,278,176 (GRCm39) S243P probably damaging Het
Ppp1r36 A T 12: 76,474,852 (GRCm39) probably null Het
Prdm16 T A 4: 154,430,601 (GRCm39) probably null Het
Prss36 A T 7: 127,533,405 (GRCm39) W97R probably damaging Het
Psmg4 A T 13: 34,362,047 (GRCm39) I112F probably damaging Het
Ptpru C T 4: 131,499,868 (GRCm39) G1259R probably damaging Het
Rsph4a T C 10: 33,785,337 (GRCm39) I416T possibly damaging Het
Scn2a C T 2: 65,532,100 (GRCm39) R571C probably damaging Het
Selenbp1 A G 3: 94,851,727 (GRCm39) M423V probably benign Het
Serpina3i G A 12: 104,234,751 (GRCm39) A361T possibly damaging Het
Serpinb3c A T 1: 107,199,434 (GRCm39) D362E probably damaging Het
Sf3a3 T C 4: 124,622,033 (GRCm39) probably null Het
Sgcg A G 14: 61,474,304 (GRCm39) V113A possibly damaging Het
Slc3a2 T C 19: 8,691,008 (GRCm39) K74R probably damaging Het
Smco1 T A 16: 32,092,694 (GRCm39) W122R probably damaging Het
Snx19 A G 9: 30,339,269 (GRCm39) K136E possibly damaging Het
Trim32 A G 4: 65,532,625 (GRCm39) N394S probably damaging Het
Uqcrb T C 13: 67,048,889 (GRCm39) D87G probably damaging Het
Wipf3 T C 6: 54,462,308 (GRCm39) S173P possibly damaging Het
Zfp473 T C 7: 44,382,062 (GRCm39) E756G probably damaging Het
Other mutations in Or51a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Or51a25 APN 7 102,372,858 (GRCm39) missense probably benign 0.01
R0505:Or51a25 UTSW 7 102,373,236 (GRCm39) missense probably damaging 0.97
R1131:Or51a25 UTSW 7 102,372,887 (GRCm39) missense probably damaging 0.99
R1449:Or51a25 UTSW 7 102,373,397 (GRCm39) missense probably damaging 1.00
R3788:Or51a25 UTSW 7 102,372,694 (GRCm39) splice site probably null
R3915:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R3980:Or51a25 UTSW 7 102,372,959 (GRCm39) missense probably damaging 0.98
R4647:Or51a25 UTSW 7 102,373,299 (GRCm39) missense probably damaging 1.00
R5242:Or51a25 UTSW 7 102,373,483 (GRCm39) missense probably benign 0.41
R5404:Or51a25 UTSW 7 102,372,807 (GRCm39) missense possibly damaging 0.95
R5807:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R5965:Or51a25 UTSW 7 102,373,467 (GRCm39) missense probably benign 0.00
R6008:Or51a25 UTSW 7 102,373,574 (GRCm39) missense probably damaging 1.00
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6036:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R6493:Or51a25 UTSW 7 102,373,287 (GRCm39) missense possibly damaging 0.85
R6756:Or51a25 UTSW 7 102,373,295 (GRCm39) missense probably benign 0.03
R7201:Or51a25 UTSW 7 102,373,692 (GRCm39) missense probably benign
R7460:Or51a25 UTSW 7 102,373,028 (GRCm39) missense probably benign 0.09
R7695:Or51a25 UTSW 7 102,372,866 (GRCm39) missense probably benign 0.37
R8145:Or51a25 UTSW 7 102,372,937 (GRCm39) missense probably damaging 0.98
R8371:Or51a25 UTSW 7 102,372,790 (GRCm39) missense probably damaging 1.00
R8499:Or51a25 UTSW 7 102,372,932 (GRCm39) missense probably damaging 1.00
R9185:Or51a25 UTSW 7 102,373,409 (GRCm39) missense possibly damaging 0.95
R9230:Or51a25 UTSW 7 102,372,795 (GRCm39) missense possibly damaging 0.95
X0025:Or51a25 UTSW 7 102,373,022 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTAGAAGACCAGGACAGCC -3'
(R):5'- TGACCGCTTTGTGGCTATC -3'

Sequencing Primer
(F):5'- CCAAGATATGGGAAACACATGTG -3'
(R):5'- GTGGCTATCTCCAACCCACTG -3'
Posted On 2016-10-06