Incidental Mutation 'R5468:Nlrp9c'
ID 433336
Institutional Source Beutler Lab
Gene Symbol Nlrp9c
Ensembl Gene ENSMUSG00000040614
Gene Name NLR family, pyrin domain containing 9C
Synonyms Nalp9c, Nalp-zeta
MMRRC Submission 043029-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5468 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 26064116-26103125 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 26064425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 968 (F968I)
Ref Sequence ENSEMBL: ENSMUSP00000083106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041845] [ENSMUST00000085944]
AlphaFold Q66X01
Predicted Effect probably benign
Transcript: ENSMUST00000041845
SMART Domains Protein: ENSMUSP00000036041
Gene: ENSMUSG00000040614

DomainStartEndE-ValueType
PYRIN 5 87 7.64e-22 SMART
Pfam:NACHT 143 310 5.2e-31 PFAM
LRR 637 664 4.36e1 SMART
Blast:LRR 666 691 3e-6 BLAST
LRR 693 720 1.02e0 SMART
LRR 722 749 3e0 SMART
LRR 750 777 6.88e-4 SMART
LRR 779 806 5.06e0 SMART
LRR 807 834 1.22e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000085944
AA Change: F968I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000083106
Gene: ENSMUSG00000040614
AA Change: F968I

DomainStartEndE-ValueType
PYRIN 5 87 7.64e-22 SMART
Pfam:NACHT 143 310 2.8e-31 PFAM
LRR 631 658 7.49e0 SMART
LRR 692 719 4.36e1 SMART
Blast:LRR 721 746 8e-6 BLAST
LRR 748 775 1.02e0 SMART
LRR 777 804 3e0 SMART
LRR 805 832 6.88e-4 SMART
LRR 834 861 2.17e0 SMART
LRR 862 889 2.12e-4 SMART
LRR 919 946 1.22e1 SMART
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700008O03Rik C T 7: 44,009,659 (GRCm39) R181Q probably damaging Het
Abca13 T A 11: 9,244,062 (GRCm39) L1975Q probably damaging Het
Acp2 T A 2: 91,036,443 (GRCm39) I180N probably benign Het
Adam12 T C 7: 133,577,202 (GRCm39) D221G probably damaging Het
Adamts4 A G 1: 171,080,178 (GRCm39) T244A probably benign Het
Adrb2 A T 18: 62,312,696 (GRCm39) I43N probably damaging Het
Anxa1 A T 19: 20,355,847 (GRCm39) Y207N probably damaging Het
Apba2 T C 7: 64,395,510 (GRCm39) L662P probably damaging Het
Arhgap18 T A 10: 26,788,667 (GRCm39) I593K probably damaging Het
Arsj T C 3: 126,232,037 (GRCm39) V261A possibly damaging Het
Atp7b A T 8: 22,549,986 (GRCm39) probably null Het
C2cd2 C T 16: 97,669,791 (GRCm39) probably null Het
Cenpf A T 1: 189,384,568 (GRCm39) S2571T probably damaging Het
Cep162 A C 9: 87,109,290 (GRCm39) L438V probably benign Het
Cfap74 A T 4: 155,510,498 (GRCm39) N361I probably benign Het
Cntn5 A G 9: 9,743,633 (GRCm39) I548T probably damaging Het
Cracd A T 5: 76,988,610 (GRCm39) probably benign Het
Dglucy A G 12: 100,816,594 (GRCm39) N382S probably benign Het
Dnah10 C A 5: 124,907,557 (GRCm39) N4306K probably damaging Het
Fam181a A T 12: 103,282,937 (GRCm39) M281L probably benign Het
Fam186b A G 15: 99,176,751 (GRCm39) I713T possibly damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Fry A T 5: 150,323,053 (GRCm39) Y1068F probably benign Het
Fubp3 A G 2: 31,493,247 (GRCm39) I231V probably benign Het
