Incidental Mutation 'R5467:Trav13n-4'
ID 433295
Institutional Source Beutler Lab
Gene Symbol Trav13n-4
Ensembl Gene ENSMUSG00000076823
Gene Name T cell receptor alpha variable 13N-4
Synonyms Gm10907, ENSMUSG00000072517
MMRRC Submission 043028-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5467 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 53599825-53601563 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 53601303 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 24 (V24E)
Ref Sequence ENSEMBL: ENSMUSP00000143372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103634] [ENSMUST00000196105]
AlphaFold A0A075B635
Predicted Effect probably damaging
Transcript: ENSMUST00000103634
AA Change: V4E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000100411
Gene: ENSMUSG00000076823
AA Change: V4E

DomainStartEndE-ValueType
IGv 18 89 2.89e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000196105
AA Change: V24E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000143372
Gene: ENSMUSG00000076823
AA Change: V24E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 38 109 1.2e-11 SMART
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.2%
  • 10x: 94.9%
  • 20x: 89.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 A G 12: 80,222,991 (GRCm39) M525T possibly damaging Het
Arpc5l T C 2: 38,903,751 (GRCm39) V80A possibly damaging Het
Atp7b G A 8: 22,501,570 (GRCm39) T781I probably damaging Het
Bltp3b G T 10: 89,640,961 (GRCm39) G711W probably damaging Het
Celsr3 A T 9: 108,705,836 (GRCm39) D773V probably damaging Het
Clcn6 A T 4: 148,102,093 (GRCm39) H330Q possibly damaging Het
Cwc22 ATCTCTCTCTCTCTCTCT ATCTCTCTCTCTCTCT 2: 77,759,803 (GRCm39) probably null Het
Dmbt1 C A 7: 130,642,723 (GRCm39) S180R probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Elovl7 T C 13: 108,416,156 (GRCm39) V182A probably benign Het
Eml3 G A 19: 8,914,946 (GRCm39) W601* probably null Het
Farp1 C T 14: 121,472,489 (GRCm39) P208L probably damaging Het
Fras1 A T 5: 96,927,912 (GRCm39) Y3775F probably benign Het
Gns T C 10: 121,227,351 (GRCm39) W454R probably benign Het
Katnip T C 7: 125,442,527 (GRCm39) F812S possibly damaging Het
Kcnh2 A T 5: 24,531,765 (GRCm39) L40* probably null Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Lrrc37 G T 11: 103,494,091 (GRCm39) C655* probably null Het
Mgl2 T A 11: 70,025,878 (GRCm39) I31N possibly damaging Het
Muc6 T C 7: 141,216,448 (GRCm39) T2677A possibly damaging Het
Ndst1 A G 18: 60,825,093 (GRCm39) S742P probably benign Het
Or10g6 G T 9: 39,933,733 (GRCm39) V15L probably benign Het
Or1o11 G T 17: 37,756,973 (GRCm39) C187F probably damaging Het
Or4d6 A C 19: 12,086,023 (GRCm39) S70A probably benign Het
Or5b112 A T 19: 13,319,521 (GRCm39) Y133F probably damaging Het
Or8g21 T C 9: 38,906,200 (GRCm39) Y177C probably benign Het
Pcdhb22 A G 18: 37,653,188 (GRCm39) D552G probably benign Het
Pikfyve T A 1: 65,291,654 (GRCm39) V1291E probably damaging Het
Ppp4r3a T C 12: 101,009,729 (GRCm39) E636G probably damaging Het
Prl5a1 A T 13: 28,333,994 (GRCm39) I166L possibly damaging Het
Rb1 T C 14: 73,449,060 (GRCm39) D690G possibly damaging Het
Sh3tc2 A G 18: 62,123,759 (GRCm39) H840R possibly damaging Het
Skida1 T C 2: 18,050,923 (GRCm39) probably benign Het
Slc31a2 A G 4: 62,210,924 (GRCm39) H19R probably damaging Het
Styxl2 C A 1: 165,939,599 (GRCm39) probably null Het
Tnks2 A T 19: 36,859,176 (GRCm39) R314W probably damaging Het
Trak1 A G 9: 121,275,864 (GRCm39) D189G probably damaging Het
Ylpm1 T C 12: 85,043,633 (GRCm39) Y124H unknown Het
Zfp703 C T 8: 27,469,233 (GRCm39) P299L probably damaging Het
Other mutations in Trav13n-4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Trav13n-4 APN 14 53,601,288 (GRCm39) missense probably benign 0.03
IGL00562:Trav13n-4 APN 14 53,601,423 (GRCm39) missense possibly damaging 0.94
IGL00563:Trav13n-4 APN 14 53,601,423 (GRCm39) missense possibly damaging 0.94
IGL01620:Trav13n-4 APN 14 53,601,473 (GRCm39) missense probably damaging 0.99
IGL01748:Trav13n-4 APN 14 53,601,470 (GRCm39) missense probably benign 0.15
IGL02327:Trav13n-4 APN 14 53,601,567 (GRCm39) unclassified probably benign
R4197:Trav13n-4 UTSW 14 53,601,378 (GRCm39) missense probably benign
R6765:Trav13n-4 UTSW 14 53,601,557 (GRCm39) missense probably benign
R6845:Trav13n-4 UTSW 14 53,599,856 (GRCm39) missense probably damaging 1.00
R7339:Trav13n-4 UTSW 14 53,601,435 (GRCm39) missense probably benign 0.02
R8744:Trav13n-4 UTSW 14 53,601,399 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CCAGAGTGGTTGTACAAGCTTG -3'
(R):5'- GTTGTGGATGTCAGTCTCCCAC -3'

Sequencing Primer
(F):5'- GGTTGTACAAGCTTGCAATCC -3'
(R):5'- ACTCTGCTTTGTCCCAGAAGG -3'
Posted On 2016-10-06