Incidental Mutation 'R5468:Wnt16'
ID 433331
Institutional Source Beutler Lab
Gene Symbol Wnt16
Ensembl Gene ENSMUSG00000029671
Gene Name wingless-type MMTV integration site family, member 16
Synonyms E130309I19Rik
MMRRC Submission 043029-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5468 (G1)
Quality Score 199
Status Not validated
Chromosome 6
Chromosomal Location 22288226-22298521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22291160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 196 (V196A)
Ref Sequence ENSEMBL: ENSMUSP00000135016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031681] [ENSMUST00000128245] [ENSMUST00000148639]
AlphaFold Q9QYS1
Predicted Effect probably benign
Transcript: ENSMUST00000031681
AA Change: V196A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000031681
Gene: ENSMUSG00000029671
AA Change: V196A

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 364 1.13e-146 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000128245
AA Change: V196A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000134822
Gene: ENSMUSG00000029671
AA Change: V196A

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.04e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148639
AA Change: V196A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000135016
Gene: ENSMUSG00000029671
AA Change: V196A

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
WNT1 48 225 1.61e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176681
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700008O03Rik C T 7: 44,009,659 (GRCm39) R181Q probably damaging Het
Abca13 T A 11: 9,244,062 (GRCm39) L1975Q probably damaging Het
Acp2 T A 2: 91,036,443 (GRCm39) I180N probably benign Het
Adam12 T C 7: 133,577,202 (GRCm39) D221G probably damaging Het
Adamts4 A G 1: 171,080,178 (GRCm39) T244A probably benign Het
Adrb2 A T 18: 62,312,696 (GRCm39) I43N probably damaging Het
Anxa1 A T 19: 20,355,847 (GRCm39) Y207N probably damaging Het
Apba2 T C 7: 64,395,510 (GRCm39) L662P probably damaging Het
Arhgap18 T A 10: 26,788,667 (GRCm39) I593K probably damaging Het
Arsj T C 3: 126,232,037 (GRCm39) V261A possibly damaging Het
Atp7b A T 8: 22,549,986 (GRCm39) probably null Het
C2cd2 C T 16: 97,669,791 (GRCm39) probably null Het
Cenpf A T 1: 189,384,568 (GRCm39) S2571T probably damaging Het
Cep162 A C 9: 87,109,290 (GRCm39) L438V probably benign Het
Cfap74 A T 4: 155,510,498 (GRCm39) N361I probably benign Het
Cntn5 A G 9: 9,743,633 (GRCm39) I548T probably damaging Het
Cracd A T 5: 76,988,610 (GRCm39) probably benign Het
Dglucy A G 12: 100,816,594 (GRCm39) N382S probably benign Het
Dnah10 C A 5: 124,907,557 (GRCm39) N4306K probably damaging Het
Fam181a A T 12: 103,282,937 (GRCm39) M281L probably benign Het
Fam186b A G 15: 99,176,751 (GRCm39) I713T possibly damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Fry A T 5: 150,323,053 (GRCm39) Y1068F probably benign Het
Fubp3 A G 2: 31,493,247 (GRCm39) I231V probably benign Het
Gbf1 A G 19: 46,272,735 (GRCm39) D1681G possibly damaging Het
Gm10999 G A 8: 129,858,130 (GRCm39) P5S probably damaging Het
Gm12689 T C 4: 99,184,402 (GRCm39) I85T unknown Het
Impg1 T C 9: 80,347,318 (GRCm39) I9V probably benign Het
Lama4 A G 10: 38,948,678 (GRCm39) probably null Het
Lamc1 A G 1: 153,109,310 (GRCm39) S1161P probably damaging Het
Lipm T A 19: 34,086,954 (GRCm39) probably null Het
Lrrc7 G T 3: 158,024,073 (GRCm39) N107K probably damaging Het
Lypd8 T C 11: 58,277,586 (GRCm39) S123P probably damaging Het
Man2a2 T C 7: 80,002,729 (GRCm39) D1084G probably damaging Het
Man2b2 A G 5: 36,964,519 (GRCm39) S1000P probably benign Het
Ms4a7 C T 19: 11,299,778 (GRCm39) C71Y probably benign Het
Mtus1 A G 8: 41,537,615 (GRCm39) S34P probably benign Het
Myo3b A G 2: 70,064,785 (GRCm39) N406S probably benign Het
Nbr1 A T 11: 101,463,290 (GRCm39) M586L probably benign Het
Nfatc1 C T 18: 80,693,070 (GRCm39) R677H probably benign Het