Gbf1 A G 19: 46,272,735 (GRCm39) D1681G possibly damaging Het
Gm10999 G A 8: 129,858,130 (GRCm39) P5S probably damaging Het
Gm12689 T C 4: 99,184,402 (GRCm39) I85T unknown Het
Impg1 T C 9: 80,347,318 (GRCm39) I9V probably benign Het
Lama4 A G 10: 38,948,678 (GRCm39) probably null Het
Lamc1 A G 1: 153,109,310 (GRCm39) S1161P probably damaging Het
Lipm T A 19: 34,086,954 (GRCm39) probably null Het
Lrrc7 G T 3: 158,024,073 (GRCm39) N107K probably damaging Het
Lypd8 T C 11: 58,277,586 (GRCm39) S123P probably damaging Het
Man2a2 T C 7: 80,002,729 (GRCm39) D1084G probably damaging Het
Man2b2 A G 5: 36,964,519 (GRCm39) S1000P probably benign Het
Ms4a7 C T 19: 11,299,778 (GRCm39) C71Y probably benign Het
Mtus1 A G 8: 41,537,615 (GRCm39) S34P probably benign Het
Myo3b A G 2: 70,064,785 (GRCm39) N406S probably benign Het
Nbr1 A T 11: 101,463,290 (GRCm39) M586L probably benign Het
Nfatc1 C T 18: 80,693,070 (GRCm39) R677H probably benign Het
Nlrc3 A C 16: 3,781,899 (GRCm39) S503R probably damaging Het
Onecut1 A T 9: 74,770,614 (GRCm39) T346S probably damaging Het
Or1j12 A T 2: 36,343,455 (GRCm39) N286I probably damaging Het
Or8b35 G A 9: 37,904,307 (GRCm39) C168Y probably damaging Het
Or8g32 A G 9: 39,305,257 (GRCm39) N57D probably benign Het
Pclo A T 5: 14,730,966 (GRCm39) K3156M unknown Het
Pigo C T 4: 43,024,562 (GRCm39) probably null Het
Plcb4 T C 2: 135,809,072 (GRCm39) F580S probably damaging Het
Plekhm2 G T 4: 141,355,411 (GRCm39) P879H probably damaging Het
Ppm1e T A 11: 87,121,716 (GRCm39) Y747F probably benign Het
Ppwd1 A G 13: 104,361,952 (GRCm39) F69L possibly damaging Het
Prss27 C A 17: 24,257,287 (GRCm39) Q3K possibly damaging Het
Prss29 T A 17: 25,540,020 (GRCm39) N139K possibly damaging Het
Qrich2 T A 11: 116,339,191 (GRCm39) T1777S probably damaging Het
Rbp3 A T 14: 33,678,584 (GRCm39) H844L possibly damaging Het
Rubcnl G A 14: 75,269,471 (GRCm39) C43Y possibly damaging Het
Sec14l5 A G 16: 4,985,004 (GRCm39) probably null Het
Sepsecs A T 5: 52,801,356 (GRCm39) N435K probably damaging Het
Sfrp1 A G 8: 23,936,226 (GRCm39) K223E probably benign Het
Sh3tc2 G A 18: 62,106,502 (GRCm39) probably null Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Tmprss7 A G 16: 45,476,811 (GRCm39) F817S probably damaging Het
Tril T C 6: 53,796,632 (GRCm39) N197D probably damaging Het
Tspan18 T C 2: 93,040,207 (GRCm39) T183A probably benign Het
Uroc1 A T 6: 90,315,586 (GRCm39) M156L probably benign Het
Wnt16 T C 6: 22,291,160 (GRCm39) V196A probably benign Het
Xpnpep1 A G 19: 52,983,950 (GRCm39) Y592H probably benign Het
Zfp553 T C 7: 126,836,202 (GRCm39) S586P probably benign Het
Zfp619 C T 7: 39,185,152 (GRCm39) A394V unknown Het
Zfp985 A G 4: 147,667,702 (GRCm39) Y190C probably benign Het
Zmynd10 T A 9: 107,427,536 (GRCm39) D309E probably benign Het
Zmynd15 T C 11: 70,352,646 (GRCm39) L73P probably damaging Het
Other mutations in Nlrp9c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00489:Nlrp9c APN 7 26,084,013 (GRCm39) missense probably benign 0.00
IGL00814:Nlrp9c APN 7 26,084,175 (GRCm39) missense probably benign 0.23
IGL00919:Nlrp9c APN 7 26,093,481 (GRCm39) nonsense probably null
IGL01762:Nlrp9c APN 7 26,084,850 (GRCm39) missense probably damaging 1.00
IGL01928:Nlrp9c APN 7 26,074,847 (GRCm39) splice site probably benign
IGL02008:Nlrp9c APN 7 26,084,576 (GRCm39) missense probably benign 0.16
IGL02389:Nlrp9c APN 7 26,093,632 (GRCm39) missense probably benign
IGL02535:Nlrp9c APN 7 26,071,522 (GRCm39) missense probably damaging 1.00
IGL02685:Nlrp9c APN 7 26,084,982 (GRCm39) missense probably damaging 0.98
IGL02904:Nlrp9c APN 7 26,074,715 (GRCm39) missense probably damaging 1.00
IGL02935:Nlrp9c APN 7 26,084,701 (GRCm39) missense probably benign 0.00
IGL03006:Nlrp9c APN 7 26,071,507 (GRCm39) missense probably damaging 0.98
IGL03140:Nlrp9c APN 7 26,079,914 (GRCm39) missense probably benign 0.30
IGL03201:Nlrp9c APN 7 26,084,533 (GRCm39) missense probably benign 0.00
IGL03243:Nlrp9c APN 7 26,064,457 (GRCm39) missense probably damaging 0.99
holy_grail UTSW 7 26,081,837 (GRCm39) missense probably benign
IGL03054:Nlrp9c UTSW 7 26,081,701 (GRCm39) splice site probably null
K7894:Nlrp9c UTSW 7 26,084,323 (GRCm39) missense possibly damaging 0.94
R0018:Nlrp9c UTSW 7 26,071,423 (GRCm39) missense possibly damaging 0.89
R0018:Nlrp9c UTSW 7 26,071,423 (GRCm39) missense possibly damaging 0.89
R0238:Nlrp9c UTSW 7 26,077,437 (GRCm39) missense possibly damaging 0.90
R0238:Nlrp9c UTSW 7 26,077,437 (GRCm39) missense possibly damaging 0.90
R0335:Nlrp9c UTSW 7 26,093,561 (GRCm39) missense possibly damaging 0.92
R0391:Nlrp9c UTSW 7 26,070,901 (GRCm39) splice site probably benign
R0433:Nlrp9c UTSW 7 26,085,244 (GRCm39) missense probably benign 0.20
R1035:Nlrp9c UTSW 7 26,070,702 (GRCm39) splice site probably benign
R1118:Nlrp9c UTSW 7 26,083,862 (GRCm39) missense probably benign 0.01
R1119:Nlrp9c UTSW 7 26,083,862 (GRCm39) missense probably benign 0.01
R1173:Nlrp9c UTSW 7 26,079,860 (GRCm39) missense probably damaging 1.00
R1519:Nlrp9c UTSW 7 26,077,526 (GRCm39) missense possibly damaging 0.88
R1528:Nlrp9c UTSW 7 26,081,723 (GRCm39) missense probably damaging 0.99
R1616:Nlrp9c UTSW 7 26,083,862 (GRCm39) missense probably benign 0.01
R1774:Nlrp9c UTSW 7 26,093,543 (GRCm39) missense probably benign 0.05
R1789:Nlrp9c UTSW 7 26,079,915 (GRCm39) missense probably benign 0.00
R1869:Nlrp9c UTSW 7 26,084,245 (GRCm39) nonsense probably null
R1870:Nlrp9c UTSW 7 26,084,245 (GRCm39) nonsense probably null
R1920:Nlrp9c UTSW 7 26,084,319 (GRCm39) missense probably damaging 1.00
R1987:Nlrp9c UTSW 7 26,077,481 (GRCm39) missense probably benign 0.31
R2022:Nlrp9c UTSW 7 26,084,221 (GRCm39) missense probably damaging 1.00
R2309:Nlrp9c UTSW 7 26,077,512 (GRCm39) missense probably damaging 1.00
R2327:Nlrp9c UTSW 7 26,074,747 (GRCm39) missense probably damaging 1.00
R3405:Nlrp9c UTSW 7 26,084,707 (GRCm39) missense probably benign 0.01
R3548:Nlrp9c UTSW 7 26,070,876 (GRCm39) missense probably damaging 1.00
R3846:Nlrp9c UTSW 7 26,081,701 (GRCm39) splice site probably null