Nlrc3 A C 16: 3,781,899 (GRCm39) S503R probably damaging Het
Nlrp9c A T 7: 26,064,425 (GRCm39) F968I probably benign Het
Onecut1 A T 9: 74,770,614 (GRCm39) T346S probably damaging Het
Or1j12 A T 2: 36,343,455 (GRCm39) N286I probably damaging Het
Or8b35 G A 9: 37,904,307 (GRCm39) C168Y probably damaging Het
Or8g32 A G 9: 39,305,257 (GRCm39) N57D probably benign Het
Pclo A T 5: 14,730,966 (GRCm39) K3156M unknown Het
Pigo C T 4: 43,024,562 (GRCm39) probably null Het
Plcb4 T C 2: 135,809,072 (GRCm39) F580S probably damaging Het
Plekhm2 G T 4: 141,355,411 (GRCm39) P879H probably damaging Het
Ppm1e T A 11: 87,121,716 (GRCm39) Y747F probably benign Het
Ppwd1 A G 13: 104,361,952 (GRCm39) F69L possibly damaging Het
Prss27 C A 17: 24,257,287 (GRCm39) Q3K possibly damaging Het
Prss29 T A 17: 25,540,020 (GRCm39) N139K possibly damaging Het
Qrich2 T A 11: 116,339,191 (GRCm39) T1777S probably damaging Het
Rbp3 A T 14: 33,678,584 (GRCm39) H844L possibly damaging Het
Rubcnl G A 14: 75,269,471 (GRCm39) C43Y possibly damaging Het
Sec14l5 A G 16: 4,985,004 (GRCm39) probably null Het
Sepsecs A T 5: 52,801,356 (GRCm39) N435K probably damaging Het
Sfrp1 A G 8: 23,936,226 (GRCm39) K223E probably benign Het
Sh3tc2 G A 18: 62,106,502 (GRCm39) probably null Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Tmprss7 A G 16: 45,476,811 (GRCm39) F817S probably damaging Het
Tril T C 6: 53,796,632 (GRCm39) N197D probably damaging Het
Tspan18 T C 2: 93,040,207 (GRCm39) T183A probably benign Het
Uroc1 A T 6: 90,315,586 (GRCm39) M156L probably benign Het
Xpnpep1 A G 19: 52,983,950 (GRCm39) Y592H probably benign Het
Zfp553 T C 7: 126,836,202 (GRCm39) S586P probably benign Het
Zfp619 C T 7: 39,185,152 (GRCm39) A394V unknown Het
Zfp985 A G 4: 147,667,702 (GRCm39) Y190C probably benign Het
Zmynd10 T A 9: 107,427,536 (GRCm39) D309E probably benign Het
Zmynd15 T C 11: 70,352,646 (GRCm39) L73P probably damaging Het
Other mutations in Wnt16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Wnt16 APN 6 22,291,012 (GRCm39) missense probably damaging 1.00
IGL01306:Wnt16 APN 6 22,297,934 (GRCm39) missense probably damaging 0.99
IGL02297:Wnt16 APN 6 22,297,990 (GRCm39) nonsense probably null
ANU23:Wnt16 UTSW 6 22,297,934 (GRCm39) missense probably damaging 0.99
R0320:Wnt16 UTSW 6 22,297,992 (GRCm39) missense possibly damaging 0.68
R1671:Wnt16 UTSW 6 22,298,178 (GRCm39) missense probably damaging 1.00
R2342:Wnt16 UTSW 6 22,288,923 (GRCm39) missense probably damaging 1.00
R3437:Wnt16 UTSW 6 22,298,133 (GRCm39) missense probably damaging 0.99
R3786:Wnt16 UTSW 6 22,298,021 (GRCm39) missense probably benign
R5301:Wnt16 UTSW 6 22,297,848 (GRCm39) missense probably damaging 0.99
R5357:Wnt16 UTSW 6 22,291,231 (GRCm39) intron probably benign
R5843:Wnt16 UTSW 6 22,290,947 (GRCm39) missense probably damaging 0.99
R6655:Wnt16 UTSW 6 22,290,965 (GRCm39) missense probably damaging 1.00
R6731:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R6988:Wnt16 UTSW 6 22,288,510 (GRCm39) missense probably damaging 1.00
R7437:Wnt16 UTSW 6 22,288,560 (GRCm39) missense probably benign 0.17
R7904:Wnt16 UTSW 6 22,297,989 (GRCm39) missense probably damaging 1.00
R7919:Wnt16 UTSW 6 22,291,049 (GRCm39) missense probably benign 0.01
R7940:Wnt16 UTSW 6 22,291,188 (GRCm39) missense possibly damaging 0.78
R8071:Wnt16 UTSW 6 22,288,997 (GRCm39) missense probably benign
R9057:Wnt16 UTSW 6 22,288,823 (GRCm39) missense probably damaging 1.00
R9195:Wnt16 UTSW 6 22,297,932 (GRCm39) missense probably benign 0.00
R9618:Wnt16 UTSW 6 22,297,892 (GRCm39) nonsense probably null
R9618:Wnt16 UTSW 6 22,297,891 (GRCm39) nonsense probably null
R9781:Wnt16 UTSW 6 22,291,114 (GRCm39) missense probably damaging 1.00
Z1177:Wnt16 UTSW 6 22,288,587 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GCAGGCAACATGACCGAATG -3'
(R):5'- CGGAATTCAACTCGTATTAGTGG -3'

Sequencing Primer
(F):5'- GCAACATGACCGAATGTTCCTGTG -3'
(R):5'- TAGTCCATGCACACTCAGGAAGG -3'
Posted On 2016-10-06