R4179:Nlrp9c UTSW 7 26,084,086 (GRCm39) missense possibly damaging 0.74
R4460:Nlrp9c UTSW 7 26,077,523 (GRCm39) missense probably damaging 1.00
R4669:Nlrp9c UTSW 7 26,074,793 (GRCm39) missense possibly damaging 0.90
R4708:Nlrp9c UTSW 7 26,084,265 (GRCm39) missense probably benign 0.07
R4810:Nlrp9c UTSW 7 26,077,602 (GRCm39) splice site probably null
R4824:Nlrp9c UTSW 7 26,079,989 (GRCm39) missense possibly damaging 0.49
R4915:Nlrp9c UTSW 7 26,083,885 (GRCm39) missense probably benign 0.34
R4996:Nlrp9c UTSW 7 26,085,172 (GRCm39) missense possibly damaging 0.92
R5525:Nlrp9c UTSW 7 26,083,926 (GRCm39) missense probably damaging 1.00
R5526:Nlrp9c UTSW 7 26,081,791 (GRCm39) missense possibly damaging 0.95
R6020:Nlrp9c UTSW 7 26,084,150 (GRCm39) missense probably benign 0.08
R6175:Nlrp9c UTSW 7 26,077,426 (GRCm39) splice site probably null
R6454:Nlrp9c UTSW 7 26,085,199 (GRCm39) missense possibly damaging 0.91
R6493:Nlrp9c UTSW 7 26,081,812 (GRCm39) missense probably damaging 1.00
R6649:Nlrp9c UTSW 7 26,070,747 (GRCm39) missense probably damaging 1.00
R6653:Nlrp9c UTSW 7 26,070,747 (GRCm39) missense probably damaging 1.00
R6739:Nlrp9c UTSW 7 26,084,850 (GRCm39) missense probably damaging 0.99
R6883:Nlrp9c UTSW 7 26,077,556 (GRCm39) missense probably benign 0.18
R7097:Nlrp9c UTSW 7 26,085,046 (GRCm39) missense probably damaging 1.00
R7122:Nlrp9c UTSW 7 26,085,046 (GRCm39) missense probably damaging 1.00
R7174:Nlrp9c UTSW 7 26,084,722 (GRCm39) missense probably benign 0.03
R7365:Nlrp9c UTSW 7 26,070,822 (GRCm39) missense possibly damaging 0.93
R7378:Nlrp9c UTSW 7 26,064,440 (GRCm39) missense probably benign 0.14
R7427:Nlrp9c UTSW 7 26,070,860 (GRCm39) missense probably benign 0.00
R7450:Nlrp9c UTSW 7 26,064,364 (GRCm39) missense probably benign 0.45
R7999:Nlrp9c UTSW 7 26,084,914 (GRCm39) missense possibly damaging 0.94
R8036:Nlrp9c UTSW 7 26,070,864 (GRCm39) missense possibly damaging 0.49
R8056:Nlrp9c UTSW 7 26,085,112 (GRCm39) missense probably damaging 1.00
R8249:Nlrp9c UTSW 7 26,074,778 (GRCm39) nonsense probably null
R8729:Nlrp9c UTSW 7 26,071,428 (GRCm39) missense probably benign 0.12
R9012:Nlrp9c UTSW 7 26,074,733 (GRCm39) missense probably benign 0.18
R9104:Nlrp9c UTSW 7 26,081,837 (GRCm39) missense probably benign
R9106:Nlrp9c UTSW 7 26,081,837 (GRCm39) missense probably benign
R9129:Nlrp9c UTSW 7 26,077,428 (GRCm39) critical splice donor site probably null
R9519:Nlrp9c UTSW 7 26,085,302 (GRCm39) missense possibly damaging 0.91
RF020:Nlrp9c UTSW 7 26,084,649 (GRCm39) missense probably benign
X0065:Nlrp9c UTSW 7 26,079,855 (GRCm39) missense probably damaging 0.99
Z1177:Nlrp9c UTSW 7 26,084,250 (GRCm39) missense possibly damaging 0.54
Z1177:Nlrp9c UTSW 7 26,084,200 (GRCm39) missense probably damaging 1.00
Z1177:Nlrp9c UTSW 7 26,081,773 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- TGGTGTACAACTTGGGACAGG -3'
(R):5'- AAAGGGTCTCTACTCTCTGGG -3'

Sequencing Primer
(F):5'- TGTACAACTTGGGACAGGGTATAC -3'
(R):5'- GGATAGATTCCCAGGAATAGTCCTC -3'
Posted On 2016-10-06